Article
Oncology
Zhihao Lu, Yu Fang, Chang Liu, Xiaotian Zhang, Xiaowei Xin, Yi He, Yanshuo Cao, Xi Jiao, Tianqi Sun, Ying Pang, Yanli Wang, Jun Zhou, Changsong Qi, Jifang Gong, Xicheng Wang, Jian Li, Lili Tang, Lin Shen
Summary: The study evaluated the effect of early integration of interdisciplinary supportive care on overall survival in patients with metastatic EGC, showing that the integrated care group had longer overall survival and significant survival benefits. Further optimization and standardization of this approach are needed.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Bridget L. Nicholson, Linda Flynn, Beth Savage, Peijia Zha, Elissa Kozlov
Summary: Cancer is a leading cause of death in the US, and patients with metastatic cancer have a high symptom burden. Palliative care services are recommended to improve quality of life for these patients. This study aimed to identify predictors of palliative care use in patients with metastatic cancer, and found that pain and certain demographic factors influenced its use.
Article
Oncology
Brenna Mossman, Laura M. Perry, James I. Gerhart, Laurie E. McLouth, Ashley B. Lewson, Michael Hoerger
Summary: This study aims to investigate the role of emotional distress in palliative care avoidance. Results showed that patients with higher emotional distress had less favorable attitudes toward palliative care. In particular, anger was found to lead to more negative attitudes towards palliative care.
Article
Oncology
Estela Garcia-Martin, Vicente Escudero-Vilaplana, Barbara Fox, Roberto Collado-Borrell, Belen Marzal-Alfaro, Maria Sanchez-Isac, Maria Luisa Solano-Garzon, Ricardo Gonzalez del Val, Jose Manuel Cano-Gonzalez, Nuria Perez de Lucas, Ana Isabel Bravo-Guillen, Javier Valero-Salinas, Eva Gonzalez-Haba, Maria Sanjurjo, Miguel Martin
Summary: The study found that end-of-life cancer care in the clinical practice of the hospital tended to be aggressive, with a significant proportion of patients receiving anti-cancer treatments close to death. However, the quality of care did not meet the high standards set by the Earle criteria. While more than half of the patients received hospice services before death, in some cases, this care started only shortly before the patients passed away.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Respiratory System
Torsten Gerriet Blum, Rebecca L. Morgan, Valerie Durieux, Joanna Chorostowska-Wynimko, David R. Baldwin, Jeanette Boyd, Corinne Faivre-Finn, Francoise Galateau-Salle, Fernando Gamarra, Bogdan Grigoriu, Georgia Hardavella, Michael Hauptmann, Erik Jakobsen, Dragana Jovanovic, Paul Knaut, Gilbert Massard, John McPhelim, Anne-Pascale Meert, Robert Milroy, Riccardo Muhr, Luciano Mutti, Marianne Paesmans, Pippa Powell, Paul Martin Putora, Janette Rawlinson, Anna L. Rich, David Rigau, Dirk de Ruysscher, Jean-Paul Sculier, Arnaud Schepereel, Dragan Subotic, Paul Van Schil, Thomy Tonia, Clare Williams, Thierry Berghmans
Summary: This guideline provides good quality recommendations in lung cancer care, based on systematic reviews and evidence syntheses. The recommendations cover various quality improvement measures, such as avoiding delays in diagnosis and treatment, integrating multidisciplinary teams, adhering to guidelines, and using specific tools for decision-making. The recommendations should be periodically updated as new evidence becomes available.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Nutrition & Dietetics
Maurizio Muscaritoli, Jann Arends, Patrick Bachmann, Vickie Baracos, Nicole Barthelemy, Hartmut Bertz, Federico Bozzetti, Elisabeth Hutterer, Elizabeth Isenring, Stein Kaasa, Zeljko Krznaric, Barry Laird, Maria Larsson, Alessandro Laviano, Stefan Muhlebach, Line Oldervoll, Paula Ravasco, Tora S. Solheim, Florian Strasser, Marian de van der Schueren, Jean-Charles Preiser, Stephan C. Bischoff
Summary: This practical guideline is based on the current scientific ESPEN guidelines on nutrition in cancer patients, providing 43 recommendations for the nutritional and metabolic management of patients with neoplastic diseases. It offers guidance to health care providers involved in the management of cancer patients to offer optimal nutritional care.
CLINICAL NUTRITION
(2021)
Article
Health Care Sciences & Services
Kim C. van Teunenbroek, Leontien C. M. Kremer, A. A. Eduard Verhagen, Johannes M. A. Verheijden, Hester Rippen, Brigitt C. M. Borggreve, Erna M. C. Michiels, Renee L. Mulder
Summary: This paper presents the methodology and identified evidence for the revision of the Dutch paediatric palliative care guideline. The guideline was developed by a multidisciplinary panel of experts and parents, and evidence was gathered through literature searches.
BMC PALLIATIVE CARE
(2023)
Article
Psychology, Multidisciplinary
Serena Moscato, Vittoria Sichi, Andrea Giannelli, Pierpaolo Palumbo, Rita Ostan, Silvia Varani, Raffaella Pannuti, Lorenzo Chiari
Summary: This study assesses the effect of immersive VR-based intervention at home on anxiety, depression, and pain in cancer patients. Results showed no significant changes in anxiety, depression, and pain between the first and fourth days, but immediate improvement was observed in pain, depression, anxiety, well-being, and shortness of breath after VR sessions. Despite non-statistically significant changes, a progressive reduction in electrodermal activity was noted during and after VR sessions. This research suggests VR could be a beneficial complementary tool for psychological treatment in advanced cancer patients at home.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Oncology
Gunnhild Jakobsen, Kari Hanne Gjeilo, Marianne Jensen Hjermstad, Pal Klepstad
Summary: This review focuses on sleep in patients with advanced cancer. It highlights the impact of cancer-related factors on sleep and emphasizes the importance of sleep assessment for patient care. Sleep disturbance is common in cancer patients and can have a negative impact on their quality of life. However, sleep problems often go unrecognized and undertreated, calling for increased knowledge and awareness among healthcare providers.
Article
Oncology
Jean A. McDougall, Linda S. Cook, Mei-Tzu C. Tang, Hannah M. Linden, Beti Thompson, Christopher Li
Summary: This study found that instrumental social support, patient support services, and communication with doctors and their staff were associated with guideline concordance in early-stage breast cancer survivors. These factors could be potential targets for interventions aimed at improving breast cancer care delivery.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Obstetrics & Gynecology
Alexandra S. Bercow, J. Alejandro Rauh-Hain, Alexander Melamed, Varvara Mazina, Whitfield B. Growdon, Marcela G. del Carmen, Annekathryn Goodman, Sara Bouberhan, Amy Bregar, Eric L. Eisenhauer, George Molina, Christina Minami
Summary: This retrospective study aimed to describe the utilization of guideline-concordant inguinofemoral lymph node evaluation in individuals with early-stage vulvar cancer. The study found that older age, Black race, and care at a low-volume hospital were associated with lower odds of undergoing lymph node evaluation.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Orthopedics
Mary Insana Fisher, Joy C. Cohn, Shana E. Harrington, Jeanette Q. Lee, Daniel Malone
Summary: Cancer-related fatigue is a common side effect of cancer treatment. A clinical practice guideline provides recommendations for healthcare professionals to screen and assess fatigue, with ten screening and 15 assessment tools recommended.
Review
Gastroenterology & Hepatology
Puneeta Tandon, Anne Walling, Heather Patton, Tamar Taddei
Summary: Palliative Care is an approach focusing on improving the quality of life for patients facing life-limiting illness, applicable in cirrhosis patients. However, there is limited guidance and promotion of PC in patients with cirrhosis.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Oncology
David Hui, Kari Bohlke, Ting Bao, Toby C. Campbell, Patrick J. Coyne, David C. Currow, Arjun Gupta, Aliza L. Leiser, Masanori Mori, Stefano Nava, Lynn F. Reinke, Eric J. Roeland, Carole Seigel, Declan Walsh, Margaret L. Campbell
Summary: This study provides guidance on the clinical management of dyspnea in adult patients with advanced cancer, including nonpharmacologic and pharmacologic interventions to alleviate dyspnea.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Alireza Irajpour, Maryam Hashemi, Fariba Taleghani
Summary: This study aimed to adapt a guideline for end-of-life care in cancer patients for use by healthcare teams through modification of the ADAPTE process, qualitative study, and consensus ratings. The adapted guideline included 85 recommendations based on source guidelines and qualitative study results, which were reviewed and categorized by a multidisciplinary panel of experts.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Medicine, General & Internal
Andy Bradshaw, Lesley Dunleavy, Ian Garner, Nancy Preston, Sabrina Bajwah, Rachel Cripps, Lorna K. Fraser, Matthew Maddocks, Mevhibe Hocaoglu, Fliss E. M. Murtagh, Adejoke O. Oluyase, Katherine E. Sleeman, Irene J. Higginson, Catherine Walshe
Summary: This study explores the experiences and impact of palliative care staff working during the COVID-19 pandemic. The findings reveal that infection control constraints hindered the ability of staff to provide care aligned with their core values, resulting in moral distress. Despite organizational and team support, the prolonged management of these constraints led to cumulative impacts of moral distress and sometimes burnout. Solidarity with colleagues and making valued contributions provided some moral comfort.
JOURNAL OF THE ROYAL SOCIETY OF MEDICINE
(2022)
Article
Health Care Sciences & Services
Joanne Bayly, Andy Bradshaw, Lucy Fettes, Muhammed Omarjee, Helena Talbot-Rice, Catherine Walshe, Katherine E. Sleeman, Sabrina Bajwah, Lesley Dunleavy, Mevhibe Hocaoglu, Adejoke Oluyase, Ian Garner, Rachel L. Cripps, Nancy Preston, Lorna K. Fraser, Fliss E. M. Murtagh, Irene J. Higginson, Matthew Maddocks
Summary: This study found that rehabilitation services in palliative care during the Covid-19 pandemic mostly shifted to remote provision, with many team members being on sick leave, redeployed, or furloughed. Free text responses were categorized into four themes showing how rehabilitation services adapted and reconfigured to the challenges posed by Covid-19, affecting both clinicians' and patients' capacity to participate in rehabilitation programs.
PALLIATIVE MEDICINE
(2022)
Article
Respiratory System
Malgorzata Krajnik, Nilay Hepgul, Andrew Wilcock, Ewa Jassem, Tomasz Bandurski, Silvia Tanzi, Steffen T. Simon, Irene J. Higginson, Caroline J. Jolley
Summary: Respiratory medicine and palliative care physicians have different approaches in managing chronic breathlessness, with PC physicians more likely to use opioids and benzodiazepines, while RM physicians focus more on exercise training. Physicians who have read non-cancer palliative care guidelines tend to adopt certain treatment methods more frequently.
BMC PULMONARY MEDICINE
(2022)
Article
Primary Health Care
Javiera Leniz, Martin Gulliford, Irene J. Higginson, Sabrina Bajwah, Deokhee Yi, Wei Gao, Katherine E. Sleeman
Summary: This study aimed to explore factors associated with hospital admissions among people dying with dementia. The study found that patients with more GP contacts had a higher risk of multiple hospital admissions, while higher continuity of care and identification of palliative care needs were associated with a lower frequency of these admissions.
BRITISH JOURNAL OF GENERAL PRACTICE
(2022)
Editorial Material
Critical Care Medicine
J. Randall Curtis, Irene J. Higginson, Douglas B. White
INTENSIVE CARE MEDICINE
(2022)
Article
Health Care Sciences & Services
Bridget M. Johnston, Barbara Daveson, Charles Normand, Karen Ryan, Melinda Smith, Regina McQuillan, Irene Higginson, Lucy Selman, Katy Tobin
Summary: This study evaluated the preferences of older patients for elements of palliative care services and found that they prioritize minimizing the burden on unpaid caregivers, easy access to services, and high quality of life. This provides evidence for prioritizing and evaluating service elements in palliative care delivery models.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Article
Health Care Sciences & Services
Eve Namisango, Katherine Bristowe, Fliss E. M. Murtagh, Julia Downing, Richard A. Powell, Mackuline Atieno, Melanie Abas, Zipporah Ali, Emmanuel B. K. Luyirika, Michelle Meiring, Faith N. Mwangi-Powell, Irene J. Higginson, Richard Harding
Summary: This study evaluates the face and content validity, comprehensiveness, comprehensibility, acceptability, and feasibility of the Children's Palliative Care Outcome Scale (C-POS). The results show that C-POS captures the core symptoms and concerns that matter to children and their families. It is considered feasible, comprehensible, and acceptable for use in clinical settings. However, further development and improvement are needed.
PALLIATIVE MEDICINE
(2022)
Article
Medicine, General & Internal
Javiera Leniz, Lesley A. Henson, Jean Potter, Wei Gao, Tom Newsom-Davis, Zia Ul-Haq, Amanda Lucas, Irene J. Higginson, Katherine E. Sleeman
Summary: The study found that increased contacts with community nurses were associated with fewer hospital admissions in the last 30 days and fewer emergency department visits in the last 2 weeks for people with end-of-life cancer. However, increased contacts with general practitioners were associated with a higher risk of more hospital admissions in the last 90 days and more emergency department visits in the last 2 weeks. Therefore, expanding community nursing could potentially reduce acute hospital use at the end of life.
Article
Respiratory System
Deokhee Yi, Charles C. Reilly, Gao Wei, Irene J. Higginson
Summary: This study found that breathlessness services were cost-effective compared to usual care, resulting in cost savings and improved quality of life. Additionally, tailoring service attributes to individual preferences increased the uptake of these services.
Article
Health Care Sciences & Services
Tushti Bhardwaj, Rachel L. Chambers, Harry Watson, Irene J. Srividya, Irene J. Higginson, Mevhibe B. Hocaoglu
Summary: This study aimed to translate and culturally adapt the Integrated Palliative Care Outcome Scale (IPOS) into Hindi. Through a standardized methodology, the Hindi IPOS was developed and found to have face and content validity for clinical practice and research. The availability of the Hindi IPOS has implications beyond Indian palliative care settings, as it provides millions of Hindi speakers with a tool to communicate their palliative care needs in their mother tongue.
PALLIATIVE MEDICINE
(2023)
Letter
Respiratory System
Natasha Lovell, Simon N. Etkind, Joanna M. Davies, Wendy Prentice, Irene J. Higginson, Katherine E. Sleeman
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Health Care Sciences & Services
Javiera Leniz, Joanna M. Davies, Anna E. Bone, Mevhibe Hocaoglu, Julia Verne, Stephen Barclay, Fliss E. M. Murtagh, Lorna K. Fraser, Irene J. Higginson, Katherine E. Sleeman
Summary: The number and proportion of home deaths in the UK increased during the Covid-19 pandemic, with evidence of socioeconomic inequality. The increase in home deaths was lowest for people living in the most deprived areas, showing a deprivation gradient. Further research is needed to understand the reasons for this change and if the inequality has been sustained. Overall rating: 7 points.
PALLIATIVE MEDICINE
(2023)
Review
Respiratory System
Claire M. Nolan, Lisa Jane Brighton, Yihan Mo, Joanne Bayly, Irene J. Higginson, William D. -C. Man, Matthew Maddocks
Summary: This systematic review examined the effect of meditative movement on breathlessness, quality of life, exercise capacity, functional performance, and psychological symptoms in advanced disease. The results showed that meditative movement did not improve breathlessness, quality of life, or exercise capacity in people with advanced COPD or cancer.
EUROPEAN RESPIRATORY REVIEW
(2023)
Article
Respiratory System
Charles C. Reilly, Matthew Maddocks, Trudie Chalder, Katherine Bristowe, Irene J. Higginson
Summary: SELF-BREATHE is a digital breathlessness intervention that aims to improve the lives of people with chronic breathlessness. This study found that SELF-BREATHE was feasible to deliver and acceptable to patients, with users reporting improved breathlessness during daily life.
Article
Health Care Sciences & Services
Hannah May Scott, Lucy Coombes, Debbie Braybrook, Anna Roach, Daney Hardardottir, Katherine Bristowe, Clare Ellis-Smith, Irene Higginson, Wei Gao, Myra Bluebond-Langner, Bobbie Farsides, Fliss E. M. Murtagh, Lorna K. Fraser, Richard Harding
Summary: The COVID-19 pandemic and lockdowns have had a negative impact on children and young people with life-limiting or life-threatening conditions and their families, resulting in loss of social support, disruption of vital services, and increased psychological distress.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)