Article
Multidisciplinary Sciences
Bolun Zhou, Fenglong Bie, Ruochuan Zang, Moyan Zhang, Peng Song, Lei Liu, Yue Peng, Guangyu Bai, Qilin Huai, Yuan Li, Liang Zhao, Shugeng Gao
Summary: This study provides a comprehensive analysis of the global geographic patterns and temporal trends in the mortality and incidence of oesophageal cancer. The results show that the mortality and incidence trends have significantly decreased in most countries of South America and Asia, but varied in European countries. The study highlights the importance of implementing preventative efforts for populations with rising mortality and incidence trends.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Eileen Morgan, Isabelle Soerjomataram, Anna T. Gavin, Mark J. Rutherford, Piers Gatenby, Aude Bardot, Jacques Ferlay, Oliver Bucher, Prithwish De, Gerda Engholm, Christopher Jackson, Serena Kozie, Alana Little, Bjorn Moller, Lorraine Shack, Hanna Tervonen, Vicky Thursfield, Sally Vernon, Paul M. Walsh, Ryan R. Woods, Christian Finley, Neil Merrett, Dianne L. O'Connell, John Reynolds, Freddie Bray, Melina Arnold
Summary: The survival of esophageal cancer has significantly improved over the past 20 years in participating countries, especially for adenocarcinoma, younger age groups, and the first year after diagnosis. Australia and Ireland consistently showed higher survival rates. However, further advancements in early detection and treatment are needed for specific groups and patients with squamous cell carcinoma.
Article
Engineering, Environmental
Adele Folino, Domenica Pangallo, Paolo Salvatore Calabro
Summary: Bioplastics are increasingly used as substitutes for conventional plastics to tackle plastic pollution. International standard methods identify the criteria for compostable and/or biodegradable bioplastics. However, biodegradation occurs under diverse conditions, and research aims to estimate biodegradation under simulated natural conditions.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Oncology
Ville E. J. Sirvio, Jari V. Rasanen, Joonas H. Kauppila
Summary: The prognosis of esophageal cancer has improved in Finland over the last 30 years, with significant increases in survival rates for patients undergoing esophagectomy. However, the prognosis for patients not undergoing surgery remains poor.
Review
Chemistry, Medicinal
Szu-Ying Ho, Che-Mai Chang, Hsin-Ni Liao, Wan-Hsuan Chou, Chin-Lin Guo, Yun Yen, Yusuke Nakamura, Wei-Chiao Chang
Summary: Cancer immunotherapies use drugs or cells to activate patients' immune systems against cancer cells, and cancer vaccines have rapidly developed based on tumor-specific antigens. These vaccines can activate cytotoxic T cells using messenger RNA or synthetic peptides, with or without dendritic cells. Neoantigen-based cancer vaccines show great promise, but the immune recognition and activation processes through the histocompatibility complex and T-cell receptor are still not clear. This article describes the features of neoantigens, the validation process, and recent progress in the development and clinical applications of neoantigen-based cancer vaccines.
Review
Medicine, General & Internal
Luigi Marano, Luigi Verre, Ludovico Carbone, Gianmario Edoardo Poto, Daniele Fusario, Dario Francesco Venezia, Natale Calomino, Karolina Kazmierczak-Siedlecka, Karol Polom, Daniele Marrelli, Franco Roviello, Johnn Henry Herrera Kok, Yogesh Vashist
Summary: Gastric cancer is the fifth most frequently diagnosed cancer, and surgery is the main treatment. Quality assurance and centralization of healthcare are still under international debate. The limitations of a single variable to define the ideal postoperative period and the importance of a multidimensional measure called textbook outcome are highlighted. Patients should have access to transparent and easily available hospital data for better decision-making.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Chemistry, Analytical
Shreya Singh Beniwal, Paula Lamo, Ajeet Kaushik, Dionisio Lorenzo Lorenzo-Villegas, Yuguang Liu, Arunsundar Mohanasundaram
Summary: Colorectal cancer is a prevalent and potentially fatal disease, and effective diagnostic strategies are needed. Microfluidic diagnostics offer non-invasive real-time monitoring of disease progression and treatment response. Advancements in microfluidic technology and integration with artificial intelligence hold promise for accurate, efficient, and personalized strategies to improve patient outcomes and transform cancer management.
Review
Health Care Sciences & Services
Loredana G. Marcu, David C. Marcu
Summary: Chemoradiotherapy remains the most common treatment for locally advanced head and neck cancer, but the quality of life and long-term survival of patients undergoing this treatment are still poor. Personalized therapy through multi-omics approach shows promising results in improving tumor response and reducing normal tissue toxicity. Incorporating dosiomics, pharmacomics, and radiomics into head and neck cancer management offers multiple viewpoints for personalized therapy.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Oncology
Mariona Riudavets, Marta Garcia de Herreros, Benjamin Besse, Laura Mezquita
Summary: Indoor radon is a significant risk factor for lung cancer, especially in non-smokers. This review discusses the potential association between indoor radon exposure and non-small cell lung cancer (NSCLC) with driver genomic alterations.
Review
Oncology
Mary E. Booth, Elizabeth C. Smyth
Summary: Initial studies have shown limited improvement in survival for immune checkpoint inhibitors in unselected gastro-oesophageal cancer. However, recent clinical trials suggest that immunotherapies may offer significant clinical benefit in certain populations. The heterogeneity of gastro-oesophageal cancer in terms of histopathological and molecular features makes it important to identify the populations most likely to benefit from immune checkpoint inhibitors. Programmed death-ligand 1 expression is an important biomarker, but its threshold for determining benefits varies across trials. Patients with certain characteristics, such as microsatellite instability, high tumour mutational burden, and Epstein-Barr Virus positivity, are more likely to benefit from immunotherapy even in programmed death-ligand 1-negative populations.
Review
Oncology
Jinyan Liu, Yi Zhang
Summary: Cancer is a complex disease with multiple factors contributing to its development and progression. Recent research has shown that the microbiome, particularly the intestinal and intratumor microbiome, plays a significant role in cancer, promoting tumor formation and immune evasion, and affecting the efficacy of cancer treatment.
BIOMARKER RESEARCH
(2022)
Review
Cell Biology
Wensi Liu, Haichao Tang, Luanfeng Li, Xiangyi Wang, Zhaojin Yu, Jianping Li
Summary: Peptide-based therapeutic cancer vaccines have gained attention in tumor immunotherapy by targeting antigens through stimulating T cell responses. The use of adjuvants and nanomaterials can enhance vaccine efficacy. Combining peptide-based vaccines with other therapies has shown superior efficacy in clinical applications.
CELL PROLIFERATION
(2021)
Review
Cell Biology
Yiyuan Yang, Fengyan Yuan, Huiqin Zhou, Jing Quan, Chongyang Liu, Yi Wang, Fen Xiao, Qiao Liu, Jie Liu, Yujing Zhang, Xing Yu
Summary: Heparanase (HPSE) is an enzyme that degrades heparan sulfate proteoglycans, and its activity is associated with tumor growth and angiogenesis. In this review, the roles and mechanisms of HPSE in cancer progression are systematically reviewed. Additionally, potential therapeutic strategies targeting HPSE, including HPSE inhibitors in clinical trials, are discussed.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Oncology
Franz Ludwig Dumoulin, Ralf Hildenbrand, Tsuneo Oyama, Ingo Steinbruck
Summary: Diagnosis of esophageal adenocarcinoma and squamous cell cancer often occur during surveillance for reflux disease or Barrett's metaplasia and other indications. Optimal detection is achieved with high definition and dye chromoendoscopy. Different resection techniques and criteria apply to each type of cancer, with curative resection criteria varying based on the maximum infiltration depth and other factors. Ablation of remaining Barrett's metaplasia is also important to reduce the risk of metachronous cancer.
Review
Health Care Sciences & Services
Ivo I. de Vos, Henk B. Luiting, Monique J. Roobol
Summary: Active surveillance (AS) emerged as a treatment modality to combat overtreatment of indolent, low-risk prostate cancer (PCa) due to increased PSA screening. This paper reviews the evolution of AS and its current landscape and challenges.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)