Article
Oncology
Michaela Patton, Victoria J. Forster, Caitlin Forbes, Mehak Stokoe, Melanie Noel, Linda E. Carlson, Kathryn A. Birnie, Kathleen Reynolds, Fiona Schulte
Summary: The study focused on describing rates and dimensions of pain, identifying patterns of chronic pain, and testing correlates of chronic pain in LTSCC. Results showed that 26% of LTSCC reported chronic pain, with factors like posttraumatic stress symptoms, age, and pain catastrophizing being significant predictors. Regular screening for chronic pain in survivors of childhood cancer is recommended for long-term follow-up care.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Cristina Priboi, Marloes van Gorp, Heleen Maurice-Stam, Gisela Michel, Leontien C. M. Kremer, Wim J. E. Tissing, Jacqueline J. Loonen, Helena J. H. van der Pal, Andrica C. H. de Vries, Marry M. van den Heuvel-eibrink, Cecile M. Ronckers, Dorine Bresters, Marloes Louwerens, Sebastian J. C. C. M. Neggers, Margriet van der van der Loo, Eline van Dulmen-den Broeder, Martha Grootenhuis
Summary: This study examined the psychosexual development, sexual functioning, and sexual satisfaction of childhood cancer survivors (CCS), as well as the determinants for these outcomes. The results showed that one third of CCS reported hindered sexuality due to childhood cancer, with body perception being the most commonly reported reason. Age, education, cancer type, mental health, and body perception were identified as determinants for sexual debut, sexual functioning, and sexual satisfaction. Emerging adult CCS had less experience with psychosexual development compared to references, but similar sexual functioning and satisfaction.
Article
Oncology
Eric J. Chow, Sanjeev Aggarwal, David R. Doody, Richard Aplenc, Saro H. Armenian, K. Scott Baker, Smita Bhatia, Nancy Blythe, Steven D. Colan, Louis S. Constine, David R. Freyer, Lisa M. Kopp, Caroline Laverdiere, Wendy M. Leisenring, Nao Sasaki, Lynda M. Vrooman, Barbara L. Asselin, Cindy L. Schwartz, Steven E. Lipshultz
Summary: Through evaluating four randomized trials of children with acute lymphoblastic leukemia or Hodgkin lymphoma and a nonrandomized trial of patients with osteosarcoma, it was found that dexrazoxane has cardioprotective effects for survivors of childhood cancer treated with doxorubicin, even after nearly 20 years.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Agnes Dumas, Karen Milcent, Nicolas Bougas, Daniel Bejarano-Quisoboni, Chiraz El Fayech, Helene Charreire, Odile Oberlin, Catherine Patte, Julie Allard, Eric Thebault, Amel Boumaraf, Amel Belhout, Vu-Bezin Giao, Vincent Souchard, Angela Jackson, Rodrigue Allodji, Dominique Valteau-Couanet, Christelle Dufour, Gilles Vassal, Nadia Haddy, Florent De Vathaire, Brice Fresneau
Summary: The study found that patients who received combined chemotherapy and radiotherapy, had bone sarcoma, central nervous system primitive tumor, or underwent autologous hematopoietic cell transplant were more likely to attend long-term follow-up visits. Additionally, factors such as health status, medical expenses, social status, and distance from the follow-up center also influenced attendance.
Article
Oncology
Kristine Eidal Tanem, Einar Stensvold, Petter Wilberg, Anne B. Skaare, Preet Bano Singh, Petter Brandal, Bente Brokstad Herlofson
Summary: This study investigated taste and smell function in survivors of childhood MB/CNS-PNET using objective measurements. The results showed impaired taste and smell function in some survivors, although subjective ratings did not reflect these objective findings.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Timothy J. D. Ohlsen, Huiqi Wang, David Buchbinder, I-Chan Huang, Arti D. Desai, Zhiyuan Zheng, Anne C. Kirchhoff, Elyse R. Park, Kevin Krull, Rena M. Conti, Yutaka Yasui, Wendy Leisenring, Gregory T. Armstrong, K. Robin Yabroff, Paul C. Nathan, Eric J. Chow
Summary: Adult siblings of childhood cancer survivors may experience greater aspects of financial hardship compared with the general population. Childhood cancer may adversely affect entire households, with potentially lasting implications.
Article
Anesthesiology
Perri R. Tutelman, Christine T. Chambers, Laura Cornelissen, Conrad Fernandez, Annette Flanders, Julia MacLeod, Simon B. Sherry, Sherry H. Stewart, Robin Urquhart, Sitara de Gagne, Gregory M. T. Guilcher, Javeria Hashmi, Lauren C. Heathcote, Melanie Noel, Fiona S. M. Schulte, Jennifer N. Stinson, Maya Stern
Summary: Cancer and its treatment have long-term consequences on pain and sensory processing in survivors of childhood cancer. This study utilized a standardized quantitative sensory testing protocol to quantify the differences in pain and sensory processing in survivors compared to reference data. The results showed that survivors exhibited reduced sensitivity and a significant minority experienced pain sensitization. Several risk factors for changes in sensory processing were identified. Further research is needed to understand the long-term implications of altered somatosensation in this population.
Article
Oncology
Natassia Robinson, John Casement, Marc J. Gunter, Inge Huybrechts, Antonio Agudo, Miguel Rodriguez Barranco, Fabian Eichelmann, Theron Johnson, Rudolf Kaaks, Valeria Pala, Salvatore Panico, Torkjel M. Sandanger, Matthias B. Schultze, Ruth C. Travis, Rosario Tumino, Paolo Vineis, Elisabete Weiderpass, Roderick Skinner, Linda Sharp, Jill A. McKay, Gordon Strathdee
Summary: This study identifies widespread DNA methylation changes in childhood cancer patients post-treatment, which may have long-term retention. Adult survivors also exhibit epigenetic age acceleration, independent of DMR methylation. Altered methylation at the DUSP6 DMR is significantly associated with early mortality. These findings highlight the importance of these methylation changes as potential biomarkers for assessing treatment toxicity and predicting long-term health outcomes in childhood cancer survivors.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Wassim Chemaitilly, Zhenghong Li, Tara M. Brinkman, Angela Delaney, Sujuan Huang, Kari L. Bjornard, Catherine G. Lam, Carmen L. Wilson, Nicole Barnes, Karen L. Clark, Matthew J. Krasin, Monika L. Metzger, Anthony Sheyn, Michael W. Bishop, Noah D. Sabin, Rebecca M. Howell, Sara Helmig, Barry L. Shulkin, Brandon M. Triplett, Ching-Hong Pui, Amar Gajjar, Deo Kumar Srivastava, Daniel M. Green, Gregory T. Armstrong, Leslie L. Robison, Melissa M. Hudson, Kristen K. Ness, Charles A. Sklar, Kevin R. Krull
Summary: This study examined the prevalence and risk factors of primary hypothyroidism in childhood cancer survivors, and found associations with physical frailty, dyslipidemia, impaired physical quality of life, and having health care insurance. The impact of thyroid hormone replacement practices on these outcomes should be further investigated.
Article
Oncology
Janette L. Vardy, Gregory R. Pond, Lucette A. Cysique, Thomas M. Gates, Jim Lagopoulos, Corrinne Renton, Louise M. Waite, Ian F. Tannock, Haryana M. Dhillon
Summary: There was no difference in cognitive capacity and function between CRC survivors and controls 6-12 years after diagnosis. Differences in neuroimaging require confirmation in a larger sample.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Solveig K. Smedsland, Kathrine F. Vandraas, Synne K. Bohn, Alv A. Dahl, Cecilie E. Kiserud, Mette Brekke, Ragnhild S. Falk, Kristin Reinertsen
Summary: This study aimed to assess the sexual health of breast cancer survivors and explore factors associated with sexual inactivity and reduced sexual functioning. The results showed that half of breast cancer survivors were sexually inactive, with lack of interest being the most common reason. Treatment with aromatase inhibitor and poor body image were associated with sexual inactivity.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Pediatrics
Melissa M. Hudson, Smita Bhatia, Jacqueline Casillas, Wendy Landier
Summary: Advancements in cancer therapy have improved survival rates for children, adolescents, and young adults with cancer, but they are still at risk for long-term therapy-related complications. Therefore, ongoing systematic follow-up and health counseling are crucial to early detection and intervention for potential late-onset complications, as well as promoting healthy lifestyles to reduce risks for common adult health problems. Healthcare providers play a key role in the ongoing care of childhood cancer survivors, beyond routine preventive care, health supervision, and guidance.
Article
Oncology
Esmee C. M. Kooijmans, Helena J. H. van der Pal, Saskia M. F. Pluijm, Margriet Van der Heiden-van der Loo, Leontien C. M. Kremer, Dorine Bresters, Eline Van Dulmen-den Broeder, Marry M. Van den Heuvel-Eibrink, Jacqueline J. Loonen, Marloes Louwerens, Sebastian J. C. Neggers, Cecile Ronckers, Wim J. E. Tissing, Andrica C. H. de Vries, Gertjan J. L. Kaspers, Arend Bokenkamp, Margreet A. Veening
Summary: This study investigated the occurrence of tubular dysfunction in childhood cancer survivors who received nephrotoxic therapy. The overall prevalence of electrolyte losses in survivors was not higher compared to controls, but some survivors had an increased risk of tubular dysfunction, especially those treated with specific chemotherapeutic agents. Therefore, these patients should be closely monitored during follow-up.
Article
Medicine, General & Internal
Shai Babecoff, Florence Mermillod, Denis Marino, Angele Gayet-Ageron, Marc Ansaria, Eugenio Fernandez, Fabienne Gumy-Pause
Summary: The study describes a long-term personalized follow-up program for childhood cancer survivors in Switzerland. It highlights the significant number of chronic health conditions these survivors face and the importance of multidisciplinary and patient-specific medical follow-up. The program received high satisfaction ratings from patients and/or their parents.
SWISS MEDICAL WEEKLY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Tushar Patni, Chun-Teh Lee, Yimei Li, Sue Kaste, Liang Zhu, Ryan Sun, Melissa M. Hudson, Kirsten K. Ness, Ana Neumann, Leslie L. Robison
Summary: This study investigated the associations between clinical, socioeconomic, and demographic factors and oral diseases in childhood cancer survivors. The results showed that survivors had a higher prevalence of microdontia, abnormal root development, hypodontia, enamel hypoplasia, xerostomia, severe gingivitis, and missing teeth compared to controls. Cancer treatment, socioeconomic factors, and access to oral health care contributed to the prevalence of dental abnormalities.
Article
Health Care Sciences & Services
Camelia Rohani, Heidar-Ali Abedi, Kay Sundberg, Ann Langius-Ekloef
HEALTH AND QUALITY OF LIFE OUTCOMES
(2015)
Article
Medicine, General & Internal
Ylva Tiblom Ehrsson, Kay Sundberg, Goeran Laurell, Ann Langius-Eklof
UPSALA JOURNAL OF MEDICAL SCIENCES
(2015)
Article
Oncology
Karin Blomberg, Yvonne Wengstrom, Kay Sundberg, Maria Browall, Ann-Kristin Isaksson, Maria Halleberg Nyman, Ann Langius-Eklof
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2016)
Article
Oncology
Tina Gustavell, Kay Sundberg, Catharina Frank, Yvonne Wengstrom, Maria Browall, Ralf Segersvard, Ann Langius-Eklof
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2017)
Article
Health Care Sciences & Services
Maria Halleberg Nyman, Catharina Frank, Ann Langius-Eklof, Karin Blomberg, Kay Sundberg, Yvonne Wengstrom
JMIR MHEALTH AND UHEALTH
(2017)
Article
Oncology
Tina Gustavell, Kay Sundberg, Ralf Segersvard, Yvonne Wengstrom, Ann Langius-Eklof
Article
Medicine, General & Internal
Helge Brandberg, Thomas Kahan, Jonas Spaak, Kay Sundberg, Sabine Koch, Athena Adeli, Carl Johan Sundberg, David Zakim
Article
Oncology
Maria Fjell, Ann Langius-Eklof, Marie Nilsson, Yvonne Wengstrom, Kay Sundberg
Article
Health Care Sciences & Services
Marie-Therese Crafoord, Maria Fjell, Kay Sundberg, Marie Nilsson, Ann Langius-Eklof
JOURNAL OF MEDICAL INTERNET RESEARCH
(2020)
Article
Health Care Sciences & Services
Tina Gustavell, Kay K. Sundberg, Ann Langius-Eklof
JMIR MHEALTH AND UHEALTH
(2020)
Review
Nursing
Kay Sundberg, Marie Nilsson, Lena-Marie Petersson, Elisabeth Kenne Sarenmalm, Ann Langius-Eklof
Summary: The concept of sense of coherence has been widely applied in clinical nursing, showing a significant relationship between a higher sense of coherence and better emotional and psychosocial well-being, quality of life, and overall well-being. Future research should focus on rigorous intervention studies to determine if recognizing patients' degree of sense of coherence enables tailored care in clinical nursing.
JOURNAL OF CLINICAL NURSING
(2022)
Correction
Health Care Sciences & Services
Marie-Therese Crafoord, Maria Fjell, Kay Sundberg, Marie Nilsson, Ann Langius-Eklof
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Health Care Sciences & Services
Linda Gellerstedt, Ann Langius-Eklof, Nazmije Kelmendi, Kay Sundberg, Asa G. Craftman
Summary: This study explores the experiences of men diagnosed with prostate cancer after opportunistic screening. The findings reveal differing opinions on screening and highlight the lack of routine screening as an injustice. The challenges faced during diagnosis and the mixed emotions that come with receiving a cancer diagnosis are also discussed. Men often feel hesitant to openly discuss their diagnosis due to the intimate nature of the condition.
HEALTH EXPECTATIONS
(2022)
Article
Health Care Sciences & Services
Kay Sundberg, Athena Adeli, Helge Brandberg, Jonas Spaak, Sabine Koch, Carl J. Sundberg, David Zakim, Thomas Kahan, Kaisa Fritzell
Summary: Most patients had a positive experience with the CLEOS program in the ED setting, although some found it to be extensive. Adjustments to the extent of the interview for better adaptation to the clinical setting should be the future development of the program.
HEALTH EXPECTATIONS
(2022)
Article
Oncology
Ann Langius-Eklof, Mats Christiansen, Veronica Lindstrom, Karin Blomberg, Maria Halleberg Nyman, Yvonne Wengstrom, Kay Sundberg
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)