Article
Medicine, General & Internal
Amir Qaseem, Curtis S. Harrod, Carolyn J. Crandall, Timothy J. Wilt
Summary: This article provides guidance for clinicians on screening asymptomatic average-risk adults for colorectal cancer. It presents recommendations on the age to start screening, age range for screening, screening methods, and when to stop screening, based on recently published and critically appraised clinical guidelines.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Kandice A. Kapinos, Ethan A. Halm, Caitlin C. Murphy, Noel O. Santini, Adam C. Loewen, Celette Sugg Skinner, Amit G. Singal
Summary: This study compared the cost-effectiveness of mailed fecal immunochemical test (FIT) kits and invitations to complete a screening colonoscopy for colorectal cancer (CRC) screening. The results showed that while mailed FIT kits were less expensive, they resulted in fewer months of screening compliance and detected fewer advanced neoplasia compared to colonoscopy invitations.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Multidisciplinary Sciences
Leonie Diedrich, Melanie Brinkmann, Maren Dreier, Siegbert Rossol, Wendelin Schramm, Christian Krauth
Summary: This systematic review analyzes the cost-effectiveness of sigmoidoscopy compared to other screening methods for colorectal cancer. The combination of sigmoidoscopy and annual stool testing is found to be a cost-effective screening strategy.
Article
Medicine, General & Internal
Zainab Aziz, Sophie Wagner, Alice Agyekum, Yoanna S. Pumpalova, Matthew Prest, Francesca Lim, Sheila Rustgi, Fay Kastrinos, William M. Grady, Chin Hur
Summary: Despite recommendations for universal screening, adherence to colorectal cancer screening in the US is low. This study evaluated the cost-effectiveness of liquid biopsy for colorectal cancer screening and found that colonoscopy was the most cost-effective strategy, while liquid biopsy was not cost-effective at its current cost and screening performance.
Article
Gastroenterology & Hepatology
Robert Benamouzig, Stephanie Barre, Jean-Christophe Saurin, Henri Leleu, Alexandre Vimont, Sabrine Taleb, Frederic De Bels
Summary: For colorectal cancer screening in high-risk individuals, colonoscopy is the most effective strategy but associated with high costs. Sigmoidoscopy and FIT at lower thresholds with higher participation rates may be considered as cost-effective alternatives.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Article
Oncology
Berbel L. M. Ykema, Andrea Gini, Lisanne S. Rigter, Manon C. W. Spaander, Leon M. G. Moons, Tanya M. Bisseling, Jan Paul de Boer, Wieke H. M. Verbeek, Pieternella J. Lugtenburg, Cecile P. M. Janus, Eefke J. Petersen, Judith M. Roesink, Richard W. M. van der Maazen, Berthe M. P. Aleman, Gerrit A. Meijer, Flora E. van Leeuwen, Petur Snaebjornsson, Beatriz Carvalho, Monique E. van Leerdam, Iris Lansdorp-Vogelaar
Summary: Colorectal cancer surveillance is cost-effective for Hodgkin lymphoma survivors, and it should start earlier than population screening programs. FIT surveillance is the most cost-effective strategy for all subgroups.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Review
Gastroenterology & Hepatology
Aasma Shaukat, Theodore R. Levin
Summary: This Review provides an overview of current CRC screening options worldwide, including colonoscopy and stool-based tests. It also highlights the key features of each modality and describes new screening tests under development.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Lapo Sali, Leonardo Ventura, Mario Mascalchi, Massimo Falchini, Beatrice Mallardi, Francesca Carozzi, Stefano Milani, Marco Zappa, Grazia Grazzini, Paola Mantellini
Summary: This study compared single CT colonography with three rounds of FIT for colorectal cancer screening, finding that the high participation rate of FIT screening makes it more efficient in detecting colorectal cancer compared to CT colonography.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Yinan Ren, Mingye Zhao, Dachuang Zhou, Qian Xing, Fangfang Gong, Wenxi Tang
Summary: This study evaluated the cost-effectiveness of colorectal cancer screening in China and found that FIT screening can save costs, while colonoscopy is cost-effective. In specific regions, high-income areas could consider strategies with more frequent electronic colonoscopy.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Gastroenterology & Hepatology
Fanny E. R. Vuik, Stella A. Nieuwenburg, Sarah Moen, Cristiano Spada, Carlo Senore, Cesare Hassan, Marco Pennazio, Emanuele Rondonotti, Silvia Pecere, Ernst J. Kuipers, Manon C. W. Spaander
Summary: CCE shows potential advantages in CRC screening, with comparable accuracy to colonoscopy in detecting CRC and polyps. Its sensitivity is superior to CTC, but improvement is needed in completion rates.
Article
Radiology, Nuclear Medicine & Medical Imaging
Anu E. Obaro, Andrew A. Plumb, Steve Halligan, Susan Mallett, Paul Bassett, Paul McCoubrie, Rachel Baldwin-Cleland, Carmen Ugarte-Cano, Phillip Lung, Janice Muckian, Rajapandian Ilangovan, Arun Gupta, Charlotte Robinson, Antony Higginson, Ingrid Britton, Rebecca Greenhalgh, Uday Patel, Evgenia Mainta, Anmol Gangi, Stuart A. Taylor, David Burling
Summary: This study aimed to investigate the impact of a one-day individualized training program on the diagnostic sensitivity of experienced radiologists in detecting 6-mm or larger lesions in CT colonography (CTC) scans, as well as the durability of the improvement and any associated factors. The results showed that the training intervention led to a significant improvement in sensitivity, and this improvement was maintained at 6 and 12 months after the intervention.
Review
Oncology
Shailavi Jain, Jetrina Maque, Artin Galoosian, Antonia Osuna-Garcia, Folasade P. May
Summary: Colorectal cancer (CRC) is a significant health issue that can be largely prevented through evidence-based screening strategies. The US Preventive Services Task Force recommends screening to start at age 45 and provides several recommended screening options. There are also emerging screening modalities for the detection of colorectal polyps and/or CRC. In order to improve screening uptake, informed decision-making and consideration of various factors are important in determining the most appropriate screening test. Health systems should also implement strategies to maximize screening participation.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Han-Mo Chiu, Grace Hsiao-Hsuan Jen, Ying-Wei Wang, Jean Ching-Yuan Fann, Chen-Yang Hsu, Ya-Chung Jeng, Amy Ming-Fang Yen, Sherry Yueh-Hsia Chiu, Sam Li-Sheng Chen, Wen-Feng Hsu, Yi-Chia Lee, Ming-Shiang Wu, Chien-Yuan Wu, Yann-Yuh Jou, Tony Hsiu-Hsi Chen
Summary: A large-scale population-based biennial FIT screening showed a significant 34% reduction in advanced-stage CRCs and a 40% reduction in death from CRC, with greater long-term effectiveness in the distal colon. The findings provide strong and consistent evidence-based policy support for sustainable population-based FIT organized service screening worldwide.
Review
Economics
Rajani Pokharel, Yi-Shu Lin, Ethna McFerran, James F. O'Mahony
Summary: This study examined the range of strategies used in European cost-effectiveness analyses of colorectal cancer screening, and concluded that the widely adopted biennial frequency of stool-based testing is suboptimal, and more frequent annual screening could potentially save more lives.
APPLIED HEALTH ECONOMICS AND HEALTH POLICY
(2023)
Article
Public, Environmental & Occupational Health
Han-Mo Chiu, Chiu-Wen Su, Weng-Feng Hsu, Grace Hsiao-Hsuan Jen, Chen-Yang Hsu, Sam Li-Sheng Chen, Hsiu-Hsi Chen
Summary: This study surveyed key indicators of CRC screening in individual countries in the Asia-Pacific region in 2019 and 2020, and simulated the impact of the pandemic on the effectiveness of CRC screening. Prolonged pauses in screening were found to lead to a 6% decrease in effectiveness in reducing CRC mortality. Screening organizers should coordinate with health authorities to address screening backlogs.
PREVENTIVE MEDICINE
(2021)
Article
Medicine, Research & Experimental
Raymond Stegeman, Maaike Nijman, Johannes M. P. J. Breur, Floris Groenendaal, Felix Haas, Jan B. Derks, Joppe Nijman, Ingrid M. van Beynum, Yannick J. H. J. Taverne, Ad J. J. C. Bogers, Willem A. Helbing, Willem P. de Boode, Arend F. Bos, Rolf M. F. Berger, Ryan E. Accord, Kit C. B. Roes, G. Ardine de Wit, Nicolaas J. G. Jansen, Manon J. N. L. Benders
Summary: This study aims to investigate whether administering allopurinol to neonates with critical congenital heart disease can reduce brain injury and improve neurodevelopmental outcomes. The study will be a 4-week trial, with interventions using allopurinol or placebo, to assess the impact on brain injury, cardiac function, and neurodevelopmental outcomes.
Article
Public, Environmental & Occupational Health
Niek Mouter, Annamarie de Ruijter, G. Ardine de Wit, Mattijs S. Lambooij, Maarten van Wijhe, Job van Exel, Roselinde Kessels
Summary: The willingness to take a COVID-19 vaccine is high among adults in the Netherlands, but a considerable proportion prefers to delay their decision to vaccinate until experiences of others are known. Age, education level, and vaccine attributes influence the willingness to vaccinate.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Adrienne H. Rotteveel, Mattijs S. Lambooij, Job van Exel, G. Ardine de Wit
Summary: This study examined the viewpoints on active disinvestment among citizens in the Netherlands and found that viewpoint support is associated with citizens' background characteristics. Financial situation, educational level, healthcare utilization, and opinions on government responsibility and healthcare costs were all related to viewpoint support.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Economics
Niek Mouter, Sander Boxebeld, Roselinde Kessels, Maarten van Wijhe, Ardine de Wit, Mattijs Lambooij, Job van Exel
Summary: The study shows that Dutch citizens generally prefer policies that reward vaccination rather than punish those who reject the vaccine. Vaccinated individuals are more willing to accept policies, while those who reject vaccination have a more negative view towards them. However, vaccination passports receive widespread support.
Article
Medicine, Research & Experimental
Anouk E. Hiensch, Evelyn M. Monninkhof, Martina E. Schmidt, Eva M. Zopf, Kate A. Bolam, Neil K. Aaronson, Jon Belloso, Wilhelm Bloch, Dorothea Clauss, Johanna Depenbusch, Milena Lachowicz, Mireia Pelaez, Helene Rundqvist, Elzbieta Senkus, Martijn M. Stuiver, Mark Trevaskis, Ander Urruticoechea, Friederike Rosenberger, Elsken van der Wall, G. Ardine de Wit, Philipp Zimmer, Yvonne Wengstrom, Karen Steindorf, Anne M. May
Summary: This study aims to evaluate the effects of a 9-month structured and individualized exercise intervention on quality of life, fatigue, and other side effects in patients with metastatic breast cancer. If proven effective, exercise should be offered as part of standard care for these patients.
Review
Oncology
Ella D. van Vliet, Anouk H. Eijkelboom, Anoukh van Giessen, Sabine Siesling, G. Ardine de Wit
Summary: This systematic review examines the effects of COVID-19 induced delays in oncological care on the physical and mental health outcomes of cancer patients. The results show varying impacts on tumor stage distribution and mental health, and suggest the need for more longitudinal observational data to draw more conclusive results on mortality and other health outcomes.
FRONTIERS IN ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Ian P. Smith, Chiara L. Whichello, Jorien Veldwijk, Maureen P. M. H. Rutten-van Molken, C. G. M. Groothuis-Oudshoorn, Rimke C. Vos, Esther W. de Bekker-Grob, G. Ardine de Wit
Summary: This study aimed to assess the relative value adults with diabetes assign to device attributes in the Netherlands and Poland. The results showed that the monthly out-of-pocket costs were the most important attribute for patients in both countries. Polish patients were more likely to choose a glucose-monitoring device and had higher willingness to pay (WTP). Dutch patients had higher WTP for device improvements in effort to check and reducing the number of finger pricks.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Review
Health Care Sciences & Services
Marjolein Duijvestijn, G. Ardine de Wit, Paul F. F. van Gils, G. C. Wanda Wendel-Vos
Summary: This systematic review examines the relationship between physical inactivity and healthcare costs. The included studies show that physical inactivity is associated with higher healthcare costs in the general population. However, aversion of physical inactivity-related diseases may lead to increased healthcare costs in life-years gained.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Oncology
Laurens S. ter Maat, Isabella A. J. van Duin, Sjoerd G. Elias, Tim Leiner, Joost J. C. Verhoeff, Eran R. A. N. Arntz, Max F. Troenokarso, Willeke A. M. Blokx, Ivana Isgum, Geraldine A. de Wit, Franchette W. P. J. van den Berkmortel, Marye J. Boers-Sonderen, Martijn F. Boomsma, Fons J. M. van den Eertwegh, Jan Willem B. de Groot, Djura Piersma, Art Vreugdenhil, Hans M. Westgeest, Ellen Kapiteijn, Paul J. van Diest, Josien P. W. Pluim, Pim A. de Jong, Karijn P. M. Suijkerbuijk, Mitko Veta
Summary: This study investigated the value of radiomics in predicting the clinical benefit of checkpoint inhibitors in melanoma patients. The radiomics model had limited predictive ability and was unable to surpass a simple clinical model. Future research should focus on the application of deep learning and multimodal approaches to accurately predict the efficacy of checkpoint inhibitor treatment in melanoma patients.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Marije Oosterhoff, Lisanne H. J. A. Kouwenberg, Adrienne H. Rotteveel, Ella D. van Vliet, Niek Stadhouders, G. Ardine de Wit, Anoukh van Giessen
Summary: This study aimed to quantify the health impact of delayed elective care for non-COVID patients during the COVID-19 pandemic. A model was developed using hospital registry data to estimate the backlog of surgical procedures and the associated non-generated Quality-adjusted life years (QALYs). The results highlight the significant health losses caused by delayed surgeries and have implications for policy evaluations and resource allocation.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Medicine, General & Internal
Joline L. H. de Sevaux, Roger A. M. J. Damoiseaux, Saskia Hullegie, Elisabeth A. M. Sanders, G. Ardine de Wit, Nicolaas P. A. Zuithoff, Lucy Yardley, Sibyl Anthierens, Paul Little, Alastair D. Hay, Anne G. M. Schilder, Roderick P. Venekamp
Summary: This study aims to investigate whether adding analgesic ear drops to usual care can provide better relief for ear pain in children with acute otitis media (AOM) presenting to primary care. The trial will recruit 300 children aged 1-6 years with a diagnosis of AOM and ear pain. The study will assess outcomes such as ear pain score, antibiotic use, duration of pain, GP reconsultations, adverse events, complications of AOM, and cost-effectiveness over a 4-week follow-up period. The results will be published in medical journals and presented at scientific meetings.
Article
Health Care Sciences & Services
Vikas Soekhai, Bas Donkers, Jennifer Viberg Johansson, Cecilia Jimenez-Moreno, Cathy Anne Pinto, G. Ardine de Wit, Esther de Bekker-Grob
Summary: This study compares the outcomes of two methods, discrete choice experiments and BWS-2, in terms of treatment preference weights and relative importance scores. The overall results show differences in attribute importance rankings between the two methods. Latent class analysis reveals similar latent classes in both methods, although there are differences in specific attributes. Careful consideration and pilot testing are necessary when choosing the appropriate method for a specific decision context.
PATIENT-PATIENT CENTERED OUTCOMES RESEARCH
(2023)
Article
Health Care Sciences & Services
Ian P. Smith, Chiara L. Whichello, Esther W. de Bekker-Grob, Maureen P. M. H. Rutten-van Moelken, Jorien Veldwijk, G. Ardine de Wit
Summary: This study found that providing patients with video-based educational materials does not necessarily lead to higher patient engagement or different preference outcomes compared to traditional text-based information. Increasing patient engagement with educational materials should be a focus of future research.
PATIENT-PATIENT CENTERED OUTCOMES RESEARCH
(2023)
Article
Health Care Sciences & Services
Rachael L. Disantostefano, Ian P. Smith, Marie Falahee, Aura Cecilia Jimenez-Moreno, Serena Oliveri, Jorien Veldwijk, G. Ardine de Wit, Ellen M. Janssen, Conny Berlin, Catharina G. M. Groothuis-Oudshoorn
Summary: This study aimed to identify prioritized topics and questions relating to health preferences based on the perspective of members of the preference research community. The survey results indicated that the research focus should be on preference synthesis, transferability across populations or related diseases, and comparison of methods. Furthermore, there were differences in research priorities among different stakeholders, highlighting the need for discussion and alignment.
PATIENT-PATIENT CENTERED OUTCOMES RESEARCH
(2023)
Article
Health Care Sciences & Services
Kirsten Visscher, Lisanne H. J. A. Kouwenberg, Marije Oosterhoff, Adrienne H. Rotteveel, G. Ardine de Wit
Summary: Dutch citizens experienced postponed healthcare during the COVID-19 pandemic, with women, individuals with chronic diseases, high-income individuals, and those with poor self-reported health being more likely to be affected. Postponed healthcare resulted in negative health effects, particularly for individuals with chronic conditions and low income levels.
FRONTIERS IN HEALTH SERVICES
(2023)
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)