Article
Medicine, General & Internal
Cathrine Fonnesbech Hjorth, Per Damkier, Bent Ejlertsen, Timothy Lash, Henrik Toft Sorensen, Deirdre Cronin-Fenton
Summary: This study aimed to investigate how socioeconomic position influences the effectiveness of cancer-directed treatment in premenopausal breast cancer patients, and found that patients with lower socioeconomic status had an increased risk of mortality, but not always recurrence.
Article
Oncology
M. T. Faber, T. A. Horsbol, L. Baandrup, S. O. Dalton, S. K. Kjaer
Summary: Ovarian/tubal cancer survival showed significant improvements over time for all histological types except mucinous tumors. There was an increase in relative survival and corresponding decrease in excess mortality for all categories of socioeconomic status except for women with localized disease in the lowest income group. The impact of histology and socioeconomic status on all-cause mortality depended on time since diagnosis.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Medicine, General & Internal
Elin Ekblom-Bak, Emil Bojsen-Moller, Peter Wallin, Sofia Paulsson, Magnus Lindwall, Helene Rundqvist, Kate A. Bolam
Summary: Cardiorespiratory fitness (CRF) levels are an important risk factor for cancer incidence and death. A cohort study in Swedish men showed that moderate and high CRF were associated with a lower risk of colon cancer, while higher CRF levels were associated with a higher risk of prostate cancer incidence.
Article
Oncology
Line Hjollund Pedersen, Friederike Erdmann, Gitte Lerche Aalborg, Lisa Lyngsie Hjalgrim, Hanne Baekgaard Larsen, Kjeld Schmiegelow, Jeanette Falck Winther, Susanne Oksbjerg Dalton
Summary: The study found that children from families with low socioeconomic status, parents with short education, and mixed workforce affiliation had more frequent healthcare contacts in the last 3 months before cancer diagnosis. Children of parents with depression or non-Western origin also had higher odds of frequent healthcare contacts. However, there was no association between socioeconomic status, parental health, and stage of disease.
Article
Oncology
Charlotte Salmon, Amelie Quesnel-Vallee, Tracie A. Barnett, Andrea Benedetti, Marie-Soleil Cloutier, Geetanjali D. Datta, Yan Kestens, Belinda Nicolau, Marie-Elise Parent
Summary: A study found that men living in socially deprived neighborhoods have an increased risk of prostate cancer, with higher risks for those who are divorced, widowed, or living alone. These findings suggest the need for targeted public health interventions.
BRITISH JOURNAL OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Zsofia Kuronya, Georgina Frohlich, Andrea Ladanyi, Tamas Martin, Lajos Geczi, Fruzsina Gyergyai, Orsolya Horvath, Gergo Kiszner, Agnes Kovacs, Tamas Dienes, Eniko Lenart, Krisztian Nagyivanyi, Tibor Szarvas, Mihaly Szonyi, Attila Toth, Krisztina Biro
Summary: The study in Hungary found a higher mortality rate for TGCC in lower social quartiles, with patient delay associated with more advanced stage in non-seminoma patients. These findings highlight the impact of socioeconomic status on the diagnosis and treatment outcomes of TGCC patients.
Article
Oncology
Cecilie Dovey de la Cour, Christian Munk, Gitte Lerche Aalborg, Susanne Kruger Kjaer
Summary: The incidence of base-of-tongue/tonsillar cancer has increased in Denmark over the past 25 years, regardless of educational level and age group. In contrast, the trends for laryngeal cancer show social inequality, with a decrease in incidence among individuals with medium and high education, and an increase among those with low education.
Article
Oncology
Maneet Kaur, Corinne E. Joshu, Kala Visvanathan, Avonne E. Connor
Summary: Breast cancer incidence rates have been increasing across race/ethnicity and subgroups in the United States, with the highest average annual percent increases observed among non-Hispanic Black women. Non-Hispanic Black women and Hispanic women also showed significant increases in some subgroups.
Article
Public, Environmental & Occupational Health
Charlotte Sturley, Paul Norman, Michelle Morris, Amy Downing
Summary: This study found an association between socio-economic status (SES) and colorectal cancer (CRC) incidence and survival, both at the individual and area levels. Individual-level factors such as educational attainment, social class, and housing tenure, as well as area-level deprivation, were found to be related to CRC incidence and survival. These findings highlight the importance of considering SES in public health interventions for CRC.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Immunology
Andreas Ronit, Lars H. Omland, Gitte Kronborg, Gitte Pedersen, Lars Nielsen, Rajesh Mohey, Lothar Wiese, Niels Obel, Magnus G. Ahlstrom
Summary: Incidence of chronic obstructive pulmonary disease is higher in people with HIV and their parents and siblings than in population controls. The most important determinants explaining this seem to be cigarette smoking and low socioeconomic status.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Gastroenterology & Hepatology
Robert J. Wong, Sammy Saab, Peter Konyn, Vinay Sundaram, Mandana Khalili
Summary: The study found that HCC incidence was higher in lower income areas and regions with lower urbanicity among US adults, likely due to differences in risk factors, health behaviors, and barriers in access to healthcare services.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Hye Yeon Koo, Su-Min Jeong, Mi Hee Cho, Sohyun Chun, Dong Wook Shin, Jinsung Park
Summary: Aspirin and metformin use may be associated with lower prostate cancer incidence and mortality, while statins are not associated with either.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Sarah M. Sorensen, Cecilie D. de la Cour, Thomas Maltesen, Aivara Urbute, Susanne K. Kjaer
Summary: The incidence of thyroid cancer in Denmark has increased over the past decades, regardless of educational and income levels.
Article
Oncology
Ariana Znaor, Niels Erik Skakkebaek, Ewa Rajpert-De Meyts, Tomislav Kulis, Mathieu Laversanne, Jason Gurney, Diana Sarfati, Katherine A. McGlynn, Freddie Bray
Summary: Testicular cancer is the most common cancer in young men of European ancestry and has been increasing in incidence, although mortality rates have been declining in high-income settings. Globally, testicular cancer is the most common cancer in men aged 15 to 44, with the highest incidence rates in Western, Northern, and Southern Europe and Oceania, and the lowest rates in Asia and Africa. Mortality rates are highest in Central and South America, and lowest in Northern Europe, Northern Africa, and Eastern Asia. There is significant variation in incidence and mortality rates among different countries.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Tina Bech Olesen, Freja L. Sand, Gitte L. Aalborg, Christian Munk, Susanne K. Kjaer
Summary: Research in Denmark showed a gradual increase in high-grade penile intraepithelial neoplasia cases, while the 5-year relative survival rate of penile squamous cell carcinoma remained relatively stable. Increased exposure to HPV infection may have contributed to the rise in high-grade PeIN and penile SCC.
CANCER CAUSES & CONTROL
(2022)
Article
Nursing
Kristoffer Marsaa, Janni Mendahl, Henriette Heilman, Helene Johansson, Mette Husum, Dorthe Lippert, Niels Sandholm, Hanne Konradsen
Summary: This study investigated the psychosocial stress among nursing staff working on the COVID-19 wards, highlighting the experiences of frontline health care workers facing major work changes. The findings emphasize the importance of continuous managerial attention and support to address increasing burden and uncertainty among nursing staff during the outbreak.
JOURNAL OF HOSPICE & PALLIATIVE NURSING
(2021)
Article
Psychology, Developmental
Beverley Lim Hoeg, Jane Christensen, Linda Banko, Kirsten Frederiksen, Charlotte Weiling Appel, Susanne Oksbjerg Dalton, Atle Dyregrov, Mai-Britt Guldin, Sanne Ellegaard Jorgensen, Martin Lytje, Per Boge, Pernille Envold Bidstrup
Summary: Losing a parent to cancer increases the risk of psychotropic medication use, especially when the parent and child have the same gender and the parent dies within a year of diagnosis. The highest risk occurs during the first six months after the loss.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Oncology
Annika von Heymann, Sierra Alef-Defoe, Hanin Salem, Elisabeth Anne Wreford Andersen, Susanne Oksbjerg Dalton, Kjeld Schmiegelow, Karin A. W. Wadt, Jeanette Falck Winther, Christoffer Johansen, Pernille Envold Bidstrup
Summary: This study attempts to document the impact of childhood cancer on parents' somatic health for the first time. Except for an increased risk of neoplasms, likely due to shared genetic or lifestyle factors, our findings suggest that caring for a child with cancer does not generally increase parents' risk for somatic diseases.
Article
Psychology, Developmental
Pernille E. Bidstrup, Hanin Salem, Elisabeth Wreford Andersen, Kjeld Schmiegelow, Steen Rosthoj, Peder Skov Wehner, Henrik Hasle, Susanne O. Dalton, Christoffer Johansen, Anne E. Kazak
Summary: This study aimed to evaluate the effect of the FAMOS family therapy program on reducing parent-reported medical traumatic stress in pediatric cancer survivors aged 2-5 years. The results showed that children in the intervention group experienced significant decreases in trauma-related behaviors at 6 and 12 months, and this effect was partly mediated through reduced symptoms of depression in mothers.
JOURNAL OF PEDIATRIC PSYCHOLOGY
(2023)
Article
Respiratory System
Kristoffer Marsaa, Janni Mendahl, Steen Nielsen, Lotte Mork, Per Sjogren, Geana Paula Kurita
Summary: Palliative medicine traditionally focuses on cancer patients, but with the increasing number of people with serious illnesses, especially lung diseases, the need for palliative care for these patients is also growing. Currently, there is a lack of research and clinical knowledge about palliative care for patients with chronic obstructive pulmonary disease and interstitial lung disease. This paper presents an easy-to-use and clinically relevant model for palliative care in severe illnesses.
EUROPEAN CLINICAL RESPIRATORY JOURNAL
(2022)
Article
Oncology
Ingrid C. Andersen, Volkert Siersma, Kristoffer Marsaa, Nikolaj Preisel, Asbjorn Hoegholm, John Brodersen, Uffe Bodtger
Summary: This study explored the psychosocial consequences of patients choosing to receive the results of lung cancer workup in-person or by telephone. The results showed that patients' choice of communication modality did not affect psychosocial outcomes, supporting the use of a simple model for preparing patients for potential bad news.
Review
Health Care Sciences & Services
Nanna Maria Hammer, Pernille Envold Bidstrup, Jesper Brok, Minna Devantier, Per Sjogren, Kjeld Schmiegelow, Anders Larsen, Geana Paula Kurita, Marianne Olsen, Hanne Baekgaard Larsen
Summary: This systematic review examined the impact of home-based specialized pediatric palliative care (SPPC) and found that receiving home-based SPPC was associated with an increased likelihood of home death, potentially improved quality of life, and reduced symptom burden. However, the limited number of studies and a high risk of bias in the included studies contribute to a low overall strength of evidence.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Health Care Sciences & Services
Nanna Maria Hammer, Helena Hansson, Line Hjollund Pedersen, Maja Abitz, Per Sjogren, Kjeld Schmiegelow, Pernille Envold Bidstrup, Hanne Baekgaard Larsen, Marianne Olsen
Summary: This study explores the key elements of home-based end-of-life care collaboration for children with cancer, as experienced by their parents, grandparents, and professionals. The study identified five main themes and developed a Home-Based Pediatric End-of-Life Care Model for Children with Cancer, providing a framework for optimizing home-based end-of-life care services for these children and their families.
PALLIATIVE MEDICINE
(2023)
Article
Nursing
Ulla Riis Madsen, Christian Bach Biesbjerg, Tina Broby Mikkelsen, Kristoffer Marsaa, Ann-Dorthe Olsen Zwisler, Thomas Vedste Aagaard
Summary: This study examines whether the fully tax-financed Danish healthcare system provides equal access to rehabilitation for patients with major lower extremity amputations. The results show significant geographic inequality in the provision of rehabilitation services, including prosthetic rehabilitation and psychosocial rehabilitation.
SCANDINAVIAN JOURNAL OF CARING SCIENCES
(2023)
Article
Rehabilitation
Sidsel Marie Bernt Jorgensen, Nina Fons Johnsen, Thomas Maribo, Stig Brondum, Gunnar Gislason, Maria Kristiansen
Summary: The study highlights the need for vocational rehabilitation programs to be incorporated into comprehensive cardiac rehabilitation programs in order to identify individuals in need of support and to improve coordination of care across healthcare and social care sectors. This includes involving employers, healthcare professionals, and social workers in personalized return-to-work strategies.
DISABILITY AND REHABILITATION
(2023)
Article
Oncology
Nanna Maria Hammer, Marianne Olsen, Hanne Baekgaard Larsen, Elisabeth Wreford Andersen, Susanne Oksbjerg Dalton, Trine Allerslev Horsbol, Pernille Envold Bidstrup
Summary: Parents who lose a child with cancer are at increased risk of reduced labor market affiliation. Younger parental age, lower education, and being a single parent were identified as the main determinants of the bereaved parents' reduced labor market affiliation.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Health Care Sciences & Services
Jens-Jakob Kjer Moller, Karen la Cour, Marc Sampedro Pilegaard, Susanne Oksbjerg Dalton, Pernille Bidstrup, Soeren Moeller, Lene Jarlbaek
Summary: This study investigates the use of physical rehabilitation and specialised palliative care services among different cohorts of cancer patients, with a focus on patients with incurable cancer and the impact of social vulnerability. The findings show that physical rehabilitation services are used throughout the cancer trajectory, while contacts regarding specialised palliative care increase significantly as the patient approaches death. The study also identifies disparities in service utilization, with socially vulnerable patients having less contact with palliative care and socially non-vulnerable patients using rehabilitation services more.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Article
Oncology
Anne Sofie Friberg, Sigrid V. V. Carlsson, Andrew J. J. Vickers, Susanne Oksbjerg Dalton, Signe Benzon Larsen, Lena Saltbaek, Beverley Lim Hoeg, Pernille Envold Bidstrup, Thomas Helgstrand, Andreas Roder, Klaus Brasso, Christoffer Johansen
Summary: The study examined the risk of suicide among prostate cancer patients compared to cancer-free men, taking into consideration clinical stage, socioeconomic position, somatic comorbidity, and previous depression. The risk of suicide was found to be similar between prostate cancer patients and cancer-free men, but it was highest within the first year after diagnosis. Prostate cancer patients with a history of depression had a higher risk of suicide. Healthcare professionals should pay attention to the risk of suicide among men with previous depression following a prostate cancer diagnosis.
Article
Oncology
Helle Pappot, Benony P. Bjoernsson, Oswin Krause, Christina Baeksted, Pernille E. Bidstrup, Susanne O. Dalton, Christoffer Johansen, Ann Knoop, Ivan Vogelius, Cecilie Hollander-Mieritz
Summary: By analyzing ePRO data using Machine Learning algorithms and permutation importance, this study found that symptoms such as aching joints and numbness/tingling may be important factors leading to nonadherence to planned adjuvant chemotherapy in breast cancer patients.
Article
Public, Environmental & Occupational Health
Gitte Wind, Helle Wendner Vedsegaard, Kristoffer Marsaa, Trine Solander True, Hanne Konradsen
Summary: This study explores the significance of the COVID-19 pandemic for family caregivers of non-COVID-19 patients. The findings indicate that the pandemic has had a significant impact on family caregivers, causing emotional despair.
INTERNATIONAL JOURNAL OF QUALITATIVE STUDIES ON HEALTH AND WELL-BEING
(2022)
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)
