Article
Multidisciplinary Sciences
Ayse Arik, Erengul Dodd, Andrew Cairns, George Streftaris
Summary: The study highlights significant socioeconomic disparities in cancer morbidity and mortality across regions in England. It also demonstrates the impact of delays in cancer diagnoses on cancer deaths, emphasizing the need for public health interventions to address these disparities and prevent avoidable deaths, particularly during the COVID-19 pandemic.
Article
Public, Environmental & Occupational Health
Maria do Carmo Ferreira, Flavia Mori Sarti, Marilisa Berti de Azevedo Barros
Summary: This study analyzed the impact of the Social Vulnerability Index (SVI) on the incidence, mortality, and survival rates of different types of cancer in women. The findings showed that women in higher social vulnerability groups had a higher risk of breast, colorectal, and thyroid cancer, while those in lower vulnerability groups had a higher risk of cervical cancer. Moreover, women in higher vulnerability groups had lower survival rates for all types of cancer. This suggests the existence of inequalities in access to early diagnosis and timely treatment.
CADERNOS DE SAUDE PUBLICA
(2022)
Article
Oncology
Birgitte Sandfeld-Paulsen, Ninna Aggerholm-Pedersen, Anne Winther-Larsen
Summary: This study found that the incidence of hyponatremia was 16% in NSCLC patients and 26% in SCLC patients. Hyponatremia was associated with poorer survival in patients with both NSCLC and SCLC, especially in NSCLC patients.
Review
Cell Biology
Geoffrey Brown
Summary: Understanding the normal tissue development is crucial for describing the origin and nature of cancer. Recent studies on hematopoietic stem cells have revealed that they can directly choose a cell lineage, resulting in a heterogeneous population of cells. Leukemia, as well as other solid tumors, follows a hierarchical model with leukemia stem cells at the top. At least two genomic insults are required for cancer development. Some signature mutations in leukemia are related to transcription factors that guide the cell lineage of developing hematopoietic stem/progenitor cells. Additionally, some oncogenes restrict the fate of leukemia stem cells to a single maturation pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Anne Weng Ekmann-Gade, Claus Kim Hogdall, Lene Seibaek, Mette Calundann Noer, Carsten Lindberg Fago-Olsen, Tine Henrichsen Schnack
Summary: The study examined clinical trends in younger and older epithelial ovarian cancer patients in Denmark, revealing a decrease in incidence, improvement in treatment options and cancer-specific survival rates, particularly in younger patients. However, older patients still experience lower survival rates. The proportion of advanced EOC patients not undergoing debulking surgery has increased significantly, while the percentage of patients debulked to no residual disease has also increased.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Roger Yat-Nork Chung, Gary Ka-Ki Chung, Michael Marmot, Jessica Allen, Dicken Chan, Peter Goldblatt, Hung Wong, Eric Lai, Jean Woo, Eng-Kiong Yeoh, Samuel Y. S. Wong
Summary: Despite relatively low COVID-19 incidence in Hong Kong, concerns over livelihood and economic activity influenced by containment measures explain part of the observed health inequalities. Looking beyond incidence is essential in addressing COVID-19 related health inequalities.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Pedro Gullon, Mario Fontan-Vela, Julia Diez, Mark Nieuwenhuijsen, David Rojas-Rueda, Francisco Escobar, Manuel Franco
Summary: The objective of this study was to investigate the relationship between surrounding greenness and the incidence of cardiovascular diseases (CVD) in Madrid, taking into consideration the level of deprivation in different areas. The researchers analyzed healthcare records for almost half a million high CVD-risk individuals over a four-year period. They found that an increase in greenness at a distance of 1000 m was associated with a 16% decrease in CVD risk. However, the protective effect of green spaces varied across different levels of deprivation and genders.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Review
Oncology
Sophia G. Kisling, Gopalakrishnan Natarajan, Ramesh Pothuraju, Ashu Shah, Surinder K. Batra, Sukhwinder Kaur
Summary: Pancreatic cancer is a highly lethal malignancy with poor prognosis mainly due to metastasis. Global studies utilizing computational methods have identified prognostic and metastatic genes, leading to the development of new treatment modalities.
CANCER AND METASTASIS REVIEWS
(2021)
Article
Oncology
Anouk Rijken, Marieke Pape, Geert A. Simkens, Ignace H. J. T. de Hingh, Misha D. P. Luyer, Johanna W. van Sandick, Hanneke W. M. van Laarhoven, Rob H. A. Verhoeven, Felice N. van Erning
Summary: The study aimed to investigate the incidence, risk factors, treatment, and survival of peritoneal metastases (PM) in patients with gastric cancer. The results showed that approximately one third of gastric cancer patients were diagnosed with PM, with about one fourth being synchronous PM. Diffuse type histology was associated with both synchronous and metachronous PM. Although patients with metachronous PM received systemic treatment less frequently, their survival rate was comparable to patients with synchronous PM.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Environmental Sciences
Rebecca B. Clarke, Heresh Amini, Peter James, My von Euler-Chelpin, Jeanette T. Jorgensen, Amar Mehta, Tom Cole-Hunter, Rudi Westendorp, Laust H. Mortensen, Steffen Loft, Jorgen Brandt, Ole Hertel, Matthias Ketzel, Claus Backalarz, Zorana J. Andersen, Youn-Hee Lim
Summary: A large cohort study of Danish female nurses found weak evidence of the association between exposure to light at night (LAN) and breast cancer incidence, with no significant association found overall but a suggestive association with ER-negative breast cancer.
ENVIRONMENTAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Mluleki Tsawe, A. Sathiya Susuman
Summary: There are inequalities in maternal healthcare use in Sierra Leone, with wealthier households, educated women, and women from urban areas having better access to maternal health services. Progress has been made in reducing inequalities, but efforts should focus on improving educational levels and reducing poverty among women of lower socioeconomic status.
Review
Biochemistry & Molecular Biology
Tuelay Karakulak, Holger Moch, Christian von Mering, Abdullah Kahraman
Summary: Alternative splicing is a crucial regulatory mechanism in mammalian cells, with disruptions often observed in cancer leading to changes in protein isoform expression. Advances in sequencing technologies and analytical methods have provided new insights into the impact of disturbed alternative splicing events.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Multidisciplinary Sciences
Laura Guarga, Alberto Ameijide, Rafael Marcos-Gragera, Maria Carulla, Joaquim Delgadillo, Josep Maria Borras, Jaume Galceran
Summary: In Catalonia, there has been a decrease in new cases of lung cancer in men under 70 years old and an increase in women over 60 years old. Adenocarcinoma is the most common type, while squamous cell carcinoma and small cell carcinoma are decreasing significantly in men. The incidence of lung cancer has increased by 16% for patients over 70 years old in both sexes.
SCIENTIFIC REPORTS
(2021)
Review
Nutrition & Dietetics
Matteo Nadile, Maria Ilektra Retsidou, Katerina Gioti, Apostolos Beloukas, Evangelia Tsiani
Summary: Cervical cancer is a global health concern, with a high number of cases and deaths each year. Resveratrol, a natural substance found in plants, has shown potential anticancer properties. Studies have found that resveratrol can inhibit proliferation, induce cell cycle arrest, and promote apoptosis in cervical cancer cells. It can also reduce the expression of HPV oncoproteins and increase the levels of tumor suppressor p53. In vivo studies on mice have shown a reduction in tumor volume and weight with resveratrol treatment. Overall, resveratrol has the ability to target certain signaling molecules involved in cervical cancer cell proliferation and survival. Further research is needed to fully understand its potential in cervical cancer treatment.
Article
Infectious Diseases
Raquel Martin-Iguacel, Josep M. Llibre, Court Pedersen, Niels Obel, Nina Breinholt Staerke, Johanna Ahsberg, Iben Orsted, Inge Holden, Gitte Kronborg, Rajesh Mohey, Line Dahlerup Rasmussen, Isik Somuncu Johansen
Summary: The study found that TB incidence rates decreased over time in Danish PLWH, but the mortality rate remained high. Late HIV presentation with concomitant TB remains a challenge, emphasizing the importance of early treatment and successful antiretroviral therapy.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Editorial Material
Substance Abuse
Anton E. Kunst
Article
Psychology, Developmental
Heiko Schmengler, Margot Peeters, Gonneke W. J. M. Stevens, Anton E. Kunst, Catharina A. Hartman, Albertine J. Oldehinkel, Wilma A. M. Vollebergh
Summary: This study examines the impacts of social causation and health-related selection on educational differences in adolescents' attention problems and externalizing behaviour. The findings indicate that attention problems predict lower educational attainment, while parental socioeconomic status plays a significant role in determining educational level, attention problems, and externalizing behaviour in adolescents.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Public, Environmental & Occupational Health
Jaana M. Kinnunen, Leena Paakkari, Arja H. Rimpela, Markus Kulmala, Matthias Richter, Mirte A. G. Kuipers, Anton E. Kunst, Pirjo L. Lindfors
Summary: This study explores the association between academic performance, health literacy, and substance use among European adolescents. The results indicate that poor academic performance and low health literacy are both associated with substance use. However, health literacy does not fully mediate the relationship between academic performance and substance use.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Renee Bolijn, Anton E. Kunst, Yolande Appelman, Henrike Galenkamp, Eric P. Moll van Charante, Karien Stronks, Hanno L. Tan, Irene G. M. van Valkengoed
Summary: This study examines the associations between gender-related characteristics and cardiovascular disease (CVD) incidence. The results show that there is no evidence of associations between gender-related characteristics and CVD incidence in men, while being a homemaker and spending a moderate amount of time on household work are associated with higher CVD incidence in women.
Article
Multidisciplinary Sciences
Heiko Schmengler, Margot Peeters, Anton E. Kunst, Albertine J. Oldehinkel, Wilma A. M. Vollebergh
Summary: Both social causation and health-related selection may influence educational gradients in alcohol use in adolescence and young adulthood. Lower education predicts increases in drinking during adolescence, while higher education predicts increases in alcohol use during early adulthood. Childhood characteristics have a strong predictive effect on education and drinking behaviors.
Article
Substance Abuse
Tessa R. D. van Deelen, Anton E. Kunst, Bas van den Putte, Els M. Veldhuizen, Mirte A. G. Kuipers
Summary: This paper presents an ex ante policy evaluation of the potential impact of tobacco control policies in the Netherlands, focusing on the ban of tobacco display and advertising, as well as future bans on tobacco sales. The study found that the display ban and sales ban in small outlets will significantly reduce tobacco outlet visibility and availability.
Article
Substance Abuse
Tessa R. D. van Deelen, Gabrielle de Vet, Anne Zijp, Bas van den Putte, Anton E. Kunst, Mirte A. G. Kuipers
Summary: Exposure to tobacco outlets is associated with pro-smoking cognitions among non-smoking adolescents in the Netherlands, with stronger associations for outlets with internal visibility.
Article
Public, Environmental & Occupational Health
Felix P. Chilunga, Lenny Stoeldraijer, Charles Agyemang, Karien Stronks, Carel Harmsen, Anton E. Kunst
Summary: By studying the association between migration background and COVID-19 deaths in the Netherlands, it was found that populations with a migration background were more likely to die from COVID-19 throughout the pandemic compared to the Dutch origin population, with the differences becoming larger in the second wave. Despite the introduction of COVID-19 prevention measures targeted at populations with a migration background, the higher risk of COVID-19 deaths persisted in the second wave.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Benjamin P. van Nieuwenhuizen, Hanno L. Tan, Marieke T. Blom, Anton E. Kunst, Irene G. M. van Valkengoed
Summary: Previous studies have shown that lower socioeconomic groups have a higher risk of out-of-hospital cardiac arrest (OHCA). However, the extent of these inequalities is uncertain due to the limitations of previous study designs. This large-scale longitudinal study provides new evidence for a significant association between income and OHCA risk across different age and sex groups.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2023)
Article
Computer Science, Information Systems
M. E. Derksen, M. W. M. Jaspers, A. E. Kunst, M. P. Fransen
Summary: This study aimed to investigate the usage and influencing factors of social and goal-setting functionalities in digital interventions for health behavior change among clients and nurses. The results showed that both functionalities were used to a limited extent, with nurses and clients preferring other social platforms like WhatsApp. Nurses were also hesitant to use the group chat function. Clients struggled with setting and achieving personal goals, while nurses found it challenging to determine appropriate rewards. Overall, these functionalities were perceived as enhancing the discussion of personal goals, but optimization is necessary before implementation to support disadvantaged groups in behavior change.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2023)
Article
Public, Environmental & Occupational Health
R. A. Smit, H. H. Garritsen, A. E. Kunst, A. D. Rozema
Summary: This study aims to understand the occurrence of smoking at various sports clubs in the Netherlands and identify the reasons for smoking at some clubs but not at others. Through semistructured interviews, four situations were identified where smoking still occurred, including directly at the entrance, at some distance from the entrance, in particular places on the premises, and in various places or on occasions when alcohol is consumed. The occurrence of these situations was influenced by the comprehensiveness of the smoke-free policy, physical characteristics of the sports club's premises, the presence or absence of children, and enforcement difficulties. To reduce second-hand smoke exposure, it is necessary to formulate a comprehensive smoke-free policy, improve policy compliance even when children are absent, and organize policy enforcement.
Article
Medicine, General & Internal
Mara de Visser, Anton E. Kunst, Maria Fleischmann
Summary: This study examined the impact of sociodemographic and geographical factors on heat-related mortality in the Netherlands. The results indicated that socioeconomic position and population density may affect the vulnerability to heat-related mortality. Low-income groups were found to be at higher risk, while areas with high population density showed weaker effects in both warm and heat segments.
Article
Public, Environmental & Occupational Health
Jesus Daniel Zazueta-Borboa, Pekka Martikainen, Jose Manuel Aburto, Giuseppe Costa, Riina Peltonen, Nicolas Zengarini, Alison Sizer, Anton E. Kunst, Fanny Janssen
Summary: This study examines the long-term trends in educational inequalities in life expectancy at age 30 in England, Finland, and Italy. The findings suggest that reducing mortality among the low-educated at young ages is crucial for decreasing educational inequalities.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Review
Substance Abuse
Heike H. Garritsen, Yoel Y. da Costa Senior, Andrea D. Rozema, Anton E. Kunst, Mirte A. G. Kuipers
Summary: This systematic review found that smoke-free legislation in hospitality venues is associated with a decrease in smoking behavior among young people, emphasizing the need for comprehensive smoke-free legislation without exemptions. The results indicate that comprehensive smoke-free legislation can reduce smoking behavior effectively.
NICOTINE & TOBACCO RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Rebecca M. F. Hewer, Sarah Hill, Amanda Amos
Summary: While smoking is banned on school premises in most European countries, young people experience wide variation in implementation, leading to limitations in the understanding and application of smoke-free school policies.
CRITICAL PUBLIC HEALTH
(2022)
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)
