Article
Sport Sciences
Marcus J. Callahan, Evelyn B. Parr, Tim Snijders, Miguel S. Conceicao, Bridget E. Radford, Ryan G. Timmins, Brooke L. Devlin, John A. Hawley, Donny M. Camera
Summary: The study found that six weeks of high-intensity interval training (HIIT) can induce widespread adaptations in middle-age men. While the increase in aerobic capacity induced by exercise training declined during a 2.5-week detraining period, gains in lean mass and muscle strength were maintained.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Geriatrics & Gerontology
Hongchun Lin, Xinxin Ma, Yuxiang Sun, Hui Peng, Yanlin Wang, Sandhya Sara Thomas, Zhaoyong Hu
Summary: This study utilized snRNA-seq to investigate transcriptional changes associated with muscle atrophy induced by denervation. The results revealed a significant increase in the proportion of type IIb2 myonuclei and robust transcriptional reprogramming in response to denervation. Gene regulatory network analysis showed enhanced activity of specific genes in denervated myonuclei, along with alterations in metabolic pathways and cell-cell communication.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Cardiac & Cardiovascular Systems
Pim Knuiman, Sam Straw, John Gierula, Aaron Koshy, Lee D. Roberts, Klaus K. Witte, Carrie Ferguson, Thomas Scott Bowen
Summary: The study quantified the relationship between distinct mitochondrial respiratory states and exercise limitation in HFrEF patients, finding that mitochondrial ETS capacity could explain over 50% of variability in V̇O2peak. This data provides potential mitochondrial targets to alleviate exercise limitations in HFrEF.
Article
Biochemistry & Molecular Biology
Yutaka Matsunaga, Yuki Tamura, Kenya Takahashi, Yu Kitaoka, Yumiko Takahashi, Daisuke Hoshino, Tomoyasu Kadoguchi, Hideo Hatta
Summary: This study found that BCAA supplementation can suppress the detraining-induced reduction of mitochondrial content, partly through inhibiting mitophagy.
Article
Biochemistry & Molecular Biology
Mu Zeng, Shanying Yan, Peng Yang, Qiaowei Li, Jiju Li, Xinhao Fan, Xiaoqin Liu, Yilong Yao, Wei Wang, Ruipu Chen, Guohao Han, Yalan Yang, Zhonglin Tang
Summary: By conducting a comprehensive analysis of circRNA expression profiles in Chinese local breed Luchuan pigs and Western commercial breed Duroc pigs, we identified a total of 56,254 circRNAs, of which 42.9% were not previously annotated. Furthermore, we found that 33.7% of these circRNAs were differentially expressed between the two breeds, and they might contribute to the phenotypic differentiation. Additionally, we discovered a tissue-specific circRNA, circPSME4, which regulates skeletal muscle development.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Physiology
Madison L. Mattingly, Bradley A. Ruple, Casey L. Sexton, Joshua S. Godwin, Mason C. Mcintosh, Morgan A. Smith, Daniel L. Plotkin, J. Max Michel, Derick A. Anglin, Nicholas J. Kontos, Shengyi Fei, Stuart M. Phillips, C. Brooks Mobley, Ivan Vechetti, Christopher G. Vann, Michael D. Roberts
Summary: This study investigated the effects of acute and subchronic resistance training on skeletal muscle protein lactylation levels. The results showed that exercise did not significantly alter muscle protein lactylation levels in both human and mouse participants. These findings challenge the hypothesis that lactate plays a role in promoting skeletal muscle hypertrophy.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cell Biology
Xavier Suarez-Calvet, Esther Fernandez-Simon, Daniel Natera, Cristina Jou, Patricia Pinol-Jurado, Elisa Villalobos, Carlos Ortez, Alexandra Monceau, Marianela Schiava, Anna Codina, Jose Verdu-Diaz, James Clark, Zoe Laidler, Priyanka Mehra, Rasya Gokul-Nath, Jorge Alonso-Perez, Chiara Marini-Bettolo, Giorgio Tasca, Volker Straub, Michela Guglieri, Andres Nascimento, Jordi Diaz-Manera
Summary: Duchenne muscular dystrophy is a genetic disease characterized by early onset muscle weakness. In this study, quadriceps muscle biopsies from DMD patients were analyzed using snRNAseq, revealing significant differences in the cellular and molecular profiles compared to controls. These findings provide insights into the disease progression and potential therapeutic targets.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Marine Gueugneau, Cecile Coudy-Gandilhon, Christophe Chambon, Julien Verney, Daniel Taillandier, Lydie Combaret, Cecile Polge, Stephane Walrand, Frederic Roche, Jean-Claude Barthelemy, Leonard Feasson, Daniel Bechet
Summary: The study found that healthy aging in old men is associated with upregulation of apoptosis and immune function, as well as downregulation of glycolysis and protein catabolism, while metabolic syndrome is mainly characterized by upregulation of proteolysis and downregulation of oxidative phosphorylation. This indicates potential muscle biomarkers for healthy aging and metabolic syndrome in old men.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jennifer Maurer, Xinjie Zhao, Martin Irmler, Anders Gudiksen, Nanna S. Pilmark, Qi Li, Thomas Goj, Johannes Beckers, Martin Hrabe de Angelis, Andreas L. Birkenfeld, Andreas Peter, Rainer Lehmann, Henriette Pilegaard, Kristian Karstoft, Guowang Xu, Cora Weigert
Summary: Metformin treatment leads to lactate production and secretion, as well as reduced glucose consumption. It inhibits respiratory chain complex I and alters cellular redox state, decreasing pyruvate oxidation. These findings suggest that metformin induces dose-dependent lactate production in skeletal muscle by shifting the equilibrium of lactate dehydrogenase reaction.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Genetics & Heredity
Yueying Yun, Rihan Wu, Xige He, Xia Qin, Lu Chen, Lina Sha, Xueyan Yun, Tadayuki Nishiumi, Gerelt Borjigin
Summary: This study investigated the expression profiles of miRNAs and mRNAs in the skeletal muscle of Wuranke sheep, and identified potential miRNA-mRNA pairs that may act as regulators during muscle development.
Article
Cell Biology
Julia Brenmoehl, Elli Brosig, Nares Trakooljul, Christina Walz, Daniela Ohde, Antonia Noce, Michael Walz, Martina Langhammer, Stefan Petkov, Monika Roentgen, Steffen Maak, Christina E. E. Galuska, Beate Fuchs, Bjoern Kuhla, Siriluck Ponsuksili, Klaus Wimmers, Andreas Hoeflich
Summary: This study investigated the contribution of non-mitochondrial and mitochondrial metabolic pathways in contracting muscles during repeated training. The results showed that marathon mice displayed increased glucose and fatty acid oxidation, reduced lactate dehydrogenase activity, and inhibited lactate formation compared to trained control mice. This suggests that marathon mice have enhanced metabolic flexibility towards lipid catabolism regulated by lactate dehydrogenase.
Article
Agriculture, Dairy & Animal Science
Hao Ding, Yueyue Lin, Tao Zhang, Lan Chen, Genxi Zhang, Jinyu Wang, Kaizhou Xie, Guojun Dai
Summary: The study utilized RNA sequencing to explore gene expression in pigeon skeletal muscle development, identifying differentially expressed genes across different developmental stages. Weighted gene co-expression network analysis (WGCNA) revealed gene modules correlated with pigeon muscle growth and embryonic development, providing insights into the molecular mechanisms. A KEGG pathway analysis highlighted pathways involved in pigeon skeletal muscle growth and development, with selected genes validated by qRT-PCR. This research enhances understanding of gene expression and regulation in pigeon muscle development.
Article
Endocrinology & Metabolism
L. Zhou, S. Y. Chen, H. J. Han, J. Q. Sun
Summary: This study investigated the effects of lactate injection on lipid metabolism in rat skeletal muscle, finding that chronic lactate administration may play a crucial role in triglyceride storage and mitochondria biogenesis. The study revealed changes in lipolytic and fat synthesis proteins, as well as mitochondrial biomarkers in response to lactate, suggesting a potential mechanism for the observed effects.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Article
Biology
Wentao Chen, Ziye Xu, Wenjing You, Yanbing Zhou, Liyi Wang, Yuqin Huang, Tizhong Shan
Summary: This study investigated the effects of acute cold exposure on lipid metabolism and transcriptomic changes in mouse skeletal muscle. The results showed that cold exposure led to increased intramuscular fat deposition, altered lipid composition, and upregulated genes involved in lipolysis and fatty acid biosynthesis. Cold-mediated mitophagy may play a critical role in modulating lipid metabolism in skeletal muscle, which is regulated by HIF-1 alpha signaling.
Article
Biochemistry & Molecular Biology
Sihui Ma, Emi Hasegawa, Yuji Nakai, Huijuan Jia, Hisanori Kato
Summary: Early-life protein restriction may have long-term detrimental effects on muscle function and skeletal muscle development at both the transcriptional and methylation levels, and may pose a hazard to future muscle health. Although most of the effects can be corrected by rebound feeding, some genes remain altered at the transcriptional level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Sport Sciences
Yuichiro Nishida, Megumi Hara, Yasuki Higaki, Naoto Taguchi, Kazuyo Nakamura, Hinako Nanri, Takeshi Imaizumi, Tatsuhiko Sakamoto, Chisato Shimanoe, Mikako Horita, Koichi Shinchi, Keitaro Tanaka
Summary: The study revealed that substitution of sedentary time with MVPA is significantly associated with reduced serum SPARC levels in middle-aged men, but not in women. Additionally, a potential interaction between LPA and the BMI on SPARC levels was also found in women.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2022)
Letter
Geriatrics & Gerontology
Chiharu Iwasaka, Yosuke Yamada, Yuichiro Nishida, Megumi Hara, Jun Yasukata, Nobuyuki Miyoshi, Chisato Shimanoe, Hinako Nanri, Takuma Furukawa, Kayoko Koga, Mikako Horita, Yasuki Higaki, Keitaro Tanaka
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Takashi Matsunaga, Yuka Kadomatsu, Mineko Tsukamoto, Yoko Kubo, Rieko Okada, Mako Nagayoshi, Takashi Tamura, Asahi Hishida, Toshiro Takezaki, Ippei Shimoshikiryo, Sadao Suzuki, Hiroko Nakagawa, Naoyuki Takashima, Yoshino Saito, Kiyonori Kuriki, Kokichi Arisawa, Sakurako Katsuura-Kamano, Nagato Kuriyama, Daisuke Matsui, Haruo Mikami, Yohko Nakamura, Isao Oze, Hidemi Ito, Masayuki Murata, Hiroaki Ikezaki, Yuichiro Nishida, Chisato Shimanoe, Kenji Takeuchi, Kenji Wakai
Summary: The present study aimed to explore the relationship between breastfeeding and metabolic syndrome in community-dwelling parous women, and to investigate whether this relationship varied by age. The results showed a negative correlation between the number of breastfed children and the prevalence of metabolic syndrome in women under 55 years old. However, no significant association was found between breastfeeding history and metabolic syndrome or cardiovascular risk factors in women over 55 years old.
Article
Multidisciplinary Sciences
Kayoko Koga, Megumi Hara, Chisato Shimanoe, Yuichiro Nishida, Takuma Furukawa, Chiharu Iwasaka, Keitaro Tanaka, Jun Otonari, Hiroaki Ikezaki, Yoko Kubo, Yasufumi Kato, Takashi Tamura, Asahi Hishida, Keitaro Matsuo, Hidemi Ito, Yohko Nakamura, Miho Kusakabe, Daisaku Nishimoto, Keiichi Shibuya, Sadao Suzuki, Miki Watanabe, Etsuko Ozaki, Daisuke Matsui, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kenji Takeuchi, Kenji Wakai
Summary: Understanding the risk factors for chronic kidney disease is crucial for preventing end-stage renal disease and reducing mortality. This study investigated the roles of psychosocial stress and stress coping behaviors in deterioration of renal function in middle-aged and older Japanese men and women. The findings showed an inverse association between perceived stress and estimated glomerular filtration rate (eGFR) in men, with this association being slightly attenuated after adjustment for hypertension and diabetes. Surprisingly, problem solving in men and positive reappraisal in women also showed an inverse association with eGFR. Further research is needed to clarify the underlying mechanisms, including hormonal and immunological aspects.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Takuma Furukawa, Yuichiro Nishida, Megumi Hara, Chisato Shimanoe, Kayoko Koga, Chiharu Iwasaka, Yasuki Higaki, Keitaro Tanaka, Ryoko Nakashima, Hiroaki Ikezaki, Asahi Hishida, Takashi Tamura, Yasufumi Kato, Yudai Tamada, Keitaro Matsuo, Hidemi Ito, Haruo Mikami, Miho Kusakabe, Rie Ibusuki, Keiichi Shibuya, Sadao Suzuki, Hiroko Nakagawa-Senda, Etsuko Ozaki, Daisuke Matsui, Kiyonori Kuriki, Yasuyuki Nakamura, Aya Kadota, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kenji Takeuchi, Kenji Wakai
Summary: This study found an interaction effect between physical activity and carbohydrate intake on HbA1c levels, especially with individuals who have high carbohydrate intake, where the negative correlation between physical activity and HbA1c levels was more pronounced.
BMJ OPEN DIABETES RESEARCH & CARE
(2022)
Article
Sport Sciences
Yuichiro Nishida, Megumi Hara, Hideki Ohmomo, Kanako Ono, Atsushi Shimizu, Mikako Horita, Chisato Shimanoe, Naoto Taguchi, Yasuki Higaki, Keitaro Tanaka
Summary: This study found that higher accelerometer-assessed total PA was associated with increased DNA methylation levels at the cg07030336 (VTI1A/ZDHHC6) site in the general population in Japan. In addition, a divergent relationship was found between methylation levels at the cg07030336 site and several inflammatory biomarkers.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Peripheral Vascular Disease
Kaori Kitaoka, Katsuyuki Miura, Naoyuki Takashima, Aya Kadota, Akiko Harada, Yasuyuki Nakamura, Yoshikuni Kita, Yuichiro Yano, Takashi Tamura, Mako Nagayoshi, Rieko Okada, Yoko Kubo, Sadao Suzuki, Takeshi Nishiyama, Shiroh Tanoue, Chihaya Koriyama, Kiyonori Kuriki, Kokichi Arisawa, Sakurako Katsuura-Kamano, Yuichiro Nishida, Chisato Shimanoe, Etsuko Ozaki, Daisuke Matsui, Hiroaki Ikezaki, Jun Otonari, Isao Oze, Yuriko N. Koyanagi, Yohko Nakamura, Miho Kusakabe, Kenji Wakai, Keitaro Matsuo
Summary: This study investigated the association between dietary patterns and serum LDL cholesterol in a large population in Japan. The results showed that certain recent dietary patterns were associated with serum LDL cholesterol levels.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Public, Environmental & Occupational Health
Mako Nagayoshi, Asahi Hishida, Tomonori Shimizu, Yasufumi Kato, Yoko Kubo, Rieko Okada, Takashi Tamura, Jun Otonari, Hiroaki Ikezaki, Megumi Hara, Yuichiro Nishida, Isao Oze, Yuriko N. Koyanagi, Yohko Nakamura, Miho Kusakabe, Rie Ibusuki, Keiichi Shibuya, Sadao Suzuki, Takeshi Nishiyama, Teruhide Koyama, Etsuko Ozaki, Kiyonori Kuriki, Naoyuki Takashima, Yasuyuki Nakamura, Sakurako Katsuura-Kamanos, Kokichi Arisawa, Masahiro Nakatochi, Yukihide Momozawa, Kenji Takeuchi, Kenji Wakai, J-MICC Study group
Summary: This study found that higher BMI in the Japanese population is causally associated with various cardiometabolic traits including high blood pressure, triglycerides, uric acid, low high-density-lipoprotein cholesterol, and eGFR. However, there was no significant association between genetic risk scores for BMI and individual-level cardiometabolic traits.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Geriatrics & Gerontology
Chiharu Iwasaka, Yosuke Yamada, Yuichiro Nishida, Megumi Hara, Jun Yasukata, Nobuyuki Miyoshi, Chisato Shimanoe, Hinako Nanri, Takuma Furukawa, Kayoko Koga, Mikako Horita, Yasuki Higaki, Keitaro Tanaka
Summary: In this cross-sectional study, it was found that the appendicular extracellular-to-intracellular water ratio (Ap ECW/ICW) is not related to muscle quality but is associated with muscle strength. The Ap ECW/ICW can be improved through physical activity.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Geriatrics & Gerontology
Chiharu Iwasaka, Yosuke Yamada, Yuichiro Nishida, Megumi Hara, Jun Yasukata, Nobuyuki Miyoshi, Chisato Shimanoe, Hinako Nanri, Takuma Furukawa, Kayoko Koga, Mikako Horita, Yasuki Higaki, Keitaro Tanaka
Summary: This study found a significant inverse association between daily step count and the prevalence of sarcopenia, with the association plateauing when the daily step count exceeded approximately 8000 steps. These findings suggest that 8000 steps per day may be the optimal dose to prevent sarcopenia.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Yora Nindita, Masahiro Nakatochi, Rie Ibusuki, Ippei Shimoshikiryo, Daisaku Nishimoto, Keiichi Shimatani, Toshiro Takezaki, Hiroaki Ikezaki, Masayuki Murata, Megumi Hara, Yuichiro Nishida, Takashi Tamura, Asahi Hishida, Mako Nagayoshi, Rieko Okada, Keitaro Matsuo, Hidemi Ito, Haruo Mikami, Yohko Nakamura, Takahiro Otani, Sadao Suzuki, Teruhide Koyama, Etsuko Ozaki, Kiyonori Kuriki, Naoyuki Takashima, Naoko Miyagawa, Kokichi Arisawa, Sakurako Katsuura-Kamano, Yukihide Momozawa, Michiaki Kubo, Kenji Takeuchi, Kenji Wakai
Summary: The study evaluated the population-based impact of smoking, drinking, and genetic factors on low HDL-C levels using data from the J-MICC Study. The findings showed that smoking, drinking, and certain genetic variants were associated with HDL-C levels, but there was no significant gene-environment interaction. The population-based impact of the genetic factor CETP rs3764261 was higher than that of smoking and lower than that of drinking.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Geriatrics & Gerontology
Chiharu Iwasaka, Yosuke Yamada, Yuichiro Nishida, Megumi Hara, Jun Yasukata, Nobuyuki Miyoshi, Chisato Shimanoe, Hinako Nanri, Takuma Furukawa, Kayoko Koga, Mikako Horita, Yasuki Higaki, Keitaro Tanaka
Summary: This study investigated the association between the appendicular extracellular-to-intracellular water ratio (A-E/I) and all-cause mortality. The study found a positive association between A-E/I and all-cause mortality in middle-aged and older Japanese adults, which remained significant after adjusting for skeletal muscle mass and handgrip strength.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Nutrition & Dietetics
Hinako Nanri, Megumi Hara, Yuichiro Nishida, Chisato Shimanoe, Yun-Shan Li, Hiroshi Kasai, Kazuaki Kawai, Yasuki Higaki, Keitaro Tanaka
Summary: This study aimed to evaluate the association between oxidative balance score (OBS) and urinary levels of 8-hydroxydeoxyguanosine (8-OHdG) among Japanese adults. The findings showed that higher OBSs were significantly associated with lower urinary 8-OHdG levels, suggesting that OBS could be a useful tool for evaluating oxidative stress-related lifestyle factors, including diet.
Article
Oncology
Satomi Tomida, Teruhide Koyama, Etsuko Ozaki, Naoyuki Takashima, Midori Morita, Koichi Sakaguchi, Yasuto Naoi, Yuichiro Nishida, Megumi Hara, Asahi Hishida, Takashi Tamura, Rieko Okada, Yoko Kubo, Jun Otonari, Hiroaki Ikezaki, Yohko Nakamura, Miho Kusakabe, Shiroh Tanoue, Chihaya Koriyama, Yuriko N. Koyanagi, Hidemi Ito, Sadao Suzuki, Takahiro Otani, Naoko Miyagawa, Yukiko Okami, Kokichi Arisawa, Takeshi Watanabe, Kiyonori Kuriki, Kenji Wakai, Keitaro Matsuo
Summary: This study aimed to investigate the association between daily sedentary time and the risk of breast cancer in a large Japanese population. The study found that spending 7 or more hours per day sedentary was significantly associated with an increased risk of breast cancer. Leisure-time physical activity and walking did not have a preventive effect on breast cancer in individuals with 7 or more hours of sedentary time.
Article
Medicine, Research & Experimental
Abdelaziz Ghanemi, Mayumi Yoshioka, Jonny St-Amand
Summary: Obesity is a heavy burden for modern healthcare, and the challenge in obesity research progress lies in the unknown underlying pathways. Mimicking obesity-induced biochemical environments in vitro can help us understand the impact on different biological organs and reveal obesity mechanisms to develop therapies.