Review
Sport Sciences
Hassane Zouhal, Ayyappan Jayavel, Kamalanathan Parasuraman, Lawrence D. Hayes, Claire Tourny, Fatma Rhibi, Ismail Laher, Abderraouf Ben Abderrahman, Anthony C. Hackney
Summary: The systematic review found that exercise training increases basal levels of testosterone, IGF-1, SHBG, hGH, and DHEA in both males and females over 40 years of age, regardless of the mode, duration, and intensity of the training programs. However, the effects of long-term exercise training on cortisol and insulin levels in elderly individuals are unclear.
Review
Endocrinology & Metabolism
Yuhan Zhou, Hector M. Arredondo, Ning Wang
Summary: This mini review summarizes the latest research developments on the roles of P2Y receptors in bone biology, particularly focusing on receptors with both anabolic and catabolic functions. Targeting these receptors pharmacologically in bone-wasting diseases presents a challenge, and further research is needed to find more precise targeting strategies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Maciej Zacharski, Alicja Tomaszek, Liliana Kiczak, Maciej Ugorski, Jacek Bania, Urszula Pas, Urszula Paslawska, Ilona Rybinska, Ewa Anita Jankowska, Adrian Janiszewski, Piotr Ponikowski
Summary: In this study using a HF pig model, an imbalanced catabolic/anabolic state was observed with an increase in aldosterone and cortisol levels and decrease in androgen signaling, accompanied by changes in steroid hormone receptor expression in heart tissue.
JOURNAL OF CARDIAC FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Michal Tkaczyszyn, Marcin Drozd, Kinga Wegrzynowska-Teodorczyk, Joanna Bojarczuk, Jacek Majda, Waldemar Banasiak, Piotr Ponikowski, Ewa A. Jankowska
Summary: Iron deficiency and hormonal imbalance contribute to decreased skeletal muscle performance in men with HFrEF, and these two pathologies are related to each other.
CARDIOLOGY JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Michael A. Lobritz, Ian W. Andrews, Dana Braff, Caroline B. M. Porter, Arnaud Gutierrez, Yoshikazu Furuta, Louis B. G. Cortes, Thomas Ferrante, Sarah C. Bening, Felix Wong, Charley Gruber, Christopher W. Bakerlee, Guillaume Lambert, Graham C. Walker, Daniel J. Dwyer, James J. Collins
Summary: β-lactam antibiotics inhibit the assembly of peptidoglycan in bacterial cell walls, leading to a futile cycle of synthesis and degradation. This study investigates the effects of beta-lactam treatment on Escherichia coli and finds that inhibition of penicillin-binding protein 2 (PBP2) results in lethal metabolic shifts caused by increased energy demand from various catabolic and anabolic processes, including accelerated protein synthesis downstream of peptidoglycan cycling. These findings suggest that disruption of normal metabolic homeostasis is a crucial factor in the lethality of beta-lactam antibiotics.
CELL CHEMICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sol Mochon-Benguigui, Almudena Carneiro-Barrera, Manuel Dote-Montero, Manuel J. Castillo, Francisco J. Amaro-Gahete
Summary: Sleep quality is not related to levels of plasma anabolic hormones, but to levels of catabolic hormones, in sedentary middle-aged adults. Changes in aging markers associated with sleep disturbances may be mediated by age-related changes in the catabolic endocrine system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Junya Takegaki, Kohei Sase, Yusuke Kono, Daiki Nakano, Takuya Fujita, Satoshi Konishi, Satoshi Fujita
Summary: The study measured the effects of intramuscular injection of MSCs on mouse muscles, and found that the injected MSCs could activate both muscle anabolic and catabolic systems, leading to accelerated muscle protein turnover.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Ekaterina A. Shmonova, Ekaterina A. Savrasova, Elizaveta N. Fedorova, Vera G. Doroshenko
Summary: The production of 3,4-dihydroxybenzoic acid is an important task due to its pharmaceutical properties and use as a precursor for high value-added chemicals. Microbial production of 3,4-DHBA using dehydroshikimate dehydratase has been demonstrated. Different sources of dehydroshikimate dehydratase were compared in terms of their kinetic properties and ability to produce 3,4-DHBA.
Article
Medicine, Research & Experimental
Daniely Messias Costa, Joao da Cruz- Filho, Alan Bruno Silva Vasconcelos, Joao Victor Gomes- Santos, Luis Carlos Reis, Waldecy de Lucca Jr, Enilton Aparecido Camargo, Sandra Lauton- Santos, Neusa Maria Zanon, Isis do Carmo Kettelhut, Luiz Carlos Navegantes, Andre de Souza Mecawi, Daniel Badaue Passos, Danilo Lustrino
Summary: The study found that oxytocin (OT) directly inhibits proteolytic activities in rat oxidative skeletal muscle by activating the Akt/FoxO signaling pathway, suppressing atrogene expression, and promoting muscle mass gain without affecting protein synthesis.
Article
Sport Sciences
Michael A. Maloney, Ian Renshaw, Damian Farrow
Summary: The study found that taekwondo fighters fluctuate between attack and defense, spending most of their time in the 101-200 cm distance range. The fighters form a dyadic system with specific behavior patterns influenced by individual intentions, action capabilities, and task constraints. The findings highlight the sensitivity of fighters to their own and their opponent's action capabilities and have implications for the design of representative practice and research tasks in combat sports.
INTERNATIONAL JOURNAL OF PERFORMANCE ANALYSIS IN SPORT
(2021)
Article
Plant Sciences
Kacper Dziewit, Ales Pencik, Katarzyna Dobrzynska, Ondrej Novak, Bozena Szal, Anna Podgorska
Summary: NH4+-mediated accelerated auxin turnover rates lead to transient and local IAA peaks. The distinct auxin pattern in tissues is correlated with the short and highly branched root system adaptations of NH4+-grown plants. The spatiotemporal distribution of auxin may act as a root-shaping signal specific for adapting to NH4+ stress conditions.
Article
Business
Sercan Sengun, Peter Mawhorter, James Bowie-Wilson, Yusef Audeh, Haewoon Kwak, D. Fox Harrell
Summary: This study examines character design in fighting videogames such as Street Fighter V and Tekken 7, revealing the presence of racism and sexism manifested in stark differences in character design by gender and skin color. The analysis also shows that characters designed in dialogue with developers from their regions of origin are less enfreaked and more positively portrayed, suggesting the potential for implementing anti-bias character designs in popular video games.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2022)
Article
Physiology
Juliana Antero, Steven Golovkine, Louis Niffoi, Alice Meignie, Tom Chassard, Quentin Delarochelambert, Martine Duclos, Carole Maitre, Hugo Maciejewski, Allison Diry, Jean-Francois Toussaint
Summary: This study investigated the impact of menstrual cycle and hormonal contraception on training, performance, and wellness in elite rowers. The results showed that rowers with a natural cycle and those on hormonal contraception had higher performance evaluations during specific phases, but experienced more menstrual symptoms during certain phases. It is crucial to consider menstrual cycle and hormonal contraception data in the monitoring of female athletes' wellness and training, as these factors can affect their perception and performance.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Daniela Peruzzu, Maria Luisa Dupuis, Marina Pierdominici, Katia Fecchi, Maria Cristina Gagliardi, Elena Ortona, Maria Teresa Pagano
Summary: This study investigated the different effects of calcitriol in modulating T cell immunity of age-matched male and female healthy donors. The results showed that calcitriol increased vitamin D receptor expression levels and reduced pro-inflammatory cytokine expression levels in T lymphocytes of both sexes. Furthermore, calcitriol only increased the expression level of the anti-inflammatory cytokine IL-10 in T lymphocytes from female healthy donors. These findings provide new insights into the sex-specific anti-inflammatory role of calcitriol in T cell immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biophysics
Imane Ait Oumghar, Abdelwahed Barkaoui, Patrick Chabrand, Abdellatif El Ghazi, Charlotte Jeanneau, Daphne Guenoun, Peter Pivonka
Summary: Bone is a hierarchical biological tissue that can be continually renewed. Breast cancer metastases can cause bone loss, with primary breast cancer enhancing bone-forming cells' activity and secondary breast cancer leading to bone loss. This study investigates the interaction between breast cancer cells and bone cells, using mathematical modeling and experimental analysis to assess their effect on bone volume fraction during the remodeling process.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2022)