Article
Pharmacology & Pharmacy
Haiyan Yang, Cancan He, Yang Bi, Xu Zhu, Dan Deng, Tingting Ran, Xiaojuan Ji
Summary: This study found that VEGF and SDF-1 alpha synergistically enhance the migration, differentiation, and proliferation capabilities of EPCs, but not VSMCs. This finding provides a promising strategy for the prevention of vascular stenosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Tays Amanda Felisberto Goncalves, Viviane Silva Lima, Arthur Jose Pontes Oliveira de Almeida, Alinne Villar de Arruda, Ana Caroline Meneses Ferreira Veras, Thais Trajano Lima, Evyllen Myllena Cardoso Soares, Adhonias Correia dos Santos, Maria Eduarda Costa de Vasconcelos, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Isac Almeida de Medeiros
Summary: This study demonstrated the regulatory effects of carvacrol on endothelial repair in spontaneously hypertensive rats. Results showed that carvacrol promoted the migration and proliferation of endothelial progenitor cells, increased eNOS expression and activity, reduced reactive oxygen species production and cellular senescence, and improved vascular function.
Article
Multidisciplinary Sciences
Yoshiya Asano, Daisuke Okano, Michiya Matsusaki, Tetsuro Watabe, Yasuhiro Yoshimatsu, Mitsuru Akashi, Hiroshi Shimoda
Summary: In this study, an artificial vascular tissue constructed by human adipose tissue-derived stromal cells (hASCs) and HUVECs (ASCVT) showed higher vascular network density and expression of angiogenesis-related factors. Subcutaneous transplantation of ASCVT into nude mice resulted in the formation of functional vessel networks within 4 weeks.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Maria Vazquez-Reza, Antia Custodia, Iria Lopez-Dequidt, Marta Aramburu-Nunez, Daniel Romaus-Sanjurjo, Alberto Ouro, Joao Botelho, Vanessa Machado, Ramon Iglesias-Rey, Juan Manuel Pias-Peleteiro, Rogelio Leira, Juan Blanco, Jose Castillo, Tomas Sobrino, Yago Leira
Summary: This study investigates the relationship between periodontitis and an increased number of circulating endothelial progenitor cells (EPCs) (CD34(+)/CD133(+)/KDR+). The results show that periodontitis patients have a higher concentration of EPCs compared to non-periodontitis patients, and there is a significant increase in EPCs over time in patients with periodontitis. These findings suggest a potential link between periodontitis and endothelial dysfunction.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Liujun Jiang, Xiaolei Sun, Jiacheng Deng, Yanhua Hu, Qingbo Xu
Summary: Significant progress has been made in understanding the nature and functions of vascular stem cells, particularly in cardiovascular research. Recent studies using genetic lineage tracing mouse models have shed light on the behaviors of these cells during physiological angiogenesis and in vascular diseases. Further research using new techniques is crucial to fully elucidate the role of vascular stem cells in development and diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Endocrinology & Metabolism
Wei Zhang, Hongdong Wang, Fangcen Liu, Xiao Ye, Wenjuan Tang, Pengzi Zhang, Tianwei Gu, Dalong Zhu, Yan Bi
Summary: The study revealed that levels of circulating CD34(+)KDR(+)CD133(+) EPCs were higher in patients with newly diagnosed type 2 diabetes compared to control subjects, and significantly decreased after intensive insulin therapy. In addition, levels of inflammatory cytokines and oxidative stress were significantly higher in patients with diabetes but markedly decreased after intensive insulin therapy.
Article
Dermatology
Andrea Luengas-Martinez, Anna Kamaly-Asl, Iskander H. Chaudhry, Paul E. C. Brenchley, Helen S. Young
Summary: This study assessed the cutaneous vascular structure and perfusion in patients with chronic plaque psoriasis, and found that blood flow, mean blood vessel area, and number of blood and lymphatic vessels was significantly higher in psoriasis plaques than in uninvolved skin. Expression of vascular endothelial growth factor (VEGF)-A(121,) VEGF-A(165) and VEGF-D was also significantly increased in plaques, and the number of blood vessels in uninvolved skin was associated with the VEGF-A (rs833061) genotype.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anna Tylutka, Barbara Morawin, Edyta Wawrzyniak-Gramacka, Eryk Wacka, Wiktoria Nowicka, Jaroslaw Hiczkiewicz, Agnieszka Zembron-Lacny
Summary: This study reveals the association between immunosenescence-related disproportion in T lymphocytes and endothelial dysfunction, highlighting its potential impact on vascular aging. Assessing the inflammatory-immune profile could help better predict and prevent vascular diseases associated with old age.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Xiaoyu Pan, Lin Yang, Shuqi Wang, Yanhui Liu, Lin Yue, Shuchun Chen
Summary: The low-grade inflammatory state in obesity can damage vascular endothelial cells and lead to cardiovascular diseases. Macrophage exosomes improve glucose tolerance and insulin sensitivity in obese mice, but the relationship with endothelial cell injury is unclear. This study examined the effects of lipopolysaccharide (LPS)-induced macrophage exosomes on endothelial progenitor cells (EPCs) and inflammatory factors. It also investigated the role of MicroRNA-155 (miR-155) in macrophage exosomes and EPCs, and the impact of semaglutide on EPC function and inflammation. The results showed that LPS-induced macrophage exosomes impaired EPCs function and increased inflammation, which was exacerbated by high miR-155 expression. In contrast, inhibition of miR-155 improved EPCs function and reduced inflammation. Semaglutide enhanced EPCs viability and reduced inflammatory factors and miR-155 expression in exosomes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Ziang Zhu, Tong Li, Jinya Chen, Jai Kumar, Princy Kumar, Jing Qin, Colleen Hadigan, Irini Sereti, Jason V. Baker, Marta Catalfamo
Summary: This study examines the impact of HIV infection on endothelial inflammation and repair by evaluating cell phenotypes and subsets in the blood of HIV-infected individuals. The researchers found that infection-induced phenotypic changes were associated with inflammatory biomarkers, suggesting that HIV infection may affect endothelial inflammation and repair.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yanhao He, Guangde Yang, Lijing Sun, Hongqian Gao, Feng Yao, Zhen Jin, Zihan Zheng, Lifang Chen, Weirong Wang, Nanbo Zheng, Rong Lin
Summary: SIRT6 protects against vascular inflammation through its deacetylase activity and the NRF2-dependent signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hyoung Won Bae, Wungrak Choi, Ah Reum Hwang, Sang Yeop Lee, Gong Je Seong, Chan Yun Kim
Summary: The study found that hypoxic preconditioning significantly increased the survival rate of primary retinal ganglion cells, with VEGF playing an important regulatory role in this process. Over-inhibition of VEGF negatively impacted the survival of RGCs mediated by hypoxic preconditioning.
Article
Chemistry, Multidisciplinary
Laura Casarrubios, Alberto Polo-Montalvo, Maria Concepcion Serrano, Maria Jose Feito, Maria Vallet-Regi, Daniel Arcos, Maria Teresa Portoles
Summary: This study demonstrated the potential of nanoparticles to enhance VEGFR2 expression and angiogenesis in endothelial progenitor cells (EPCs) by intracellular incorporation through endocytosis mechanisms. The nanospheres showed angiogenic effects on EPCs even in the presence of phagocytic cells, confirming their role in promoting vascularization and tissue regeneration.
Article
Medicine, Research & Experimental
Tianying Hong, Xianmei Pan, Han Xu, Zhijuan Zheng, Lizhen Wen, Jing Li, Mingfeng Xia
Summary: Vascular inflammation is a common pathological basis for many cardiovascular diseases. Jatrorrhizine, a component of Rhizoma Coptidis, has been found to reduce carotid intimal hyperplasia and vascular inflammation in mice, and inhibit endothelial cell inflammation induced by H2O2.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Letter
Medicine, General & Internal
Benjamin Sommer Thinggaard, Frederik Pedersen, Jakob Grauslund, Lonny Stokholm
Summary: This cohort study examines the use and forecast of intravitreal injections of vascular endothelial growth factor inhibitor in Denmark from 2007 through 2022.
Article
Multidisciplinary Sciences
Kristina Svennerholm, Michael Haney, Bjorn Biber, Erik Ulfhammer, Ott Saluveer, Pia Larsson, Elmir Omerovic, Sverker Jern, Niklas Bergh
Article
Multidisciplinary Sciences
Elin Ekblom-Bak, Gustav Olsson, Orjan Ekblom, Bjorn Ekblom, Goran Bergstrom, Mats Borjesson
Article
Multidisciplinary Sciences
Mia Magnusson, Emma Xuchun Lu, Pia Larsson, Erik Ulfhammer, Niklas Bergh, Helena Caren, Sverker Jern
Article
Cardiac & Cardiovascular Systems
Smita DuttaRoy, Jonas Nilsson, Ola Hammarsten, Asa Cider, Maria Back, Thomas Karlsson, Bertil Wennerblom, Mats Borjesson
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2015)
Article
Chemistry, Analytical
Jonatan Fridolfsson, Mats Borjesson, Daniel Arvidsson
Editorial Material
Sport Sciences
Daniel Neunhaeuserer, Josef Niebauer, Gino Degano, Veronica Baioccato, Mats Borjesson, Maurizio Casasco, Norbert Bachl, Nicolas Christodoulou, Juergen Michael Steinacker, Theodora Papadopoulou, Fabio Pigozzi, Andrea Ermolao
BRITISH JOURNAL OF SPORTS MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
P. Sorensson, M. Dellborg, M. Borjesson
Summary: This article provides an overview of different non-invasive imaging methods for diagnosing CAD and discusses the risks and benefits of evaluating athletes before sports participation. Gathering relevant information and complementing anatomical evaluations with functional evaluations can help assess the risk of CAD in athletes.
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Sport Sciences
Matilda Frisk Torell, Anneli Stromsoe, Johan Herlitz, Andreas Claesson, Araz Rawshani, Mats Borjesson
Summary: Survival rates are higher for younger victims of exercise-related OHCA. Exercise-related OHCA is rare in females, and their survival rates are lower compared to males, partly due to less witnessed events, longer time to CPR, and lower rates of shockable rhythms.
BRITISH JOURNAL OF SPORTS MEDICINE
(2022)
Review
Sport Sciences
Andreas Serner, Joao Araujo, Ian Beasley, Stephen H. Boyce, Alan Byrne, Mats Borjesson, Liesel Geertsema, Katharina Grimm, Andrew Massey
Summary: Using injury spotters and video footage review, this study aimed to examine the frequency and characteristics of head impacts during the FIFA Arab Cup 2021, as well as the subsequent medical assessment. The results showed that head impacts were common, with an average of 2 impacts per match, and 50% of them required on-pitch medical assessment. Head-to-head contact was the most common mechanism, but only 8% of the impacts showed video signs of potential concussion, and 3% resulted in a concussion substitution.
SCIENCE AND MEDICINE IN FOOTBALL
(2022)
Article
Cardiac & Cardiovascular Systems
Amanda Lonn, Mats Borjesson, Kristina Hambraeus, Orjan Ekblom
Summary: This cohort study among MI survivors showed that remaining physically active or changing physical activity levels during the first year post-MI was associated with a lower risk of recurrent nonfatal CVD events.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Frida Griffin, Elin Ekblom-Bak, Daniel Arvidsson, Sofia Paulsson, Mats Boerjesson
Summary: The study found that an increase in cardiorespiratory fitness is associated with a lower risk of cardiovascular disease and all-cause hospital admission. Maintaining cardiorespiratory fitness is associated with a reduced risk of cardiovascular disease and all-cause admission, compared to a decline. Furthermore, increasing cardiorespiratory fitness further reduces the risk, especially for individuals with prior admission. Efforts to maintain or improve cardiorespiratory fitness should be included in disease-preventive strategies, and it can lead to reduced healthcare utilization and costs.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, Research & Experimental
Susanne Bernhardsson, Charlotte Boman, Stefan Lundqvist, Daniel Arvidsson, Mats Borjesson, Maria E. H. Larsson, Hannah Lundh, Karin Melin, Per Nilsen, Katarina Lauruschkus
Summary: This project aims to evaluate the feasibility of implementing physical activity on prescription (PAP) in children with obesity and explore the experiences of children, parents, and healthcare providers with PAP through clinical studies and focus group discussions. The design and analysis of the studies are guided by the Normalization Process Theory.
PILOT AND FEASIBILITY STUDIES
(2022)
Article
Public, Environmental & Occupational Health
Amanda Ek, Orjan Ekblom, Mattias Ekstrom, Mats Borjesson, Lena Viktoria Kallings
Summary: The study found a gap between the stated importance and actual clinical work in promoting healthy lifestyle habits among healthcare professionals. Tobacco cessation was considered the most important behavior change and received more attention in clinical work compared to promoting physical activity, healthy eating habits, and limiting alcohol use. The clinical work was mainly influenced by the clarity of organizational routines and objectives perceived by healthcare professionals.
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2021)
Article
Psychiatry
Markus Gerber, Magnus Lindwall, Mats Borjesson, Emina Hadzibajramovic, Ingibjorg H. Jonsdottir
MENTAL HEALTH AND PHYSICAL ACTIVITY
(2017)
Article
Peripheral Vascular Disease
Erik Ulfhammer, Pia Larsson, Mia Magnusson, Lena Karlsson, Niklas Bergh, Sverker Jern
INTERNATIONAL JOURNAL OF VASCULAR MEDICINE
(2016)