Article
Medicine, Research & Experimental
Zhitao Li, Jiachun Cai, Jiexiong Li, Xianghui Xu, Limin Zheng
Summary: The study found high correlation between BIS and BISpro, both correlating well with OAA/S scores. BIS was able to accurately distinguish all investigated OAA/S states, while the ability to predict OAA/S scores 5 to loss of response was comparable between BIS and BISpro. The calculated cut-off values were 68 for BIS and 70 for BISpro.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Daniela Biggs, Gonzalo Boncompte, Juan C. C. Pedemonte, Carlos Fuentes, Luis I. I. Cortinez
Summary: There are age-related biases in EEG measures of anesthesia hypnosis in elderly patients, and these biases should be taken into consideration when interpreting and designing EEG monitors for clinical settings. Permutation entropy (PE) shows promise as an age-independent measure of hypnotic depth for future monitor development.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
David Yuen Chung Chan, Lai Fung Li, Wai Man Lui, Clara Ching Mei Poon, Anderson Chun On Tsang, Gilberto Ka Kit Leung
Summary: This study evaluates the prognostic value of measuring the Bispectral Index (BIS) and its correlation to propofol dosage in early post-operative sedation in neurosurgical patients. The results show a significant correlation between BIS readings and propofol dosage in the functional outcomes at 3 months.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Anesthesiology
Thomas W. Schnider, Charles F. Minto
Summary: Variability is high in predicted propofol concentrations during clinical anesthesia, and improving pharmacokinetic models is unlikely to reduce variability in target anesthetic concentrations across patients in clinical practice.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Biology
Ryan T. Jarrett, James L. Blair, Matthew S. Shotwell
Summary: During closed-loop induction of anesthesia, a framework is introduced to define and optimize clinical outcomes by replacing the traditional fixed reference point with a time-varying reference function. The reference function is selected to minimize an objective function that encapsulates clinical goals, considering population variability.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Medicinal
Tingting Li, Wenjing Han, Xinlu Yang, Yu Wang, Li Peng, Lingwei He, Lianjia Hu, Jiayuan Liu, Min Xia, Sheng Wang
Summary: The study aimed to investigate the effects of different injection rates of propofol on postoperative cognition in elderly patients undergoing laparoscopic inguinal hernia repair. The results showed that lowering the injection rate of propofol (such as 30 mg kg-1 h-1) did not decrease the incidence of early postoperative cognitive decline (POCD), but reduced the induction dose of propofol and use of vasoactive drugs, making the patient's hemodynamics more stable.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Neurosciences
Xuewei Qin, Xuanling Chen, Bo Wang, Xin Zhao, Yi Tang, Lan Yao, Zhenhu Liang, Jianghong He, Xiaoli Li
Summary: This study compared the EEG changes in vegetative state (VS) patients and non-craniotomy, non-vegetative state (NVS) patients during general anesthesia with low-dose propofol and investigated if it affects the arousal rate of VS patients. The results showed that low doses of propofol caused significant differences in the EEG of different types of VS patients, indicating unique responses of damaged nerve cell residual function to propofol. These weak responses may be the basis of brain recovery.
Letter
Anesthesiology
Sean Coeckelenbergh, Maxime Soucy-Proulx, Finn Radtke
Summary: Mesenchymal stem cells can improve postoperative cognitive recovery in aging mice by inhibiting hippocampus ferroptosis through activating the SIRT1/Nrf2/HO-1 signaling pathway. Exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells can also ameliorate postoperative cognitive dysfunction in mice with diabetes.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Medicine, General & Internal
Gokcen Duymaz, Tuncay Ozgur, Ali Giray Kara, Veysel Erden
Summary: This study aimed to investigate the impact of testosterone levels on the depth of anesthesia in patients undergoing septoplasty. It was found that sedation anesthesia was influenced by testosterone levels, making it more challenging for patients with higher testosterone levels to switch to sedation.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Multidisciplinary Sciences
Xia Wang, Yong Wang, Zhen-Wei Zheng, Yu-Rui Liu, Wu-Hua Ma
Summary: Upper airway collapsibility after anesthesia induction may contribute to difficult airway. This study used pre-anesthetic ultrasound measurements to evaluate the changes of upper airway after anesthesia induction and predict Difficult Laryngoscopy. The results suggest that the DSE assessed by ultrasound may serve as a valuable predictor of Difficult Laryngoscopy.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Xiaoyun Guo, Hui Li, Hua Zhang, Jinhu Su, Mingzhi Hu, Yan Sun, Xiyan He, Gongxiao Wang
Summary: This study found that the combination of butorphanol and propofol in elderly patients undergoing ultrasonic bronchoscopy can lower blood pressure and heart rate, shorten anesthesia onset time and recovery time, reduce adverse reactions, and improve pulse oximetry saturation.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
J. Deng, M. -T. Li, M. -C. Yang, Z. -M. Wen, X. -K. Li, C. -Y. Zhu, T. Wang, T. Yan, M. Tang, Y. Pu, H. -Y. Zuo
Summary: This study compared the sedation profiles and safety characteristics between Ciprofol and Propofol at different dose levels in healthy Chinese male subjects.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Manoj Kumar, Atit Kumar, Jay Brijesh Singh Yadav, Sunil K. Bhardwaj, Amit K. Singh
Summary: This study aimed to compare the anesthetic stability of propofol, dexmedetomidine, and isoflurane by measuring bispectral index (BIS) and hemodynamic indices. Results showed that dexmedetomidine is superior to propofol and isoflurane in maintaining BIS score and hemodynamic parameters during the intraoperative period.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Clinical Neurology
Ashraf A. Dahaba, Han Lin, Xue Fei Ye, Nu Zhang, Kun Wang, Gilbert Reibnegger, Qing Quan Lian
Summary: The study investigated the sensitivity of post-cerebral hemorrhage hydrocephalus patients to hypnotic agents and the use of BIS as a surrogate marker for their hypnotic effect, showing a pattern of response that was similar but significantly lower compared to healthy subjects.
CLINICAL EEG AND NEUROSCIENCE
(2021)
Editorial Material
Medicine, General & Internal
Nadir A. Ratanshi, Yasser Mandour
Summary: Anaesthetists often discuss the pros and cons of adding lidocaine to propofol for anaesthetic induction, weighing the benefits of pain relief and patient satisfaction against potential drawbacks such as effects on the emulsion, efficacy of propofol post-mixing, and bacterial growth in the syringe.
BRITISH JOURNAL OF HOSPITAL MEDICINE
(2021)
