Article
Cardiac & Cardiovascular Systems
Krishna K. Patel, A. Iain Mcghie, Kevin F. Kennedy, Randall C. Thompson, John A. Spertus, Brett W. Sperry, Leslee J. Shaw, Timothy M. Bateman
Summary: PET LVEF-R can be a significant predictor of prognosis in patients with cardiovascular disease. It can identify patients who benefit from revascularization within 90 days and improve survival, especially in the absence of prior myocardial infarction or revascularization.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
K. Lance Gould, Tung Nguyen, Richard Kirkeeide, Amanda E. Roby, Linh Bui, Danai Kitkungvan, Monica B. Patel, Mohammad Madjid, Mary Haynie, Dejian Lai, Ruosha Li, Jagat Narula, Nils P. Johnson
Summary: This study aimed to quantify subendocardial ischemia and assess its clinical associations and outcomes. The results showed that severely reduced coronary flow capacity (CFC) was associated with a higher risk of major adverse cardiac events and mortality. For patients without severe CFC abnormality, although they had subendocardial perfusion defects, the risk of adverse cardiac events was relatively low.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexis Poitrasson-Riviere, Jonathan B. Moody, Jennifer M. Renaud, Tomoe Hagio, Liliana Arida-Moody, Christopher J. Buckley, Mouaz H. Al-Mallah, Brahmajee K. Nallamothu, Richard L. Weinberg, Edward P. Ficaro, Venkatesh L. Murthy
Summary: This study combines MFR and relative perfusion quantification to create an integrated MFR (iMFR) for distinguishing obstructive epicardial coronary artery disease (CAD) from microvascular dysfunction. The results show that iMFR can serve as a powerful predictor for diagnosing obstructive stenosis, and the absence of transient ischemic dilation (TID) can help rule out obstructive and high-risk CAD.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Keiichiro Kuronuma, Robert J. H. Miller, Serge D. Van Kriekinge, Donghee Han, Ananya Singh, Heidi Gransar, Damini Dey, Daniel S. Berman, Piotr J. Slomka
Summary: PurposePhase analysis can evaluate left ventricular dyssynchrony, but the prognostic value of phase variables over PET-MPI variables has not been studied. This study aimed to explore the prognostic value of phase variables for predicting mortality. A total of 3963 patients who underwent pharmacological stress-rest Rb-82 PET study were enrolled. Cox proportional hazard analyses showed that stress phase entropy was significantly associated with all-cause mortality, and its addition improved the discriminatory power for mortality prediction.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elia von Felten, Dominik C. Benz, Georgios Benetos, Jessica Baehler, Dimitri Patriki, Georgios P. Rampidis, Andreas A. Giannopoulos, Adam Bakula, Christoph Graeni, Aju P. Pazhenkottil, Catherine Gebhard, Tobias A. Fuchs, Philipp A. Kaufmann, Ronny R. Buechel
Summary: Assessing regional quantitative myocardial flow measures through N-13-ammonia PET myocardial perfusion imaging can predict adverse cardiac outcomes and all-cause death in patients with suspected coronary artery disease.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Mahmoud Al Rifai, Ahmed Ibrahim Ahmed, Jean Michel Saad, Fares Alahdab, Faisal Nabi, Mouaz H. Al-Mallah
Summary: This study observed that positron emission tomography (PET)-derived myocardial flow reserve (MFR) can predict the future cardiovascular risk among high-risk coronary artery bypass grafting (CABG) patients, especially heart failure. This method can be independent of cardiovascular risk factors and perfusion data.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Georgios Benetos, Dominik C. Benz, Georgios P. Rampidis, Andreas A. Giannopoulos, Elia von Felten, Adam Bakula, Aleksandra Sustar, Tobias A. Fuchs, Aju P. Pazhenkottil, Catherine Gebhard, Philipp A. Kaufmann, Christoph Grani, Ronny R. Buechel
Summary: CAVi, derived from CCTA, is proposed as an indicator of diffuse atherosclerosis. This study found that CAVi is moderately correlated with stress MBF and MFR, and has incremental value in predicting abnormal stress MBF and ischemia compared to CCTA alone.
EUROPEAN RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ana Carolina do A. H. de Souza, Hendrik J. Harms, Laurel Martell, Courtney Bibbo, Meagan Harrington, Kyle Sullivan, Jon Hainer, Sharmila Dorbala, Ron Blankstein, Viviany R. Taqueti, Marie Foley Kijewski, Mi-Ae Park, Alejandro Meretta, Christopher Breault, Nathaniel Roth, Alexis Poitrasson-Riviere, Prem Soman, Grant T. Gullberg, Marcelo F. Di Carli
Summary: This study aimed to validate the accuracy of Tc-99m-sestamibi SPECT in quantifying MBF and MFR, as well as evaluate its reproducibility. The results showed that using splines in SPECT imaging improved the correlation with N-13-ammonia positron emission tomography and demonstrated good test/retest reproducibility.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Jamshid Maddahi, Denis Agostini, Timothy M. Bateman, Jeroen J. Bax, Rob S. B. Beanlands, Daniel S. Berman, Sharmila Dorbala, Ernest V. Garcia, James Feldman, Gary V. Heller, Juhani M. Knuuti, Pedro Martinez-Clark, Matthieu Pelletier-Galarneau, Benjamin Shepple, Nagara Tamaki, Francois Tranquart, James E. Udelson
Summary: This study demonstrates that Flurpiridaz F-18 is a novel PET tracer with high diagnostic efficacy and safety for detecting coronary artery disease. It has higher sensitivity and specificity compared to traditional SPECT technique, especially in women and obese patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Krishna K. Patel, Leslee Shaw, John A. Spertus, Brett Sperry, A. Iain McGhie, Kevin Kennedy, Randall C. Thompson, Paul S. Chan, Timothy M. Bateman
Summary: Coronary vasomotor dysfunction, as indicated by reduced MBFR, is associated with higher risk of all-cause and cardiac death in patients with suspected or known coronary artery disease. The prognostic value of reduced MBFR does not differ by sex, regardless of extent of coexisting atherosclerosis or baseline perfusion abnormality.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Clinical Neurology
Hiroshi Yamauchi, Shinya Kagawa, Kuninori Kusano, Miki Ito, Chio Okuyama
Summary: This pilot study with a small sample size suggests that cerebral hypoperfusion may be associated with increased tau deposition in patients with atherosclerotic internal carotid artery or middle cerebral artery disease.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jennifer M. Renaud, Alexis Poitrasson-Riviere, Jonathan B. Moody, Tomoe Hagio, Edward P. Ficaro, Venkatesh L. Murthy
Summary: By establishing normal databases, the diagnostic accuracy of PET MPI analysis can be improved. Normal databases built using 3D PET images have significant advantages in evaluating TPD in patients. The clinical application of these techniques should be considered to support accurate image interpretation.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Medicine, General & Internal
Dan L. Li, Marvin W. Kronenberg
Summary: Coronary artery disease is a major global health concern with noninvasive imaging tests playing a crucial role in its diagnosis and management. Myocardial perfusion imaging, along with other noninvasive tests such as stress echocardiography, coronary computed tomography angiography, and cardiac magnetic resonance imaging, have been widely used for evaluating ischemia and myocardial viability. The accuracy and clinical significance of these tests are essential in guiding risk stratification and revascularization decisions.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Teemu Maaniitty, Iida Stenstrom, Antti Saraste, Juhani Knuuti
Summary: Quantitative PET analysis revealed that a proportion of symptomatic patients with suspected obstructive coronary artery disease (CAD) have myocardial perfusion abnormalities, with approximately one quarter showing balanced reduction in perfusion.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Yi, Cheng Xu, Wei Wu, Zhu-Jun Shen, Whal Lee, Chun-Ho Yun, Bin Lu, Jia-Yin Zhang, Zheng-Yu Jin, Yi-Ning Wang
Summary: The study aimed to investigate the diagnostic performance of 70-kVp stress dynamic myocardial CT perfusion as a low-dose, one-stop cardiac CT examination in clinical application. The results showed that CTP-derived SP-CTA significantly improved the diagnostic accuracy compared to CTP and SP-CTA alone, with high sensitivity and specificity for identifying ischemia.
EUROPEAN RADIOLOGY
(2021)
Article
Orthopedics
Julia C. A. Noorduyn, M. M. H. Teuwen, V. A. van de Graaf, N. W. Willigenburg, M. Schavemaker, R. van Dijk, G. G. M. Scholten-Peeters, M. W. Heymans, M. W. Coppieters, R. W. Poolman, V. A. B. Scholtes, E. L. A. R. Mutsaerts, J. Wolkenfelt, M. R. Krijnen, D. F. P. van Deurzen, D. J. F. Moojen, C. H. Bloembergen, Gast A. de Gast, T. Snijders, J. J. Halma, D. B. F. Saris, N. Wolterbeek, C. Neeter, D. M. M. J. Kerkhoffs, R. W. Peters, I. C. J. B. van den Brand, S. de Vos-Jakobs, A. B. Spoor, T. Gosens, W. Rezaie, D. J. Hofstee, B. J. Burger, D. Haverkamp, A. M. J. S. Vervest, T. A. van Rheenen, A. E. Wijsbek, E. R. A. van Arkel, B. J. W. Thomassen, S. Sprague, B. W. J. Mol, M. W. van Tulder, J. van der Kraan
Summary: Despite physical therapy being the recommended treatment for patients with degenerative meniscal tears over 45 years old, a significant percentage still opt for surgery, especially those with worse knee function, lower education level, and better general physical health status. However, the prognostic models developed in this study had low explained variance and insufficient predictive accuracy to accurately predict non-responders to physical therapy.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Cardiac & Cardiovascular Systems
Henk Everaars, Pepijn A. van Diemen, P. Stefan Biesbroek, Luuk H. G. A. Hopman, Michiel J. Bom, Stefan P. Schumacher, Ruben W. de Winter, Peter M. van de Ven, Pieter G. Raijmakers, Adriaan A. Lammertsma, Mark B. M. Hofman, Robin Nijveldt, Marco J. Gotte, Albert C. van Rossum, Ibrahim Danad, Roel S. Driessen, Paul Knaapen
Summary: This study aimed to compare cardiac magnetic resonance (CMR) measurement of T1 reactivity (Delta T1) with [O-15]H2O positron emission tomography (PET) measurements of quantitative myocardial perfusion. The results showed poor agreement between CMR stress T1 mapping and PET measurements of absolute myocardial perfusion. CMR stress T1 and Delta T1 were lower in vascular territories with reduced stress MBF, but had limited accuracy in detecting impaired myocardial perfusion.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Eric Guedj, Andrea Varrone, Ronald Boellaard, Nathalie L. Albert, Henryk Barthel, Bart van Berckel, Matthias Brendel, Diego Cecchin, Ozgul Ekmekcioglu, Valentina Garibotto, Adriaan A. Lammertsma, Ian Law, Ivan Penuelas, Franck Semah, Tatjana Traub-Weidinger, Elsmarieke van de Giessen, Donatienne Van Weehaeghe, Silvia Morbelli
Summary: The guidelines summarize the current views of the EANM Neuro-Imaging Committee on [F-18]FDG-PET imaging of the brain, aiming to improve diagnostic impact in neurological, neurosurgical, and psychiatric practice. Updates include advances in PET technology, the impact of hyperglycemia in patients undergoing brain [F-18]FDG-PET, and typical brain metabolic patterns for neurodegenerative diseases.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Statistics & Probability
Oludare Ariyo, Emmanuel Lesaffre, Geert Verbeke, Martijn Huisman, Martijn Heymans, Jos Twisk
Summary: This study investigates the performance of different selection criteria for multilevel mediation models and finds that marginal criteria are superior to conditional criteria. The research demonstrates this superiority through simulation studies and an application to real data. Additionally, the usefulness of a self-written R function for multilevel mediation models is shown.
STATISTICA NEERLANDICA
(2022)
Review
Clinical Neurology
Mariam Ali, Hendrikus J. A. van Os, Nelleke van der Weerd, Jan W. Schoones, Martijn W. Heymans, Nyika D. Kruyt, Marieke C. Visser, Marieke J. H. Wermer
Summary: This study investigated sex differences in the clinical presentation of acute stroke or transient ischemic attack. The results showed substantive differences in nonfocal and focal stroke symptoms between men and women. However, high-quality studies are lacking and more research is needed to address this issue.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Adrienne H. Brouwers, Joyce van Sluis, Johannes H. van Snick, Carolina P. Schroder, Inge O. Baas, Ronald Boellaard, Andor W. J. M. Glaudemans, Ronald J. H. Borra, Adriaan A. Lammertsma, Rudi A. J. O. Dierckx, Charalampos Tsoumpas
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chris W. J. van der Weijden, Jan F. Meilof, Anouk van der Hoorn, Junqing Zhu, Chunying Wu, Yanming Wang, Antoon T. M. Willemsen, Rudi A. J. O. Dierckx, Adriaan A. Lammertsma, Erik F. J. de Vries
Summary: This study aimed to evaluate [C-11]MeDAS as a PET tracer for myelin imaging in humans. The 2T3k model was found to be the optimal compartment model, and MLAIR2 was the best simplified method for quantification. [C-11]MeDAS PET can be used for quantification of myelin density in MS patients and is able to distinguish differences in myelin density within MS lesions.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Oncology
N. George Mikhaeel, Martijn W. Heymans, Jakoba J. Eertink, Henrica C. W. de Vet, Ronald Boellaard, Ulrich Duhrsen, Luca Ceriani, Christine Schmitz, Sanne E. Wiegers, Andreas Huttmann, Pieternella J. Lugtenburg, Emanuele Zucca, Gerben J. C. Zwezerijnen, Otto S. Hoekstra, Josee M. Zijlstra, Sally F. Barrington
Summary: This study aimed to determine the best statistical relationship between metabolic tumor volume (MTV) and survival in diffuse large B-cell lymphoma (DLBCL), and compare it with the International Prognostic Index (IPI). The results showed that MTV was a better predictor for progression-free survival (PFS) and overall survival (OS) than IPI. A new prognostic model combining MTV, age, and stage outperformed IPI and provided individualized estimates of patient outcome.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gerben J. C. Zwezerijnen, Jakoba J. Eertink, Maria C. Ferrandez, Sanne E. Wiegers, Coreline N. Burggraaff, Pieternella J. Lugtenburg, Martijn W. Heymans, Henrica C. W. de Vet, Josee M. Zijlstra, Ronald Boellaard
Summary: This study evaluates the variation in liver standardised uptake value (SUV) measurements in lymphoma [18F]FDG PET/CT studies using different uptake metrics. The results show that SUVmean(liver) is the most reproducible metric for liver uptake.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Endocrinology & Metabolism
Fiona Heeman, Denise Visser, Maqsood Yaqub, Sander Verfaillie, Tessa Timmers, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, Bart N. M. van Berckel, Ronald Boellaard, Adriaan A. Lammertsma, Sandeep S. Golla
Summary: Alzheimer's disease is characterized by reduced cerebral blood flow. This study compared the precision of different methods for measuring cerebral blood flow and found that relative blood flow methods had better repeatability than absolute blood flow methods. The high precision of relative blood flow may be due to a compensatory effect of the extraction fraction.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anne M. Smith, Nancy A. Obuchowski, Norman L. Foster, Gregory Klein, P. David Mozley, Adriaan A. Lammertsma, Richard L. Wahl, John J. Sunderland, Jean-Luc Vanderheyden, Tammie L. S. Benzinger, Paul E. Kinahan, Dean F. Wong, Eric S. Perlman, Satoshi Minoshima, Dawn Matthews
Summary: Standardized approach in acquiring amyloid PET images increases their value as disease and drug response biomarkers. The Quantitative Imaging Biomarkers Alliance amyloid PET biomarker committee developed and validated a profile to characterize and reduce the variability of SUVRs, increasing statistical power for these assessments.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jerney de Jongh, Nicki J. F. Verweij, Maqsood Yaqub, Christiaan J. van Denderen, Irene E. van der Horst-bruinsma, Joost C. J. Bot, Bouke J. H. Boden, Robert Hemke, Frank F. Smithuis, Willem F. Lems, Adriaan A. Lammertsma, Alexandre E. Voskuyl, Maarten Boers, Gerben J. C. Zwezerijnen, Conny J. van der Laken
Summary: Lesions detected on [F-18]fluoride PET scans often fall outside the scope of MRI and CR, with partial overlap with abnormalities seen on MRI (especially BME) and CR (especially ankylosis). PET activity shows the strongest association with BME on MRI and ankylosis on CR.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Oncology
Mostafa Roya, Samaneh Mostafapour, Philipp Mohr, Laura Providencia, Zekai Li, Johannes H. van Snick, Adrienne H. Brouwers, Walter Noordzij, Antoon T. M. Willemsen, Rudi A. J. O. Dierckx, Adriaan A. Lammertsma, Andor W. J. M. Glaudemans, Charalampos Tsoumpas, Riemer H. J. A. Slart, Joyce van Sluis
Summary: Recently, a new type of PET scanner with long axial field-of-view (LAFOV) has been introduced in clinical practice. Compared to conventional PET scanners, LAFOV scanners have a larger coverage and higher sensitivity, providing new opportunities for clinical applications, such as reducing scan time, decreasing the amount of radiotracer used, and using dynamic or parametric imaging. Emerging technologies like artificial intelligence and imaging with multiple radiotracers can further enhance the clinical application of LAFOV PET.
Article
Hematology
Julia Driessen, Gerben J. C. Zwezerijnen, Heiko Schoeder, Marie Jose Kersten, Alison J. Moskowitz, Craig H. Moskowitz, Jakoba J. Eertink, Martijn W. Heymans, Ronald Boellaard, Josee M. Zijlstra
Summary: We developed a prognostic model for progression-free survival (PFS) in patients with relapsed or primary refractory classical Hodgkin lymphoma (R/R cHL) using baseline quantitative F-18-fluorodeoxyglucose positron emission tomography (PET) radiomics features and clinical characteristics. The model can help predict PFS outcomes and guide risk-stratified treatment strategies for R/R cHL patients.
Review
Pharmacology & Pharmacy
Johan A. den Boer, Erik J. F. de Vries, Ronald J. H. Borra, Aren van Waarde, Adriaan A. Lam-mertsma, Rudi A. Dierckx
Summary: This review discusses translational, diagnostic, and methodological issues in drug development for CNS disorders, with a focus on psychiatry. The role of preclinical models and brain imaging using PET and fMRI in early stages of drug development is critically reviewed. The review emphasizes the importance of collaborations between industry, academia, and phase I units in drug development. Brain imaging has revolutionized the study of psychiatric illnesses, providing insights at different levels of analysis and supporting preclinical and clinical drug development.
CURRENT REVIEWS IN CLINICAL AND EXPERIMENTAL PHARMACOLOGY
(2022)