Diagnosis and treatment of familial hypercholesterolaemia

Inhibition of pre-protein convertase serine kexin-9 (PCSK-9) as a treatment for hyperlipidaemia

(2012) Anthony S Wierzbicki et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Contributions of treatment and lifestyle to declining CVD mortality: why have CVD mortality rates declined so much since the 1960s?

(2012) Martin O'Flaherty et al.   HEART

New lipid-lowering drugs: an update

(2012) A. S. Wierzbicki et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

THE EFFECTS OF CO-ADMINISTERING A MONOCLONAL ANTIBODY TO PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 SERINE PROTEASE, REGN727/SAR236553, WITH 10 AND 80 MG ATORVASTATIN COMPARED TO 80 MG ATORVASTATIN ALONE IN PATIENTS WITH PRIMARY HYPERCHOLESTEROLEMIA (NCT: 01288469)

(2012) Eli M. Roth et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

EFFECTS OF AMG 145, A FULLY HUMAN MONOCLONAL ANTIBODY AGAINST PCSK9, ON LOW-DENSITY LIPOPROTEIN CHOLESTEROL IN SUBJECTS TAKING STATINS: A PHASE 1, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, ASCENDING MULTIPLE-DOSE STUDY

(2012) Clapton Dias et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Safety and Efficacy of a Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 Serine Protease, SAR236553/REGN727, in Patients With Primary Hypercholesterolemia Receiving Ongoing Stable Atorvastatin Therapy

(2012) James M. McKenney et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised controlled trial

(2012) Evan A Stein et al.   LANCET

Effect of a Monoclonal Antibody to PCSK9 on LDL Cholesterol

(2012) Evan A. Stein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular characterization of familial hypercholesterolemia in Spain

(2011) Lourdes Palacios et al.   ATHEROSCLEROSIS

2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult – 2009 recommendations

(2011) Jacques Genest et al.   CANADIAN JOURNAL OF CARDIOLOGY

Molecular Basis of Autosomal Dominant Hypercholesterolemia

(2011) Anouk van der Graaf et al.   CIRCULATION

Assessment of Carotid Atherosclerosis in Normocholesterolemic Individuals With Proven Mutations in the Low-Density Lipoprotein Receptor or Apolipoprotein B Genes

(2011) Roeland Huijgen et al.   Circulation-Cardiovascular Genetics

Familial hypercholesterolemia: epidemiology, Neolithic origins and modern geographic distribution

(2011) Khemanganee E. Liyanage et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Treatment of Familial Hypercholesterolemia: Is There a Need Beyond Statin Therapy?

(2011) Anna Raper et al.   Current Atherosclerosis Reports

ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)

(2011) et al.   EUROPEAN HEART JOURNAL

Management of Familial Hypercholesterolemias in adult patients: Recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia

(2011) Matthew K. Ito et al.   Journal of Clinical Lipidology

Familial Hypercholesterolemia: Screening, diagnosis and management of pediatric and adult patients

(2011) Anne C. Goldberg et al.   Journal of Clinical Lipidology

Emerging therapeutic strategies to enhance HDL function

(2011) Santiago Redondo et al.   Lipids in Health and Disease

Familial Hypercholesterolemia: The Lipids or the Genes?

(2011) Akl C Fahed et al.   Nutrition & Metabolism

Familial Hypercholesterolemia: Present and Future Management

(2011) B. Sjouke et al.   Current Cardiology Reports

Effect of Mipomersen, an Apolipoprotein B Synthesis Inhibitor, on Low-Density Lipoprotein Cholesterol in Patients With Familial Hypercholesterolemia

(2010) Fatima Akdim et al.   AMERICAN JOURNAL OF CARDIOLOGY

Effect of Corneal Arcus on Central Corneal Thickness, Intraocular Pressure, and Primary Open-angle Glaucoma

(2010) Renyi Wu   ARCHIVES OF OPHTHALMOLOGY

Lipoprotein(a) as a cardiovascular risk factor: current status

(2010) Børge G. Nordestgaard et al.   EUROPEAN HEART JOURNAL

Defining the challenges of FH Screening for familial hypercholesterolemia

(2010) Joep C. Defesche   Journal of Clinical Lipidology

A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo

(2010) Yan G. Ni et al.   JOURNAL OF LIPID RESEARCH

Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial

(2010) Frederick J Raal et al.   LANCET

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials

(2010)   LANCET

Safety of Anacetrapib in Patients with or at High Risk for Coronary Heart Disease

(2010) Christopher P. Cannon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Two Years after Molecular Diagnosis of Familial Hypercholesterolemia: Majority on Cholesterol-Lowering Treatment but a Minority Reaches Treatment Goal

(2010) Roeland Huijgen et al.   PLoS One

Differences in characteristics and risk of cardiovascular disease in familial hypercholesterolemia patients with and without tendon xanthomas: A systematic review and meta-analysis

(2009) Daniëlla M. Oosterveer et al.   ATHEROSCLEROSIS

Evaluation of cholesterol lowering treatment of patients with familial hypercholesterolemia: a large cross-sectional study in The Netherlands

(2009) A.H. Pijlman et al.   ATHEROSCLEROSIS

Other Therapies for Reducing Low-Density Lipoprotein Cholesterol: Medications in Development

(2009) Evan A. Stein   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities

(2009) Majambu Mbikay et al.   FEBS LETTERS

Mutations and polymorphisms in the proprotein convertase subtilisin kexin 9 (PCSK9) gene in cholesterol metabolism and disease

(2009) Marianne Abifadel et al.   HUMAN MUTATION

Longitudinal Evaluation and Assessment of Cardiovascular Disease in Patients With Homozygous Familial Hypercholesterolemia

(2008) Daniel M. Kolansky et al.   AMERICAN JOURNAL OF CARDIOLOGY

Update and Analysis of the University College London Low Density Lipoprotein Receptor Familial Hypercholesterolemia Database

(2008) S. E. A. Leigh et al.   ANNALS OF HUMAN GENETICS

Recommendations for the use of LDL apheresis

(2008) G.R. Thompson   ATHEROSCLEROSIS

Infusion of Reconstituted High-Density Lipoprotein Leads to Acute Changes in Human Atherosclerotic Plaque

(2008) James A. Shaw et al.   CIRCULATION RESEARCH

Correlating corneal arcus with atherosclerosis in familial hypercholesterolemia

(2008) Loren A Zech et al.   Lipids in Health and Disease

Simvastatin with or without Ezetimibe in Familial Hypercholesterolemia

(2008) John J.P. Kastelein et al.   NEW ENGLAND JOURNAL OF MEDICINE