Article
Medicine, General & Internal
Pal Maurovich-Horvat, Maria Bosserdt, Klaus F. Kofoed, Nina Rieckmann, Theodora Benedek, Patrick Donnelly, Jose Rodriguez-Palomares, Andrejs Erglis, Cyril Stechovsk, Gintare Sakalyte, Nada Cemerlic Adic, Matthias Gutberlet, Jonathan D. Dodd, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kepka, Radosav Vidakovic, Marco Francone, Malgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schroder, Colin Berry, Luca Saba, Balazs Ruzsics, Christine Kubiak, Inaki Gutierrez-Ibarluzea, Kristian Schultz Hansen, Jacqueline Muller-Nordhorn, Bela Merkely, Andreas D. Knudsen, Imre Benedek, Clare Orr, Filipa Xavier Valente, Ligita Zvaigzne, Vojtech Suchanek, Laura Zajanckauskiene, Flip Adic, Michael Woinke, Mark Hensey, Inigo Lecumberri, Erica Thwaite, Michael Laule, Mariusz Kruk, Aleksandar N. Neskovic, Massimo Mancone, Gudrun Feuchtner, Donata Kugrnierz, Mikko Pietila, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Gildo Matta, Michael Fisher, Balint Szilveszter, Linnea Larsen, Mihaela Ratiu, Stephanie Kelly, Bruno Garcia del Blanco, Ainhoa Rubio, Zsofia D. Drobni, Birgit Jurlander, Ioana Rodean, Susan Regan, Hug Cuellar Calabria, Melinda Boussoussou, Thomas Engstrom, Roxana Hodas, Adriane E. Napp, Robert Haase, Sarah Feger, Lina M. Serna-Higuita, Konrad Neumann, Henryk Dreger, Matthias Rief, Viktoria Wieske, Melanie Estrella, Peter Martus, Marc Dewey
Summary: This study compared the effectiveness of CT and ICA in diagnosing obstructive CAD. The results showed that among patients with stable chest pain and intermediate pretest probability of CAD, the risk of major adverse cardiovascular events was similar between the CT group and the ICA group. However, the frequency of major procedure-related complications was lower in the CT group.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Pontus Thorild, Georgios Mourtzinis
Summary: This retrospective observational study assessed the usefulness of exercise ECG in patients with low pre-test probability (PTP) of significant coronary artery disease and stable chest pain. The study found that exercise ECG had a high negative predictive value and a low positive predictive value in this population.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Min-Kyung Kang, Dong Geum Shin, Donghoon Han, Seonghoon Choi, Jung Rae Cho, Namho Lee
Summary: In patients with elevated cardiac troponin I (cTnI), 60% were diagnosed with coronary artery disease (CAD), 17% were suspected to have microvascular angina (MVA), and the remaining 23% had non-angina (NA). Patients with CAD had elevated blood pressure and slightly decreased heart rate, while those with NA had higher levels of high-density lipoprotein (HDL). Reduced HDL level was independently associated with the presence of CAD.
Article
Cardiac & Cardiovascular Systems
Aitor Hernandez-Hernandez, Carles Diez-Lopez, Olga Azevedo, Julian Palomino-Doza, Fernando Alfonso, Maria Eugenia Fuentes-Canamero, Maria Victoria Mogollon Jimenez, Carlos Casanova Rodriguez, Aurora Ruz, Coloma Tiron, Vicente Climent, Pablo Garcia-Pavia
Summary: A study of 663 chest pain patients showed that AFD is rare in patients without obstructive coronary artery disease, with an overall prevalence of only 0.15%. Screening efforts for AFD should not be conducted in this patient population.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, General & Internal
Klaus F. Kofoed, Maria Bosserdt, Pal Maurovich-Horvat, Nina Rieckmann, Theodora Benedek, Patrick Donnelly, Jose Rodriguez Palomares, Andrejs Erglis, Cyril Stechovsky, Gintare Sakalyte, Filip Adic, Matthias Gutberlet, Jonathan D. Dodd, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kepka, Radosav Vidakovic, Marco Francone, Malgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schroeder, Colin Berry, Luca Saba, Balazs Ruzsics, Christine Kubiak, Kristian Schultz Hansen, Jacqueline Mueller-Nordhorn, Bela Merkely, Tem S. Jorgensen, Imre Benedek, Clare Orr, Filipa Xavier Valente, Ligita Zvaigzne, Vojtech Suchanek, Laura Zajanckauskiene, Milenko Cankovic, Michael Woinke, Stephen Keane, Inigo Lecumberri, Erica Thwaite, Michael Laule, Mariusz Kruk, Aleksandar N. Neskovic, Massimo Mancone, Donata Kusmierz, Gudrun Feuchtner, Mikko Pietila, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Bruno Loi, Michael Fisher, Balint Szilveszter, Per E. Sigvardsen, Mihaela Ratiu, Stephanie Kelly, Bruno Garcia del Blanco, Ainhoa Rubio, Zsofia D. Drobni, Charlotte Kragelund, Ioana Rodean, Susan Regan, Hug Cuellar Calabria, Melinda Boussoussou, Thomas Engstrom, Roxana Hodas, Adriane E. Napp, Robert Haase, Sarah Feger, Mahmoud M. A. Mohamed, Lina M. Serna-Higuita, Konrad Neumann, Henryk Dreger, Matthias Rief, Viktoria Wieske, Melanie Estrella, Peter Martus, Marc Dewey
Summary: This study compared the effectiveness of computed tomography (CT) and invasive coronary angiography (ICA) in the management of stable chest pain in men and women. The results showed that for patients with an intermediate pretest probability of coronary artery disease, an initial CT scan was associated with fewer major complications in women and a lower frequency of a composite endpoint in men.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Kristian Taekker Madsen, Karsten Tange Veien, Pia Larsen, Majed Husain, Lone Deibjerg, Anders Junker, Martin Weber Kusk, Kristian Korsgaard Thomsen, Allan Rohold, Lisette Okkels Jensen, Niels Peter Ronnow Sand
Summary: This study aimed to evaluate the association between CCTA-derived FFRCT and recurrent chest pain in patients with SAP. The results showed that an abnormal FFRCT test result was associated with an increased risk of recurrent chest pain, independent of coronary calcification and stenosis. Additionally, a negative association between per-patient minimal d-FFRCT and recurrent chest pain was demonstrated, highlighting the importance of FFRCT testing in predicting long-term outcomes for patients with SAP.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Nello Cambise, Alessandro Telesca, Saverio Tremamunno, Tamara Felici, Antonio De Vita, Monica Filice, Gessica Ingrasciotta, Eleonora Ruscio, Filippo Crea, Gaetano A. Lanza
Summary: This study compared the clinical characteristics and outcomes of patients with stable angina and non-ST segment elevation acute coronary syndrome (NSTE-ACS). The results showed that the two groups of patients had similar clinical characteristics and exercise test results. However, stable angina patients had a worse symptomatic outcome compared to NSTE-ACS patients, regardless of the results of the acetylcholine test.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Andrea Zito, Mattia Galli, Giuseppe Biondi-Zoccai, Antonio Abbate, Pamela S. Douglas, Giuseppe Princi, Domenico D'Amario, Cristina Aurigemma, Enrico Romagnoli, Carlo Trani, Francesco Burzotta
Summary: Comparing different diagnostic strategies for initial assessment of suspected stable CAD, CCTA shows similar health effects to direct ICA referral and better health outcomes compared to exercise ECG and SPECT-MPI. However, it is associated with more index revascularization compared to exercise ECG.
ANNALS OF INTERNAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Divaka Perera, Colin Berry, Stephen P. Hoole, Aish Sinha, Haseeb Rahman, Paul D. Morris, Rajesh K. Kharbanda, Ricardo Petraco, Keith Channon
Summary: Nearly half of patients with angina have non-obstructive coronary artery disease (ANOCA), with two-thirds of these patients having coronary microvascular disease (CMD). Impaired coronary flow reserve (CFR) is associated with myocardial ischemia and adverse cardiovascular outcomes. The CMD workstream aims to improve accuracy of diagnosis and treatment through standardized procedures and various assessment methods.
Article
Cardiac & Cardiovascular Systems
Morten Krogh Christiansen, Simon Winther, Louise Nissen, Bjarni Johann Vilhjalmsson, Lars Frost, Jane Kirk Johansen, Peter Loof Moller, Samuel Emil Schmidt, Jelmer Westra, Niels Ramsing Holm, Henrik Kjaerulf Jensen, Evald Hoj Christiansen, Daniel Fannar Guobjartsson, Hilma Holm, Kari Stefansson, Hans Erik Botker, Morten Bottcher, Mette Nyegaard
Summary: The study suggests that combining PRS with CRFs can improve risk stratification of obstructive CAD in patients, indicating modest clinical potential for using PRS to guide diagnostic testing in the contemporary clinical setting.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2021)
Review
Medicine, General & Internal
Rasha K. Al-Lamee, Michael Foley, Christopher A. Rajkumar, Darrel P. Francis
Summary: The management of stable coronary artery disease focuses on preventing myocardial infarction and death. Recent studies have questioned the effectiveness of revascularization procedures. It is important to consider high-risk patients and address communication issues in doctor-patient consultations.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Review
Medicine, General & Internal
Alexandra N. Nowbar, Christopher Rajkumar, Rasha K. Al-Lamee, Darrel P. Francis
Summary: Recent randomised controlled trials have overturned traditional beliefs about necessary hospital procedures for stable coronary artery disease patients, leading to discussions about the implications for physicians and patients.
Article
Cardiac & Cardiovascular Systems
Jurrien H. Kuneman, Sophie E. van Rosendael, Pieter van der Bijl, Alexander R. van Rosendael, Pieter H. Kitslaar, Johan H. C. Reiber, J. Wouter Jukema, Martin B. Leon, Nina Ajmone Marsan, Juhani Knuuti, Jeroen J. Bax
Summary: This study compared the pericoronary adipose tissue (PCAT) attenuation between acute coronary syndrome and stable coronary artery disease patients. The results showed that the PCAT attenuation in culprit lesion precursors of acute coronary syndrome patients was significantly higher than nonculprit lesions and lesions of stable coronary artery disease patients. Therefore, PCAT attenuation may be a novel marker for identifying high-risk plaques.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Gaetano Antonio Lanza, Doralisa Morrone, Carmine Pizzi, Isabella Tritto, Luca Bergamaschi, Antonio De Vita, Angelo Villano, Filippo Crea
Summary: Numerous studies have shown that abnormalities in coronary microcirculation may be the cause of acute and chronic cardiac ischemic syndromes. The microvascular origin of myocardial ischemia and angina is considered in clinical practice when patients have normal or near-normal coronary arteries during angiography. This article reviews the diagnostic approach for patients suspected of having coronary microvascular dysfunction as the cause of ischemic syndromes and proposes a classification for chronic and acute microvascular coronary ischemic syndrome, including myocardial infarction with normal coronary arteries.
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Letter
Medicine, General & Internal
Rita Redberg, Diane Jeon
Summary: This article presents the results of a trial conducted ten years ago on coronary computed tomographic angiography, which aimed to evaluate whether this method could shorten emergency department stays more quickly than usual testing. The article also raises a question for discussion regarding the necessity of further diagnostic testing.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Hematology
Hannah E. Suhrs, Marie M. Michelsen, Eva Prescott
Article
Geriatrics & Gerontology
Hannah Elena Suhrs, Anna. Meta Kristensen, Anna Bay Rask, Marie Mide Michelsen, Darla Frestad, Naja Dam Mygind, Kira Bove, Eva Prescott
Article
Cardiac & Cardiovascular Systems
Jacob Reeh, Christina Bachmann Therming, Merete Heitmann, Soren Hojberg, Charlotte Sorum, Jan Bech, Dorte Husum, Helena Dominguez, Thomas Sehestedt, Thomas Hermann, Kim Wadt Hansen, Lene Simonsen, Soren Galatius, Eva Prescott
EUROPEAN HEART JOURNAL
(2019)
Article
Public, Environmental & Occupational Health
Kazi Ishtiak-Ahmed, Ase Marie Hansen, Erik Lykke Mortensen, Anne Helene Garde, Ane Norgaard, Finn Gyntelberg, Naja Hulvej Rod, Sabrina Islamoska, Rikke Lund, Thien Kieu Thi Phung, Eva Prescott, Gunhild Waldemar, Kirsten Nabe-Nielsen
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2019)
Article
Neurosciences
Sabrina Islamoska, Kazi Ishtiak-Ahmed, Ase Marie Hansen, Matias Brodsgaard Grynderup, Erik Lykke Mortensen, Anne Helene Garde, Finn Gyntelberg, Eva Irene Bossano Prescott, Eszter Torok, Gunhild Waldemar, Kirsten Nabe-Nielsen
JOURNAL OF ALZHEIMERS DISEASE
(2019)
Article
Cardiac & Cardiovascular Systems
Nicolai Mikkelsen, Christian Have Dall, Marianne Frederiksen, Annette Holdgaard, Hanne Rasmusen, Eva Prescott
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Eva Prescott
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
John Munkhaugen, Vidar Ruddox, Sigrun Halvorsen, Toril Dammen, Morten W. Fagerland, Kjersti H. Hernaes, Nils Tore Vethe, Eva Prescott, Svend Eggert Jensen, Olaf Rodevand, Jade Jortveit, Bjorn Bendz, Henrik Schirmer, Lars Kober, Hans Erik Botker, Alf Inge Larsen, Kjell Vikenes, Terje Steigen, Rune Wiseth, Terje Pedersen, Thor Edvardsen, Jan Erik Otterstad, Dan Atar
AMERICAN HEART JOURNAL
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
Flemming Javier Olsen, Louisa M. Christensen, Derk W. Krieger, Soren Hojberg, Nis B. Host, Finn M. Karlsen, Gunnar H. Gislason, Jesper Hastrup Svendsen, Hanne K. Christensen, Tor Biering-Sorensen
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Flemming J. Olsen, Louisa M. Christensen, Derk W. Krieger, Soren Hojberg, Nis Host, Finn M. Karlsen, Jesper H. Svendsen, Hanne Christensen, Tor Biering-Sorensen
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2020)
Article
Cardiac & Cardiovascular Systems
Soren Zoga Diederichsen, Ketil Jorgen Haugan, Axel Brandes, Claus Graff, Derk Krieger, Christian Kronborg, Anders Gaarsdal Holst, Jonas Bille Nielsen, Lars Kober, Soren Hojberg, Jesper Hastrup Svendsen
AMERICAN HEART JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Litten Bertelsen, Soren Zoga Diederichsen, Ketil Jorgen Haugan, Axel Brandes, Claus Graff, Derk Krieger, Christian Kronborg, Lars Kober, Soren Hojberg, Niels Vejlstrup, Jesper Hastrup Svendsen
Article
Cardiac & Cardiovascular Systems
Soren Zoga Diederichsen, Ketil Jorgen Haugan, Axel Brandes, Mathias Buus Lanng, Claus Graff, Derk Krieger, Christian Kronborg, Anders Gaarsdal Holst, Lars Kober, Soren Hojberg, Jesper Hastrup Svendsen
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Article
Physiology
Daria Frestad Bechsgaard, Ida Gustafsson, Jesper James Linde, Klaus Fuglsang Kofoed, Eva Prescott, Jens Dahlgaard Hove
CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
(2019)