Article
Peripheral Vascular Disease
Roland E. Schmieder, Felix Mahfoud, Giuseppe Mancia, Michael Azizi, Michael Boehm, Kyriakos Dimitriadis, Kazuomi Kario, Abraham A. Kroon, Melvin D. Lobo, Christian Ott, Atul Pathak, Alexandre Persu, Filippo Scalise, Markus Schlaich, Reinhold Kreutz, Costas Tsioufis
Summary: This paper presents updated recommendations based on new pivotal sham-controlled randomized clinical trials, demonstrating the efficacy and safety of endovascular device-based renal denervation for hypertension treatment. Meta-analyses show a significant reduction in blood pressure and a decreased incidence of cardiovascular events with this treatment option.
JOURNAL OF HYPERTENSION
(2021)
Article
Peripheral Vascular Disease
Lindsea C. Booth, R. Anethra U. de Silva, Roberto B. Pontes, Song T. Yao, Sally G. Hood, Yugeesh R. Lankadeva, Junko Kosaka, Nina Eikelis, Gavin W. Lambert, Markus P. Schlaich, Clive N. May
Summary: Clinical studies suggest that renal denervation (RDN) has beneficial effects on the autonomic control of the heart in heart failure, with experimental evidence showing improvements in sodium handling and clearance. In sheep with established heart failure, catheter-based RDN led to decreased heart rate, increased parasympathetic control, and improved kidney function, indicating potential benefits for both the heart and kidneys in heart failure.
Article
Cardiac & Cardiovascular Systems
Alessandro Zorzi, Flavio 'Ascenzi, Daniele Andreini, Silvia Castelletti, Michela Casella, Elena Cavarretta, Alberto Cipriani, Paolo Compagnucci, Pietro Delise, Antonio Dello Russo, Francesca Graziano, Zefferino Palam, Antonio Pelliccia, Patrizio Sarto, Domenico Corrado, Luigi Sciarra
Summary: In this expert opinion document, the Italian Society of Sports Cardiology proposes a multiparametric interpretation approach and stepwise diagnostic algorithm for premature ventricular beats (PVBs) in athletes. Most athletes can be reassured of the benign nature of PVBs and cleared for competition based on initial evaluations. However, high clinical suspicion may require further non-invasive and invasive tests to rule out high-risk conditions.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Wilfried Mullens, Pieter Martens, Jeffrey M. Testani, W. H. Wilson Tang, Hadi Skouri, Frederik H. Verbrugge, Marat Fudim, Massimo Iacoviello, Jennifer Franke, Andreas J. Flammer, Alberto Palazzuoli, Paola Morejon Barragan, Thomas Thum, Marta Cobo Marcos, Oscar Miro, Patrick Rossignol, Marco Metra, Johan Lassus, Francesco Orso, Ewa A. Jankowska, Ovidiu Chioncel, Davor Milicic, Loreena Hill, Petar Seferovic, Giuseppe Rosano, Andrew Coats, Kevin Damman
Summary: Novel pharmacologic treatment options reduce mortality and morbidity in patients with heart failure, despite the concerns about potential risks to renal function. These treatments have been shown to be beneficial even in patients with poor renal function.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Review
Medicine, General & Internal
Tzung-Dau Wang
Summary: Given the unsatisfactory control rates and non-adherence to antihypertensive medications, device therapy such as renal denervation (RDN) can provide durable blood pressure-lowering effects. Consensus documents recommend RDN as an alternative or complementary treatment for uncontrolled hypertension, and as an initial treatment for drug-naive hypertensive patients. However, there is inconsistency regarding the use of ambulatory blood pressure monitoring and the treatment of patients with treatment-resistant secondary hypertension.
CHINESE MEDICAL JOURNAL
(2022)
Article
Dermatology
T. Meyer-Gonzalez, D. Bacqueville, R. Grimalt, V. Mengeaud, B. M. Piraccini, L. Rudnicka, D. Saceda-Corralo, A. Vogt, S. Vano-Galvan
Summary: This study aimed to gather information and achieve consensus on the latest advances in alopecia, trichoscopy, and hair dermocosmetics. Through a two-round Delphi procedure among 45 European dermatologists, consensus was reached on all recommendations, providing guidance for clinical practice. Additionally, the participants highlighted the need for further clinical studies to assess the benefits of emerging tools and treatments in improving patients' quality of life.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Wouter B. van Dijk, Ewoud Schuit, Rieke van der Graaf, Rolf H. H. Groenwold, Sara Laurijssen, Barbara Casadei, Marco Roffi, Seye Abimbola, Martine C. de Vries, Diederick E. Grobbee
Summary: This study evaluated the feasibility of implementing ESC guidelines on general cardiology in 102 countries and found that compliance varied based on the country's income level. High-income countries had better compliance, while low-income countries had lower compliance, largely due to lack of reimbursement and financial barriers.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Emanuele Barbato, Michel Azizi, Roland E. Schmieder, Lucas Lauder, Michael Boehm, Sofie Brouwers, Rosa Maria Bruno, Dariusz Dudek, Thomas Kahan, David E. Kandzari, Thomas F. Luscher, Gianfranco Parati, Atul Pathak, Flavio L. Ribichini, Markus P. Schlaich, Andrew S. P. Sharp, Isabella Sudano, Massimo Volpe, Costas Tsioufis, William Wijns, Felix Mahfoud
Summary: Since the publication of the 2018 ESC/ESH Guidelines, high-quality studies have confirmed the efficacy and safety of RDN in patients with hypertension. The consensus document recommends RDN as an adjunct treatment for uncontrolled resistant hypertension and for patients who cannot tolerate antihypertensive medications. A shared decision-making process is crucial, taking into account the patient's overall cardiovascular risk and the presence of hypertension-mediated organ damage or complications. Multidisciplinary hypertension teams involving experts and interventionalists are needed to evaluate indications and perform RDN procedures. Future research should focus on clinical outcomes and potential indications beyond hypertension.
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
David E. Kandzari
Summary: Device-based therapies for hypertension, such as renal denervation, have shown promising results in reducing blood pressure. Additional studies are underway to explore the potential incorporation of renal denervation into standard treatment pathways, considering factors such as durability of blood pressure lowering and patient selection. Identifying predictors of treatment effect and patient-reported outcomes are also evolving areas of investigation to further inform the use of renal denervation in broader populations with hypertension.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Andras P. Durko, Philippe Pibarot, Pavan Atluri, Vinayak Bapat, Duke E. Cameron, Filip P. A. Casselman, Edward P. Chen, Gry Dahle, B. John A. Elefteriades, Patrizio Lancellotti, Richard L. Prager, Raphael Rosenhek, Alan Speir, Marco Stijnen, Giordano Tasca, Ajit Yoganathan, Thomas Walther, Ruggero De Paulis
Summary: Comprehensive information on the characteristics of surgical heart valves is crucial for optimal valve selection and assessing valve function after replacement. Despite existing regulatory frameworks, obtaining this information in a uniform manner remains challenging.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Adam Timmis, Panos Vardas, Nick Townsend, Aleksandra Torbica, Hugo Katus, Delphine De Smedt, Chris P. Gale, Aldo P. Maggioni, Steffen E. Petersen, Radu Huculeci, Dzianis Kazakiewicz, Victor de Benito Rubio, Barbara Ignatiuk, Zahra Raisi-Estabragh, Agnieszka Pawlak, Efstratios Karagiannidis, Roderick Treskes, Dan Gaita, John F. Beltrame, Alex McConnachie, Isabel Bardinet, Ian Graham, Marcus Flather, Perry Elliott, Elias A. Mossialos, Franz Weidinger, Stephan Achenbach
Summary: This report updates and expands upon the 2019 report, providing cardiovascular disease statistics for the 57 ESC member countries. The report highlights the determinants of CVD and the disparities among different countries.
EUROPEAN HEART JOURNAL
(2022)
Article
Peripheral Vascular Disease
Gianni Sesa-ashton, Janis M. Nolde, Ida Muente, Revathy Carnagarin, Rebecca Lee, Vaughan G. Macefield, Tye Dawood, Yusuke Sata, Elisabeth A. Lambert, Gavin W. Lambert, Antony Walton, Marcio G. Kiuchi, Murray D. Esler, Markus P. Schlaich
Summary: Long-term follow-up studies on catheter-based renal denervation in patients with resistant hypertension show that the method can still effectively reduce blood pressure and decrease medication usage after nearly 9 years of follow-up, without any adverse effects on renal function.
Article
Cardiac & Cardiovascular Systems
Daniele Andreini, Carlos Collet, Jonathon Leipsic, Koen Nieman, Marcio Bittencurt, Johan De Mey, Nico Buls, Yoshinobu Onuma, Saima Mushtaq, Edoardo Conte, Antonio L. Bartorelli, Giulio Stefanini, Jeroen Sonck, Paul Knaapen, Brian Ghoshhajra, Patrick W. Serruys
Summary: Coronary CT angiography plays a critical role in the diagnosis of coronary artery disease, but it has limitations in patients with diffuse and complex CAD and in surgical planning. However, recent technological advancements have improved the accuracy of CCTA and introduced new tools for evaluating coronary stenosis functional relevance. CCTA provides valuable information for interventional procedures, including detailed plaque evaluation, prediction of procedural success, identification of additional techniques, and selection of revascularization mode.
Article
Clinical Neurology
Felice Occhigrossi, Roberta Carpenedo, Matteo Luigi Giuseppe Leoni, Giustino Varrassi, Elisabetta Chine, Marco Cascella
Summary: A modified Delphi strategy was used to obtain recommendations for the management of percutaneous radiofrequency treatment of lumbar facet joint syndrome due to poor quality literature. A comprehensive literature search was conducted, and a semi-structured questionnaire was developed. The need for standardized protocols to address this clinical problem and fill gaps in scientific evidence was emphasized.
Article
Peripheral Vascular Disease
Kazuomi Kario, Yoshiaki Yokoi, Keisuke Okamura, Masahiko Fujihara, Yukako Ogoyama, Eiichiro Yamamoto, Hidenori Urata, Jin-Man Cho, Chong-Jin Kim, Seung-Hyuk Choi, Keisuke Shinohara, Yasushi Mukai, Tomokazu Ikemoto, Masato Nakamura, Shuichi Seki, Satoaki Matoba, Yoshisato Shibata, Shigeo Sugawara, Kazuhiko Yumoto, Kouichi Tamura, Fumiki Yoshihara, Satoko Nakamura, Woong Chol Kang, Taro Shibasaki, Keigo Dote, Hiroyoshi Yokoi, Akiko Matsuo, Hiroshi Fujita, Toshiyuki Takahashi, Hyun-Jae Kang, Yasushi Sakata, Kazunori Horie, Naoto Inoue, Ken-ichiro Sasaki, Takafumi Ueno, Hirofumi Tomita, Yoshihiro Morino, Yuhei Nojima, Chan Joon Kim, Tomoaki Matsumoto, Hisashi Kai, Shinsuke Nanto
Summary: This study found no significant difference in ambulatory blood pressure reductions between renal denervation and a sham procedure in treated patients with resistant hypertension. Although the blood pressure reduction after renal denervation was similar to other sham-controlled studies, the unexpected greater reduction in the sham control group in this study highlights design issues that will be addressed in a new trial.
HYPERTENSION RESEARCH
(2022)
Article
Peripheral Vascular Disease
Dean S. Picone, Elif Stoneman, Antoine Cremer, Martin G. Schultz, Petr Otahal, Alun D. Hughes, J. Andrew Black, Willem Jan Bos, Chen-Huan Chen, Hao-Min Cheng, Nathan Dwyer, Peter Lacy, Esben Laugesen, Fuyou Liang, Hack-Lyoung Kim, Nobuyuki Ohte, Sho Okada, Stefano Omboni, Christian Ott, Telmo Pereira, Giacomo Pucci, Ronak Rajani, Roland Schmieder, Manish D. Sinha, Ralph Stewart, George A. Stouffer, Kenji Takazawa, Jiguang Wang, Thomas Weber, Berend E. Westerhof, Bryan Williams, Hirotsugu Yamada, James E. Sharman
Summary: Accurate blood pressure measurement is crucial for cardiovascular risk management. A study found that for the same cuff systolic blood pressure, women had higher invasive aortic systolic blood pressure than men. Cuff measurements may underestimate cardiovascular risk in women.
Review
Cardiac & Cardiovascular Systems
Aletta E. Schutte, Tazeen H. Jafar, Neil R. Poulter, Albertino Damasceno, Nadia A. Khan, Peter M. Nilsson, Jafar Alsaid, Dinesh Neupane, Kazuomi Kario, Hind Beheiry, Sofie Brouwers, Dylan Burger, Fadi J. Charchar, Myeong Chan Cho, Tomasz J. Guzik, Ghazi F. Haji Al-Saedi, Muhammad Ishaq, Hiroshi Itoh, Erika S. W. Jones, Taskeen Khan, Yoshihiro Kokubo, Praew Kotruchin, Elizabeth Muxfeldt, Augustine Odili, Mansi Patil, Udaya Ralapanawa, Cesar A. Romero, Markus P. Schlaich, Abdulla Shehab, Ching Siew Mooi, U. Muscha Steckelings, George Stergiou, Rhian M. Touyz, Thomas Unger, Richard D. Wainford, Ji-Guang Wang, Bryan Williams, Brandi M. Wynne, Maciej Tomaszewski
Summary: Hypertension is the leading cause of preventable death globally, but there are significant challenges in its detection, treatment, and control, particularly in low-resource settings. Disparities based on resources, sociodemographic environment, and race contribute to the disproportionate burden of hypertension-related outcomes. Immediate action is needed to address these challenges and reduce inequities in hypertension care.
CARDIOVASCULAR RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Birgitte Krogsgaard Andersen, Daixin Ding, Lone Juul Hune Mogensen, Shengxian Tu, Niels Ramsing Holm, Jelmer Westra, William Wijns
Summary: This systematic review and study-level meta-analysis investigated the relationship between post-PCI FFR and the rate of major adverse cardiac events (MACE) including all-cause death, myocardial infarction (MI), and target vessel revascularization (TVR). The results showed no clear continuous association between post-PCI FFR and clinical outcomes, but in studies comparing high vs. low post-PCI FFR, high FFR was associated with better clinical outcomes.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Valerie Pavlicek, Felix Mahfoud, Katharina Bubel, Peter Fries, Sebastian Ewen, Michael Boehm, Bruno Scheller, Christian Ukena
Summary: The aim of this study was to investigate clinical, anatomical, procedural, and electrophysiological parameters predicting intraventricular conduction disturbances (ICA) after transcatheter aortic valve replacement (TAVR). The results showed that new-onset left bundle branch block (BBB) and diabetes mellitus independently predicted high-degree atrioventricular block (HAVB) requiring permanent pacemaker (PPM) implantation, and helped identify high-risk patients.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Massimo Volpe, Carlo Patrono
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Massimo Volpe, Giovanna Gallo, Speranza Rubattu
Summary: The heart has an endocrine function, producing biologically active substances such as natriuretic peptides (NPs). NPs play important roles in regulating cardiovascular and renal systems through their interaction with guanylate cyclase-A coupled receptors. They also have potential therapeutic applications in treating heart failure and hypertension, and are used as biomarkers in cardiovascular diseases. Furthermore, research on the regulation of NP synthesis and secretion by microRNAs and epigenetics, as well as their interactions with other endocrine systems, is ongoing.
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Martine Gilard, William Wijns
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Emanuele Barbato, Emanuele Gallinoro, Mohamed Abdel-Wahab, Daniele Andreini, Didier Carrie, Carlo Di Mario, Dariusz Dudek, Javier Escaned, Jean Fajadet, Giulio Guagliumi, Jonathan Hill, Margaret McEntegart, Kambis Mashayekhi, Nikolasos Mezilis, Yoshinobu Onuma, Krzyszstof Reczuch, Richard Shlofmitz, Giulio Stefanini, Giuseppe Tarantini, Gabor G. Toth, Beatriz Vaquerizo, William Wijns, Flavio L. Ribichini
Summary: Since the publication of the 2015 EAPCI consensus, there has been a significant increase in PCI performed in cases of severely calcified coronary artery disease. This has been driven by the growing need for interventions in elderly patients and the availability of new technologies. The current EAPCI clinical consensus statement provides comprehensive guidance on the management of heavily calcified coronary stenoses, including imaging assessment, tool and technique selection, and considerations for complications and training.
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Felix Goetzinger, Lucas Lauder, Andrew S. P. Sharp, Irene M. Lang, Stephan Rosenkranz, Stavros Konstantinides, Elazer R. R. Edelman, Michael Boehm, Wissam Jaber, Felix Mahfoud
Summary: Pulmonary embolism (PE) is a major cause of in-hospital and cardiovascular death. The treatment of PE traditionally involved anticoagulation, thrombolysis, or surgery, but newer percutaneous interventional technologies have emerged for intermediate-high-risk or high-risk PE patients. This review discusses the pathophysiology of PE, assists with patient selection, and evaluates the clinical evidence for interventional, catheter-based approaches for PE treatment.
NATURE REVIEWS CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Leonarda Galiuto, Massimo Volpe
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Daniela Pedicino, Massimo Volpe
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Margarita Brida, Salvatore De Rosa, Antoine Legendre, Magalie Ladouceur, Laura Dos Subira, Giancarlo Scognamiglio, Carlo Di Mario, Jolien Roos-Hesselink, Eva Goossens, Gerhard Diller, Michael A. Gatzoulis
Summary: The rates of successful surgical repair and life expectancy for patients with congenital heart disease have significantly increased in recent decades. However, exposure to cardiovascular risk factors has led to a shift in the clinical trajectory of adult congenital heart disease, with an increasing burden of acquired cardiovascular disease, primarily atherosclerotic cardiovascular disease (ASCVD). Currently, comprehensive guidance for the prevention and management of acquired heart disease in adult congenital heart disease patients is lacking. This document provides an overview of acquired heart disease and offers guidance on ASCVD prevention for both specialists and non-specialists in adult congenital heart disease, aiming to reduce the cardiovascular burden in this growing population.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Emanuele Barbato, Michel Azizi, Roland E. Schmieder, Lucas Lauder, Michael Boehm, Sofie Brouwers, Rosa Maria Bruno, Dariusz Dudek, Thomas Kahan, David E. Kandzari, Thomas F. Luescher, Gianfranco Parati, Atul Pathak, Flavio L. Ribichini, Markus P. Schlaich, Andrew S. P. Sharp, Isabella Sudano, Massimo Volpe, Costas Tsioufis, William Wijns, Felix Mahfoud
Summary: According to the 2018 ESC/ESH guidelines, radiofrequency and ultrasound renal denervation (RDN) have been proven effective and safe in lowering blood pressure in a broad range of patients with hypertension, including resistant hypertension. The expert group suggests that RDN can be used as an adjunct treatment option in uncontrolled resistant hypertension, especially in patients with high cardiovascular risk or hypertension-mediated organ damage. Multidisciplinary hypertension teams should evaluate the indication and perform the RDN procedure.
Meeting Abstract
Peripheral Vascular Disease
Dawid Jedrzejewski, Ewan McFarlane, Peter Lacy, Bryan Williams
JOURNAL OF HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Felix Mahfoud, Michel Azizi, Joost Daemen, Andrew S. P. Sharp, Atul Patak, Juan F. Iglesias, Ajay Kirtane, Naomi D. L. Fisher, Andrea Scicli, Melvin D. Lobo
Summary: This study aims to investigate the long-term safety and effectiveness of ultrasound renal denervation (uRDN) with the Paradise System in a large population of hypertensive patients. It will provide real-world information and patient-reported outcomes through home blood pressure measurements and routine clinical follow-up.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
