Interdisciplinary therapy changes superoxide dismutase activity and adiponectin in obese adolescents: a randomised controlled trial

The objective of this study is to evaluate the effect of interdisciplinary therapy in the parameters of the oxidative stress and the anti-inflammatory responses of obese adolescents. We selected 57 participants, who were randomly divided into 2 groups: interdisciplinary therapy group and a control group. After 6months of intervention, 17 participants of the interdisciplinary therapy group and 8 of the control group returned for re-evaluation. The interdisciplinary therapy group participated in a treatment with 4 weekly sessions of exercise, a weekly group therapy session and a weekly nutritional education session. Blood parameters of oxidative stress and anti-inflammatory response were evaluated. The results demonstrated that there were significant increases in the interdisciplinary therapy group for superoxide dismutase activity (6.56 +/- 3.22 to 11.40 +/- 7.49) and ferric-reducing antioxidant potential concentration (532.91 +/- 106.48 to 573.25 +/- 112.57), although adiponectin levels did not reduce (40.9 +/- 29.34 to 49.05 +/- 41.22). A significant decrease in nitrite levels was also found (14.23 +/- 8.48 to 11.45 +/- 6.05). In the control group, significant reduction was found in adiponectin (31.56 +/- 18.88 to 18.01 +/- 11.66). This study suggests that interdisciplinary therapy for 6months was effective in improving the anti-inflammatory responses and the antioxidant defences in obese adolescents.