Article
Clinical Neurology
Marta Francisca Corra, Nuno Vila-Cha, Ana Sardoeira, Clint Hansen, Ana Paula Sousa, Ines Reis, Firmina Sambayeta, Joana Damasio, Margarida Calejo, Andreas Schicketmueller, Ines Laranjinha, Paula Salgado, Ricardo Taipa, Rui Magalhaes, Manuel Correia, Walter Maetzler, Luis F. Maia
Summary: Peripheral neuropathy is common in Parkinson's disease patients and has a negative impact on gait and balance.
Article
Neurosciences
Steffen Paschen, Clint Hansen, Julius Welzel, Judith Albrecht, Arash Atrsaei, Kamiar Aminian, Kirsten E. Zeuner, Robbin Romijnders, Elke Warmerdam, Paul Peter Urban, Daniela Berg, Walter Maetzler
Summary: Orthostatic hypotension (OH) is common in Parkinson's disease (PD) and affects quality of life and daily activities. Abdominal binders (AB) and compression stockings (CS) are effective non-pharmacological treatments, but do not significantly impact physical activity in PD patients. AB therapy shows superiority over CS therapy in improving non-motor symptoms.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Edoardo Bianchini, Elke Warmerdam, Robbin Romijnders, Clint Hansen, Francesco E. E. Pontieri, Walter Maetzler
Summary: This study investigated the effects of dual-tasking on cognitive cost, and the results showed that regardless of age and disease group, simple cognitive tasks showed the largest and most stable effects during dual-tasking.
FRONTIERS IN NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Laura Delgado-Ortiz, Ashley Polhemus, Alison Keogh, Norman Sutton, Werner Remmele, Clint Hansen, Felix Kluge, Basil Sharrack, Clemens Becker, Thierry Troosters, Walter Maetzler, Lynn Rochester, Anja Frei, Milo A. Puhan, Judith Garcia-Aymerich
Summary: This study examined the personal experiences of individuals living with walking impairment and identified seven themes describing the walking experience across different health conditions. A novel conceptual framework was proposed to guide patient-centered clinical practice, research, and public health.
Article
Engineering, Biomedical
Kirsty Scott, Tecla Bonci, Francesca Salis, Lisa Alcock, Ellen Buckley, Eran Gazit, Clint Hansen, Lars Schwickert, Kamiar Aminian, Stefano Bertuletti, Marco Caruso, Lorenzo Chiari, Basil Sharrack, Walter Maetzler, Clemens Becker, Jeffrey M. Hausdorff, Ioannis Vogiatzis, Philip Brown, Silvia Del Din, Bjoern Eskofier, Anisoara Paraschiv-Ionescu, Alison Keogh, Cameron Kirk, Felix Kluge, Encarna M. Mico-Amigo, Arne Mueller, Isabel Neatrour, Martijn Niessen, Luca Palmerini, Henrik Sillen, David Singleton, Martin Ullrich, Beatrix Vereijken, Marcel Froehlich, Gavin Brittain, Brian Caulfield, Sarah Koch, Anne-Elie Carsin, Judith Garcia-Aymerich, Arne Kuederle, Alison Yarnall, Lynn Rochester, Andrea Cereatti, Claudia Mazza
Summary: This study proposes a protocol for simulating real-world gait that takes into account multiple factors and ensures participant safety. The protocol has been found to be safe and feasible, and can measure gait in various pathological conditions. It can be used for the validation of monitoring devices used in real-life situations.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2022)
Article
Chemistry, Analytical
Edoardo Bianchini, Bianca Calio, Marika Alborghetti, Domiziana Rinaldi, Clint Hansen, Nicolas Vuillerme, Walter Maetzler, Francesco E. Pontieri
Summary: Commercial smartwatches may not accurately count steps in Parkinson's disease patients, especially when they are in the OFF pharmacological state and worn on the most-affected body side. However, they show good performance in healthy subjects at a self-selected speed.
Article
Geriatrics & Gerontology
Johanna Geritz, Julius Welzel, Clint Hansen, Corina Maetzler, Markus A. Hobert, Morad Elshehabi, Henrike Knacke, Milda Aleknonyte-Resch, Jennifer Kudelka, Nico Bunzeck, Walter Maetzler
Summary: This study aimed to investigate the predictive value of cognitive and affective parameters for changes in walking performance after early geriatric rehabilitation in patients with Parkinson's disease. The results showed that deficits in executive function and divided attention were less associated with a reduction in step time asymmetry after treatment, while poorer performance on the Trail Making Test was more associated with a decrease in stride time and double limb support. Furthermore, higher global cognitive performance was associated with an increase in gait speed after treatment.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Environmental Sciences
Tracy Milane, Clint Hansen, Matthias Chardon, Edoardo Bianchini, Nicolas Vuillerme
Summary: Parkinson's disease (PD) is characterized by motor symptoms and gait impairments, with freezing of gait (FOG) being one of the most disabling manifestations. Studies have shown that gait impairments are more pronounced in backward walking (BW) for PD patients with FOG. However, there has been no systematic review comparing BW performance between PD patients with and without FOG. This study aimed to evaluate the differences in BW performance between these two groups.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Multidisciplinary Sciences
Luca Palmerini, Luca Reggi, Tecla Bonci, Silvia Del Din, M. Encarna Mico-Amigo, Francesca Salis, Stefano Bertuletti, Marco Caruso, Andrea Cereatti, Eran Gazit, Anisoara Paraschiv-Ionescu, Abolfazl Soltani, Felix Kluge, Arne Kuederle, Martin Ullrich, Cameron Kirk, Hugo Hiden, Ilaria D'Ascanio, Clint Hansen, Lynn Rochester, Claudia Mazza, Lorenzo Chiari
Summary: This study provides an example of organizing, integrating, and storing movement data recorded from different wearables and gold standard technologies. The guidelines derived from the experience of a large multi-centric study offer support for accessing, understanding, and reusing available data, promoting standardization and integration in other studies, and facilitating comparison of recorded data in the scientific community.
Article
Chemistry, Analytical
Clint Hansen, Baraah Chebil, John Cockroft, Edoardo Bianchini, Robbin Romijnders, Walter Maetzler
Summary: This study collected skeletal kinematics data from 21 healthy participants and 24 neurogeriatric participants using wearable sensors and an accelerometer-based functional calibration method. The study found that IMU-based parameters significantly correlated with the SPPB score and showed significant differences between SPPB subgroups. Lower limb range of motion and joint segment coordination were positively correlated with the SPPB score, while segment coordination variability was negatively correlated.
Article
Chemistry, Analytical
Enrique Coronado, Toshifumi Shinya, Gentiane Venture
Summary: In recent years, there has been a growing interest in developing robotic systems to improve the quality of life for individuals of all ages. This article introduces a novel system architecture that enables the Pepper robot to walk side-by-side while holding hands and communicate with the surrounding environment. The system achieves this by estimating the applied force using an observer and utilizing object recognition for communication. The integration of these components demonstrates the system's capability to achieve its intended purpose.
Article
Chemistry, Analytical
Johannes Hoffmann, Sebastian Roldan-Vasco, Karolin Krueger, Florian Niekiel, Clint Hansen, Walter Maetzler, Juan Rafael Orozco-Arroyave, Gerhard Schmidt
Summary: This study presents a novel approach for evaluating swallowing using magnetic sensors and actuators. The results show the detection capability of swallowing-related movements and suggest the potential for dysphagia screening and biofeedback-based therapies.
Article
Chemistry, Analytical
Edoardo Bianchini, Silvia Galli, Marika Alborghetti, Lanfranco De Carolis, Alessandro Zampogna, Clint Hansen, Nicolas Vuillerme, Antonio Suppa, Francesco E. Pontieri
Summary: This study found that monitoring the daily steps of Parkinson's disease patients through commercial smartwatches can reliably estimate their average daily steps after four consecutive days. The daily steps did not vary significantly across different days or between working days and weekends. These findings are important for developing monitoring, preventive, and rehabilitation strategies for people with Parkinson's disease.
Article
Cardiac & Cardiovascular Systems
Tobias Braun, Anna Wiegard, Johanna Geritz, Clint Hansen, Kim Eng Tan, Hanna Hildesheim, Jennifer Kudelka, Corina Maetzler, Julius Welzel, Robbin Romijnders, Walter Maetzler, Philipp Bergmann
Summary: This study investigated the association of HF severity with digital mobility outcomes and handgrip strength, finding that sway path and handgrip strength may be the most promising parameters for monitoring mobility aspects in the treatment of HF.
JOURNAL OF GERIATRIC CARDIOLOGY
(2022)
Article
Computer Science, Information Systems
Elke Warmerdam, Clint Hansen, Robbin Romijnders, Markus A. Hobert, Julius Welzel, Walter Maetzler
Summary: Gait and balance dysfunctions have a negative impact on quality of life and quantifying these limitations is important for monitoring disease progression. Inertial measurement units can be used to measure mobility in different contexts, but algorithms for extracting valuable parameters need to be validated.