Cinaciguat, a soluble guanylate cyclase activator, unloads the heart but also causes hypotension in acute decompensated heart failure†

Treatment of acute decompensated heart failure with the soluble guanylate cyclase activator cinaciguat: The COMPOSE program – three randomized, controlled, phase IIb studies

(2011) Mihai Gheorghiade et al.   JOURNAL OF CARDIAC FAILURE

Short-term survival by treatment among patients hospitalized with acute heart failure: the global ALARM-HF registry using propensity scoring methods

(2010) Alexandre Mebazaa et al.   INTENSIVE CARE MEDICINE

Structure of Cinaciguat (BAY 58–2667) Bound toNostocH-NOX Domain Reveals Insights into Heme-mimetic Activation of the Soluble Guanylyl Cyclase

(2010) Faye Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cinaciguat (BAY 58–2667) Improves Cardiopulmonary Hemodynamics in Patients With Acute Decompensated Heart Failure

(2009) Harald Lapp et al.   CIRCULATION

Cardioprotective effects in aged spontaneously hypertensive rats due to chronic stimulation/activation of sGC without hypotension

(2009) Emma S Jones et al.   BMC Pharmacology & Toxicology

Comparison of Clinical Features and Outcomes of Patients Hospitalized With Heart Failure and Normal Ejection Fraction (≥55%) Versus Those With Mildly Reduced (40% to 55%) and Moderately to Severely Reduced (

(2008) Nancy K. Sweitzer et al.   AMERICAN JOURNAL OF CARDIOLOGY

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM)

(2008) et al.   EUROPEAN HEART JOURNAL

Pharmacokinetics, Pharmacodynamics, Tolerability, and Safety of the Soluble Guanylate Cyclase Activator Cinaciguat (BAY 58-2667) in Healthy Male Volunteers

(2008) Reiner Frey et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Cardiac Troponin and Outcome in Acute Heart Failure

(2008) W. Frank Peacock et al.   NEW ENGLAND JOURNAL OF MEDICINE