Journal
EUROPEAN HEART JOURNAL
Volume 32, Issue 7, Pages 904-912Publisher
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehq244
Keywords
Myocardial infarction; Exercise training; Cardiac function; Autonomic function; Blood flow
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP-01/00009-0, 07/57595-5, FAPESP-06/53800-0]
- Conselho Nacional de Pesquisa e Desenvolvimento (CNPq)
- Conselho Nacional de Pesquisa e Desenvolvimento (CNPq-BPQ)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [01/00009-0] Funding Source: FAPESP
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Aims To test the effects of early exercise training (ET) on left ventricular (LV) and autonomic functions, haemodynamics, tissues blood flows (BFs), maximal oxygen consumption (VO2 max), and mortality after myocardial infarction (MI) in rats. Methods and results Male Wistar rats were divided into: control (C), sedentary-infarcted (SI), and trained-infarcted (TI). One week after MI, TI group underwent an ET protocol (90 days, 50-70% VO2 max). Left ventricular function was evaluated noninvasively and invasively. Baroreflex sensitivity, heart rate variability, and pulse interval were measured. Cardiac output (CO) and regional BFs were determined using coloured microspheres. Infarcted area was reduced in TI (19 +/- 6%) compared with SI (34 +/- 5%) after ET. Exercise training improved the LV and autonomic functions, the CO and regional BF changes induced by MI, as well as increased SERCA2 expression and mRNA vascular endothelial growth factor levels. These changes brought about by ET resulted in mortality rate reduction in the TI (13%) group compared with the SI (54%) group. Conclusion Early aerobic ET reduced cardiac and peripheral dysfunctions and preserved cardiovascular autonomic control after MI in trained rats. Consequently, these ET-induced changes resulted in improved functional capacity and survival after MI.
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