Review
Cardiac & Cardiovascular Systems
Jinping Lin, Shuwei Chen, Yuanyuan Yao, Min Yan
Summary: Abdominal aortic aneurysms (AAAs) are characterized by localized dilation of the abdominal aorta and can lead to serious consequences. Aortic rupture is the main complication and causes a significant number of deaths worldwide. Despite progress in research, there is still a lack of established methods to slow down aneurysm dilation, emphasizing the need for further studies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
David Sanchez-Infantes, Meritxell Nus, Miquel Navas-Madronal, Joan Fite, Belen Perez, Antonio J. Barros-Membrilla, Begona Soto, Jose Martinez-Gonzalez, Mercedes Camacho, Cristina Rodriguez, Ziad Mallat, Maria Galan
Summary: The study found extensive inflammatory infiltration in the aneurysmal wall, mainly composed of T cells, macrophages, and B cells, and altered levels of ROS, IgM, IgG, CD38, GDF15, S100A4, and CD36 in the plasma and aneurysmal tissue of AAA patients compared to controls. Circulating levels of IgG, CD38, and GDF15 were positively correlated with abdominal aortic diameter, and CD38 was correlated with PWS.
Review
Medicine, General & Internal
Li Yin, Kaijie Zhang, Yuting Sun, Zhenjie Liu
Summary: Abdominal aortic aneurysm (AAA) is a serious condition involving localized dilation of the aorta, with ruptured AAA being a major cause of acute death in older adults. Nanoparticles (NPs) offer a potential for more effective treatment through targeted imaging and drug delivery systems, reducing systemic toxicity and improving drug solubility and efficacy in AAA management.
FRONTIERS IN MEDICINE
(2021)
Article
Biology
Sebastian Fernandez-Alonso, Esther Martinez-Aguilar, Susana Ravassa, Josune Orbe, Jose A. Paramo, Leopoldo Fernandez-Alonso, Carmen Roncal
Summary: Predicting the progression of abdominal aortic aneurysm is a challenge. Plasma TAT complexes and D-dimer are associated with the severity of the disease and can be used to evaluate tumor growth and progression.
Article
Medicine, General & Internal
Tan Li, Bo Jiang, Yijun Wu, Jun Yang, Chunyan Ma, Yuan Yuan
Summary: This study investigated the correlation of single nucleotide polymorphisms (SNPs) in pri-miR-1-3p and mature miR-1-3p expression with postoperative mortality of abdominal aortic aneurysm (AAA) patients. The results showed that the variant genotypes of rs2155975 and rs4591246 were associated with increased all-cause mortality. Furthermore, low serum miR-1-3p levels before surgery were independently related to the incidents of all-cause death. This study demonstrated the importance of rs2155975 and rs4591246 polymorphisms and baseline serum miR-1-3p levels as promising markers to predict mortality among AAA patients following surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Petroula Nana, Konstantinos Dakis, Alexandros Brodis, Konstantinos Spanos, George Kouvelos
Summary: A systematic review examined the correlation of abdominal aortic aneurysm expansion rates with serum circulating biomarkers, identifying specific biomarkers potentially useful for individualized surveillance of patients with increased AAA growth rates. Various biomarkers, including D-dimers, LDL-C, HDL-C, and genetic factors, were found to be significantly associated with AAA growth rates, suggesting a potential role for serum biomarkers in patient monitoring.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Shivshankar Thanigaimani, Vikram Iyer, John Bingley, Daniel Browne, James Phie, Denise Doolan, Jonathan Golledge
Summary: This study examined the association between serum microRNAs (miRNAs) and diagnosis and growth of abdominal aortic aneurysm (AAA), and tested their diagnostic and prognostic value. The expression levels of 800 miRNA tags were assessed in AAA patients, healthy controls, and patients with peripheral artery disease (PAD). The miRNAs let-7b-5p and miR-548n improved the ability to diagnose AAA, but none of the miRNAs had independent prognostic value in predicting AAA growth.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Review
Cardiac & Cardiovascular Systems
John Anagnostakos, Brajesh K. Lal
Summary: Abdominal aortic aneurysms (AAA) are common in older adults and can lead to serious morbidity and mortality if not treated promptly. The causes include trauma, infection, and inflammatory disorders, with risk factors such as smoking, advanced age, dyslipidemia, hypertension, and coronary artery disease. The pathophysiology involves arterial insult leading to inflammation and weakening of the arterial wall, requiring monitoring of size and growth rate to prevent rupture. Management options include controlling risk factors, surgical intervention based on risk assessment, and post-operative monitoring for complications. Advancements in technology have improved the diagnosis and treatment of AAA in recent years.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Article
Surgery
Sydney L. Olson, Annalise M. Panthofer, William Blackwelder, Michael L. Terrin, John A. Curci, B. Timothy Baxter, Fred A. Weaver, Jon S. Matsumura
Summary: This study examines the predictors of abdominal aortic aneurysm (AAA) volume growth and finds that baseline volume, tortuosity, maximum transverse diameter (MTD), current tobacco use, angiotensin II receptor blocker use, and history of diabetes mellitus are predictive of volume growth over time.
JOURNAL OF VASCULAR SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Ruihua Li, Yang Liu, Jianjun Jiang
Summary: Abdominal aortic aneurysm (AAA) rupture can be fatal. Surgical treatment is the best option for large AAA (>= 50 mm). However, pharmacological treatment for small AAA (30-50 mm) to reduce expansion rate and rupture risk remains uncertain. Current research on drug treatment for AAA lacks effective agents.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alexandra M. M. Filipkowski, Suman Kundu, Svetlana K. K. Eden, Charles W. W. Alcorn, Amy C. C. Justice, Kaku A. A. So-Armah, Hilary A. A. Tindle, Quinn S. S. Wells, Joshua A. A. Beckman, Matthew S. S. Freiberg, Aaron W. W. Aday
Summary: Compared with individuals without HIV infection, people with HIV do not have an increased risk of abdominal aortic aneurysm (AAA), but the risk of AAA is increased among HIV-infected individuals with low CD4+ T-cell counts or high HIV viral load.
Review
Cardiac & Cardiovascular Systems
Li Yin, Eric William Kent, Bowen Wang
Summary: Abdominal aortic aneurysm (AAA) is a common focal dilation of the aorta in the elderly population, which can lead to aneurysmal rupture with a mortality rate of around 80%. Despite increased screening efforts, there is currently no cure to halt the expansion of AAA, partly due to incomplete understanding of its pathogenesis. Animal models provide valuable insights into AAA pathophysiology, but no single experimental model fully captures the complexity of the disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Leander Gaarde Melin, Julie Husted Dall, Jes S. Lindholt, Lasse B. Steffensen, Hans Christian Beck, Sophie L. Elkrog, Pernille D. Clausen, Lars Melholt Rasmussen, Jane Stubbe
Summary: Supplementation of cycloastragenol can inhibit the progression of abdominal aortic aneurysm, possibly by reducing matrix metalloprotease-2 activity, preserving elastin, and reducing calcification.
Article
Biochemistry & Molecular Biology
Juri Lieberg, Anders Wanhainen, Aigar Ottas, Mare Vahi, Mihkel Zilmer, Ursel Soomets, Martin Bjorck, Jaak Kals
Summary: The study found that levels of certain amino acids and phosphatidylcholines were significantly lower in abdominal aortic aneurysm (AAA) patients compared to controls. However, there were no significant differences in metabolites distinguishing between patients with slow or fast growth of the AAA.
Review
Immunology
Zhen Yuan, Yi Lu, Jia Wei, Jiaqi Wu, Jin Yang, Zhejun Cai
Summary: Abdominal aortic aneurysms (AAAs) are local dilations of the infrarenal segment of aortas, with inflammation playing a central role in their development. In addition to inflammatory cells like T cells, macrophages, and neutrophils, special structures such as inflammasomes and neutrophil extracellular traps are investigated for their roles in aneurysm formation. Understanding the impacts and interactions of these inflammatory cells and structures is crucial for developing new screening and pharmacological interventions for AAA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yutang Wang, Yan Fang, Dianna J. Magliano, Fadi J. Charchar, Christopher G. Sobey, Grant R. Drummond, Jonathan Golledge
Summary: This study investigates the association between fasting triglycerides and cardiovascular disease mortality. The results show that higher triglyceride levels are associated with an increased risk of CVD mortality in patients with diabetes, but not in those without diabetes. This suggests that future treatments targeting triglyceride reduction should focus on patients with diabetes.
CARDIOVASCULAR RESEARCH
(2023)
Review
Endocrinology & Metabolism
Peter A. Lazzarini, Susanna M. Cramb, Jonathan Golledge, Jedidiah I. Morton, Dianna J. Magliano, Jaap J. Van Netten
Summary: Diabetic foot disease (DFD) is a major cause of hospital admissions and amputations. This review analyzed the incidence of hospital admissions for DFD conditions and diabetes-related amputations in representative populations. The findings suggest that hospital admission rates for DFD conditions are higher than amputation rates, and the hospital admission rates for DFD conditions are not decreasing in many populations. Consistent definitions and data from low- and middle-income countries should be included in future studies.
Article
Surgery
Shivshankar Thanigaimani, Vikram Iyer, John Bingley, Daniel Browne, James Phie, Denise Doolan, Jonathan Golledge
Summary: This study examined the association between serum microRNAs (miRNAs) and diagnosis and growth of abdominal aortic aneurysm (AAA), and tested their diagnostic and prognostic value. The expression levels of 800 miRNA tags were assessed in AAA patients, healthy controls, and patients with peripheral artery disease (PAD). The miRNAs let-7b-5p and miR-548n improved the ability to diagnose AAA, but none of the miRNAs had independent prognostic value in predicting AAA growth.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Surgery
Chanika Alahakoon, Tejas P. Singh, Charith Galappaththy, James Charles, Malindu Fernando, Peter Lazzarini, Joseph Moxon, Jonathan Golledge
Summary: This study aimed to identify the rates and predictive factors for hospital re-admission among patients with diabetes related foot disease (DFD). The results showed that over 50% of patients were re-admitted within one year, and patients with absent pedal pulses and loss of protective sensation (LOPS) were twice as likely to be re-admitted.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Yutang Wang, Dinh Tam Nguyen, Jack Anesi, Ahmed Alramahi, Paul K. Witting, Zhonglin Chai, Abdul Waheed Khan, Jason Kelly, Kate M. Denton, Jonathan Golledge
Summary: This study aimed to investigate the effect of the sympatholytic drug moxonidine on atherosclerosis. The results showed that moxonidine increased the uptake of oxidised LDL by vascular smooth muscle cells (VSMCs), as well as the expression of LDL receptors and the lipid efflux transporter ABCG1. Moxonidine also inhibited inflammatory gene expression and increased VSMC migration. In vivo experiments on ApoE(-/-) mice showed that moxonidine administration reduced atherosclerosis formation and increased plasma lipid hydroperoxide levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Jack Paterson, Michelle Trevenen, Keith Hill, Osvaldo P. Almeida, Bu B. Yeap, Jonathan Golledge, Graeme J. Hankey, Leon Flicker
Summary: This study found that poorer balance and strength performance are associated with future all-cause and cardiovascular mortality, and balance is equal to strength as a modifiable risk factor for cause-specific mortality.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Endocrinology & Metabolism
Benjamin Crowley, Aaron Drovandi, Leonard Seng, Malindu E. Fernando, Diane Ross, Jonathan Golledge
Summary: The purpose of this study was to understand patients' perspectives on the impact and prevention of diabetes-related foot disease (DFD). A survey was conducted among patients with a history of DFD, and the results showed that foot ulcers were the most common complication, with a significant number of patients having been admitted to the hospital or undergone amputation due to DFD. The study also revealed varying perceptions on the effect of DFD on health, the importance of offloading footwear for prevention, and mixed views on telehealth.
SCIENCE OF DIABETES SELF-MANAGEMENT AND CARE
(2023)
Article
Psychiatry
Osvaldo P. Almeida, Graeme J. Hankey, Bu B. Yeap, Jonathan Golledge, Christopher Etherton-Beer, Suzanne Robinson, Leon Flicker
Summary: This study examined the prevalence of common mental disorders among older Australian men and found that the rates of depressive and anxiety disorders increase with age, especially among the older old, which is different from the results of the NSMHW conducted in 2020-2021.
AUSTRALASIAN PSYCHIATRY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Jonathan Golledge
CARDIOVASCULAR RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Jonathan Golledge
Summary: This article summarizes recent research on treatment targets for peripheral artery disease (PAD)-related limb ischemia. The current treatments for PAD have limitations and complications, and new therapies including exercise programs, drugs, stem cell treatments, and RNA therapeutics are being developed and tested. Multiple clinical trials are expected to provide results within the next 5 years.
CLINICAL THERAPEUTICS
(2023)
Review
Endocrinology & Metabolism
Aaron Drovandi, Leonard Seng, Jonathan Golledge
Summary: This systematic review and meta-analysis examined the effectiveness of educational programs for individuals with or at risk of diabetes-related foot disease (DFD). The analysis found that these programs reduced the risk of foot ulcers and amputations, improved DFD knowledge and self-care behaviors, and lowered HbA1c levels. However, larger trials with longer follow-up are needed to further confirm these findings.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Endocrinology & Metabolism
Jonathan Golledge, Shivshankar Thanigaimani, Kristen S. Barratt, Gian Paolo Fadini
Summary: Diabetes is a major risk factor for ischaemic foot disease, which can lead to severe complications such as tissue loss and amputation. Current treatment options focus on revascularisation, but there are limitations in both surgical eligibility and success rates. Recent research in animal models and clinical trials have identified potential novel medical targets for ischaemia, aiming to improve wound healing and enhance blood supply recovery. However, translating these findings to human patients remains challenging due to limitations in clinically relevant animal models. Promising results have been reported in small clinical trials with certain therapies, but further research and larger clinical trials are needed to determine their broader applicability.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Yutang Wang, Owen Sargisson, Dinh Tam Nguyen, Ketura Parker, Stephan J. R. Pyke, Ahmed Alramahi, Liam Thihlum, Yan Fang, Morgan E. Wallace, Stuart P. Berzins, Ernesto Oqueli, Dianna J. Magliano, Jonathan Golledge
Summary: The study found that hydralazine inhibits the formation and rupture of AAA by suppressing inflammatory gene expression and apoptosis, providing new insights for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Jesus Romo-Rico, Richard Bright, Smriti Murali Krishna, Krasimir Vasilev, Jonathan Golledge, Mohan V. Jacob
Summary: In this research, graphene (Gr) was deposited on a medical-grade cobalt-chromium (CoCr) alloy surface using Origanum vulgare as a precursor material. The biocompatibility and antibacterial properties of CoCr-Gr were investigated. The results suggest that CoCr-Gr could be a potential antibacterial coating material for implantable devices.
Article
Environmental Sciences
Joshua S. Jones, Lee Nedkoff, Jane S. Heyworth, Osvaldo P. Almeida, Leon Flicker, Jonathan Golledge, Graeme J. Hankey, Elizabeth H. Lim, Mark Nieuwenhuijsen, Bu B. Yeap, Michelle L. Trevenen
Summary: This study aimed to determine the dose-response relationship between long-term exposure to low-concentration PM2.5 air pollution and incident ischemic heart disease (IHD), heart failure (HF), and atrial fibrillation (AF) in older men. The results showed a trend of increased incidence of IHD, HF, and AF, but none were statistically significant under low-concentration PM2.5 air pollution exposure.
ENVIRONMENTAL EPIDEMIOLOGY
(2023)
