Article
Pharmacology & Pharmacy
Dor Yadin, Tali Guetta, Zachary Petrover, Ronny Alcalai, Jon Seidman, Christine E. Seidman, Efrat Ofek, Ran Kornowski, Edith Hochhauser, Michael Arad
Summary: Danon disease is a rare X-linked genetic disease resulting from LAMP2 mutations. Heart failure is the main cause of morbidity and mortality. This study shows that RAAS inhibitors are highly effective in preventing the progression of cardiomyopathy in an experimental mouse model of Danon's and should be considered as a treatment option for human patients.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Francesca Caspani, Antonino Carmelo Tralongo, Leonardo Campiotti, Riccardo Asteggiano, Luigina Guasti, Alessandro Squizzato
Summary: Cardioprotective drugs show a positive effect in preventing anthracycline-induced cardiac damage, with RAAS blockers, beta-blockers, and aldosterone antagonists demonstrating significant benefits in preventing left ventricular ejection fraction reduction based on echocardiographic parameters.
INTERNAL AND EMERGENCY MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Elizabeth M. Sajdel-Sulkowska
Summary: SARS-CoV-2 is now recognized to have gastrointestinal aspects in addition to its respiratory effects. The virus binds to ACE-2 receptors, particularly abundant in the gastrointestinal tract, which could contribute to multiorgan pathology in COVID-19. Therapeutic approaches targeting local ACE-2 activity in the gut and lungs may be more effective in treating the disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Huseyin C. Yalcin, Vijayakumar Sukumaran, Mahmoud Khatib A. A. Al-Ruweidi, Samar Shurbaji
Summary: The SARS-CoV-2 virus uses angiotensin converting enzyme (ACE-2) to enter cells and infect them. ACE-2 has important functions in various tissues, but the exact role in organs like the lungs and brain is still largely unknown. The levels of ACE-2 can be altered in disease and by medications, and it is unclear how these alterations affect the virus's virulence and complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Danyelle S. Miotto, Francine Duchatsch, Anderson G. Macedo, Thalles F. R. Ruiz, Carlos A. Vicentini, Sandra L. Amaral
Summary: The study investigated the effects of perindopril treatment and exercise training on blood pressure control mechanisms in hypertensive rats. The results showed that all three strategies significantly lowered blood pressure and sympathetic activity, with significant changes in arteriolar vessel structure. This suggests that perindopril could be a beneficial pharmacological option for hypertensive individuals who engage in exercise.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Ovidio De Filippo, Caterina Russo, Rossella Manai, Irene Borzillo, Federica Savoca, Guglielmo Gallone, Francesco Bruno, Mahmood Ahmad, Gaetano Maria De Ferrari, Fabrizio D'Ascenzo
Summary: This study evaluated the impact of secondary prevention medical therapies on patients with myocardial infarction with nonobstructive coronary artery disease. Results showed that beta-blockers, statins, and DAPT were associated with a survival benefit among these patients, while ACE-inhibitors/ARBs reduced the risk of MACE.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Physiology
Anderson G. Macedo, Danyelle S. Miotto, Lidieli P. Tardelli, Carlos F. Santos, Sandra L. Amaral
Summary: Angiogenesis is an important exercise-induced response to improve blood flow, but certain antihypertensive drugs can attenuate this effect. This study compared the effects of captopril and perindopril on exercise-induced angiogenesis in cardiac and skeletal muscles. The results showed that both drugs attenuated angiogenesis, with perindopril having a smaller effect, possibly due to higher levels of eNOS.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Gregory L. Hundemer, Manish M. Sood
Summary: RAAS inhibitors are evidence-based treatments for various conditions, but can lead to hyperkalemia, which increases the risk for cardiovascular events. Managing hyperkalemia while maintaining the benefits of RAAS inhibitors is essential to prevent adverse outcomes.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Pediatrics
Steve Balgobin, Sanjukta Basak, Chia Wei Teoh, Damien Noone
Summary: Diabetes mellitus and hypertension share common pathophysiological mechanisms and have overlapping effects on morbidity and mortality. This educational review explores the connections between inflammation and oxidative stress, the sympathetic nervous system, vascular remodeling, and the renin-angiotensin-aldosterone system in the context of diabetes and hypertension. It also examines current guidelines for the diagnosis and management of hypertension in both adult and pediatric populations with diabetes. While many guidelines recommend the use of RAAS blockers, the evidence for their superiority over other anti-hypertensive medications is inconclusive.
PEDIATRIC NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Ranjit Banwait, Devina Singh, Anamarys Blanco, Vaibhav Rastogi, Khalid Abusaada
Summary: This study found that prior use of ACEIs and ARBs before admission for COVID-19 was independently associated with decreased need for mechanical ventilation and in-hospital mortality.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Wei-Guang Chen, Bai-Chun Wang, Yong-Ri Jiang, Ye-Yang Wang, Yang Lou
Summary: The study conducted total arterial coronary artery bypass grafting surgery on patients with non-single-vessel coronary artery disease, using individualized arterial graft targets based on anatomical characteristics. The surgeries were successful with satisfactory short-term graft patency rates, leading to relief of angina symptoms and improvement in NYHA cardiac function classification postoperatively.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Cardiac & Cardiovascular Systems
Curtis Williams, Donghee Han, Hidenobu Takagi, Christopher B. Fordyce, Stephanie Sellers, Philipp Blanke, Fay Y. Lin, Leslee J. Shaw, Sang-Eun Lee, Daniele Andreini, Mouaz H. Al-Mallah, Matthew J. Budoff, Filippo Cademartiri, Kavitha Chinnaiyan, Jung Hyun Choi, Edoardo Conte, Hugo Marques, Pedro de Araujo Gonsalves, Ilan Gottlieb, Martin Hadamitzky, Erica Maffei, Gianluca Pontone, Sanghoon Shin, Yong-Jin Kim, Byoung Kwon Lee, Eun Ju Chun, Ji Min Sung, Renu Virmani, Habib Samady, Peter H. Stone, Daniel S. Berman, Jagat Narula, Jeroen J. Bax, Jonathon A. Leipsic, Hyuk-Jae Chang
Summary: The study aimed to investigate the effects of RAAS inhibitor on plaque progression and composition assessed by CCTA. Results showed that over nearly 4 years, RAAS inhibitor use did not significantly impact total atherosclerotic plaque progression, but there was a significant decrease in progression of non-calcified plaque in patients with a higher burden of baseline atherosclerosis.
Article
Cardiac & Cardiovascular Systems
Son Kim Tran, An Bao Truong, Phi Hoang Nguyen, Toan Hoang Ngo, Tuyen Long Vu, Khoa Dang Tran, Phuong Minh Vo, Bao The Nguyen, Tuong Le Trong Huynh, Kien Trung Nguyen, Hung Do Tran
Summary: This study evaluated the effect of perindopril on blood pressure and blood homocysteine levels in patients with primary hypertension. The results showed that perindopril effectively controlled blood pressure and reduced homocysteine levels.
INTERNATIONAL JOURNAL OF HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Lucy H. Her, Xinwen Wang, Jian Shi, Hee Jae Choi, Sun Min Jung, Logan S. Smith, Audrey H. Wu, Barry E. Bleske, Hao-Jie Zhu
Summary: The CES1 loss-of-function G143E variant significantly impaired enalapril activation and its systolic blood pressure-lowering effect in healthy volunteers, as demonstrated in a prospective multi-dose PK/PD study.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Review
Oncology
Sudeshna Rakshit, Geetha Shanmugam, Koustav Sarkar
Summary: Cancer and coronary artery disease (CAD) are common causes of death, and their coexistence is influenced by lifestyle and genetic factors. The CRISPR-Cas9 system is a promising tool for treating both cancer and CAD, and understanding the complex link between the two can lead to better prevention and treatment strategies.
Article
Peripheral Vascular Disease
Katie Harris, Paul Muntner, Mark Woodward, Min Jun, Megumi Oshima, Jessica Gong, Stephen Harrap, Joel Menard, John Chalmers
Summary: Using blood pressure and ASCVD risk to guide antihypertensive treatment can reduce the risk of major macrovascular events and death in patients with diabetes, but it has limited predictive ability for major microvascular events.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Immunology
Robert Kraaij, Isabel K. Schuurmans, Djawad Radjabzadeh, Henning Tiemeier, Timothy G. Dinan, Andre G. Uitterlinden, Manon Hillegers, Vincent W. V. Jaddoe, Liesbeth Duijts, Henriette Moll, Fernando Rivadeneira, Carolina Medina-Gomez, Pauline W. Jansen, Charlotte A. M. Cecil
Summary: This study examined the association between the gut microbiome and mental health problems in a large sample of 1,784 ten-year-old children. The results did not provide clear evidence of associations between gut microbiome diversity, taxonomies, or functions and mental health problems in the general pediatric population.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Cardiac & Cardiovascular Systems
Patrick B. Mark, Juan J. Carrero, Kunihiro Matsushita, Yingying Sang, Shoshana H. Ballew, Morgan E. Grams, Josef Coresh, Aditya Surapaneni, Nigel J. Brunskill, John Chalmers, Lili Chan, Alex R. Chang, Rajkumar Chinnadurai, Gabriel Chodick, Massimo Cirillo, Dick de Zeeuw, Marie Evans, Amit X. Garg, Orlando M. Gutierrez, Hiddo J. L. Heerspink, Gunnar H. Heine, William G. Herrington, Junichi Ishigami, Florian Kronenberg, Jun Young Lee, Adeera Levin, Rupert W. Major, Angharad Marks, Girish N. Nadkarni, David M. J. Naimark, Christoph Nowak, Mahboob Rahman, Charumathi Sabanayagam, Mark Sarnak, Simon Sawhney, Markus P. Schneider, Varda Shalev, Jung-Im Shin, Moneeza K. Siddiqui, Nikita Stempniewicz, Keiichi Sumida, Jose M. Valdivielso, Jan van den Brand, Angela Yee-Moon Wang, David C. Wheeler, Lihua Zhang, Frank L. J. Visseren, Benedicte Stengel
Summary: This study investigated the association between cardiovascular disease (CVD) and future risk of kidney failure with replacement therapy (KFRT). It found that both prevalent and incident CVD were strongly associated with KFRT risk, with incident HF showing the strongest association.
EUROPEAN HEART JOURNAL
(2023)
Article
Peripheral Vascular Disease
Nelson Wang, Katie Harris, Mark Woodward, Stephen Harrap, Giuseppe Mancia, Neil Poulter, John Chalmers, Anthony Rodgers
Summary: The utility of short-term blood pressure changes in determining long-term treatment response was assessed in two randomized trials, and it was found that changes in blood pressure immediately after starting treatment did not significantly affect subsequent treatment response.
Article
Nutrition & Dietetics
Alexandra P. M. de Koning-Backus, Jessica Kiefte-de C. Jong, Jeroen G. J. van Rooij, Andre G. G. Uitterlinden, Trudy A. Voortman, Magda Meester-Smoor, Caroline C. W. Klaver
Summary: Age-related macular degeneration (AMD) has a strong genetic basis, which can be reduced by environmental factors such as smoking and a healthy diet. However, many ophthalmologists do not inform patients about these beneficial lifestyle changes due to lack of trust and measurement methods. To address this, the AMD-Life study aims to investigate if personalized risk-profiling and coaching can motivate patients to change their lifestyle. The study also aims to identify biomarkers that reflect lifestyle changes beneficial for AMD.
Article
Public, Environmental & Occupational Health
Grigory Sidorenkov, Ralph Stadhouders, Colin Jacobs, Firdaus A. A. Mohamed Hoesein, Hester A. Gietema, Kristiaan Nackaerts, Zaigham Saghir, Marjolein A. Heuvelmans, Hylke C. Donker, Joachim G. Aerts, Roel Vermeulen, Andre Uitterlinden, Virissa Lenters, Jeroen van Rooij, Cornelia Schaefer-Prokop, Harry J. M. Groen, Pim A. de Jong, Robin Cornelissen, Mathias Prokop, Geertruida H. de Bock, Rozemarijn Vliegenthart
Summary: Trials have shown that low-dose computed tomography (CT) lung cancer screening can reduce lung cancer mortality in long-term (ex-)smokers, although many individuals have been subjected to unnecessary diagnostic procedures. This project aims to improve the efficiency of lung cancer screening by identifying high-risk participants and improving risk discrimination for nodules. The study will gather new data on genetics, air pollution, malignancy risk for lung nodules, and CT biomarkers beyond lung nodules, and develop prediction models for pre-screening and post-baseline-screening participant selection and nodule management.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Medicine, General & Internal
Sadiya S. Khan, Wendy S. Post, Xiuqing Guo, Jingyi Tan, Fang Zhu, Daniel Bos, Bahar Sedaghati-Khayat, Jeroen van Rooij, Aaron Aday, Norrina B. Allen, Maxime M. Bos, Andre G. Uitterlinden, Matthew J. Budoff, Donald M. Lloyd-Jones, Jonathan D. Mosley, Jerome I. Rotter, Philip Greenland, Maryam Kavousi
Summary: Coronary artery calcium score and polygenic risk score were evaluated for their ability to predict risk of coronary heart disease (CHD) in two population-based studies. The results showed that coronary artery calcium score had better discrimination and improved risk prediction when added to traditional risk factors compared to the polygenic risk score.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Genetics & Heredity
Nick Shrine, Abril G. Izquierdo, Jing Chen, Richard Packer, Robert J. Hall, Anna L. Guyatt, Chiara Batini, Rebecca J. Thompson, Chandan Pavuluri, Vidhi Malik, Brian D. Hobbs, Matthew Moll, Wonji Kim, Ruth Tal-Singer, Per Bakke, Katherine A. Fawcett, Catherine John, Kayesha Coley, Noemi Nicole Piga, Alfred Pozarickij, Kuang Lin, Iona Y. Millwood, Zhengming Chen, Liming Li, Sara R. A. Wijnant, Lies Lahousse, Guy Brusselle, Andre G. Uitterlinden, Ani Manichaikul, Elizabeth C. Oelsner, Stephen S. Rich, R. Graham Barr, Shona M. Kerr, Veronique Vitart, Michael R. Brown, Matthias Wielscher, Medea Imboden, Ayoung Jeong, Traci M. Bartz, Sina A. Gharib, Claudia Flexeder, Stefan Karrasch, Christian Gieger, Annette Peters, Beate Stubbe, Xiaowei Hu, Victor E. Ortega, Deborah A. Meyers, Eugene R. Bleecker, Stacey B. Gabriel, Namrata Gupta, Albert Vernon Smith, Jian'an Luan, Jing-Hua Zhao, Ailin F. Hansen, Arnulf Langhammer, Cristen Willer, Laxmi Bhatta, David Porteous, Blair H. Smith, Archie Campbell, Tamar Sofer, Jiwon Lee, Martha L. Daviglus, Bing Yu, Elise Lim, Hanfei Xu, George T. O'Connor, Gaurav Thareja, Omar M. E. Albagha, Said I. Ismail, Wadha Al-Muftah, Radja Badji, Hamdi Mbarek, Dima Darwish, Tasnim Fadl, Heba Yasin, Maryem Ennaifar, Rania Abdellatif, Fatima Alkuwari, Muhammad Alvi, Yasser Al-Sarraj, Chadi Saad, Asmaa Althani, Eleni Fethnou, Fatima Qafoud, Eiman Alkhayat, Nahla Afifi, Sara Tomei, Wei Liu, Stephan Lorenz, Najeeb Syed, Hakeem Almabrazi, Fazulur Rehaman Vempalli, Ramzi Temanni, Tariq Abu Saqri, Mohammedhusen Khatib, Mehshad Hamza, Tariq Abu Zaid, Ahmed El Khouly, Tushar Pathare, Shafeeq Poolat, Rashid Al-Ali, Souhaila Al-Khodor, Mashael Alshafai, Ramin Badii, Lotfi Chouchane, Xavier Estivill, Khalid Fakhro, Younes Mokrab, Jithesh Puthen, Zohreh Tatari, Karsten Suhre, Raquel Granell, Tariq O. Faquih, Pieter S. Hiemstra, Annelies M. Slats, Benjamin H. Mullin, Jennie Hui, Alan James, John Beilby, Karina Patasova, Pirro Hysi, Jukka T. Koskela, Annah B. Wyss, Jianping Jin, Sinjini Sikdar, Mikyeong Lee, Sebastian May-Wilson, Nicola Pirastu, Katherine A. Kentistou, Peter K. Joshi, Paul R. H. J. Timmers, Alexander T. Williams, Robert C. Free, Xueyang Wang, John L. Morrison, Frank D. Gilliland, Zhanghua Chen, Carol A. Wang, Rachel E. Foong, Sarah E. Harris, Adele Taylor, Paul Redmond, James P. Cook, Anubha Mahajan, Lars Lind, Teemu Palviainen, Terho Lehtimaki, Olli T. Raitakari, Jaakko Kaprio, Taina Rantanen, Kirsi H. Pietilainen, Simon R. Cox, Craig E. Pennell, Graham L. Hall, W. James Gauderman, Chris Brightling, James F. Wilson, Tuula Vasankari, Tarja Laitinen, Veikko Salomaa, Dennis O. Mook-Kanamori, Nicholas J. Timpson, Eleftheria Zeggini, Josee Dupuis, Caroline Hayward, Ben Brumpton, Claudia Langenberg, Stefan Weiss, Georg Homuth, Carsten Oliver Schmidt, Nicole Probst-Hensch, Marjo-Riitta Jarvelin, Alanna C. Morrison, Ozren Polasek, Igor Rudan, Joo-Hyeon Lee, Ian Sayers, Emma L. Rawlins, Frank Dudbridge, Edwin K. Silverman, David P. Strachan, Robin G. Walters, Andrew P. Morris, Stephanie J. London, Michael H. Cho, Louise Wain, Ian P. Hall, Martin Tobin
Summary: Through a large-scale multi-ancestry genome-wide association meta-analysis, 1020 independent association signals implicating 559 genes related to COPD were identified. These genes were enriched in 29 pathways. Variants showed heterogeneity across ancestries, age and smoking groups, and the genetic risk score was strongly associated with COPD across ancestry groups. New potential causal variants, genes, proteins and pathways were highlighted, including those targeted by existing drugs. These findings contribute to a better understanding of lung function and COPD mechanisms and have implications for functional genomics experiments and future COPD therapies.
Article
Medicine, General & Internal
Chen Chen, Menglu Ouyang, Sheila Ong, Luyun Zhang, Guobin Zhang, Candice Delcourt, Grant Mair, Leibo Liu, Laurent Billot, Qiang Li, Xiaoying Chen, Mark Parsons, Joseph P. Broderick, Andrew M. Demchuk, Philip M. Bath, Geoffrey A. Donnan, Christopher Levi, John Chalmers, Richard I. Lindley, Sheila O. Martins, Octavio M. Pontes-Neto, Paula Munoz Venturelli, Veronica Olavarria, Pablo Lavados, Thompson G. Robinson, Joanna M. Wardlaw, Gang Li, Xia Wang, Lili Song, Craig S. Anderson
Summary: This study aimed to investigate the effect of intensive blood pressure lowering on the size of cerebral infarction in patients with acute ischemic stroke after thrombolysis. The results showed that intensive blood pressure lowering to a systolic target of 130-140 mm Hg within 24-36 hours did not increase the size of cerebral infarction.
Letter
Cardiac & Cardiovascular Systems
Janis M. Nolde, Emily Atkins, Simone Marschner, Graham S. Hillis, John Chalmers, Laurent Billot, Mark R. Nelson, Christopher M. Reid, Peter Hay, Michael Burke, Shirley Jansen, Tim Usherwood, Anthony Rodgers, Clara K. Chow, Markus P. Schlaich
Article
Cardiac & Cardiovascular Systems
Emily R. Atkins, Alexander Chye, Thomas Lung, Janis M. Nolde, Laurent Billot, Michael Burke, John Chalmers, Gemma A. Figtree, Peter Hay, Graham S. Hillis, Shirley Jansen, Simone Marschner, Bruce Neal, Mark R. Nelson, Christopher M. Reid, Tim Usherwood, Markus Schlaich, Clara K. Chow, Anthony Rodgers
Summary: This study aimed to evaluate the cost-effectiveness and cost-utility of a quadpill containing multiple drugs for hypertension treatment. The results showed that quadpill therapy was comparably cost-effective for short-term blood pressure lowering and likely to be cost-effective in the long-term.
Letter
Dermatology
Fuduan Peng, Ziyi Xiong, Gu Zhu, Pirro G. Hysi, Ryan J. Eller, Sijie Wu, Kaustubh Adhikari, Yan Chen, Yi Li, Rolando Gonzalez-Jose, Lavinia Schuler-Faccini, Maria-Catira Bortolini, Victor Acuna-Alonzo, Samuel Canizales-Quinteros, Carla Gallo, Giovanni Poletti, Gabriel Bedoya, Francisco Rothhammer, Andre G. Uitterlinden, M. Arfan Ikram, Tamar Nijsten, Andres Ruiz-Linares, Sijia Wang, Susan Walsh, Timothy D. Spector, Nicholas G. Martin, Manfred Kayser, Fan Liu
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Shirin Ibrahim, Jeroen van Rooij, Annemieke J. M. H. Verkerk, Jard de Vries, Linda Zuurbier, Joep Defesche, Jorge Peter, Willemijn A. M. Schonck, Bahar Sedaghati-Khayat, G. Kees Hovingh, Andre G. Uitterlinden, Erik S. G. Stroes, Laurens F. Reeskamp
Summary: This study evaluated the accuracy of a low-cost, high-throughput genotyping array for diagnosing familial hypercholesterolemia (FH). The results showed that the array had a high coverage and sensitivity for FH-causing variants, and could identify additional FH-causing variants. The array has the potential to increase accessibility to genetic testing for FH at a low cost.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2023)
Article
Biology
Carolina Medina-Gomez, Benjamin H. Mullin, Alessandra Chesi, Vid Prijatelj, John P. Kemp, Chen Shochat-Carvalho, Katerina Trajanoska, Carol Wang, Raimo Joro, Tavia E. Evans, Katharina E. Schraut, Ruifang Li-Gao, Tarunveer S. Ahluwalia, M. Carola Zillikens, Kun Zhu, Dennis O. Mook-Kanamori, Daniel S. Evans, Maria Nethander, Maria J. Knol, Gudmar Thorleifsson, Ivana Prokic, Babette Zemel, Linda Broer, Fiona E. McGuigan, Natasja M. van Schoor, Sjur Reppe, Mikolaj A. Pawlak, Stuart H. Ralston, Nathalie van der Velde, Mattias Lorentzon, Kari Stefansson, Hieab H. H. Adams, Scott G. Wilson, M. Arfan Ikram, John P. Walsh, Timo A. Lakka, Kaare M. Gautvik, James F. Wilson, Eric S. Orwoll, Cornelia M. van Duijn, Klaus Bonnelykke, Andre G. Uitterlinden, Unnur Styrkarsdottir, Kristina E. Akesson, Timothy D. Spector, Jonathan H. Tobias, Claes Ohlsson, Janine F. Felix, Hans Bisgaard, Struan F. A. Grant, J. Brent Richards, David M. Evans, Bram van der Eerden, Jeroen van de Peppel, Cheryl Ackert-Bicknell, David Karasik, Erika Kague, Fernando Rivadeneira
Summary: Skull bone mineral density (SK-BMD) is a suitable trait for studying bone biology, particularly related to intramembranous ossification. A genome-wide association meta-analysis identified 59 loci associated with SK-BMD, which collectively explained 12.5% of the variance in the trait. These loci are involved in skeletal development and osteoporosis, and four of them are related to intramembranous ossification and craniofacial abnormalities.
COMMUNICATIONS BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
K. J. Ploegmakers, E. P. van Poelgeest, L. J. Seppala, S. C. van Dijk, L. C. P. G. M. de Groot, S. Oliai Araghi, N. M. van Schoor, B. Stricker, K. M. A. Swart, A. G. Uitterlinden, R. A. A. Mathot, N. van Der Velde
Summary: This study investigated whether the use of beta-blockers in older adults increased the risk of falls and found that elevated plasma concentrations of metoprolol were associated with an increased risk of falls. No association was found between nonselective beta-blocker concentrations and fall risk. Changes in concentration over time were also not associated with increased fall risk.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2023)