Article
Cardiac & Cardiovascular Systems
Caio V. Spaggiari, Sergio F. de Siqueira, Camila Parente de Oliveira, Cinthya I. Guiarao I. Gomes, Maria Janieire de N. N. Alves, Martino Martinelli Filho
Summary: This study aimed to evaluate the feasibility of physiological pacing rate (PPR) in cardiac resynchronization therapy (CRT) patients. The results showed that PPR improved functional capacity in mildly symptomatic CRT patients, but further confirmation is needed through controlled randomized trials.
Article
Biology
Mohammad Albatat, Hermenegild Arevalo, Jacob Bergsland, Vilde Strom, Ilangko Balasingham, Hans Henrik Odland
Summary: This study aimed to investigate the performance of a newly developed method to analyze electrical wavefront propagation in a heart model and compare it to clinical benchmark studies. The results demonstrated the utility of maximum activation front (MAF) in predicting optimal electrode placements in different pacing scenarios including scar and multi-site LV pacing, showing the potential value of computational simulations in understanding and planning CRT.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Juan Carlos Diaz, William H. Sauer, Mauricio Duque, Bruce A. Koplan, Eric D. Braunstein, Jorge Eduardo Marin, Julian Aristizabal, Cesar Daniel Nino, Oriana Bastidas, Juan Manuel Martinez, Carolina Hoyos, Carlos D. Matos, Nestor Lopez-Cabanillas, Nathaniel A. Steiger, Sunil Kapur, Thomas M. Tadros, David T. Martin, Paul C. Zei, Usha B. Tedrow, Jorge E. Romero
Summary: This study compares the outcomes of LBBAP and BiVp as initial implant strategies for CRT. The results show that LBBAP as an initial CRT strategy can reduce the risk of hospitalization due to heart failure compared to BiVp, and improvements in procedural and fluoroscopy times, QRS duration, and left ventricular ejection fraction were observed.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Henry Chubb, Anica Bulic, Douglas Mah, Jeremy P. Moore, Jan Janousek, Jennifer Fumanelli, S. Yukiko Asaki, Andreas Pflaumer, Allison C. Hill, Carolina Escudero, Sit Yee Kwok, Jasveer Mangat, Luis A. Ochoa Nunez, Seshadri Balaji, Eric Rosenthal, William Regan, Michaela Horndasch, Hiroko Asakai, Ronn Tanel, Richard J. Czosek, Ming-Lon Young, David J. Bradley, Thomas Paul, Peter Fischbach, Lindsey Malloy-Walton, Doff B. McElhinney, Anne M. Dubin
Summary: This study aimed to quantify the risk of permanent ventricular pacing (PPMv) in patients with single ventricle (SV) and identify modifiable risk factors. The results showed that PPMv was associated with an increased risk of heart transplantation and death. Higher ventricular pacing percentage (Vp), higher QRS z-score, and nonapical ventricular lead position were all associated with a higher risk of adverse outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Peter Kubus, Jana Rubackova Popelova, Jan Kovanda, Kamil Sedlacek, Jan Janousek
Summary: This study evaluated the long-term impact of cardiac resynchronization therapy (CRT) in patients with congenital heart disease, finding that approximately 50% of patients had a good treatment response during long-term follow-up with acceptable survival rates. However, the probability of experiencing complications during continued CRT therapy was relatively high.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Bela Merkely, Robert Hatala, Jerzy K. Wranicz, Gabor Duray, Csaba Foldesi, Zoltan Som, Marianna Nemeth, Kinga Goscinska-Bis, Laszlo Geller, Endre Zima, Istvan Osztheimer, Levente Molnar, Julia Karady, Gerhard Hindricks, Ilan Goldenberg, Helmut Klein, Matyas Szigeti, Scott D. Solomon, Valentina Kutyifa, Attila Kovacs, Annamaria Kosztin, BUDAPEST CRT Upgrade Invest
Summary: De novo implanted cardiac resynchronization therapy with defibrillator (CRT-D) reduces the risk of morbidity and mortality in patients with left bundle branch block, heart failure and reduced ejection fraction (HFrEF). However, among HFrEF patients with right ventricular pacing (RVP), the efficacy of CRT-D upgrade is uncertain.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Rohit K. Kharbanda, Jeremy P. Moore, Michael S. Lloyd, Robert Galotti, Ad J. J. C. Bogers, Yannick J. H. J. Taverne, Malini Madhavan, Christopher J. McLeod, Anne M. Dubin, Douglas Y. Mah, Philip M. Chang, Anna N. Kamp, Jens C. Nielsen, Alper Aydin, Ronn E. Tanel, Maully J. Shah, Thomas Pilcher, Reinder Evertz, Paul Khairy, Reina B. Tan, Richard J. Czosek, Kalyanam Shivkumar, Natasja M. S. de Groot
Summary: This international multicenter study investigated the outcomes of cardiac resynchronization therapy (CRT) in patients with a systemic right ventricle (SRV) and identified predictors for congestive heart failure readmissions and mortality. The study found that CRT significantly improved functional class and QRS duration in patients with pre-CRT ventricular pacing who underwent an upgrade to a CRT device. However, no beneficial change was observed in patients who underwent de novo CRT. A quarter of all patients were readmitted for heart failure and the mortality rate was 21.3%.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Cardiac & Cardiovascular Systems
Jiyi Liu, Fengzhi Sun, Zefeng Wang, Jiao Sun, Xue Jiang, Weilong Zhao, Zhipeng Zhang, Lu Liu, Shulong Zhang
Summary: In patients with heart failure eligible for cardiac resynchronization therapy (CRT), left bundle branch area pacing (LBBAP) showed significant improvements in QRS duration, left ventricular ejection fraction, left ventricular end-diastolic dimension, New York Heart Association class, and CRT response compared to biventricular pacing (BVP). The current evidence from non-randomized studies suggests that LBBAP is a promising method for CRT, offering more remarkable improvements in symptoms and cardiac function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yixiu Liang, Zilong Xiao, Xi Liu, Jingfeng Wang, Ziqing Yu, Xue Gong, Hongyang Lu, Shengwen Yang, Min Gu, Lei Zhang, Minghui Li, Lei Pan, Xiao Li, Xueying Chen, Yangang Su, Wei Hua, Junbo Ge
Summary: This study compared the morbidity and mortality associated with left bundle branch area pacing (LBBAP) and biventricular pacing (BVP) in patients undergoing cardiac resynchronization therapy (CRT). The results showed that there was no significant difference in the risk of morbidity and mortality between LBBAP and BVP in patients with indications for CRT.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Yixiu Liang, Jingfeng Wang, Xue Gong, Hongyang Lu, Ziqing Yu, Lei Zhang, Minghui Li, Lei Pan, Xueying Chen, Jie Cui, Weiwei Zhang, Ruogu Li, Xiaohong Zhou, Weijian Huang, Yangang Su, Junbo Ge
Summary: The study compared the acute improvement of left bundle branch pacing (LBBP) and biventricular pacing (BVP) in patients with heart failure. The results showed that LBBP provided greater improvements in electrical and mechanical synchrony, as well as hemodynamics, compared to BVP.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yao Wang, Haojie Zhu, Xiaofeng Hou, Zhao Wang, Fengwei Zou, Zhiyong Qian, Yongyue Wei, Xiang Wang, Longyao Zhang, Xiaofei Li, Zhimin Liu, Siyuan Xue, Chaotong Qin, Jiaxin Zeng, Hui Li, Hongping Wu, Hong Ma, Kenneth A. Ellenbogen, Michael R. Gold, Xiaohan Fan, Jiangang Zou
Summary: Left bundle branch pacing (LBBP) shows greater improvement in left ventricular ejection fraction (LVEF) compared to biventricular pacing (BiVP) in heart failure patients with nonischemic cardiomyopathy and left bundle branch block (LBBB).
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Joaquin Osca, Jaume Francisco-Pascual, Javier Martinez-Basterra, Juan Gabriel Martinez, Hipolito Reis, Mario Oliveira, Bieito Campos, Javier Balaguer, Jeronimo Rubio, Ricardo Pavon-Jimenez, Julio Hernandez, Jose Miguel Ormaetxe, Jose Luis Zamorano, Pilar Santamaria, Javier Alzueta
Summary: This study aimed to evaluate the response rate of cardiac resynchronization therapy (CRT) in patients implanted with a CRT device with multipoint left ventricle pacing (MPP) activated. The results showed a response rate of 64.6% at 6 months, with a decrease in left ventricular end-systolic volume (LVESV) of 25.3% and an increase in left ventricular ejection fraction (LVEF) of 9.4%. Early activation of MPP was associated with a low incidence of clinical endpoints at 6 months.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
Hilary C. Bowman, Kevin M. Shannon, Reshma Biniwale, Jeremy P. Moore
Summary: In adult congenital heart disease (ACHD) patients, overall dysfunction and reintervention rates of cardiac implantable electronic devices (CIEDs) are similar between transvenous (TV) and epicardial (EPI) approaches, but lead dysfunction is more severe in EPI devices.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Yuping Fu, Peng Liu, Lingyan Jin, Yingqi Li, Yudi Zhang, Xinghua Qin, Qiangsun Zheng
Summary: Cardiac resynchronization therapy (CRT) is considered as the first-line treatment for heart failure patients with conduction disorders. Conventional biventricular pacing (BVP) has limitations, and left bundle branch pacing (LBBP) has emerged as a promising alternative. LBBP has shown superior outcomes compared to BVP in terms of CRT delivery, QRS complex width, left ventricular ejection fraction improvement, and functional class.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Fabian Barbieri, Agne Adukauskaite, Anna Heidbreder, Elisabeth Brandauer, Melanie Bergmann, Ambra Stefani, Evi Holzknecht, Thomas Senoner, Andrea Rubatscher, Wilfried Schgoer, Markus Stuehlinger, Bernhard Erich Pfeifer, Axel Bauer, Florian Hintringer, Birgit Hoegl, Wolfgang Dichtl
Summary: The study investigates the role of CSA in pacing-induced cardiomyopathy and shows that CRT upgrading significantly improves CSA, leading to similar outcomes in PICM patients without pre-existent CSA.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jan Kovanda, Miroslav Lozek, Shin Ono, Peter Kubus, Viktor Tomek, Jan Janousek
Article
Cardiac & Cardiovascular Systems
Lucie Riedlbauchova, Theodor Adla, Vojtech Suchanek, Miroslav Lozek, Jan Tomis, Jiri Hozman, Viktor Tomek, Josef Veselka, Jan Janousek
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Ondrej Fabian, Roman Gebauer, Viktor Tomek, Ludmila Hornofova, Mariia Havova, Ondrej Materna, Jan Janousek
Summary: This study reviewed congenital heart defects assessed in the center from 2010 to 2020, finding that most cases required surgical correction or resulted in induced abortion or stillbirth. Autopsy provided crucial information about the morphology of congenital heart defects, placing high demands on pathologists.
CARDIOVASCULAR PATHOLOGY
(2021)
Article
Medicine, Research & Experimental
Najim Lahrouchi, Alex V. Postma, Christian M. Salazar, Daniel M. De Laughter, Fleur Tjong, Lenka Piherova, Forrest Z. Bowling, Dominic Zimmerman, Elisabeth M. Lodder, Asaf Ta-Shma, Zeev Perles, Leander Beekman, Aho Ilgun, Quinn Gunst, Mariam Hababa, Doris Skoric-Milosavljevic, Viktor Stranecky, Viktor Tomek, Peter de Knijff, Rick de Leeuw, Jamille Y. Robinson, Sabrina C. Burn, Hiba Mustafa, Matthew Ambrose, Timothy Moss, Jennifer Jacober, Dmitriy M. Niyazov, Barry Wolf, Katherine H. Kim, Sara Cherny, Andreas Rousounides, Aphrodite Aristidou-Kallika, George Tanteles, Bruel Ange-Line, Anne-Sophie Denomme-Pichon, Christine Francannet, Damara Ortiz, Monique C. Haak, Arend D. J. Ten Harkel, Gwendolyn T. R. Manten, Annemiek C. Dutman, Katelijne Bouman, Monia Magliozzi, Francesca Clementina Radio, Gijs W. E. Santen, Johanna C. Herkert, H. Alex Brown, Orly Elpeleg, Maurice J. B. van den Hoff, Barbara Mulder, Michael V. Airola, Stanislav Kmoch, Joey V. Barnett, Sally-Ann Clur, Michael A. Frohman, Connie R. Bezzina
Summary: Through whole-exome sequencing of 2718 patients with congenital heart disease, the study found that PLD1 gene variants are associated with cardiac valve defects and isolated neonatal cardiomyopathy. Some variants were overrepresented in critical protein regions, leading to reduced enzymatic activity and decreased endothelial-mesenchymal transition.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Peter Kubus, Jana Rubackova Popelova, Jan Kovanda, Kamil Sedlacek, Jan Janousek
Summary: This study evaluated the long-term impact of cardiac resynchronization therapy (CRT) in patients with congenital heart disease, finding that approximately 50% of patients had a good treatment response during long-term follow-up with acceptable survival rates. However, the probability of experiencing complications during continued CRT therapy was relatively high.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Ondrej Materna, Karel Koubsky, Radek Padr, Jan Janousek
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Karel Koubsky, Roman Gebauer, Tomas Tlaskal, Tomas Matejka, Rudolf Poruban, Denisa Jicinska, Bohumil Hucin, Jan Janousek, Vaclav Chaloupecky
Summary: The long-term survival of children undergoing ASO is excellent with low rates of coronary artery reinterventions. Patients with intramural coronary artery are at higher risk of coronary artery reintervention and mortality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Genetics & Heredity
Amber E. L. van Nisselrooij, Anita J. Moon-Grady, Annette Wacker-Gussmann, Viktor Tomek, Ivan Malcic, Agnieszka Grzyb, Anna Pavlova, Kalliopi Kazamia, Varsha Thakur, Elena Sinkovskaya, A. Derk Jan Ten Harkel, Monique C. Haak
Summary: This study retrospectively reviewed 20 cases of congenital heart defect ALVT and observed their prenatal and postnatal conditions. The results showed that the prognosis of these infants was good in the absence of fetal hydrops.
PRENATAL DIAGNOSIS
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Ondrej Materna, Jan Kovanda, Viktor Tomek
REVISTA ESPANOLA DE CARDIOLOGIA
(2022)
Article
Pediatrics
Theodor Adla, Martin Koci, Vojtech Suchanek, Zuzana Salagovicova, Michal Polovincak, Lukas Miksik, Jan Janousek, Miloslav Rocek
Summary: This study assessed the impact of different clinical questions on radiation doses in pediatric cardiac CT scans. The results showed that cardiac function assessment and coronary artery assessment resulted in significantly higher radiation doses.
Article
Pediatrics
Karel Koubsky, Roman Gebauer, Rudolf Poruban, Pavel Vojtovic, Ondrej Materna, Vojtech Melenovsky, Lenka Hoskova, Ivan Netuka, Jan Burkert, Jan Janousek
Summary: This study evaluated the mid-term characteristics and outcomes of a comprehensive pediatric nationwide heart transplantation program in the Czech Republic, and compared them with international data. The results showed that the program's mid-term results were comparable to worldwide data, confirming the possibility of establishing a successful nationwide pediatric heart transplantation program in a relatively small population country with well-developed pediatric cardiovascular care and other transplantation programs.
PEDIATRIC TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Roman Gebauer, Vaclav Chaloupecky, Bohumil Hucin, Tomas Tlaskal, Arnost Komarek, Jan Janousek
Summary: In a nationwide cohort, tetralogy of Fallot repair showed a favorable long-term outcome with a survival rate of over 90% at 30 years after repair. Each reintervention increased the risk of mortality, and the type of initial repair predicted the need for specific surgical or catheter reinterventions.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Vaclav Chaloupecky, Denisa Jicinska, Viktor Tomek, Ondrej Materna, Roman Gebauer, Rudolf Poruban, Petra Antonova, Theodor Adla, Matej Stefanek, Vojtech Illinger, Karel Kotaska, Jan Janousek
Summary: This study analyzed the relationship between hepatic fibrosis markers, liver morphology, and hemodynamics assessed by MRI after total cavopulmonary connection. The results showed that the formation of liver nodules caused hepatic arterialization, leading to increased inferior vena cava flow and ventricular volume overload, which may further compromise single ventricle functional reserve in adult patients after TCPC.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
P. Antonova, V Chaloupecky, T. Adla, V Tomek, K. Slaby, J. Zeman, V Rohn
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
(2020)
