Article
Biochemistry & Molecular Biology
Francesco Piarulli, Cristina Banfi, Maura Brioschi, Alessandra Altomare, Eugenio Ragazzi, Chiara Cosma, Giovanni Sartore, Annunziata Lapolla
Summary: This study aimed to verify the burden of various forms of albumin and their relationship with diseases in patients with diabetes and coronary heart disease. The results showed that levels of AGE and pentosidine were significantly higher in diabetic patients compared to non-diabetic patients, and RAGE levels were higher in diabetic patients, especially those with coronary heart disease. Different forms of albumin could discriminate between different patient groups. Additionally, oxidized forms of albumin were found to increase the expression of the inflammatory cytokine TNF alpha.
Article
Endocrinology & Metabolism
Masanori Iwase, Toshiaki Ohkuma, Hiroki Fujii, Yutaro Oku, Taiki Higashi, Ayaka Oshiro, Hitoshi Ide, Udai Nakamura, Takanari Kitazono
Summary: This study aimed to investigate the incidence, risk factors, and prognosis of coronary heart disease (CHD) and heart failure (HF) in Japanese patients with type 2 diabetes. The results showed that the incidence of heart disease was low and circulating adiponectin and sarcopenia may predict the development of heart disease in patients with type 2 diabetes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Mehdi Karamian, Maryam Moossavi, Mina Hemmati
Summary: Recent studies have shown that adiponectin plays a key role in diabetes-related kidney diseases by affecting oxidative stress and signaling pathways to decrease diabetes-associated aging. This suggests that adiponectin signaling in target tissues is a promising area of research for developing antidiabetic and anti-aging drugs.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Review
Endocrinology & Metabolism
Yong-Tian Zheng, Tian-Mei Xiao, Chan-Xian Wu, Jin-Yan Cheng, Le-Yu Li
Summary: The study identified that the polymorphisms rs266729 and rs3774261 in the adiponectin gene may be risk factors for NAFLD and remained significantly associated in different samples, holding potential for novel therapeutic strategies. However, these findings still need to be validated in larger, well-designed studies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Liu Luo, Senmao Zhang, Tingting Wang, Jingyi Diao, Jinqi Li, Yihuan Li, Lijuan Zhao, Letao Chen, Ziwei Ye, Peng Huang, Jiabi Qin
Summary: This study found significant associations between maternal diabetes mellitus, adiponectin gene polymorphisms, and their interactions with risk of congenital heart disease in offspring. Further studies in different ethnic populations with larger samples and prospective designs are needed to confirm these findings.
Article
Biochemistry & Molecular Biology
Naris Thengchaisri, Lih Kuo, Travis W. Hein
Summary: In diabetes, the increased activity of the enzyme arginase competes with endothelial nitric oxide synthase (eNOS) for their common substrate L-arginine, leading to compromised vasodilation mediated by nitric oxide (NO). However, eNOS uncoupling in diabetes may result in the production of superoxide and compensatory hydrogen peroxide (H2O2) formation to restore NO deficiency. This study found that in early type 1 diabetes, the vasodilation response in coronary arterioles was partially impaired due to reduced availability of L-arginine as a result of upregulated arginase activity. Nevertheless, the increased production of H2O2 during eNOS uncoupling and PI3K activation seemed to compensate for the NO deficiency and mask the disturbance caused by arginase activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Estefania Bravo-Sanchez, Donovan Pena-Montes, Sarai Sanchez-Duarte, Alfredo Saavedra-Molina, Elizabeth Sanchez-Duarte, Rocio Montoya-Perez
Summary: The study showed that treatment with apocynin significantly improved blood glucose levels and insulin resistance in diabetic rats, attenuated oxidative stress responses, enhanced mitochondrial function and antioxidant defense. Apocynin has a protective effect against diabetic complications.
Review
Biochemistry & Molecular Biology
Rami S. Najjar, Arielle M. Schwartz, Brett J. Wong, Puja K. Mehta, Rafaela G. Feresin
Summary: Ischemia with no obstructive coronary artery disease (INOCA) is a common diagnosis with a higher prevalence in women, associated with major adverse cardiovascular outcomes and angina. Coronary microvascular dysfunction (CMD) is a major feature, driven by inflammatory and oxidative stress signaling, and treatment focuses on addressing cardiovascular risk factors. Potential treatment options include berry-derived polyphenols to modulate these pathways, with future clinical trials needed to investigate their effectiveness in INOCA patients with CMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Catrin Herpich, Bastian Kochlik, Ulrike Hass, Daniela Weber, Tilman Grune, Kristina Norman
Summary: The study found that in older women, adiponectin levels increased after glucose intake and decreased after high-fat intake; the adiponectin response was associated with the type of dietary challenge, age, and FGF21 response; age-group differences were partly due to metabolic parameters and oxidative stress.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Dandan Jia, Jun Zhang, Jia Nie, John-Paul Andersen, Samantha Rendon, Yue Zheng, Xueling Liu, Zhenjun Tian, Yuguang Shi
Summary: Cardiolipin is crucial for maintaining cardiac health, and the loss of TLCL is linked to the pathogenesis of CHD. ALCAT1 acts as a key link between hypoxia and CHD, promoting mitochondrial dysfunction in the process. Ablation or inhibition of ALCAT1 could effectively mitigate CHD and its associated pathologies.
Review
Physiology
Jinit K. K. Mehta, Ginpreet Kaur, Harpal S. S. Buttar, Hala Abubaker Bagabir, Rania Abubaker Bagabir, Sali Abubaker Bagabir, Shafiul Haque, Hardeep S. S. Tuli, Istvan G. G. Telessy
Summary: The renin-angiotensin system (RAS) plays a pivotal role in blood pressure regulation and its overactivation can lead to cardiovascular damage, including coronary heart disease (CHD) and chronic heart failure (CHF). The incidence of cardiovascular diseases has been increasing rapidly and understanding the involvement of RAS in CHD can help improve current treatments and reduce side effects.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ji-Wei Liu, Hai-Tao Liu, Lin Chen
Summary: Slit2 treatment reduced the levels of LDH, CK-MB, cTnI, TG, TC, and LDL-C, and increased HDL-C level in CHD rats, alleviating myocardial fibrosis, inflammation, and oxidative stress. The expression of Slit2 in cardiac tissues was associated with cardiac fibroblasts, and the effects of Slit2 on reversing the myocardial fibrosis in CHD rats were dose-dependent.
CARDIOVASCULAR TOXICOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Mingxuan Liu, Ying Wu
Summary: Coronary heart disease (CHD) is a leading cause of death globally. The pathogenesis of CHD involves mitochondrial dysfunction and mitophagy disorders, which play crucial roles in regulating myocardial ischemia/hypoxia. Maintaining mitochondrial homeostasis and quality control are essential in understanding the pathological mechanism of CHD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Raija Lithovius, Anni A. Antikainen, Stefan Mutter, Erkka Valo, Carol Forsblom, Valma Harjutsalo, Niina Sandholm, Per-Henrik Groop
Summary: This study explores the use of a genetic risk score (GRS) for coronary artery disease (CAD) risk prediction in individuals with type 1 diabetes. The GRS showed similar predictive performance to established clinical markers and was more effective in younger individuals.
Article
Biochemistry & Molecular Biology
Chiara Caselli, Raffaele De Caterina, Rosetta Ragusa, Riccardo Liga, Alessia Gimelli, Arthur J. H. A. Scholte, Aldo Clerico, Juhani Knuuti, Danilo Neglia
Summary: The study aimed to evaluate the relationship between plasma HO-1 levels, clinical/molecular profiles, and coronary disease patterns in patients with chronic coronary syndromes (CCS). Results showed that patients with higher HO-1 levels were more often male, had higher BMI, and presented with a more diffuse but mainly non-obstructive coronary atherosclerosis, suggesting a potential protective role for the Nrf2/HO-1 pathway.
Article
Genetics & Heredity
Cibelle Mariano, Ana Catarina Alves, Ana Margarida Medeiros, Joana Rita Chora, Marilia Antunes, Marta Futema, Steve E. Humphries, Mafalda Bourbon
Article
Genetics & Heredity
Alice Bonomi, Fabrizio Veglia, Damiano Baldassarre, Rona J. Strawbridge, Zahra Golabkesh, Bengt Sennblad, Karin Leander, Andries J. Smit, Philippe Giral, Steve E. Humphries, Elena Tremoli, Anders Hamsten, Ulf de Faire, Bruna Gigante, C. R. Sirtori, S. Castelnuovo, L. Calabresi, M. Amato, B. Frigerio, A. Ravani, D. Sansaro, D. Coggi, C. C. Tedesco, P. Eriksson, A. Silveira, F. Laguzzi, J. Cooper, J. Acharya, K. Huttunen, E. Rauramaa, H. Pekkarinen, I. M. Penttila, J. Torronen, R. Rauramaa, A. I. Van Gessel, A. M. Van Roon, G. C. Teune, W. D. Kuipers, M. Bruin, A. Nicolai, P. Haarsma-Jorritsma, D. J. Mulder, H. J. G. Bilo, G. H. Smeets, J. L. Beaudeux, J. F. Kahn, V. Carreau, A. Kontush, J. Karppi, T. Nurmi, K. Nyyssonen, R. Salonen, T. P. Tuomainen, J. Tuomainen, J. Kauhanen, S. Kurl, G. Vaudo, A. Alaeddin, D. Siepi, G. Lupattelli, E. Mannarino
GENES AND IMMUNITY
(2020)
Article
Nutrition & Dietetics
Federica Laguzzi, Damiano Baldassarre, Fabrizio Veglia, Rona J. Strawbridge, Steve E. Humphries, Rainer Rauramaa, Andries J. Smit, Philippe Giral, Angela Silveira, Elena Tremoli, Anders Hamsten, Ulf de Faire, Paolo Frumento, Karin Leander
Summary: Based on data from a European multicentre study, this research found an inverse association between moderate alcohol consumption and carotid subclinical atherosclerosis and its 30-month progression. The relationship between alcohol consumption and C-IMT appears to be linear.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Sven W. Meckelmann, Jade Hawksworth, Daniel A. White, Robert Andrews, Patricia R. S. Rodrigues, Anne O'Connor, Jorge Alvarez-Jarreta, Victoria Tyrrell, Christine Hinz, You Zhou, Julie Williams, Maceler Aldrovandi, William John Watkins, Adam Engler, David A. Slatter, Stuart Allen, Jay Acharya, Jacquie Mitchell, Jackie Cooper, Junken Aoki, Kuniyuki Kano, Steve Humphries, Valerie O'Donnell, Valentina Lo Sardo
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2020)
Review
Biochemistry & Molecular Biology
Handrean Soran, Jackie A. Cooper, Paul N. Durrington, Nigel Capps, Ian Fw McDowell, Steve E. Humphries, Andrew Neil
CURRENT OPINION IN LIPIDOLOGY
(2020)
Review
Pediatrics
Uma Ramaswami, Steve E. Humphries
CURRENT OPINION IN PEDIATRICS
(2020)
Article
Medical Laboratory Technology
Roshni Joshi, Goya Wannamethee, Jorgen Engmann, Tom Gaunt, Deborah A. Lawlor, Jackie Price, Olia Papacosta, Tina Shah, Therese Tillin, Peter Whincup, Nishi Chaturvedi, Mika Kivimaki, Diana Kuh, Meena Kumari, Alun D. Hughes, Juan P. Casas, Steve E. Humphries, Aroon D. Hingorani, A. Floriaan Schmidt
Summary: This study measured 14 triglyceride-containing lipoprotein subfraction metabolites using nuclear magnetic resonance in a general population sample, establishing reference interval ranges. The results showed that triglyceride subfraction concentrations increased with age and body mass index, were higher in smokers, and in individuals with cardiovascular disease or type 2 diabetes. These findings emphasize the importance of appropriate reference interval ranges for clinical decision making regarding the role of triglycerides in cardiovascular disease.
ANNALS OF CLINICAL BIOCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Rona J. Strawbridge, Keira J. A. Johnston, Mark E. S. Bailey, Damiano Baldassarre, Breda Cullen, Per Eriksson, Ulf deFaire, Amy Ferguson, Bruna Gigante, Philippe Giral, Nicholas Graham, Anders Hamsten, Steve E. Humphries, Sudhir Kurl, Donald M. Lyall, Laura M. Lyall, Jill P. Pell, Matteo Pirro, Kai Savonen, Andries J. Smit, Elena Tremoli, Tomi-Pekka Tomainen, Fabrizio Veglia, Joey Ward, Bengt Sennblad, Daniel J. Smith
Summary: This study identified genetic associations between psychiatric disorders and cardiometabolic diseases in individuals of European ancestry, leading to the identification of sub-groups with distinct metabolic profiles. These findings were consistent across different samples, indicating potential implications for personalized approaches to managing cardiometabolic risks in individuals with severe mental illness.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Marta Futema, Uma Ramaswami, Lukas Tichy, Martin P. Bogsrud, Kirsten B. Holven, Jeanine Roeters van Lennep, Albert Wiegman, Olivier S. Descamps, Anne De Leener, Elodie Fastre, Michal Vrablik, Tomas Freiberger, Harald Esterbauer, Hans Dieplinger, Susanne Greber-Platzer, Ana M. Medeiros, Mafalda Bourbon, Vasiliki Mollaki, Euridiki Drogari, Steve E. Humphries
Summary: The most common cause of familial hypercholesterolaemia in children from eight European countries was found to be LDLR mutation, with significant variations in the prevalence of APOB p.(Arg3527Gln) mutation across different countries. LDLR-FH was associated with higher concentrations of LDL-C and a family history of coronary heart disease compared to APOB-FH in children.
Article
Biochemistry & Molecular Biology
Tarunveer S. Ahluwalia, Bram P. Prins, Mohammadreza Abdollahi, Nicola J. Armstrong, Stella Aslibekyan, Lisa Bain, Barbara Jefferis, Jens Baumert, Marian Beekman, Yoav Ben-Shlomo, Joshua C. Bis, Braxton D. Mitchell, Eco de Geus, Graciela E. Delgado, Diana Marek, Joel Eriksson, Eero Kajantie, Stavroula Kanoni, John P. Kemp, Chen Lu, Riccardo E. Marioni, Stela McLachlan, Yuri Milaneschi, Ilja M. Nolte, Alexandros M. Petrelis, Eleonora Porcu, Maria Sabater-Lleal, Elnaz Naderi, Ilkka Seppala, Tina Shah, Gaurav Singhal, Marie Standl, Alexander Teumer, Anbupalam Thalamuthu, Elisabeth Thiering, Stella Trompet, Christie M. Ballantyne, Emelia J. Benjamin, Juan P. Casas, Catherine Toben, George Dedoussis, Joris Deelen, Peter Durda, Jorgen Engmann, Mary F. Feitosa, Harald Grallert, Ann Hammarstedt, Sarah E. Harris, Georg Homuth, Jouke-Jan Hottenga, Sirpa Jalkanen, Yalda Jamshidi, Magdalene C. Jawahar, Tine Jess, Mika Kivimaki, Marcus E. Kleber, Jari Lahti, Yongmei Liu, Pedro Marques-Vidal, Dan Mellstrom, Simon P. Mooijaart, Martina Muller-Nurasyid, Brenda Penninx, Joana A. Revez, Peter Rossing, Katri Raikkonen, Naveed Sattar, Hubert Scharnagl, Bengt Sennblad, Angela Silveira, Beate St Pourcain, Nicholas J. Timpson, Julian Trollor, Jenny van Dongen, Diana Van Heemst, Sophie Visvikis-Siest, Peter Vollenweider, Uwe Volker, Melanie Waldenberger, Gonneke Willemsen, Delilah Zabaneh, Richard W. Morris, Donna K. Arnett, Bernhard T. Baune, Dorret Boomsma, Yen-Pei C. Chang, Ian J. Deary, Panos Deloukas, Johan G. Eriksson, David M. Evans, Manuel A. Ferreira, Tom Gaunt, Vilmundur Gudnason, Anders Hamsten, Joachim Heinrich, Aroon Hingorani, Steve E. Humphries, J. Wouter Jukema, Wolfgang Koenig, Meena Kumari, Zoltan Kutalik, Deborah A. Lawlor, Terho Lehtimaki, Winfried Marz, Karen A. Mather, Silvia Naitza, Matthias Nauck, Claes Ohlsson, Jackie F. Price, Olli Raitakari, Ken Rice, Perminder S. Sachdev, Eline Slagboom, Thorkild I. A. Sorensen, Tim Spector, David Stacey, Maria G. Stathopoulou, Toshiko Tanaka, S. Goya Wannamethee, Peter Whincup, Jerome Rotter, Abbas Dehghan, Eric Boerwinkle, Bruce M. Psaty, Harold Snieder, Behrooz Z. Alizadeh
Summary: This study identified novel genetic loci influencing circulating IL-6 levels, uncovering new immunological and inflammatory pathways that may impact the pathobiology of IL-6.
HUMAN MOLECULAR GENETICS
(2021)
Article
Multidisciplinary Sciences
Federica Laguzzi, Buamina Maitusong, Rona J. Strawbridge, Damiano Baldassarre, Fabrizio Veglia, Steve E. Humphries, Rainer Rauramaa, Sudhir Kurl, Andries J. Smit, Philippe Giral, Angela Silveira, Elena Tremoli, Anders Hamsten, Ulf de Faire, Bruna Gigante, Karin Leander
Summary: The study aimed to investigate the relationship between intake of saturated fats and subclinical atherosclerosis, as well as the potential influence of genetic variants. Results showed an association between high intake of saturated fats and C-IMT thickness, but this association was no longer significant in multivariate analysis. There was no clear association between high intake of saturated fats and risk of atherosclerotic progression. Additionally, no significant genetic-dietary fat interactions were identified in relation to risk of subclinical atherosclerosis.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Massimo R. Mannarino, Matteo Pirro, Bruna Gigante, Kai Savonen, Sudhir Kurl, Philippe Giral, Andries Smit, Fabrizio Veglia, Elena Tremoli, Damiano Baldassarre
Summary: The study found a U-shaped association between SUA levels and VEs in men at moderate-to-high CVD risk, with both low and high SUA levels being associated with an increased risk of VEs. Elevated SUA levels were also independently associated with cIMT progression in men. However, no significant associations were found in women between SUA levels, CVD end points, and cIMT progression.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biotechnology & Applied Microbiology
Saleem Ullah Shahid, N. A. Shabana, Steve Humphries
Summary: Coronary artery disease is the leading cause of death worldwide, with Pakistan facing a high epidemic. While genetic markers have been associated with CAD, a study on LPA gene SNPs in Pakistani subjects showed that they do not significantly contribute to CAD progression.
Article
Cardiac & Cardiovascular Systems
Nadeem Qureshi, Ralph Kwame Akyea, Brittany Dutton, Steve E. Humphries, Hasidah Abdul Hamid, Laura Condon, Stephen F. Weng, Joe Kai
Summary: By utilizing electronic case-finding and genetic testing in primary care, this intervention study was able to improve the identification of patients at risk of familial hypercholesterolaemia and target them for specialist assessment. The results showed that patients with FH-causing genetic variants had higher total cholesterol and low-density lipoprotein-cholesterol levels compared to those with other genetic test results.
Article
Cardiac & Cardiovascular Systems
Nadeem Qureshi, Ralph K. Akyea, Brittany Dutton, Jo Leonardi-Bee, Steve E. Humphries, Stephen Weng, Joe Kai
Summary: A novel case-finding algorithm, FAMCAT 2, shows better performance in detecting genetically confirmed FH in the general population compared to other established criteria, without the need for prior clinical review.