Article
Nutrition & Dietetics
Katarzyna Slizewska, Michal Wlodarczyk, Martyna Sobczak, Renata Barczynska, Janusz Kapusniak, Piotr Socha, Aldona Wierzbicka-Rucinska, Aneta Kotowska
Summary: Obesity is a serious issue in modern societies, with significant health implications including increased mortality and development of various disorders. This research aimed to investigate the effects of overweight and obesity on selected health markers in children. The findings showed that obese children had different fecal enzyme activity and a different fatty acid profile compared to children of normal weight, indicating a potential higher risk of developing serious diseases.
Article
Microbiology
Ninik Rustanti, Agnes Murdiati, Mohammad Juffrie, Endang Sutriswati Rahayu
Summary: This study aimed to assess the effect of the probiotic L. plantarum Dad-13 on metabolic profiles and gut microbiome (GM) of women with type 2 diabetes (T2D) in Yogyakarta, Indonesia. The results showed that supplementation with L. plantarum Dad-13 significantly reduced HbA1c levels, but had no significant effect on fasting blood sugar and total cholesterol levels. Furthermore, L. plantarum Dad-13 supplementation significantly increased the number of L. plantarum in the GM, but had no significant impact on the populations of Bifidobacterium and Prevotella.
Article
Food Science & Technology
Jing Yu, Yongjun Xia, Guangqiang Wang, Zhiqiang Xiong, Hui Zhang, Phoency F-H Lai, Xin Song, Lianzhong Ai
Summary: The study found that the strain AR495 of Lactobacillus plantarum significantly inhibited osteoporosis and improved intestinal health in ovx mice. AR495 modulated bone resorption and intestinal inflammatory responses, as well as enhanced intestinal microbial stability and short-chain fatty acid production in ovx mice.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biotechnology & Applied Microbiology
Camila S. S. Marcolla, Tingting Ju, Benjamin P. P. Willing
Summary: This study aimed to identify bacteria that can colonize and persist in the chicken gut after a single exposure. The research found that various bacteria can successfully colonize the chicken gut, and different delivery methods such as oral gavage, spraying, and cohousing can be used for microbial transplantation. These findings will guide future research on the development of next-generation probiotics that can colonize and persist in the chicken intestinal tract.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Chemistry, Applied
Yunqing Wang, Thuy Do, Lisa J. Marshall, Christine Boesch
Summary: With a 14-day intervention trial, this pilot study investigated the changes in gut microbial populations following red beetroot consumption. The study found transient changes in the abundance of certain bacteria taxa after different days of intervention (p < 0.05). Akkermansia muciniphila was enriched and Bacteroides fragilis decreased after 3 days of juice consumption, followed by restoration in abundance after 14 days (p < 0.05). The presence of native betacyanins and catabolites in stool after juice consumption was also observed, with betacyanins positively correlated with Bifidobacterium and Coprococcus, and inversely correlated with Ruminococcus (p < 0.1), leading to a significant rise in (iso)butyric acid content (172.7 +/- 30.9 mu mol/g stool). These findings suggest the potential benefits of red beetroot on gut microbial populations and associated catabolites, highlighting its impact on intestinal and systemic health.
Article
Food Science & Technology
Ryuji Nagata, Kotomi Taneda, Samanthi Wathsala Pelpolage, Hiroki Bochimoto, Naoki Fukuma, Kenichiro Shimada, Masayuki Tani, Kyu-Ho Han, Michihiro Fukushima
Summary: It was found in this study that calcium-fortified potato starch can enhance cecal fermentation in rats, especially in terms of cecal acetate production, which further suppresses fat accumulation. This is the first report on the physiological effects of calcium-fortified potato starch.
Article
Chemistry, Medicinal
Bin Wei, Qiao-Li Xu, Bo Zhang, Tao-Shun Zhou, Song-Ze Ke, Si-Jia Wang, Bin Wu, Xue-Wei Xu, Hong Wang
Summary: High-fat diet significantly alters the cecal and fecal microbiota in mice, while seaweed polysaccharides SfW and SfA can more effectively regulate cecal microbiota. This study provides important groundwork for seaweed polysaccharide-based gut microbiota regulators.
Article
Agriculture, Multidisciplinary
Meng-Xin Hu, Fei He, Ya-Xin Guo, Li-Zhen Mo, Xuan Zhu
Summary: This study compares the differences between probiotic biofilms and planktonic cells in pathogen inhibition and microbiota remodeling. The results show that probiotic biofilms are more effective in modulating the microbiota and producing short-chain fatty acids than planktonic cells.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Microbiology
Valeria Agamennone, Tim J. van den Broek, Alie de Kat Angelino-Bart, Femke P. M. Hoevenaars, Jan Willem van der Kamp, Frank H. J. Schuren
Summary: The development of microbiome-targeted strategies is hindered by individual variations in gut microbiome composition and metabolic responses. In vitro models have been used to replicate this variation, allowing for pre-clinical studies and efficacy assessment. This study exposed 16 individual fecal microbiota samples to different dietary fibers in an in vitro system, demonstrating differences in microbiota composition and metabolite profiles between subjects with different intestinal health and subjects with Inflammatory Bowel Disease (IBD) after fiber incubation. The combination of all fibers showed stronger effects on microbiota composition and metabolite production compared to single fibers when tested on IBD subjects' microbiota.
Article
Biotechnology & Applied Microbiology
Deyuan Wu, Wenyu Xiong, Shuo Ma, Jinxi Luo, Hongxuan Ye, Shuangbo Huang, Fuyong Li, Xi'en Xiang, Qiling Chen, Binghui Gao, Jinping Deng, Yulong Yin, Chengquan Tan
Summary: Our study demonstrates that dietary konjac flour (KF) can improve the reproductive performance of obese sows. KF supplementation remodels the gut microbiota, reducing stillbirth rate and insulin resistance while increasing placental efficiency and piglet weight. Additionally, KF supplementation increases placental vascular density and protein expression of angiogenesis markers.
Article
Gastroenterology & Hepatology
Dusan Radojevic, Sergej Tomic, Dusan Mihajlovic, Maja Tolinacki, Bojan Pavlovic, Dragana Vucevic, Svetlana Bojic, Natasa Golic, Miodrag Colic, Jelena Dokic
Summary: The composition of gut microbiota in healthy donors is significantly correlated with the immunogenic properties of dendritic cells generated in vitro, indicating the important role of gut microbiota in donor precursor cells differentiation into immunogenic DCs suitable for cancer therapy.
Article
Microbiology
Vineet Singh, Nakwon Hwang, Gwangpyo Ko, Unno Tatsuya
Summary: This study investigates the impact of personal gut microbiota differences and external factors on the results of in vitro fecal fermentation assays. The findings suggest that the fermentation of CGJ by fecal bacteria produces SCFAs and alters microbiota composition, with certain microbial activities affected. The study discusses the use of in vitro gastrointestinal digestion and fecal fermentation to mimic diet-induced microbiome modulation and its effects on the host.
JOURNAL OF MICROBIOLOGY
(2021)
Article
Food Science & Technology
Xin Guo, Jing Wang, Ruiyan Niu, Rui Li, Jixiang Wang, Xinfeng Fan, Xiaowen Wang, Zilong Sun
Summary: This study optimized the fermentation conditions of apple juice to produce fermented apple juice (FAJ) with high probiotic and tannic acid content. Results showed that ingestion of FAJ helped alleviate antibiotic-induced diarrhea in mice by regulating intestinal microbiota and barrier function.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Nutrition & Dietetics
Mengzhen Han, Meina Zhang, Xiaowei Wang, Xue Bai, Tianli Yue, Zhenpeng Gao
Summary: The fermented cloudy apple juice rich in polyphenols showed potential to inhibit weight gain, reduce fat accumulation, and regulate blood lipid levels in obese mice. It achieved this by modifying the gut microbiota composition and improving intestinal tract health, as well as increasing the abundance of beneficial bacteria associated with short-chain fatty acids. These findings suggest that the fermented cloudy apple juice could be developed as a healthy food to prevent obesity and hyperglycemia.
Article
Biochemistry & Molecular Biology
J. I. Ramirez-Perez, M. Abud-Archila, S. L. Ovando-Chacon, R. E. Soria-Guerra, M. A. Ruiz-Cabrera, C. I. Godinez-Hernandez, A. Grajales-Lagunes
Summary: A completely randomized experimental design was conducted to evaluate the effect of coadministration of Lpb. fabifermentans and inulin/agave fructans mixtures on gut microbiota. The results showed that the combination of fructan mixtures and Lpb. fabifermentans significantly decreased glucose, cholesterol, and triglycerides levels, and improved short-chain fatty acids concentration throughout the gastrointestinal tract. It also promoted an increase in the abundance of beneficial intestinal microbiota. Therefore, the inclusion of fructan mixtures in combination with Lpb. fabifermentans could be a good alternative for the development of functional foods that enhance consumer health.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Endocrinology & Metabolism
A. Stepniowska, K. Tutaj, J. Juskiewicz, K. Ognik
Summary: The study found that organic forms of chromium are better retained in the body of rats than chromium nanoparticles. However, only chromium picolinate was shown to increase insulin levels, indicating a beneficial effect on carbohydrate metabolism. High-fat diet was associated with increased serotonin levels and decreased noradrenaline levels in the blood plasma of rats, while chromium supplementation was found to increase serotonin levels, which is considered beneficial. Rats fed a high-fat diet had reduced plasma concentrations of calcium, phosphorus, magnesium, and zinc, and supplementation with chromium picolinate or chromium nanoparticles may exacerbate the negative effects on phosphorus levels induced by the high-fat diet.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Ewelina Cholewinska, Jerzy Juskiewicz, Michal Majewski, Radoslaw Smagiel, Piotr Listos, Bartosz Fotschki, Irena Godycka-Klos, Katarzyna Ognik
Summary: The aim of this experiment was to investigate the impact of replacing traditional CuCO3 with copper nanoparticles (CuNPs) on the biochemical parameters, redox status, and histomorphometry of rat tissues. The results showed that the substitution of CuCO3 with CuNPs exacerbated the negative changes induced by hypertension, particularly in the heart, liver, and intestines.
Article
Biochemistry & Molecular Biology
Monika Cendrowska-Pinkosz, Marta Ostrowska-Lesko, Katarzyna Ognik, Magdalena Krauze, Jerzy Juskiewicz, Anna Dabrowska, Jaroslaw Szponar, Slawomir Mandziuk
Summary: Copper is necessary for brain cells and is involved in energy metabolism pathways. Deficiency in copper homeostasis may contribute to neurodegeneration. The regulation of copper in brain tissue remains unclear. This study examines the effects of replacing inorganic copper with copper nanoparticles or completely removing copper from the diet on gene expression related to energy metabolism in the rat prefrontal cortex. The results suggest that these changes in gene expression may be due to an increased demand for NADH in the rat brain's prefrontal cortex, possibly as an adaptation effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Dariusz Mikulski, Jerzy Juskiewicz, Katarzyna Ognik, Przemysaw Zdunczyk, Radosaw Smagiel, Jan Jankowski
Summary: This study investigated the effects of early and short-term administration of antibiotics and coccidiostat-containing feed on gastrointestinal function and hormone levels in young turkeys. The results showed that the cecal microbiota of turkeys were less sensitive to monensin compared to the other two antibiotics. The use of antibiotics affected the enzymatic activity of the microbiota, but had no effect on the concentrations of short-chain fatty acids and ammonia in the cecal digesta. Additionally, different treatments had significant effects on blood hormone levels and growth performance of turkeys.
Correction
Chemistry, Applied
Katarzyna Grzelak-Blaszczyk, Andrzej Czarnecki, Robert Klewicki, Maria Grzegorzewska, Elzbieta Klewicka
Summary: The authors apologize for an incorrect affiliation of one of the authors in the article, and provide the correct affiliation information. They apologize for any inconvenience caused.
Article
Chemistry, Applied
Katarzyna Grzelak-Blaszczyk, Andrzej Czarnecki, Robert Klewicki, Maria Grzegorzewska, Elzbieta Klewicka
Summary: The study found that osmotic dehydration has a positive effect on the efficiency of lactic fermentation and the content of polyphenols and oligosaccharides in onions. Onion dehydration does not have a negative impact on the growth or number of tested bacteria, and osmotic dehydration before lactic fermentation can modify the profile of lactic acid isomers.
Article
Biochemistry & Molecular Biology
Bartosz Fotschki, Katarzyna Ognik, Joanna Fotschki, Dorota Napiorkowska, Ewelina Cholewinska, Magdalena Krauze, Jerzy Juskiewicz
Summary: The study investigated the effects of chromium supplementation and switching dietary habits on lipid metabolism, inflammation, and oxidative stress in Wistar rats. The combination of chromium nanoparticles and dietary changes showed the strongest reduction in fat content and cholesterol in the liver. This combination also had favorable antioxidative effects. Supplementation with chromium nanoparticles alone also improved lipid metabolism and oxidative stress, although to a lesser extent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Bartosz Fotschki, Ewelina Cholewinska, Katarzyna Ognik, Michal Sojka, Joanna Milala, Joanna Fotschki, Wieslaw Wiczkowski, Jerzy Juskiewicz
Summary: The required amount of berry polyphenols for health benefits is difficult to achieve through fresh fruit consumption, suggesting polyphenol-rich extracts as a dietary alternative. This study fed rats high-fat diets supplemented with 0.1 or 0.3% raspberry polyphenols and found that the higher dose of extract had more noticeable health-promoting effects, including reduced white adipose tissue weight, hepatic triglyceride content, and plasma IL-6 concentration, as well as increased acetic acid concentration in the cecal digesta. The enhanced content of ellagitannin and anthocyanin metabolites in the blood plasma of rats administered the high dose extract may partially explain these effects.
Review
Biochemistry & Molecular Biology
Joanna Fotschki, Anna M. M. Ogrodowczyk, Barbara Wroblewska, Jerzy Juskiewicz
Summary: The vegetable processing industry generates large amounts of by-products that are susceptible to microbial degradation. Inadequate management leads to the loss of valuable compounds in vegetable by-products. Scientists are exploring the possibility of reusing discarded biomass to create higher value products. The by-products contain bioactive compounds with health-promoting properties. This review emphasizes the importance of these by-products in promoting health through their impact on the microbiota, immune system, and gut milieu.
Article
Nutrition & Dietetics
Ewelina Cholewinska, Aleksandra Marzec, Przemyslaw Solek, Bartosz Fotschki, Piotr Listos, Katarzyna Ognik, Jerzy Juskiewicz
Summary: The aim of this study was to investigate the effects of different types of dietary fibre (cellulose, inulin, pectin, and psyllium) in combination with recommended or enhanced levels of CuNPs on selected biological parameters of intestinal integrity in rats. The results showed that replacing CuCO3 with CuNPs in the diet reduced lactic acid and apoptosis markers levels in the small intestine, but it also increased DNA oxidation. Inulin had the most beneficial effect on DNA repair mechanisms, while pectin had the highest ability to inhibit inflammatory processes and apoptotic cell death in the small intestine. These findings suggest that dietary fibre supplementation can protect the small intestine against oxidative effects of CuNPs by enhancing the intestinal barrier.
Article
Biochemistry & Molecular Biology
Monika Cendrowska-Pinkosz, Magdalena Krauze, Jerzy Juskiewicz, Bartosz Fotschki, Katarzyna Ognik
Summary: The aim of this study is to evaluate the effect of different forms and dosages of copper on neurodegenerative markers in the brain and jejunum. The experiment involved feeding male Wistar rats a rat diet with two CuCO3 dosages and two CuNP dosages. Nanoparticles reduced the level of GAChE, increased the levels of AChE and LRP1, and decreased β-amyloid and Tau protein in both the brain and intestine of rats. The highest levels of beneficial markers and lowest levels of toxic markers were observed in rats receiving a standard dose of Cu.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Michal Majewski, Leszek Gromadzinski, Ewelina Cholewinska, Katarzyna Ognik, Bartosz Fotschki, Jerzy Juskiewicz
Summary: This study aimed to investigate the effects of dietary fiber supplementation with different types of nanoparticles on the cardiovascular system in rats. The results showed that compared to pectin, inulin and psyllium supplementation with a standard dose of copper nanoparticles improved antioxidant capacity and reduced heart malondialdehyde levels. Furthermore, with an enhanced dose of copper nanoparticles, inulin and psyllium enhanced vasodilation through up-regulation of COX-2-derived vasodilator prostanoids.
Article
Nutrition & Dietetics
Jerzy Juskiewicz, Katarzyna Ognik, Joanna Fotschki, Dorota Napiorkowska, Ewelina Cholewinska, Katarzyna Grzelak-Blaszczyk, Magdalena Krauze, Bartosz Fotschki
Summary: This study assessed the changes in faecal microbial activity in obese rats fed high-fat or low-fat diets supplemented with different forms of chromium. The results showed that switching from a high-fat to a low-fat diet had beneficial effects, and supplementing with chromium nanoparticles further modulated microbial activity.
Article
Nutrition & Dietetics
Bartosz Fotschki, Michal Sojka, Monika Kosmala, Jerzy Juskiewicz
Summary: Previous studies have shown that dietary supplementation with prebiotic fructooligosaccharides (FOSs) and polyphenols can alleviate disorders related to the early stage of nonalcoholic fatty liver disease (NAFLD). This experiment aimed to investigate whether raspberry polyphenols together with FOSs can regulate advanced-stage NAFLD in genetically obese Zucker rats. The results showed that the addition of FOSs and raspberry polyphenolic extract to the diet reduced liver fat accumulation, improved antioxidant potential, lowered plasma enzyme activities, and increased insulin sensitivity. These effects may be attributed to the upregulation of specific receptors in the liver responsible for regulating lipid metabolism and glucose and bile acid synthesis.
Article
Nutrition & Dietetics
Bartosz Fotschki, Katarzyna Ognik, Ewelina Cholewinska, Katarzyna Grzelak-Blaszczyk, Kamil Myszczynski, Magdalena Krauze, Jerzy Juskiewicz
Summary: This study aimed to investigate the effects of supplementation with chromium nanoparticles (Cr-NPs) on the gut microenvironment in rats fed a high-fat diet. The results showed that Cr-NPs mainly acted by altering the activity of gut microbiota, leading to decreased concentration of short-chain fatty acids and increased level of cecal lithocholic acid. Switching to a low-fat diet had a more significant impact on obesity-related disorders, improving microbial activity, composition, and the production of short-chain fatty acids.
