Insights into the mechanism of HIV-1 envelope induced membrane fusion as revealed by its inhibitory peptides

Virus-cell and cell-cell fusion mediated by the HIV-1 envelope glycoprotein is inhibited by short gp41 N-terminal membrane-anchored peptides lacking the critical pocket domain

(2010) Yael Wexler-Cohen et al.   FASEB JOURNAL

Topological Layers in the HIV-1 gp120 Inner Domain Regulate gp41 Interaction and CD4-Triggered Conformational Transitions

(2010) Andrés Finzi et al.   MOLECULAR CELL

Crystal Structure of HIV-1 gp41 Including Both Fusion Peptide and Membrane Proximal External Regions

(2010) Victor Buzon et al.   PLoS Pathogens

Distinct Mechanisms of Lipid Bilayer Perturbation Induced by Peptides Derived from the Membrane-Proximal External Region of HIV-1 gp41

(2009) Beatriz Apellániz et al.   BIOCHEMISTRY

Detailed Mechanistic Insights into HIV-1 Sensitivity to Three Generations of Fusion Inhibitors

(2009) Dirk Eggink et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Amphiphilicity and Negative Charge in Glycoprotein 41 Interactions in the Hydrophobic Pocket

(2009) Miriam Gochin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Addition of a cholesterol group to an HIV-1 peptide fusion inhibitor dramatically increases its antiviral potency

(2009) P. Ingallinella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early Steps of HIV-1 Fusion Define the Sensitivity to Inhibitory Peptides That Block 6-Helix Bundle Formation

(2009) Kosuke Miyauchi et al.   PLoS Pathogens

Membrane-Anchored HIV-1 N-Heptad Repeat Peptides Are Highly Potent Cell Fusion Inhibitors via an Altered Mode of Action

(2009) Yael Wexler-Cohen et al.   PLoS Pathogens

Conserved Salt Bridge between the N- and C-Terminal Heptad Repeat Regions of the Human Immunodeficiency Virus Type 1 gp41 Core Structure Is Critical for Virus Entry and Inhibition

(2008) Y. He et al.   JOURNAL OF VIROLOGY

Identification of a Critical Motif for the Human Immunodeficiency Virus Type 1 (HIV-1) gp41 Core Structure: Implications for Designing Novel Anti-HIV Fusion Inhibitors

(2008) Y. He et al.   JOURNAL OF VIROLOGY

Viral membrane fusion

(2008) Stephen C Harrison   NATURE STRUCTURAL & MOLECULAR BIOLOGY