Article
Multidisciplinary Sciences
Eugenia Annunzi, Loreta Cannito, Fabio Bellia, Francesca Mercante, Matteo Vismara, Beatrice Benatti, Alberto Di Domenico, Riccardo Palumbo, Walter Adriani, Bernardo Dell'Osso, Claudio D'Addario
Summary: This study investigated the epigenetic and genetic regulation of the oxytocin receptor, dopamine transporter, and serotonin transporter genes in relation to Internet addiction. The results showed significant changes in DNA methylation levels and their correlation with psychometric properties. These findings contribute to our understanding of the neurobiology of Internet addiction and offer potential biological predictors for early diagnosis and treatment.
SCIENTIFIC REPORTS
(2023)
Review
Behavioral Sciences
Margus Kanarik, Oliver Grimm, Nina Roth Mota, Andreas Reif, Jaanus Harro
Summary: This review summarizes the current knowledge on gene x environment (GxE) interactions related to the dopamine system in ADHD and its comorbid conditions. Studies mainly focused on candidate genes, including DRD4, DAT1, and MAOA, suggesting that variable number tandem repeats in these genes may mediate GxE interactions in ADHD and specific comorbid disorders. However, evidence for other polymorphisms is contradictory and less convincing. Lack of longitudinal studies testing the interaction between well-defined environmental factors and polygenic risk scores of the dopamine system as a whole is particularly notable.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Maria Ptukha, Zoia Fesenko, Anastasia Belskaya, Arina Gromova, Arseniy Pelevin, Natalia Kurzina, Raul R. Gainetdinov, Anna Volnova
Summary: This study evaluated the effect of atomoxetine on the behavior and brain activity of dopamine transporter knockout (DAT-KO) rats, which exhibit ADHD-like behavior. Atomoxetine improved PPI and reduced repetitive behaviors in DAT-KO rats and also influenced the behavior of wild-type rats. Furthermore, it led to significant changes in power spectra and coherence of both DAT-KO and wild type rats.
Editorial Material
Health Care Sciences & Services
Edward Justin Modestino, Kenneth Blum, Catherine A. Dennen, B. William Downs, Debasis Bagchi, Luis Llanos-Gomez, Igor Elman, David Baron, Panayotis K. Thanos, Rajendra D. Badgaiyan, Eric R. Braverman, Ashim Gupta, Mark S. Gold, Abdalla Bowirrat
Summary: Scientific studies have shown a relationship between violent and aggressive behaviors and addictions, specifically in genes associated with the reward system. The research supports the involvement of at least two gene risk alleles in adolescent violent/aggressive behaviors.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Claudia Sagheddu, Enzo Cancedda, Farshid Bagheri, Predrag Kalaba, Anna Lisa Muntoni, Jana Lubec, Gert Lubec, Fabrizio Sanna, Marco Pistis
Summary: CE-158 potentiates dopamine neurotransmission, promotes behavioral flexibility, and restores learning and memory in rats. Chronic administration of CE-158 does not induce abuse potential or pro-psychotic-like effects. These findings provide important evidence for the clinical application of CE-158.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
David Devos, Julien Labreuche, Olivier Rascol, Jean-Christophe Corvol, Alain Duhamel, P. Guyon Delannoy, Werner Poewe, Yaroslau Compta, Nicola Pavese, Evzen Ruzicka, Petr Dusek, Bart Post, Bastiaan R. Bloem, Daniela Berg, Walter Maetzler, Markus Otto, Marie-Odile Habert, Stephane Lehericy, Joaquim Ferreira, Richard Dodel, Christine Tranchant, Alexandre Eusebio, Stephane Thobois, Ana-Raquel Marques, Wassilios G. Meissner, Fabienne Ory-Magne, Uwe Walter, Rob M. A. de Bie, Miguel Gago, Dolores Vilas, Jaime Kulisevsky, Cristina Januario, Miguel V. S. Coelho, Stefanie Behnke, Paul Worth, Klaus Seppi, Thavarak Ouk, Camille Potey, Celine Leclercq, Romain Viard, Gregory Kuchcinski, Renaud Lopes, Jean-Pierre Pruvo, Pascal Pigny, Guillaume Garcon, Ophelie Simonin, Jessica Carpentier, Anne-Sophie Rolland, Dag Nyholm, Christoph Scherfler, Jean-Francois Mangin, Marie Chupin, Regis Bordet, David T. Dexter, Caroline Fradette, Michael Spino, Fernando Tricta, Scott Ayton, Ashley I. Bush, Jean-Christophe Devedjian, James A. Duce, Ioav Cabantchik, Luc Defebvre, Dominique Deplanque, Caroline Moreau
Summary: In a 36-week trial involving participants with early Parkinson's disease who had not received levodopa, treatment with the iron chelator deferiprone led to worse scores in measures of parkinsonism compared to placebo.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Zahra Kavian, Saman Sargazi, Mahdi Majidpour, Mohammad Sarhadi, Ramin Saravani, Mansour Shahraki, Shekoufeh Mirinejad, Milad Heidari Nia, Maryam Piri
Summary: This study investigated the association between SLC11A1 gene polymorphisms and Type 2 Diabetes Mellitus (T2DM). The results showed that rs3731864 G/A and rs17235416 + TGTG/- TGTG had a negative association with T2DM and provided protection against the disease, while rs3731865 G/C was associated with an increased risk of T2DM. Additionally, SLC11A1-rs3731864 G/A was significantly associated with triglyceride levels in T2DM patients.
SCIENTIFIC REPORTS
(2023)
Article
Agriculture, Dairy & Animal Science
Yingting He, Xiaofeng Zhou, Rongrong Zheng, Yao Jiang, Zhixiang Yao, Xilong Wang, Zhe Zhang, Hao Zhang, Jiaqi Li, Xiaolong Yuan
Summary: This study identified a SNP in the EXOC4 gene associated with reproductive traits in pigs, and explored the potential molecular mechanisms through genotype and allele frequency analysis as well as transcriptional regulatory element investigation, providing valuable information for marker-assisted selection in pig breeding.
Review
Biochemistry & Molecular Biology
Artem Savchenko, Giorgia Targa, Zoia Fesenko, Damiana Leo, Raul R. Gainetdinov, Ilya Sukhanov
Summary: The key element of dopamine neurotransmission is the dopamine transporter (DAT), responsible for the synaptic reuptake of dopamine. Changes in DAT function can be a mechanism of pathological conditions associated with high dopamine levels. Rodents lacking DAT exhibit increased levels of dopamine, resulting in hyperactivity, stereotypic behaviors, cognitive deficits, and other behavioral abnormalities. Pharmacological studies and the use of dopaminergic agents can alleviate these abnormalities. This review aims to analyze known data on changes in DAT expression in experimental animals, pharmacological studies in these animals, and evaluate the validity of DAT-deficient animals as models for discovering new treatments for dopamine-related disorders.
Article
Biochemistry & Molecular Biology
Krzysztof Chmielowiec, Jolanta Chmielowiec, Jolanta Masiak, Aleksandra Stronska-Pluta, Milena Lachowicz, Agnieszka Boron, Dariusz Larysz, Magdalena Dzitkowska-Zabielska, Pawel Cieszczyk, Anna Grzywacz
Summary: DNA methylation is an important epigenetic mechanism that is involved in regulating dopamine release. The study found that nicotine-dependent individuals and athletes had higher levels of DNA methylation compared to the control group.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Behavioral Sciences
Gabriella E. DiCarlo, Mark T. Wallace
Summary: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and restricted interests/repetitive behaviors. Over 1000 genes and 2000 copy number variants have been implicated in ASD. It is believed that there is not a single genetic cause or neurobiological basis for ASD, but rather multiple subtypes with different genetic and neurobiological perturbations. Dopamine dysfunction may be one potential subtype associated with ASD. This research provides a framework for subcategorizing ASD based on genetic changes, neurobiological differences, and behavioral features.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Anna Volnova, Natalia Kurzina, Anastasia Belskaya, Arina Gromova, Arseniy Pelevin, Maria Ptukha, Zoia Fesenko, Alla Ignashchenkova, Raul R. Gainetdinov
Summary: Investigating the mechanisms of ADHD and other dopamine-associated conditions is crucial for developing new treatment approaches. This study evaluated the effects of alpha 2A-adrenoceptor agonist guanfacine on behavioral deficits in DAT-KO rats. The results showed that repeated administration of guanfacine improved spatial working memory and behavioral deficits in DAT-KO rats, suggesting the potential use of this drug in balancing dopamine and norepinephrine levels for treatment.
Article
Biochemistry & Molecular Biology
Marzieh Eslami Rasekh, Yozen Hernandez, Samantha D. Drinan, Juan I. Fuxman Bass, Gary Benson
Summary: VNTRs are tandem repeat loci that vary in copy number across a population. Commonly polymorphic VNTR loci, enriched in genomic regions with regulatory function, can be used for population ancestry classification and show correlation with gene expression differences.
NUCLEIC ACIDS RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Joanna Moncrieff, Ruth E. Cooper, Tom Stockmann, Simone Amendola, Michael P. Hengartner, Mark A. Horowitz
Summary: The serotonin hypothesis of depression, which suggests that depression is caused by lowered serotonin activity or concentrations, lacks consistent evidence based on the synthesis and evaluation of research in this field. This umbrella review found no substantial association between serotonin and depression, while suggesting that long-term antidepressant use may reduce serotonin concentration.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Willian Goulart Salgueiro, Marcell Valandro Soares, Cassiano Fiad Martins, Favero Reisdorfer Paula, Rafaela Maria Rios-Anjos, Thiago Carrazoni, Marcelo A. Mori, Roman-Ulrich Mueller, Michael Aschner, Chariston Andre Dal Belo, Daiana Silva Avila
Summary: Quercetin has been found to restore neuronal function in disease models, especially in diseases related to impaired dopaminergic neurotransmission. This study suggests that quercetin may act as a dopaminergic modulator by interacting with the dopamine transporter, thus altering the behavior of the nematode.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Psychology, Developmental
Julia Luiza Schafer, Katie A. McLaughlin, Gisele Gus Manfro, Pedro Pan, Luis Augusto Rohde, Euripedes Constantino Miguel, Andre Simioni, Mauricio Scopel Hoffmann, Giovanni Abrahao Salum
Summary: Exposure to childhood adversity has been consistently associated with poor developmental outcomes, but it is unclear whether these associations vary across different forms of adversity. This study examined the associations between threat and deprivation with cognition, emotional processing, and psychopathology in a middle-income country using a longitudinal design. The results showed differential associations between threat and deprivation with cognitive development and psychopathology.
DEVELOPMENTAL SCIENCE
(2023)
Article
Psychology, Developmental
Cezar H. Lorenzi, Douglas Teixeira Leffa, Rodrigo Bressan, Sintia Belangero, Ary Gadelha, Marcos L. Santoro, Giovanni A. Salum, Luis Augusto Rohde, Arthur Caye
Summary: This study validates the performance of an ADHD predictive model, showing it to be effective in developed countries but not in a developing country. The findings suggest that the model can be used in different clinical and research settings.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Psychology, Developmental
Luiza K. Axelrud, Mauricio S. Hoffmann, Daniel E. Vosberg, Marcos Santoro, Pedro M. Pan, Ary Gadelha, Sintia Belangero, Euripedes C. Miguel, Jean Shin, Anita Thapar, Jordan W. Smoller, Zdenka Pausova, Luis A. Rohde, Matthew C. Keller, Tomas Paus, Giovanni A. Salum
Summary: This study aimed to investigate the influence of parental genetics on offspring cognition, educational attainment, and psychopathology. The findings suggest that parental genetics influence offspring outcomes through genetic and phenotypic pathways, and multiple mediations may be an effective approach for understanding intergenerational transmission of behavioral traits.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Review
Psychology, Developmental
Edmund J. S. Sonuga-Barke, Stephen P. Becker, Sven Bolte, Francisco Xavier Castellanos, Barbara Franke, Jeffrey H. Newcorn, Joel T. Nigg, Luis Augusto Rohde, Emily Simonoff
Summary: The article provides a comprehensive overview of the scientific field of ADHD, covering clinical characteristics, risk factors, causal processes, and neurobiological pathways. The authors also discuss the future of the ADHD construct in light of recent conceptual reformulations.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Genetics & Heredity
Ditte Demontis, G. Bragi Walters, Georgios Athanasiadis, Raymond Walters, Karen Therrien, Trine Tollerup Nielsen, Leila Farajzadeh, Georgios Voloudakis, Jaroslav Bendl, Biau Zeng, Wen Zhang, Jakob Grove, Thomas D. Als, Jinjie Duan, F. Kyle Satterstrom, Jonas Bybjerg-Grauholm, Marie Baekved-Hansen, Olafur O. Gudmundsson, Sigurdur H. Magnusson, Gisli Baldursson, Katrin Davidsdottir, Gyda S. Haraldsdottir, Esben Agerbo, Gabriel E. Hoffman, Soren Dalsgaard, Joanna Martin, Marta Ribases, Dorret Boomsma, Maria Soler Artigas, Nina Roth Mota, Daniel Howrigan, Sarah E. Medland, Tetyana Zayats, Veera M. Rajagopal, Merete Nordentoft, Ole Mors, David M. Hougaard, Preben Bo Mortensen, Mark J. Daly, Stephen Faraone, Hreinn Stefansson, Panos Roussos, Barbara Franke, Thomas Werge, Benjamin M. Neale, Kari Stefansson, Anders D. Borglum
Summary: This study conducted a meta-analysis of genome-wide association studies on ADHD and identified 27 significant genetic loci associated with ADHD. They also found that these loci were enriched with genes involved in early brain development. Moreover, they discovered an increased load of rare protein-truncating variants in ADHD, implicating SORCS3 as a potential gene involved in ADHD.
Article
Psychiatry
Luiz Roberto Carvalho, Leticia M. Haas, Gregory Zeni, Marcelo M. Victor, Stefania P. Techele, Julia Marrone Castanho, Isabel Meneghetti Coimbra, Anthony de Freitas de Sousa, Nathalia Ceretta, Alia Garrudo, Eugenio Horacio Grevet, Luis Augusto Rohde
Summary: This study evaluated the performance of the FOCUS ADHD mobile health application in improving medication adherence and ADHD knowledge among patients. The addition of a financial incentive for using the app resulted in higher medication intake registrations. However, app use did not increase ADHD knowledge. Overall, the FOCUS ADHD app received high adoption and positive evaluations from users.
EUROPEAN PSYCHIATRY
(2023)
Article
Behavioral Sciences
Joao Ricardo Sato, Claudinei Eduardo Biazoli, Ana Paula Arantes Bueno, Arthur Caye, Pedro Mario Pan, Marcos Santoro, Jessica Honorato-Mauer, Giovanni Abrahao Salum, Marcelo Queiroz Hoexter, Rodrigo Affonseca Bressan, Andrea Parolin Jackowski, Euripedes Constantino Miguel, Sintia Belangero, Luis Augusto Rohde
Summary: Neuroimaging studies suggest that brain development mechanisms may explain some ADHD symptoms. However, the mechanisms by which genetic factors influence brain development in relation to ADHD remain largely unknown. This study aimed to investigate the associations between an ADHD polygenic risk score and brain network functioning. The findings suggest correlations between the ADHD polygenic risk score and the segregation of cingulo-opercular networks and the default mode network, supporting the role of attentional networks and DMN in attention processes. However, these associations were not found at follow-up.
GENES BRAIN AND BEHAVIOR
(2023)
Article
Psychology, Developmental
Marcelo Moraes Victor, Leticia Mueller Haas, Eugenio Horacio Grevet, Luis Augusto Rohde
Summary: This report presents a case of attentional symptoms and fatigue that emerged after SARS-CoV-2 infection. The patient achieved remission of his symptoms through several changes in the therapeutic regimen. This case highlights the importance of treating PCS inattention and fatigue as an ADHD-like syndrome.
JOURNAL OF ATTENTION DISORDERS
(2023)
Article
Clinical Neurology
Maria Eduarda de Araujo Tavares, Renata Basso Cupertino, Cibele Edom Bandeira, Bruna Santos da Silva, Eduardo Schneider Vitola, Carlos Alberto Iglesias Salgado, Robson dos Santos Soares, Felipe Almeida Picon, Luis Augusto Rohde, Diego Luiz Rovaris, Eugenio Horacio Grevet, Claiton Henrique Dotto Bau
Summary: GWAS studies have found associations between the MEF2C gene and white matter microstructure as well as psychiatric disorders. Our study in a Brazilian population further supports these findings and suggests a common biological factor underlying these phenotypes. Specifically, we identified independent variants in the MEF2C gene associated with temporal-frontal circuitry, which is relevant to executive and cognitive functions.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Review
Neurosciences
Nicolas Pereira Ciochetti, Beatriz Lugli-Moraes, Bruna Santos da Silva, Diego Luiz Rovaris
Summary: Physiological systems are influenced by interindividual genetic variations. Genome-wide association studies (GWAS) examine thousands of genetic variants in a large number of individuals to determine their relationship to a specific trait. GWAS can provide insights into physiological functions, diseases, and shared biological processes. For example, a GWAS on thyroid hormone levels led to the discovery of new thyroid hormone transporter and metabolizing enzyme genes. GWAS have greatly contributed to understanding genetic control of complex traits and will continue to do so with global collaborations and advances in genotyping technology.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Psychiatry
Thiago Henrique Roza, Francisco Diego Rabelo-da-Ponte, Daniel Tornaim Spritzer, Mauricio Scopel Hoffmann, Raffael Massuda, Giovanni Abrahao Salum, Euripedes Constantino Miguel, Luis Augusto Rohde, Pedro Mario Pan, Felix Henrique Paim Kessler, Ary Gadelha, Ives Cavalcante Passos
Summary: This study aimed to investigate the relationship between maternal depression in childhood and problematic gaming in late adolescence/young adulthood. Data from a large Brazilian school-based cohort were collected and analyzed, and it was found that maternal depression in childhood was significantly associated with problematic gaming in later developmental stages, partially mediated by internalizing psychopathology.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Correction
Genetics & Heredity
Ditte Demontis, G. Bragi Walters, Georgios Athanasiadis, Raymond Walters, Karen Therrien, Trine Tollerup Nielsen, Leila Farajzadeh, Georgios Voloudakis, Jaroslav Bendl, Biau Zeng, Wen Zhang, Jakob Grove, Thomas D. Als, Jinjie Duan, F. Kyle Satterstrom, Jonas Bybjerg-Grauholm, Marie H. Baekved-Hansen, Olafur Gudmundsson, Sigurdur Magnusson, Gisli Baldursson, Katrin C. Davidsdottir, Gyda Haraldsdottir, Esben Agerbo, Gabriel M. Hoffman, Soren Dalsgaard, Jonna Martin, Marta Ribases, Dorret H. Boomsma, Maria Soler Artigas, Nina Roth Mota, Daniel Howrigan, Sarah J. Medland, Tetyana J. Zayats, Veera Rajagopal, Merete Nordentoft, Ole Mors, David M. Hougaard, Preben Bo Mortensen, Mark J. Daly, Stephen V. Faraone, Hreinn Stefansson, Panos Roussos, Barbara Franke, Thomas Werge, Benjamin M. Neale, Kari Stefansson, Anders D. Borglum
Article
Psychiatry
Matheus Ghossain Barbosa, Viviane Machado, Carolina Ziebold, Tais Moriyama, Rodrigo A. Bressan, Pedro Pan, Luis Augusto Rohde, Euripedes Constantino Miguel, Lais Fonseca, Jim Van Os, Ary Gadelha
Summary: The Brazilian High-Risk Cohort study examined the measurement invariance of the CAPE-positive scale in children and adolescents over a three-year period. The results show that the scale is not invariant over time, indicating the need for further investigation into the factors influencing its results.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychology, Clinical
Mauricio Scopel Hoffmann, Tyler Maxwell Moore, Luiza Kvitko Axelrud, Nim Tottenham, Pedro Mario Pan, Euripedes Constantino Miguel, Luis Augusto Rohde, Michael Peter Milham, Theodore Daniel Satterthwaite, Giovanni Abrahao Salum
Summary: Data aggregation in mental health is complicated due to the use of different questionnaires, and the impact of item harmonization strategies on measurement precision is not well understood. This study aimed to assess the impact of various item harmonization strategies for a target and proxy questionnaire. The results showed that the one-by-one expert-based semantic item harmonization was the best strategy, resulting in scalar-invariant models for both samples and factor models. Furthermore, item harmonization strategies had little impact on p-factors and first-order correlated factors when harmonizing the child behavior checklist (CBCL) and strengths and difficulties questionnaire (SDQ), but were relevant for specific factors in bifactor models.