Review
Urology & Nephrology
Margherita Trinchieri, Gianpaolo Perletti, Vittorio Magri, Konstantinos Stamatiou, Emanuele Montanari, Alberto Trinchieri
Summary: Antidepressant therapy may lead to bladder voiding disorders rather than urological disease symptoms; Patients with dementia receiving antipsychotic treatment may experience urinary incontinence.
NEUROUROLOGY AND URODYNAMICS
(2021)
Review
Biochemistry & Molecular Biology
Aminah Alchakee, Munazza Ahmed, Leen Eldohaji, Hamid Alhaj, Maha Saber-Ayad
Summary: The review focuses on cytochrome P450 enzymes and their association with the metabolism of psychotropic medications, variations among different populations, impact on neurotransmitters, and the influence of non-genetic factors. It also discusses the association between adverse effects of psychiatric medications and human leukocytic antigen genotypes. The importance of pharmacogenetics implementation in psychiatry clinics is emphasized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Paula Soria-Chacartegui, Gonzalo Villapalos-Garcia, Pablo Zubiaur, Francisco Abad-Santos, Dora Koller
Summary: Olanzapine, aripiprazole, and risperidone are widely used for schizophrenia treatment and can induce various adverse drug reactions. The metabolism and individual genetic polymorphisms of these drugs affect pharmacokinetics and drug responses, necessitating consideration of patient genotypes and potential drug interactions during treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Psychiatry
Yusuke Okada, Manabu Akazawa
Summary: The 2018 revision of Japanese medical service fees aimed at reducing irrational psychotropic polypharmacy by reducing fees for patients prescribed more than the standard number of drugs. A study using a large administrative claims database found that only the proportion of patients prescribed the sum of anxiolytics and hypnotics exceeding the standard significantly decreased after the revision, while other drug groups did not show significant changes. The revision resulted in a promotion of reduction in the number of prescribed drugs, which was an important factor in decreasing the proportion of patients prescribed more than the standard number of drugs.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Psychiatry
Naoki Hashimoto, Norio Yasui-Furukori, Naomi Hasegawa, Shuhei Ishikawa, Shusuke Numata, Hikaru Hori, Hitoshi Iida, Kayo Ichihashi, Ryuji Furihata, Atsunobu Murata, Takashi Tsuboi, Masahiro Takeshima, Yoshitaka Kyou, Hiroshi Komatsu, Chika Kubota, Shinichiro Ochi, Yoshikazu Takaesu, Masahide Usami, Tatsuya Nagasawa, Akitoyo Hishimoto, Kenichiro Miura, Junya Matsumoto, Kazutaka Ohi, Hisashi Yamada, Ken Inada, Koichiro Watanabe, Kazutaka Shimoda, Ryota Hashimoto
Summary: The analysis of discharge prescription data for patients with schizophrenia and MDD revealed differences in prescription patterns for antipsychotics and hypnotics/anxiolytics among patients of different age groups, as well as the common practice of polypharmacy.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Review
Chemistry, Medicinal
Marina Caldara, Nelson Marmiroli
Summary: Research has shown that antidepressants and antipsychotics can inhibit the growth of different yeasts and bacteria, potentially becoming new antimicrobial treatments. Drug repositioning, which involves finding new clinical targets for old drugs, could reduce the cost and speed up the approval timeline for developing new drugs.
Review
Clinical Neurology
Giulia Cattarinussi, Giuseppe Delvecchio, Cecilia Prunas, Chiara Moltrasio, Paolo Brambilla
Summary: The review found that pharmacological treatments have minimal to no effect on brain activity and connectivity in borderline personality disorder (BPD) patients during emotional tasks. However, limitations such as small sample size, observational design, and high percentage of female participants affect the conclusion of the study.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medical Laboratory Technology
Hazuki Komahashi-Sasaki, Norio Yasui-Furukori, Taro Sasaki, Masataka Shinozaki, Yuki Hayashi, Kazuko Kato, Yoshimasa Inoue, Shoko Tsuchimine, Takashi Watanabe, Norio Sugawara, Kazutaka Shimoda
Summary: This study evaluated the effects of the CYP2D6*10 and CYP2D6*5 genotypes on the steady-state plasma concentrations of VEN and ODV in Japanese patients. The findings showed that while CYP2D6 polymorphism did not affect the plasma concentrations of VEN or ODV, it did influence the ODV/VEN ratio. Further research is necessary to validate the clinical significance of these results.
THERAPEUTIC DRUG MONITORING
(2021)
Article
Psychiatry
Naoki Hashimoto, Norio Yasui-Furukori, Naomi Hasegawa, Shuhei Ishikawa, Hikaru Hori, Hitoshi Iida, Kayo Ichihashi, Kenichiro Miura, Junya Matsumoto, Shusuke Numata, Fumitoshi Kodaka, Ryuji Furihata, Kazutaka Ohi, Kazuyoshi Ogasawara, Jun-ichi Iga, Hiroyuki Muraoka, Hiroshi Komatsu, Masahiro Takeshima, Kiyokazu Atake, Mikio Kido, Toshinori Nakamura, Taishiro Kishimoto, Akitoyo Hishimoto, Toshiaki Onitsuka, Tsuyoshi Okada, Shinichiro Ochi, Tatsuya Nagasawa, Manabu Makinodan, Hiroki Yamada, Takashi Tsuboi, Hisashi Yamada, Ken Inada, Koichiro Watanabe, Ryota Hashimoto
Summary: The study aimed to compare psychotropic prescriptions in Japan between hospital admission and discharge, aligning them with international standards and reducing facility differences. Patients who received monotherapy with the main drug at admission were likely to continue with monotherapy at discharge. Polypharmacy was more common in patients who switched from monotherapy to polypharmacy. Over 10% of patients had no changes in prescription throughout their hospital stay.
Review
Clinical Neurology
Giulia Cattarinussi, Giuseppe Delvecchio, Chiara Moltrasio, Adele Ferro, Fabio Sambataro, Paolo Brambilla
Summary: Studies have shown that medications have an impact on brain metabolism in individuals with borderline personality disorder, particularly in the frontal and temporal areas. However, the effects on brain hemodynamics remain inconclusive or absent. Limitations such as small sample sizes, high percentage of women, heterogeneity in pharmaceutical agents, and comorbidities restrict the conclusions of current research on this topic.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Pharmacology & Pharmacy
Irina Iaru, Camelia Bucsa, Andreea Farcas, Cristina Pop, Anamaria Cristina, Sebastian Armean, Irina Brumboiu, Oliviu Vostinaru, Cristina Mogosan
Summary: The utilization patterns of anxiolytics, antidepressants, and antipsychotics in Romania between 1998 and 2018 showed stability in anxiolytic use, a significant increase in antidepressant use, and a rising trend in antipsychotic use.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Przemyslaw Solek, Jennifer Mytych, Anna Tabecka-Lonczynska, Marek Koziorowski
Summary: The study investigated the differential toxicity of antidepressants on mouse spermatogenic cells, revealing significant reprotoxic potency and telomere-focused DNA damage response which leads to apoptotic cell death. These findings suggest a need for further research on the reproductive toxicity of antidepressants and neuroleptic drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Toxicology
Nevena Todorovic Vukotic, Jelena Dordevic, Snezana Pejic, Neda Dordevic, Snezana B. Pajovic
Summary: Drug-induced liver injury (DILI) is a significant health burden with increasing incidence due to the rise in psychotropic drug use. This study comprehensively reviews and discusses the hepatotoxic effects of commonly prescribed antidepressants (ADs) and antipsychotics (APs), highlighting those that can cause severe DILI cases. By exploring the pathophysiology of DILI and the effects of ADs and APs on drug metabolism enzymes, the study emphasizes the importance of continuous data collection for easier diagnosis and risk assessment of DILI. Increased awareness of the hepatotoxicity of ADs and APs is crucial for their safe and optimal use.
ARCHIVES OF TOXICOLOGY
(2021)
Review
Psychiatry
Temi Toba-Oluboka, Philip G. Tibbo, Kara Dempster, Martin Alda
Summary: This article reviews the interplay between genetic risk and medication exposure in psychiatric treatment, specifically focusing on medication-induced QT prolongation (MIQTP). The findings suggest a genetic contribution to MIQTP and highlight the importance of monitoring heart parameters and potential role of genetic profiling in increasing treatment safety in psychiatry.
PSYCHIATRY RESEARCH
(2022)
Article
Neurosciences
Bryan McClarty, Guadalupe Rodriguez, Hongxin Dong
Summary: The study showed that the HDAC inhibitor CI-994 at different doses could reduce motor and memory side effects induced by haloperidol in aged mice. A dose of 20 mg/kg was effective in improving motor coordination and mitigating memory impairment in aged mice. Biochemical analyses indicated an increase in histone acetylation and expression of the dopamine 2 receptor gene in aged mice after administration of CI-994 at 20 mg/kg.
FRONTIERS IN NEUROSCIENCE
(2021)