Journal
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
Volume 258, Issue -, Pages 40-43Publisher
DR DIETRICH STEINKOPFF VERLAG
DOI: 10.1007/s00406-008-5011-5
Keywords
schizophrenia; endophenotypes; prepulse inhibition; serotonin 2 alpha-receptor (5HT2a); 5HT2a-gene
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Decomposition of schizophrenia into neurobiological vulnerability traits is necessary to understand the complex genetic underpinnings of this phenomenologically defined disorder. This issue is discussed with a focus on prepulse inhibition (PPI) as a neurobiological phenotype and the 5HT2a-receptor as a candidate gene. A series of recent studies illuminates that PPI and 5HT2a-receptors present as vulnerability markers for schizophrenia; a functional sequence variant in the 5HT2a-gene is contributing to this relationship and might consequently contribute to the genetic predisposition to schizophrenia with a very small risk increase.
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