Article
Clinical Neurology
Jason Gurewitz, Zane Schnurman, Aya Nakamura, Ralph E. Navarro, Dev N. Patel, Sean O. McMenomey, J. Thomas Roland, John G. Golfinos, Douglas Kondziolka
Summary: This study aimed to investigate the relationship between hearing loss and tumor volumetric growth rates in patients with untreated vestibular schwannoma (VS). The results showed that larger initial tumor size and faster tumor growth rates were associated with an elevated risk of loss of class A and serviceable hearing.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Assaf Berger, Juan Diego Alzate, Kenneth Bernstein, Reed Mullen, Sean McMenomey, Daniel Jethanemest, David R. Friedmann, Eric Smouha, Erik P. Sulman, Joshua S. Silverman, J. Thomas Roland, John G. Golfinos, Douglas Kondziolka
Summary: This study evaluates hearing outcomes in patients with vestibular schwannoma (VS) during the modern era of cochlear dose restriction. The results show that factors such as age, baseline GR score, cochlear dose, and biological effective dose are correlated with hearing preservation. Increased tumor-free canal space is associated with better outcomes. Furthermore, patients who meet specific criteria have higher hearing preservation rates compared to the rest of the population.
Review
Clinical Neurology
Anne Balossier, Constantin Tuleasca, Christine Delsanti, Lucas Troude, Jean-Marc Thomassin, Pierre-Hugues Roche, Jean Regis
Summary: This study conducted a systematic literature review and meta-analysis on long-term hearing preservation after stereotactic radiosurgery (SRS). The results showed that nearly 60% of patients can maintain their hearing after a median follow-up of 6.7 years. Young age, good hearing status, early treatment, small tumor volume, low marginal irradiation dose, and maximal dose to the cochlea were identified as favorable prognostic factors.
Article
Clinical Neurology
Zhiyuan Fan, Zhen Fan, Zongze Li, Hongfei Zhang, Liuxun Hu, Tianming Qiu, Wei Zhu
Summary: This study aimed to provide a cognitive profile of patients with untreated vestibular schwannoma (VS). The results showed that patients with VS exhibited impaired cognitive function in memory, psychomotor speed, visuospatial ability, attention and processing speed, and executive function compared to the control group. In addition, patients with right-sided VS performed worse than those with left-sided VS in memory, attention and processing speed, and executive function. The study also found a correlation between worse hearing and longer hearing loss duration with poorer cognitive performance in patients with VS. Therefore, including cognitive assessment in the routine clinical management of patients with VS may improve clinical decision-making and patients' quality of life.
Article
Otorhinolaryngology
Yavor Bozhkov, Julia Shawarba, Julian Feulner, Fabian Winter, Stefan Rampp, Ullrich Hoppe, Arnd Doerfler, Heinrich Iro, Michael Buchfelder, Karl Roessler
Summary: Surgery for small vestibular schwannomas can achieve excellent hearing preservation. Different grading systems have a significant impact on and correlate with postoperative hearing preservation. Tumor size appears to be more important than anatomical relationships.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Clinical Neurology
Zane Schnurman, Jason Gurewitz, Eric Smouha, Sean O. McMenomey, J. Thomas Roland, John G. Golfinos, Douglas Kondziolka
Summary: Through propensity score matching, this study found no significant difference in the loss of class A or serviceable hearing between patients managed with SRS or observation alone when controlling for potential confounders.
Article
Biochemistry & Molecular Biology
Zdenek Fik, Ales Vlasak, Eduard Zverina, Jaroslav Syba, Jan Lazak, Lenka Peterkova, Vladimir Koucky, Jan Betka
Summary: The incidence of sporadic vestibular schwannoma has increased, but there is no method to predict tumor growth risk. Different management strategies were evaluated for five patient groups. Out of 463 patients, 32.4% initially recommended for observation eventually required active treatment. Younger patients were more likely to undergo surgery while older patients were more likely to receive stereoradiotherapy. Tumor growth was more common in patients under 60 years and those with tumors over 10 mm. Conservative treatment was preferred for elderly patients, including those with larger tumors. Follow-up scan duration remains debated as tumors can grow after 5 years from diagnosis.
Review
Medicine, General & Internal
Makoto Hosoya, Takeshi Wakabayashi, Koichiro Wasano, Takanori Nishiyama, Nobuyoshi Tsuzuki, Naoki Oishi
Summary: This article reviews recent advances in the management and treatment of vestibular schwannoma, particularly in hearing preservation. By improving intraoperative monitoring systems and conducting precise genomic analysis, the treatment of vestibular schwannomas is expected to be improved.
Article
Clinical Neurology
Anne Morgan Selleck, Kelli L. Hicks, Kevin D. Brown
Summary: Intralabyrinthine schwannomas differ from intracanalicular schwannomas in the severity of hearing loss at presentation. However, they present in a similar fashion in terms of age, presenting signs and symptoms. Otolaryngologists should have a high suspicion for ILS in patients with asymmetric hearing loss, vertigo, and tinnitus.
OTOLOGY & NEUROTOLOGY
(2022)
Article
Multidisciplinary Sciences
Cheng-chia Lee, Wei-Kai Lee, Chih-Chun Wu, Chia-Feng Lu, Huai-Che Yang, Yu-Wei Chen, Wen-Yuh Chung, Yong-Sin Hu, Hsiu-Mei Wu, Yu-Te Wu, Wan-Yuo Guo
Summary: This study aims to automate the volumetric measurement of vestibular schwannoma (VS) using AI, with results showing minimal differences compared to clinical measurements, allowing for effective evaluation of treatment responses regardless of tumor state. The proposed deep learning AI scheme is applicable for longitudinal follow-up assessments following various therapeutic interventions.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Douglas M. M. Hildrew, Philip L. L. Perez, Leila J. J. Mady, Jinhong Li, Marci L. L. Nilsen, Barry E. E. Hirsch
Summary: The objective of this study was to determine tumor control rates and hearing outcomes for treating growing vestibular schwannoma (VS) with CyberKnife stereotactic radiosurgery (CK SRS) and propose a predictive model for hearing outcomes. A retrospective case series review was conducted on 127 patients who received CK SRS for growing VS. The tumor control rate was 94.5% and hearing preservation was achieved in a third of patients. The final predictive model included variables such as age, fundal cap distance (FCD), tumor volume, and maximum radiation dose to the cochlea.
Article
Clinical Neurology
Yuichi Fujita, Yoichi Uozumi, Takashi Sasayama, Eiji Kohmura
Summary: This study analyzed 143 patients and found that the presence of a fundal fluid cap on preoperative MRI was associated with better preservation of facial nerve function after surgery. The preservation rate was higher in patients with a fundal fluid cap, especially at 24 months postoperatively. Therefore, the presence of a fundal fluid cap has a positive effect on the long-term preservation of facial nerve function.
JOURNAL OF NEUROSURGERY
(2023)
Article
Otorhinolaryngology
Kimberley S. S. Koetsier, Heiko Locher, Radboud W. W. Koot, Andel G. L. van Der Mey, Peter-Paul G. van Benthem, Jeroen C. C. Jansen, Erik F. F. Hensen
Summary: This study evaluates the natural course of hearing loss prior to treatment in patients with progressive tumors and an indication for active intervention. The majority of patients (58%) with radiologically confirmed progressive vestibular schwannomas experience progressive sensorineural HL during observation.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Clinical Neurology
Norio Ichimasu, Michihiro Kohno, Nobuyuki Nakajima, Hiroki Sakamoto, Ken Matsushima, Masanori Yoshino, Kiyoaki Tsukahara
Summary: This study investigates the auditory effect of tumors around the cerebellopontine angle (CPA) and temporal bone in patients other than vestibular schwannomas (VSs). Preoperative retrocochlear hearing disturbance is found to be a prognostic factor for hearing improvement after surgery. Trigeminal schwannomas (TS) and jugular foramen schwannomas (JFS) have particularly favorable hearing prognoses.
JOURNAL OF NEUROSURGERY
(2023)
Article
Medicine, Research & Experimental
Stefanie Seo, Sarek Shen, Andy S. Ding, Francis X. Creighton
Summary: The study investigated variables that affect the long-term performance of cochlear implants (CIs) among patients with neurofibromatosis type 2 (NF2). The results showed that CIs provide audiological benefits for NF2 patients despite the recurrent nature of the disease. However, larger tumor size may lead to long-term failure of the CIs.
Article
Clinical Neurology
Fabio Ferrari, Luigi Cirillo, Fabio Calbucci, Fiorina Bartiromo, Paolo Ambrosetto, Antonio Fioravanti, Marco Leonardi
JOURNAL OF NEUROSURGICAL SCIENCES
(2019)
Letter
Clinical Neurology
Antonio Fioravanti, Stefano Bartolini, Francesca Nicolini, Valentina Ricci, Pietro Fiaschi, Filippo Badaloni
JOURNAL OF NEUROSURGICAL SCIENCES
(2020)
Article
Infectious Diseases
Daniele Generali, Giancarlo Bosio, Fabio Malberti, Antonio Cuzzoli, Sophie Testa, Laura Romanini, Antonio Fioravanti, Alessandro Morandini, Luca Pianta, Guglielmo Giannotti, Erika Maria Viola, Matteo Giorgi-Pierfranceschi, Marina Foramitti, Rosa Angela Tira, Ilaria Zangrandi, Giulia Chiodelli, Andrea Machiavelli, Maria Rosa Cappelletti, Alessia Giossi, Valeria De Giuli, Chiara Costanzi, Chiara Campana, Ottavia Bernocchi, Marianna Sirico, Alessia Zoncada, Alfredo Molteni, Sergio Venturini, Fabiola Giudici, Maurizio Scaltriti, Angelo Pan
Summary: Treatment with canakinumab in patients with moderate COVID-19-related pneumonia is effective and safe, rapidly restoring normal oxygen status, reducing the need for invasive mechanical ventilation, and leading to earlier hospital discharge and a favorable prognosis compared to standard care.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Clinical Neurology
Francesco Doglietto, Marika Vezzoli, Antonio Biroli, Giorgio Saraceno, Luca Zanin, Marta Pertichetti, Stefano Calza, Edoardo Agosti, Jahard Mijail Aliaga Arias, Roberto Assietti, Silvio Bellocchi, Claudio Bernucci, Simona Bistazzoni, Daniele Bongetta, Andrea Fanti, Antonio Fioravanti, Alessandro Fiorindi, Alberto Franzin, Davide Locatelli, Raffaelino Pugliese, Elena Roca, Giovanni Marco Sicuri, Roberto Stefini, Martina Venturini, Oscar Vivaldi, Costanza Zattra, Cesare Zoia, Marco Maria Fontanella
NEUROSURGICAL FOCUS
(2020)
Article
Clinical Neurology
Carmine Antonio Donofrio, Lucia Riccio, Omar N. Pathmanaban, Antonio Fioravanti, Anthony J. Caputy, Pietro Mortini
Summary: This study compared the surgical operability of three endoscopic approaches within the inferior orbit and found that ESTMax provided the most favorable operative window, broadest surgical field area, widest surgical angles of attack, and greatest surgical mobility areas, making it a promising minimally invasive orbital approach.
NEUROSURGICAL REVIEW
(2021)
Article
Clinical Neurology
Antonio Fioravanti, Angela Elia, Alessandro Morandini, Carlo Valtulina, Alessandro Bertuccio
Summary: This study aimed to analyze the potential role of an anatomo-functional classification in guiding the management of insular cavernous malformations (iCMs). The results of the study showed that different types of iCMs require different surgical approaches. Additionally, pre-operative work-up and surgical evaluation are important for the success of the surgery.
ACTA NEUROCHIRURGICA
(2022)
Article
Clinical Neurology
Alessandro Fiorindi, Marika Vezzoli, Francesco Doglietto, Luca Zanin, Giorgio Saraceno, Edoardo Agosti, Antonio Barbieri, Silvio Bellocchi, Claudio Bernucci, Daniele Bongetta, Andrea Cardia, Emanuele Costi, Marcello Egidi, Antonio Fioravanti, Roberto Gasparotti, Carlo Giussani, Gianluca Grimod, Nicola Latronico, Davide Locatelli, Dikran Mardighian, Giovanni Nodari, Jacopo Carlo Poli, Frank Rasulo, Elena Roca, Giovanni Marco Sicuri, Giannantonio Spena, Roberto Stefini, Oscar Vivaldi, Cesare Zoia, Stefano Calza, Marco Maria Fontanella, Marco Cenzato
Summary: During the initial outbreak of COVID-19, Lombardy experienced significantly increased diagnostic delay for subarachnoid hemorrhages. However, the regional reorganization model effectively prevented therapeutic delays, leading to overall comparable outcomes to the control period.
ACTA NEUROCHIRURGICA
(2022)
Correction
Medicine, Research & Experimental
Francesco Perrone, Maria Carmela Piccirillo, Paolo Antonio Ascierto, Carlo Salvarani, Roberto Parrella, Anna Maria Marata, Patrizia Popoli, Laurenzia Ferraris, Massimiliano M. Marrocco-Trischitta, Diego Ripamonti, Francesca Binda, Paolo Bonfanti, Nicola Squillace, Francesco Castelli, Maria Lorenza Muiesan, Miriam Lichtner, Carlo Calzetti, Nicola Duccio Salerno, Luigi Atripaldi, Marco Cascella, Massimo Costantini, Giovanni Dolci, Nicola Cosimo Facciolongo, Fiorentino Fraganza, Marco Massari, Vincenzo Montesarchio, Cristina Mussini, Emanuele Alberto Negri, Gerardo Botti, Claudia Cardone, Piera Gargiulo, Adriano Gravina, Clorinda Schettino, Laura Arenare, Paolo Chiodini, Ciro Gallo
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Oncology
Victoria Bouche, Giovanni Aldegheri, Carmine Antonio Donofrio, Antonio Fioravanti, Samuel Roberts-Thomson, Stephen B. Fox, Francesco Schettini, Daniele Generali
Summary: IDH-wild type glioblastoma accounts for the majority of GB cases and has limited therapeutic options. Inhibiting the BRAF pathway shows potential efficacy, but current results are not definitive, requiring further research to better understand treatment response predictors and address limitations in penetrating the blood-brain barrier and developing resistance mechanisms.
FRONTIERS IN ONCOLOGY
(2021)
Article
Clinical Neurology
Marco M. Fontanella, Luca Zanin, PierPaolo Panciani, Francesco Belotti, Francesco Doglietto, Alice Cremonesi, Karol Migliorati, Elena Roca, Lucio De Maria, Alberto Franzin, Oscar Vivaldi, Federico Griva, Alessandro Narducci, Riccardo Draghi, Fabio Calbucci, Ignazio Borghesi, Emanuela Crobeddu, Christian Cossandi, Antonio Fioravanti, Jahard Aliaga Arias, Alba Scerrati, Pasquale De Bonis, Davide Locatelli, Edoardo Agosti, Pierlorenzo Veiceschi, Marco Ceraudo, Gianluigi Zona, Roberto Gasparotti, Lodovico Terzi di Bergamo, Daniele Rigamonti
Summary: This study proposed a new grading system for cerebral cavernous malformations (CCMs) and validated its applicability through statistical analysis. The cutoff score of 4 in the grading system effectively separated patients who would benefit from surgical intervention. The outcome analysis showed that patients who received correct treatment based on the grading system had a better outcome.
WORLD NEUROSURGERY
(2022)
Article
Microscopy
V. P. Fabbri, Valentina Papa, C. Tonon, R. Agati, F. Toni, M. Zoli, D. Mazzatenta, A. Fioravanti, F. Badaloni, G. Cenacchi, M. P. Foschini, S. Asioli
Summary: This article describes a rare case of isolated olfactory schwannoma, emphasizing the importance of multiple ancillary tests, including electron microscopy, for studying intracranial lesions of the anterior skull base. Additionally, the enigmatic origin of this disease is discussed, starting from a comparison between the normal histology of the olfactory nerve and a peripheral nerve.
ULTRASTRUCTURAL PATHOLOGY
(2022)
Article
Clinical Neurology
Carmine Antonio Donofrio, Filippo Badaloni, Lucia Riccio, Alessandro Morandini, Alessandro Bertuccio, Daniele Generali, Fabio Calbucci, Franco Servadei, Antonio Fioravanti
Summary: This study provides an anatomical description and classification of primary posterior petrous meningiomas (PPMs), which lack a standardized definition and classification. Based on tumor origin, growth direction, and cranial nerve displacement, PPMs are classified into four types, predicting clinical presentation, postoperative morbidity, and resection rates.
WORLD NEUROSURGERY
(2023)
Letter
Clinical Neurology
Carlo Giussani, Erik Sganzerla, Giannantonio Spena, Diego Spagnoli, Roberto Assietti, Silvio Bellocchi, Oscar Vivaldi, Claudio Bernucci, Lorenzo Magrassi, Cesare Zoia, Marcello Egidi, Federico De Gonda, Marco Locatelli, Lorenzo Bello, Michele Incerti, Domenico Servello, Mario Vitale, Federico Nicolosi, Antonio Fioravanti, Marco Fontanella, Roberto Stefini
JOURNAL OF NEUROSURGICAL SCIENCES
(2021)
Letter
Clinical Neurology
Antonio Fioravanti, Pietro Fiaschi, Filippo Badaloni, Fabio Calbucci
JOURNAL OF NEUROSURGICAL SCIENCES
(2020)
Article
Otorhinolaryngology
E. Zanoletti, A. Mazzoni, A. Martini, R. V. Abbritti, R. Albertini, E. Alexandre, V. Baro, S. Bartolini, D. Bernardeschi, R. Bivona, M. Bonali, I. Borghesi, D. Borsetto, R. Bovo, M. Breun, F. Calbucci, M. L. Carlson, A. Caruso, P. Caye-Thomasen, D. Cazzador, P. -O. Champagne, R. Colangeli, G. Conte, D. D'Avella, G. Danesi, L. Deantonio, L. Denaro, F. Di Berardino, R. Draghi, F. H. Ebner, N. Favaretto, G. Ferri, A. Fioravanti, S. Froelich, A. Giannuzzi, L. Girasoli, B. R. Grossardt, M. Guidi, R. Hagen, S. Hanakita, D. G. Hardy, V. C. Iglesias, S. Jefferies, H. Jia, M. Kalamarides, I. N. Kanaan, M. Krengli, A. Landi, L. Lauda, D. Lepera, S. Lieber, S. L. K. Lloyd, A. Lovato, F. Maccarrone, R. Macfarlane, J. Magnan, L. Magnoni, D. Marchioni, J. P. Marinelli, G. Marioni, V. Mastronardi, C. Matthies, D. A. Moffat, S. Munari, M. Nardone, R. Pareschi, C. Pavone, E. Piccirillo, G. Piras, L. Presutti, G. Restivo, M. Reznitsky, E. Roca, A. Russo, M. Sanna, L. Sartori, M. Scheich, W. Shehata-Dieler, D. Soloperto, F. Sorrentino, O. Sterkers, A. Taibah, M. Tatagiba, G. Tealdo, D. Vlad, H. Wu, D. Zanetti
ACTA OTORHINOLARYNGOLOGICA ITALICA
(2019)