Article
Medicine, Research & Experimental
Jeffrey D. Steimle, Francisco J. Grisanti Canozo, Minjun Park, Zachary A. Kadow, Md Abul Hassan Samee, James F. Martin
Summary: This study reveals the association between gene variants related to atrial fibrillation and cell states through single nuclei multiomic profiling and spectral clustering, and identifies the correlation between atrial fibrillation predisposition genes, cell dysfunction, and cell-to-cell signaling.
Article
Cardiac & Cardiovascular Systems
Kimito Minami, Masahiro Kazawa, Takashi Kakuta, Satsuki Fukushima, Tomoyuki Fujita, Daijiro Kabata, Yoshihiko Ohnishi
Summary: This study analyzed 610 patients who underwent the modified Cryo-Maze procedure and investigated the impact of early ATA recurrence on late ATA recurrence. The results showed that early ATA recurrence was an independent predictor of late ATA recurrence. This suggests that the blanking period may not be necessary for patients undergoing the modified Cryo-Maze procedure.
CIRCULATION JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Bindu Kodati, Shawn A. Merchant, J. Cameron Millar, Yang Liu
Summary: Mutations in the PITX2 gene can lead to Axenfeld-Rieger syndrome, including congenital glaucoma as a symptom. The egl1 mouse strain, carrying a chemically induced Pitx2 mutation, develops early-onset glaucoma characterized by elevated intraocular pressure, retinal ganglion cell loss, and anterior segment dysgenesis.
Article
Cardiac & Cardiovascular Systems
Anne Bjerg Nielsen, Kristoffer Grundtvig Skaarup, Kasper Djernaes, Raphael Hauser, Raul San Jose Estepar, Samuel Kiil Sorensen, Martin Huth Ruwald, Morten Lock Hansen, Rene Husted Worck, Arne Johannessen, Jim Hansen, Tor Biering-Sorensen
Summary: This study found that left atrial deformation analysis by echocardiography may be useful in predicting the risk of ATA recurrence in patients undergoing CA for AF, even in those with a normal-sized LA.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jieyun Bai, Yaosheng Lu, Yijie Zhu, Huijin Wang, Dechun Yin, Henggui Zhang, Diego Franco, Jichao Zhao
Summary: Atrial fibrillation (AF) is a common arrhythmia with genetic predispositions playing a major role in its development. Genetic variants near the PITX2 gene on chromosome 4q25 have been identified in association with AF populations. Computational models are useful for understanding the functional impacts of PITX2 and may lead to improved anti-AF therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Inseok Hwang, Je-Wook Park, Oh-Seok Kwon, Byounghyun Lim, Myunghee Hong, Min Kim, Hee-Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Boyoung Joung, Moon-Hyoung Lee, Hui-Nam Pak
Summary: Computational modeling revealed that PITX2 gene deficiency affects the response of patients with atrial fibrillation to antiarrhythmic drugs, showing distinct differences in electrophysiological and wave-dynamic characteristics compared to wild-type models.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jieyun Bai, Yijie Zhu, Andy Lo, Meng Gao, Yaosheng Lu, Jichao Zhao, Henggui Zhang
Summary: This study aimed to evaluate the efficacy of AADs disopyramide, quinidine, and propafenone on human atrial arrhythmias mediated by Pitx2-induced remodelling. The findings suggested that disopyramide may be more effective against Pitx2-induced AF than propafenone and quinidine by prolonging wavelength.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Mathias A. Christensen, Alexander Bonde, Martin Sillesen
Summary: This study conducted a Genome-Wide Association Study (GWAS) using the UK Biobank and identified two Single Nucleotide Polymorphisms (rs17042171 and rs17042081) near the PITX2-gene that were significantly associated with postoperative atrial fibrillation (AF). These variants were replicated in a non-surgical cohort, providing new insights into the genetics of postoperative AF and potential applications in patient risk identification and management.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Motoki Nakao, Masaya Watanabe, Lucile Miquerol, Hiroyuki Natsui, Takuya Koizumi, Takahide Kadosaka, Taro Koya, Hikaru Hagiwara, Rui Kamada, Taro Temma, Antoine A. F. de Vries, Toshihisa Anzai
Summary: Recent studies have shown that optogenetic therapy using light-gated ion channels can effectively terminate atrial fibrillation without causing pain. This study investigated the mechanism of optogenetic termination of atrial tachyarrhythmia by examining the changes in action potential duration and refractory period induced by brief pulsed light stimulation in transgenic mice.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Physiology
Patrizia Benzoni, Lorenzo Da Dalt, Noemi Elia, Vera Popolizio, Alessandro Cospito, Federica Giannetti, Patrizia Dell'Era, Morten S. Olesen, Annalisa Bucchi, Mirko Baruscotti, Giuseppe Danilo Norata, Andrea Barbuti
Summary: Atrial fibrillation (AF) is a common cardiac arrhythmia and its initiation is not well understood. Recent research has shown that genetic background plays an important role in the onset of AF. Patient-specific iPSC-derived cardiomyocytes can be used to study the initial cell-autonomous changes in disease development. The transcription factor PITX2 has been identified as a key regulator in AF development.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Martijn J. Tilly, Sven Geurts, Angelo M. Pezzullo, Wichor M. Bramer, Natasja M. S. de Groot, Maryam Kavousi, Moniek P. M. de Maat
Summary: This study aims to summarize and analyze the evidence on the associations between coagulation factors and atrial fibrillation (AF) in both longitudinal and cross-sectional studies. The findings suggest that higher levels of coagulation factors are associated with both prevalent and incident AF, with the associations being more pronounced in cross-sectional studies. Limited evidence from longitudinal studies suggests a prothrombotic state underlying AF development.
Article
Cardiac & Cardiovascular Systems
Ze Jin, Inseok Hwang, Byounghyun Lim, Oh-Seok Kwon, Je-Wook Park, Hee-Tae Yu, Tae-Hoon Kim, Boyoung Joung, Moon-Hyoung Lee, Hui-Nam Pak
Summary: This study investigated the effects of patient genotype on the efficacy of catheter ablation and antiarrhythmic drugs in the treatment of atrial fibrillation. The results showed that virtual circumferential pulmonary vein isolation (V-CPVI) based on computational modeling was effective regardless of the patient genotype, while antiarrhythmic drugs exhibited better effects in specific genotype of atrial fibrillation patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Emad Elmusa, Hannan Asghar, Ameer Hamza, Muhammad Waleed Raza, Ismael Rodriguez
Summary: This study presents a case of a patient who developed atrial flutter following the consumption of tonic water, highlighting the association between tonic water consumption and cardiovascular risks.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Kyungsoo Kim, Daniel J. Blackwell, Samantha L. Yuen, Madelaine P. Thorpe, Jeffrey N. Johnston, Razvan L. Cornea, Bjorn C. Knollmarnn
Summary: Atrial fibrillation (AF) is a common cardiac arrhythmia that increases the risk of stroke and morbidity. Variants on chromosome 4q25, near the PITX2 gene, have been identified as the strongest genetic risk factors for AF in humans. This study found that deficiency in Pitx2 leads to hyperactivation of the cardiac ryanodine receptor (RyR2), which is associated with increased susceptibility to AF. Treatment with the RyR2 inhibitor ent-verticilide reduces the incidence and duration of AF, suggesting that targeting hyperactive RyR2 may be a promising approach to treat atrial arrhythmias caused by Pitx2 deficiency.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ching-Yao Chou, Fa-Po Chung, Hung-Yu Chang, Yenn-Jiang Lin, Li-Wei Lo, Yu-Feng Hu, Tze-Fan Chao, Jo-Nan Liao, Ta-Chuan Tuan, Chin-Yu Lin, Ting-Yung Chang, Chih-Min Liu, Cheng- Wu, Sung-Hao Huang, Chun-Chao Chen, Wen-Han Cheng, Shin-Huei Liu, Isaiah Carlos Lugtu, Ankit Jain, An-Ning Feng, Shih-Lin Chang, Shih-Ann Chen
Summary: This study focused on investigating the outcome and predictor of recurrent atrial tachyarrhythmia after catheter ablation in patients with prior cardiac surgery for valvular heart disease (VHD) who presented with atrial flutter (AFL). Concomitant atrial fibrillation (AF) was found to be associated with a higher recurrence of typical AFL, while chronic kidney disease (CKD) and left atrial diameter (LAD) were identified as independent predictors of recurrence after AFL ablation in this patient population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Transplantation
Solene M. Laville, Aymeric Couturier, Oriane Lambert, Marie Metzger, Nicolas Mansencal, Christian Jacquelinet, Maurice Laville, Luc Frimat, Denis Fouque, Christian Combe, Bruce M. Robinson, Benedicte Stengel, Sophie Liabeuf, Ziad A. Massy
Summary: This study aimed to determine the association between serum urea levels and adverse cardiovascular events and death in patients with chronic kidney disease (CKD) before renal replacement therapy (RRT). The study found that elevated serum urea levels were associated with increased risk of atheromatous and non-atheromatous cardiovascular events, as well as higher mortality rates.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Pediatrics
Fabio R. Salerno, Alireza Akbari, Sandrine Lemoine, Timothy J. Scholl, Christopher W. McIntyre, Guido Filler
Summary: Pediatric CKD is associated with altered tissue sodium concentration compared to healthy controls, with increased sodium concentration in glomerular disease and reduced sodium concentration in tubular disorders.
PEDIATRIC NEPHROLOGY
(2023)
Article
Hematology
Florian Mourre, Roch Giorgi, Antonio Gallo, Franck Boccara, Eric Bruckert, Alain Carrie, Regis Hankard, Jocelyn Inamo, Sandrine Laboureau, Philippe Moulin, Rene Valero, Sophie Beliard
Summary: Background: Animal studies have shown that fetal exposure to high maternal cholesterol levels during pregnancy increases the risk of aortic atheroma in the offspring. However, little is known about the consequences of this exposure on the development of atherosclerotic cardiovascular disease in humans. This study aimed to investigate whether maternal/paternal inheritance of familial hypercholesterolemia (FH) gene mutation could be associated with subclinical coronary atherosclerosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Charles Fauvel, Guillaume Bonnet, Wilfried Mullens, Clara Ines Saldarriaga Giraldo, Anja Zupan Meznar, Anders Barasa, Mariya Tokmakova, Anastasia Shchendrygina, Francisco Moscoso Costa, Massimo Mapelli, Filip Zemrak, Laurens F. Tops, Nina Jakus, Arian Sultan, Fadel Bahouth, Chahr-Eddine Hadjseyd, Muriel Salvat, Matteo Anselmino, Daniel Messroghli, Vanessa Weberndorfer, Ilya Giverts, Thomas Bochaton, Emmanuelle Berthelot, Damien Legallois, Florence Beauvais, Fabrice Bauer, Nicolas Lamblin, Thibaud Damy, Nicolas Girerd, Laurent Sebbag, Theo Pezel, Alain Cohen-Solal, Giuseppe Rosano, Francois Roubille, Nathan Mewton
Summary: This study aimed to understand the perception of practicing cardiologists and heart failure (HF) specialists regarding the recommendation of initiating four major therapeutic classes simultaneously in patients with heart failure and reduced ejection fraction. The survey findings showed that most cardiologists still preferred the historical approach of sequential initiation, although accelerated introduction and titration were also considered important treatment goals.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Transplantation
Maelys Granal, Denis Fouque, Micher Ducher, Jean-Pierre Fauvel
Summary: This study used artificial intelligence to define the relationship between kalemia, dietary potassium intake, and renal function in chronic kidney disease (CKD) patients. The results showed that strict dietary potassium control is not necessary to regulate kalemia in CKD1-4 patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Anfisa Puchkova-Sistac, Blandine de Lauzon-Guillain, Nicolas Girerd, Jean-Marc Boivin, Erwan Bozec, Ludovic Merckle, Julie-Anne Nazare, Martine Laville, Patrick Rossignol, Sandra Wagner
Summary: This study aimed to assess the associations between eating behavior and cardiovascular damage or metabolic syndrome after 13 years. The results showed that emotional eating was associated with an increased risk of diastolic dysfunction after 13 years. External eating was slightly associated with lower pulse-wave velocity. These findings suggest that cardiovascular prevention should take into account eating behavior and include teaching emotion regulation skills.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Clinical Neurology
Marlene Heinze, Bastian Cheng, Tae-Hee Cho, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Jens Fiehler, Josep Puig, Robin Lemmens, Vincent Thijs, Keith W. Muir, Norbert Nighoghossian, Alina Koenigsberg, Marit Jensen, Ewgenia Barow, Iris Lettow, Salvador Pedraza, Claus Z. Z. Simonsen, Christian Gerloff, Gotz Thomalla
Summary: This study evaluated the impact of clinical and imaging baseline factors and treatment on early neurological improvement (ENI) in MRI-guided intravenous thrombolysis for unknown onset stroke. The results showed that early neurological improvement is an important indicator of treatment effect, and early administration of thrombolysis increases the likelihood of ENI.
CEREBROVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Victor Waldmann, Francis Bessiere, Kevin Gardey, Mohamed Bakloul, Emre Belli, Damien Bonnet, Anne-Solene Chaussade, Sarah Cohen, Hubert Delasnerie, Nabil Dib, Sylvie Di Filippo, Arnaud Dulac, Sebastien Hascoet, Roland Henaine, Laurence Iserin, Clement Karsenty, Magalie Ladouceur, Antoine Legendre, Sophie Malekzadeh-Milani, Mansour Mostefa Kara, Jelena Radojevic, Miarisoa Ratsimandresy, Eloi Marijon, Alice Maltret, Paul Khairy, Nicolas Combes
Summary: This study aims to assess the role of EPS in predicting ventricular arrhythmias in patients with tetralogy of Fallot before pulmonary valve replacement. The results show that EPS can effectively predict the presence of ventricular tachycardia and guide treatment decisions.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Julien Dreyfus, Yohann Bohbot, Augustin Coisne, Yoan Lavie-Badie, Michele Flagiello, Baptiste Bazire, Florian Eggenspieler, Florence Viau, Elisabeth Riant, Yannick Mbaki, Damien Eyharts, Thomas Senage, Thomas Modine, Martin Nicol, Fabien Doguet, Thierry Le Tourneau, Christophe Tribouilloy, Erwan Donal, Jacques Tomasi, Gilbert Habib, Christine Selton-Suty, Costin Radu, Pascal Lim, Richard Raffoul, Bernard Iung, Jean-Francois Obadia, Etienne Audureau, David Messika-Zeitoun
Summary: This study aimed to evaluate the predictive value of TRI- SCORE for in-hospital mortality in redo ITVS patients and compare its accuracy with conventional surgical risk scores. The study found that TRI- SCORE was the only surgical risk score associated with in-hospital mortality, with an AUC value of 0.83, much higher than logistic EuroSCORE and EuroSCORE II. Therefore, TRI- SCORE can guide the clinical decision-making process.
Article
Critical Care Medicine
Romain Sonneville, Etienne de Montmollin, Damien Contou, Ricard Ferrer, Mohan Gurjar, Kada Klouche, Benjamine Sarton, Sophie Demeret, Pierre Bailly, Daniel da Silva, Etienne Escudier, Loic Le Guennec, Russel Chabanne, Laurent Argaud, Omar Ben Hadj Salem, Martial Thyrault, Aurelien Frerou, Guillaume Louis, Gennaro De Pascale, Janneke Horn, Raimund Helbok, Guillaume Geri, Fabrice Bruneel, Ignacio Martin-Loeches, Fabio Silvio Taccone, Jan De Waele, Stephane Ruckly, Quentin Staiquly, Giuseppe Citerio, Jean-Francois Timsit, EURECA Investigator Study Grp
Summary: This study aimed to characterize the outcomes of severe meningoencephalitis patients requiring intensive care. A multicenter international cohort study was conducted from 2017 to 2020 in 68 centers across 7 countries. Among the enrolled patients, 50.5% had a poor functional outcome at 3 months, and the independent factors associated with this outcome included age > 60 years, immunodepression, delayed ICU admission, low Glasgow Coma Scale score, motor deficits, respiratory and cardiovascular complications, while administration of certain medications on ICU admission was protective.
INTENSIVE CARE MEDICINE
(2023)
Review
Medicine, Research & Experimental
Elisa B. Monteiro, Matheus Ajackson, Milena B. Stockler-Pinto, Fitsum Guebre-Egziabher, Julio B. Daleprane, Christophe O. Soulage
Summary: This review analyzed the renoprotective effects of sulforaphane (SFN) in preclinical models of kidney diseases. The results showed that SFN improved renal function, reduced kidney injury, and decreased urinary protein excretion and kidney fibrosis. These findings suggest that SFN supplementation may be a potential therapeutic strategy for kidney disease.
Article
Multidisciplinary Sciences
Yves Gouriou, Fabrice Gonnot, Mariam Wehbi, Camille Brun, Ludovic Gomez, Gabriel Bidaux
Summary: Genetically encoded biosensors based on fluorescent proteins (FPs) are widely used to monitor calcium ion (Ca2+) dynamics and sub-cellular spatial distribution in cells. The mitochondrial-associated membranes (MAMs), which connect the endoplasmic reticulum (ER) and mitochondria, have recently gained attention due to their role in calcium homeostasis and mitochondrial function. However, the sensitivity of the existing Ca2+ biosensors on the outer-mitochondrial membrane (OMM) is not sufficient to measure sub-micromolar changes in Ca2+ concentration. In this study, a new highly sensitive Ca2+ biosensor was developed and demonstrated to detect smaller differences in Ca2+ levels in or near the MAMs. Notably, the study also revealed the endogenous activity of IP3-receptors in the Ca2+ leak channel on the OMM during hypoxia or when SERCA activity is blocked.
Article
Nutrition & Dietetics
Luc Gaussens, Emmanuel Gonzalez-Bautista, Marc Bonnefoy, Marguerite Briand, Neda Tavassoli, Philipe De Souto Barreto, Yves Rolland
Summary: This study described the vitality domain of intrinsic capacity (IC) in community-dwelling older people and examined the associations of appetite and weight loss with other IC domains. The results showed that appetite and weight loss are common among older adults and are related to impairments in psychological and locomotion abilities.
Article
Hematology
Oriane Marmontel, Yara Abou-Khalil, Olivier Bluteau, Bertrand Cariou, Valerie Carreau, Sybil Charriere, Eleonore Divry, Antonio Gallo, Philippe Moulin, Francois Paillard, Noel Peretti, Jean-Pierre Rabes, Mathilde Varret, Alain Carrie, Mathilde Di Filippo
Summary: This study investigated the phenotype of 21 adult patients who carried rare LDLR and APOE variants in a French cohort. The results showed that LDLR+APOE carriers had higher blood lipid levels and a higher incidence of premature atherosclerotic cardiovascular diseases compared to LDLR carriers alone.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Hematology
Rozenn Quarck, Lynn Willems, Birger Tielemans, Leanda Stoian, Alicja Ronisz, Allard Wagenaar, Frederic Perros, Guido Claessen, Agnieszka Ciarka, Laurent Godinas, Catharina Belge, Marc Jacquemin, Marion Delcroix
Summary: The crucial role of angiogenesis in clot resolution and fibrothrombotic obstruction of the pulmonary arterial bed in CTEPH was validated using a rabbit model. Inhibiting intrathrombus angiogenesis resulted in elevated pulmonary arterial pressure, increased pulmonary vascular resistance, and right ventricular hypertrophy, accompanied by pulmonary vessel remodeling and inflammation.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
