Article
Cardiac & Cardiovascular Systems
Samuel K. Sorensen, Arne Johannessen, Rene Worck, Morten L. Hansen, Jim Hansen
Summary: Radiofrequency and cryoballoon catheter ablation demonstrate similar moderate to high durability in pulmonary vein isolation. However, about 5% of patients experienced recurrence of atrial fibrillation despite complete and durable PVI. The reduction in AF burden is associated with the number of durably isolated pulmonary veins.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Oussama M. Wazni, Gopi Dandamudi, Nitesh Sood, Robert Hoyt, Jaret Tyler, Sarfraz Durrani, Mark Niebauer, Kevin Makati, Blair Halperin, Andre Gauri, Gustavo Morales, Mingyuan Shao, Jeffrey Cerkvenik, Rachelle E. Kaplon, Steven E. Nissen
Summary: In this multicenter trial, cryoballoon ablation as initial therapy was found to be superior to drug therapy in preventing atrial arrhythmia recurrence in patients with paroxysmal atrial fibrillation. Serious procedure-related adverse events were uncommon.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Michael Kuhne, Sven Knecht, Florian Spies, Stefanie Aeschbacher, Philip Haaf, Michael Zellweger, Beat Schaer, Stefan Osswald, Christian Sticherling
Summary: The study showed that performing pulmonary vein isolation without demonstrating vein occlusion is feasible, reduces radiation exposure, and increases procedural efficiency.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Ana Isabel Molina-Ramos, Amalio Ruiz-Salas, Carmen Medina-Palomo, Francisco Javier Pavon-Moron, Jorge Rodriguez-Capitan, Mario Gutierrez-Bedmar, German Berteli-Garcia, Ignacio Fernandez-Lozano, Juan Jose Gomez-Doblas, Manuel Jimenez-Navarro, Javier Alzueta-Rodriguez, Alberto Barrera-Cordero
Summary: This study compared cryoballoon ablation and radiofrequency ablation in terms of their efficacy after the first procedure. The results showed that cryoballoon ablation had a lower need for reablation and a lower rate of pulmonary vein reconnection during follow-up.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jonas Woermann, Jakob Lueker, Jan-Hendrik van den Bruck, Karlo Filipovic, Susanne Erlhoefer, Cornelia Scheurlen, Sebastian Dittrich, Jan-Hendrik Schipper, Daniel Steven, Arian Sultan
Summary: This study compared the efficacy and procedural differences between high power short duration radiofrequency ablation (HPSD) and cryoballoon ablation (CB) in the treatment of atrial fibrillation. The results showed that HPSD and CB had similar success rates and safety profiles, but HPSD had a longer procedure duration. In conclusion, HPSD is a feasible and effective option for the ablation treatment of atrial fibrillation.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Jason G. Andrade, Oussama M. Wazni, Malte Kuniss, Nathaniel M. Hawkins, Marc W. Deyell, Gian-Battista Chierchia, Steven Nissen, Atul Verma, George A. Wells, Ricky D. Turgeon
Summary: Cryoballoon catheter ablation has been shown to significantly improve arrhythmia outcomes, produce clinically meaningful improvements in patient-reported outcomes, reduce subsequent health care resource use, and not increase the risk of serious adverse events compared with initial antiarrhythmic drug therapy in patients with treatment-naive AF.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
J. Pongratz, L. Riess, S. Hartl, B. Brueck, C. Tesche, U. Ebersberger, T. Helmberger, A. Crispin, M. Wankerl, U. Dorwarth, E. Hoffmann, F. Straube
Summary: In patients with persistent atrial fibrillation (AF) undergoing cryoballoon ablation, the volume of the left atrial appendage (LAA) and the severity of mitral regurgitation were identified as independent predictors for arrhythmia recurrence.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Daehoon Kim, Taehyun Hwang, Min Kim, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Boyoung Joung, Moon-Hyoung Lee, Hui-Nam Pak
Summary: Extra-pulmonary vein triggers are commonly found in atrial fibrillation patients and associated with poorer rhythm outcomes after both de novo and repeat catheter ablation procedures.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Charlotte Eitel, Vanessa Sciacca, Nina Bartels, Roza Saraei, Thomas Fink, Ahmad Keelani, Andre Gassmann, Karl-Heinz Kuck, Julia Vogler, Christian-Hendrik Heeger, Roland Richard Tilz
Summary: This study analyzed the safety and efficacy of cryoballoon-based pulmonary vein isolation (CB-PVI) for symptomatic AF in patients with past or present cancer disease. The results showed that the frequency of complications and arrhythmia-free survival after 12 months did not significantly differ between patients with and without a history of cancer. Therefore, CB-PVI for symptomatic AF is equally safe and effective in patients with and without a history of cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Dhiraj Gupta, Wern Yew Ding, Peter Calvert, Emmanuel Williams, Moloy Das, Lilith Tovmassian, Muzahir H. Tayebjee, Guy Haywood, Claire A. Martin, Kim Rajappan, Matthew G. D. Bates, Ian Peter Temple, Tobias Reichlin, Zhong Chen, Richard N. Balasubramaniam, Christina Ronayne, Nichola Clarkson, Maureen Morgan, Janet Barton, Ian Kemp, Saagar Mahida, Christian Sticherling
Summary: The study compared cryoballoon pulmonary vein isolation (PVI) with standard radiofrequency cavotricuspid isthmus (CTI) ablation for the first-line treatment of typical atrial flutter (AFL). The results showed that cryoballoon PVI was equally effective as CTI ablation in preventing the recurrence of atrial arrhythmia and better at preventing new-onset atrial fibrillation (AF).
Article
Cardiac & Cardiovascular Systems
Florian Straube, Janis Pongratz, Alexander Kosmalla, Benedikt Brueck, Lukas Riess, Stefan Hartl, Christian Tesche, Ullrich Ebersberger, Michael Wankerl, Uwe Dorwarth, Ellen Hoffmann
Summary: Cryoballoon ablation is a reasonable strategy for symptomatic persistent AF in the initial AF ablation procedure, with a high acute isolation success rate. Although there are potential complications and recurrence risks, Cryoballoon ablation has shown good outcomes in the treatment of persistent AF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Hanjin Park, Je-Wook Park, Daehoon Kim, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Boyoung Joung, Moon-Hyoung Lee, Chun Hwang, Hui-Nam Pak
Summary: This study compared the efficacy and safety of cryoballoon, high-power short-duration, and conventional radiofrequency ablation in treating atrial fibrillation. The results showed that the Cryo-PVI group had similar major complication and clinical recurrence rates compared to the other groups. However, the Cryo-PVI group had a lower risk of recurrent AF in patients with paroxysmal AF and a higher risk in patients with persistent AF. Additionally, the Cryo-PVI group had higher post-procedural sympathetic nervous activity and sympatho-vagal balance compared to the conventional-PVI group.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Lara Wagner, Fabrice F. Darche, Dierk Thomas, Patrick Lugenbiel, Panagiotis Xynogalos, Svenja Seide, Eberhard P. Scholz, Hugo A. Katus, Patrick A. Schweizer
Summary: Background modulation of the cardiac autonomic nervous system by pulmonary vein isolation (PVI) influences the sinoatrial nodal rate. Cryo-PVI causes a significant rise of sinus rate that is more pronounced in subjects with previous sinus bradycardia, with an increased risk of AF recurrence in patients with postprocedural bradycardia.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Julian Mueller, Karin Nentwich, Artur Berkovitz, Kai Sonne, Olena Kozlova, Sebastian Barth, Alexandru Deacanu, Christian Waechter, Philipp Halbfass, Heiko Lehrmann, Thomas Deneke
Summary: This study investigated the characteristics of patients undergoing redo AF ablation and the impact of different ablation strategies. The results showed that pulmonary vein reconnection was common among all techniques of AF ablation, and different ablation strategies did not improve long-term success.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Chunying Jiang, Jun Zhang, Zhongyuan Ren, Rong Guo, Hailing Li, Shuang Li, Mengyun Zhu, Peng Jia, Kai Tang, Dongdong Zhao, Yawei Xu
Summary: This study analyzed data from 29 patients with recurrent AF undergoing repeat RF ablation, finding a higher incidence of conduction gaps and reconnection in the right superior pulmonary vein during cryoablation. Strategies such as close touch of CB on specific segments of RSPV may help achieve durable PV isolation during follow-up.
Article
Geriatrics & Gerontology
Regina von Rennenberg, Thomas Liman, Christian H. Nolte, Alexander H. Nave, Jan F. Scheitz, Sandra Duezel, Vera Regitz-Zagrosek, Denis Gerstorf, Elisabeth Steinhagen-Thiessen, Ilja Demuth, Matthias Endres
Summary: There is evidence of an association between levels of high-sensitivity cardiac troponin T (hs-cTnT) and cognitive decline in older men, as measured by the Digit Symbol Substitution Test (DSST). This association remained significant even after adjusting for age, sex, education, and cardiovascular risk factors. However, there was no significant association between hs-cTnT and different cognitive domains at baseline.
Article
Clinical Neurology
Regina von Rennenberg, Juliane Herm, Thomas Krause, Simon Hellwig, Helena Stengl, Jan F. Scheitz, Thomas Elgeti, Sebastian N. Nagel, Matthias Endres, Karl Georg Haeusler, Christian H. Nolte
Summary: This study found that elevated cardiac biomarkers, such as high-sensitivity cardiac troponin T (hs-cTnT) and brain natriuretic peptide (BNP), in acute stroke patients are strongly associated with pathological findings on cardiac magnetic resonance imaging (CMR). The elevation of these biomarkers may help identify patients who require a more comprehensive cardiology work-up.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Marios K. Georgakis, Rong Fang, Marco Duering, Frank A. Wollenweber, Felix J. Bode, Sebastian Stoesser, Christine Kindlein, Peter Hermann, Thomas G. Liman, Christian H. Nolte, Lucia Kerti, Benno Ikenberg, Kathleen Bernkopf, Holger Poppert, Wenzel Glanz, Valentina Perosa, Daniel Janowitz, Michael Wagner, Katja Neumann, Oliver Speck, Laura Dobisch, Emrah Duezel, Benno Gesierich, Anna Dewenter, Annika Spottke, Karin Waegemann, Michael Goertler, Silke Wunderlich, Matthias Endres, Inga Zerr, Gabor Petzold, Martin Dichgans
Summary: The global burden of small vessel disease (SVD) predicts cognitive and functional outcomes in stroke patients, but the current score used for assessment does not improve prediction capability. Assessing the severity of SVD lesions adds value in predicting outcomes beyond known predictors.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Maerit Jensen, Susanne Sehner, Bastian Cheng, Eckhard Schlemm, Fanny Quandt, Ewgenia Barow, Karl Wegscheider, Florent Boutitie, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Vincent Thijs, Robin Lemmens, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Goetz Thomalla, Christian Gerloff
Summary: The study found that intravenous alteplase may have a potential benefit for health-related quality of life (HRQoL) beyond its effect on functional outcome.
Article
Clinical Neurology
Anke Wouters, Lauranne Scheldeman, Hannelore Liessens, Patrick Dupont, Florent Boutitie, Bastian Cheng, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Christian Gerloff, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Vincent Thijs, Goetz Thomalla, Robin Lemmens
Summary: This study aimed to explore the sex-based differences in acute ischemic stroke within the WAKE-UP trial. It was found that women, compared to men, were older, had higher baseline NIHSS scores, and smoked less frequently. However, the treatment effect of alteplase on mRS scores was not modified by sex.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Tim Bastian Braemswig, Madeleine Kusserow, Barbara Bellmann, Frederik Beckhoff, Markus Reinthaler, Regina von Rennenberg, Hebun Erdur, Jan F. Scheitz, Ivana Galinovic, Kersten Villringer, David M. Leistner, Heinrich J. Audebert, Matthias Endres, Ulf Landmesser, Karl Georg Haeusler, Jochen B. Fiebach, Alexander Lauten, Andreas Rillig, Christian H. Nolte
Summary: New cerebral microbleeds (CMBs) occur in approximately one third of patients after catheter based structural heart interventions, and longer procedure duration may be a risk factor for new CMBs.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Biology
Hana Haseljic, Soumick Chatterjeeb, Robert Frysch, Vojtech Kulvait, Vladimir Semshchikov, Bennet Hensenj, Frank Wackerj, Inga Brueschk, Thomas Wernckej, Oliver Speck, Andreas Nuernberger, Georg Rose
Summary: Model-based reconstruction with TST improves dynamic perfusion imaging of the liver using CBCT. Accurate liver segmentation is required for applying TST with prior knowledge from CT perfusion data. Turbolift learning sequentially trains a modified Attention UNet on different liver segmentation tasks, achieving significant improvement in liver segmentation from CBCT TST. This research demonstrates the potential of segmenting the liver from CT, CBCT, and CBCT TST for visualizing and evaluating perfusion maps in liver disease treatment.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Clinical Neurology
Lauranne Scheldeman, Anke Wouters, Jeroen Bertels, Patrick Dupont, Bastian Cheng, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Christian Gerloff, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Vincent Thijs, Goetz Thomalla, Robin Lemmens
Summary: The study aims to investigate the reversibility of diffusion-weighted imaging (DWI) lesions and its association with thrombolysis, reperfusion, and functional outcomes. It found that reversibility of DWI lesions is common in patients from the WAKE-UP trial, and it is more pronounced after thrombolysis.
Article
Clinical Neurology
Benedikt Frey, Farhad Shenas, Florent Boutitie, Bastian Cheng, Tae-Hee Cho, Martin Ebinger, Matthias B. Endres, Jochen Fiebach, Jens Fiehler, Ivana Galinovic, Ewgenia Barow, Alina Koenigsberg, Eckhard Schlemm, Salvador Pedraza, Robin Lemmens, Vincent W. Thijs, Keith Muir, Norbert Z. Nighoghossian, Claus Simonsen, Christian Gerloff, Goetz Thomalla, WAKE-UP Investigators
Summary: This study aimed to evaluate the impact of white matter hyperintensities burden on the efficacy and safety of thrombolysis in stroke patients with unknown onset. The results showed that WMH burden was associated with worse functional outcome, but did not increase the risk of hemorrhagic transformation. In patients with severe WMH, intravenous thrombolysis was associated with a higher likelihood of excellent outcome without a significant increase in the rate of hemorrhagic transformation.
Article
Clinical Neurology
Nils Heinzinger, Anne Maass, David Berron, Renat Yakupov, Oliver Peters, Jochen Fiebach, Kersten Villringer, Lukas Preis, Josef Priller, Eike Jacob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Claudia Bartels, Frank Jessen, Franziska Maier, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Killimann, Doreen Goeerss, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Michael T. Heneka, Frederic Brosseron, Laura Dobisch, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Steffen Wolfsgruber, Luca Kleineidam, Matthias Schmid, Moritz Berger, Emrah Duezel, Gabriel Ziegler
Summary: This study used voxel-based morphometry to validate the classification system of Alzheimer's disease biomarkers. The results showed that early amyloid conversion is associated with brain volume loss, supporting the monotonic progression model of the amyloid-tau-neurodegeneration (ATN) system.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Simon Hellwig, Thomas Krause, Jan F. Scheitz, Juliane Herm, Ulrike Grittner, Nadja Jauert, Jochen B. Fiebach, Mario Kasner, Wolfram Doehner, Matthias Endres, Rolf Wachter, Thomas Elgeti, Christian H. Nolte, Karl Georg Haeusler
Summary: This study compared the rate of pathological findings in patients with acute ischemic stroke (AIS) between enhanced diagnostic workup and routine diagnostic care. The results showed that enhanced diagnostic workup yielded a higher rate of pathological findings and reduced the proportion of patients with cryptogenic stroke.
STROKE AND VASCULAR NEUROLOGY
(2023)
Article
Environmental Sciences
Babak Alikhani, Hans-Juergen Raatschen, Frank Wacker, Thomas Werncke
Summary: The study evaluated the image quality of ADMIRE using image texture and visual impression as supplements to physical parameters. It found that the Haralick texture parameters, contrast and entropy, decreased with increasing ADMIRE levels, but still offered comparable image quality to FBP with a dose reduction of up to 50%. The low-contrast detectability improved with higher ADMIRE levels, and the spatial resolution was retained even with a 90% dose reduction. Taking texture analysis and visual perception into account allows for a more realistic assessment of ADMIRE's dose reduction potential beyond physical measurements alone.
JOURNAL OF RADIOLOGICAL PROTECTION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sarah C. Scharm, Cornelia Schaefer-Prokop, Hinrich B. Winther, Carolin Huisinga, Thomas Werncke, Jens Vogel-Claussen, Frank K. Wacker, Hoen-Oh Shin
Summary: This study presents the initial experience and evaluation of a modified chest CT protocol and photon-counting CT (PCCT) for comprehensive analysis of pulmonary vasculature, perfusion, ventilation, and morphologic structure. The results demonstrate the robustness and efficiency of the proposed PCCT protocol in simultaneously evaluating multiple functional parameters of the lungs.
Article
Clinical Neurology
Anke Wouters, Lauranne Scheldeman, Hannelore Liessens, Patrick Dupont, Florent Boutitie, Bastian Cheng, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Christian Gerloff, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Vincent Thijs, Goetz Thomalla, Robin Lemmens
Summary: This study aimed to explore the differences between women and men in acute ischemic stroke. The results showed that although there were more men in the WAKE-UP trial, sex did not modify the treatment effect of alteplase.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)