☆ 4.6 Editorial Material

About Brugada syndrome and its prevalence

EUROPACE (2012)

Journal

EUROPACE

Volume 14, Issue 7, Pages 925-928

Publisher

OXFORD UNIV PRESS

DOI: 10.1093/europace/eus042

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Cardiac & Cardiovascular Systems

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Article Genetics & Heredity

Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Julien Barc, Rafik Tadros, Charlotte Glinge, David Y. Chiang, Mariam Jouni, Floriane Simonet, Sean J. Jurgens, Manon Baudic, Michele Nicastro, Franck Potet, Joost A. Offerhaus, Roddy Walsh, Seung Hoan Choi, Arie O. Verkerk, Yuka Mizusawa, Soraya Anys, Damien Minois, Marine Arnaud, Josselin Duchateau, Yanushi D. Wijeyeratne, Alison Muir, Michael Papadakis, Silvia Castelletti, Margherita Torchio, Cristina Gil Ortuno, Javier Lacunza, Daniela F. Giachino, Natascia Cerrato, Raphael P. Martins, Oscar Campuzano, Sonia Van Dooren, Aurelie Thollet, Florence Kyndt, Andrea Mazzanti, Nicolas Clementy, Arnaud Bisson, Anniek Corveleyn, Birgit Stallmeyer, Sven Dittmann, Johan Saenen, Antoine Noel, Shohreh Honarbakhsh, Boris Rudic, Halim Marzak, Matthew K. Rowe, Claire Federspiel, Sophie Le Page, Leslie Placide, Antoine Milhem, Hector Barajas-Martinez, Britt-Maria Beckmann, Ingrid P. Krapels, Johannes Steinfurt, Bo Gregers Winkel, Reza Jabbari, Moore B. Shoemaker, Bas J. Boukens, Doris Skoric-Milosavljevic, Hennie Bikker, Federico C. Manevy, Peter Lichtner, Marta Ribases, Thomas Meitinger, Martina Muller-Nurasyid, Jan H. Veldink, Leonard H. van den Berg, Philip Van Damme, Daniele Cusi, Chiara Lanzani, Sidwell Rigade, Eric Charpentier, Estelle Baron, Stephanie Bonnaud, Simon Lecointe, Audrey Donnart, Herve Le Marec, Stephanie Chatel, Matilde Karakachoff, Stephane Bezieau, Barry London, Jacob Tfelt-Hansen, Dan Roden, Katja E. Odening, Marina Cerrone, Larry A. Chinitz, Paul G. Volders, Maarten P. van de Berg, Gabriel Laurent, Laurence Faivre, Charles Antzelevitch, Stefan Kaab, Alain Al Arnaout, Jean-Marc Dupuis, Jean-Luc Pasquie, Olivier Billon, Jason D. Roberts, Laurence Jesel, Martin Borggrefe, Pier D. Lambiase, Jacques Mansourati, Bart Loeys, Antoine Leenhardt, Pascale Guicheney, Philippe Maury, Eric Schulze-Bahr, Tomas Robyns, Jeroen Breckpot, Dominique Babuty, Silvia G. Priori, Carlo Napolitano, Carlo de Asmundis, Pedro Brugada, Ramon Brugada, Elena Arbelo, Josep Brugada, Philippe Mabo, Nathalie Behar, Carla Giustetto, Maria Sabater Molina, Juan R. Gimeno, Can Hasdemir, Peter J. Schwartz, Lia Crotti, Pascal P. McKeown, Sanjay Sharma, Elijah R. Behr, Michel Haissaguerre, Frederic Sacher, Caroline Rooryck, Hanno L. Tan, Carol A. Remme, Pieter G. Postema, Mario Delmar, Patrick T. Ellinor, Steven A. Lubitz, Jean-Baptiste Gourraud, Michael W. Tanck, Alfred L. George, Calum A. MacRae, Paul W. Burridge, Christian Dina, Vincent Probst, Arthur A. Wilde, Jean-Jacques Schott, Richard Redon, Connie R. Bezzina

Summary: This study identifies new susceptibility loci for Brugada syndrome through a genome-wide association meta-analysis. Functional studies suggest that microtubule-related trafficking effects on sodium channel expression may be an underlying molecular mechanism. These findings provide new insights into the genetic architecture and molecular underpinnings of Brugada syndrome.

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Article Cardiac & Cardiovascular Systems

Fractionated Epicardial Electrograms Implication for Mechanism of the Brugada Pattern

Anna Sarcon, Henry Hsia, Pieter G. Postema, Arthur A. M. Wilde, Bence Patocskai, Jose M. Di Diego, Charles Antzelevitch, Melvin Scheinman

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