Review
Medicine, General & Internal
Andrzej Osiecki, Waclaw Kochman, Klaus K. K. Witte, Malgorzata Manczak, Robert Olszewski, Dariusz Michalkiewicz
Summary: Right ventricular apical pacing is associated with progressive deterioration of left ventricular systolic function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Christopher E. D. Saunderson, Maria F. Paton, Louise A. E. Brown, John Gierula, Pei G. Chew, Arka Das, Anshuman Sengupta, Thomas P. Craven, Amrit Chowdhary, Aaron Koshy, Hazel White, Eylem Levelt, Erica Dall'Armellina, Pankaj Garg, Klaus K. Witte, John P. Greenwood, Sven Plein, Peter P. Swoboda
Summary: The presence of fibrosis detected on CMR is associated with immediate- and medium-term deterioration in left ventricular function following RV pacing. These patients did not experience improvement in quality of life, biomarkers, or functional class after pacemaker implantation. Fibrosis detected on CMR could be used to identify those at risk of heart failure before pacemaker implantation.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Francesco Bruno, Isabel Munoz Pousa, Francesco Saia, Matteo Pio Vaira, Enrico Baldi, Pier Pasquale Leone, Pilar Cabanas-Grandio, Nicola Corcione, Enrico Guido Spinoni, Gianmarco Annibali, Caterina Russo, Matteo Ziacchi, Carlo Alberto Caruzzo, Marco Ferlini, Giuseppe Lanzillo, Ovidio De Filippo, Veronica Dusi, Guglielmo Gallone, Davide Castagno, Giuseppe Patti, Michele La Torre, Giuseppe Musumeci, Arturo Giordano, Giulio Stefanini, Stefano Salizzoni, Federico Conrotto, Mauro Rinaldi, Roberto Rordorf, Emad Abu-Assi, Sergio Raposeiras-Roubin, Mauro Biffi, Fabrizio D'Ascenzo, Gaetano Maria De Ferrari
Summary: This study aims to evaluate the impact of high degree of right ventricular pacing on adverse outcomes in patients with permanent pacemaker implantation after transcatheter aortic valve replacement (TAVR). The study found that high degree of right ventricular pacing was associated with increased risk of heart failure and cardiovascular death. Therefore, in TAVR patients, opportunities to minimize right ventricular pacing could be explored to improve prognosis and cardiac function.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Bela Merkely, Robert Hatala, Jerzy K. Wranicz, Gabor Duray, Csaba Foldesi, Zoltan Som, Marianna Nemeth, Kinga Goscinska-Bis, Laszlo Geller, Endre Zima, Istvan Osztheimer, Levente Molnar, Julia Karady, Gerhard Hindricks, Ilan Goldenberg, Helmut Klein, Matyas Szigeti, Scott D. Solomon, Valentina Kutyifa, Attila Kovacs, Annamaria Kosztin, BUDAPEST CRT Upgrade Invest
Summary: De novo implanted cardiac resynchronization therapy with defibrillator (CRT-D) reduces the risk of morbidity and mortality in patients with left bundle branch block, heart failure and reduced ejection fraction (HFrEF). However, among HFrEF patients with right ventricular pacing (RVP), the efficacy of CRT-D upgrade is uncertain.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Toshinori Chiba, Takatsugu Kajiyama, Yusuke Kondo, Noriko Suzuki, Masahiro Nakano, Miyo Nakano, Ryo Ito, Mari Kitagawa, Masafumi Sugawara, Yutaka Yoshino, Satoko Ryuzaki, Yukiko Takanashi, Yuya Komai, Yoshio Kobayashi
Summary: This study aimed to evaluate the association of right ventricular fractional area change (RVFAC) with appropriate implantable cardioverter-defibrillator (ICD) therapy. The study found that right ventricular dysfunction (low RVFAC) may be associated with an increased risk of appropriate ICD therapy.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Zefeng Wang, Xiao Du, Liting Cheng, Zhuo Liang, Ruiqing Dong, Fei Hang, Jieruo Chen, Xinlu Wang, Ziyu Wang, Junjun Chen, Yongquan Wu, Junmeng Zhang
Summary: This study aims to compare the efficacy and safety of left bundle branch area pacing (LBBaP) versus right ventricular apex pacing (RVAP) in patients with atrioventricular block (AVB) through a single-center, randomized controlled superiority trial. The primary outcome measure is left ventricular ejection fraction (LVEF), with secondary outcomes including measures of cardiac synchrony, NT-proBNP levels, and quality of life. The results of this trial will be disseminated at national and international conferences, with the hypothesis that LBBaP will be superior to RVAP for treating AVB patients.
Article
Cardiac & Cardiovascular Systems
Xiaofei Li, Junmeng Zhang, Chunguang Qiu, Zhao Wang, Hui Li, Kunjing Pang, Yan Yao, Zhimin Liu, Ruiqin Xie, Yangxin Chen, Yongquan Wu, Xiaohan Fan
Summary: Left bundle branch area pacing (LBBAP) may reduce the risk of heart failure hospitalization or upgrade to biventricular pacing compared to right ventricular pacing (RVP) in patients with atrioventricular block requiring a high burden of ventricular pacing. The difference in clinical outcomes between LBBAP and RVP was mainly observed in patients with high ventricular pacing burden or baseline lower LVEF levels. Independent predictors of the primary outcome included LBBAP, previous myocardial infarction, and baseline LVEF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Eugene S. J. Tan, Rodney Soh, Jie-Ying Lee, Elaine Boey, Kian-Hui Ho, Shana Aguirre, Jhobeleen de Leon, Siew-Pang Chan, Swee-Chong Seow, Pipin Kojodjojo
Summary: This study evaluated the differences in clinical outcomes between two different methods of cardiac pacing. The results showed that His-bundle pacing significantly reduced the occurrence of adverse clinical outcomes and should be the preferred pacing modality.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Michio Ogano, Ippei Tsuboi, Yu-ki Iwasaki, Jun Tanabe, Wataru Shimizu
Summary: This study found that predictors of QRS prolongation during RV apical pacing include baseline QRS duration, interventricular septum thickness, left atrial diameter, and E/e' ratio. The QRS duration during RV pacing is largely influenced by underlying structural heart diseases rather than the pacing site.
Article
Cardiac & Cardiovascular Systems
Tasneem Z. Naqvi, Chieh-Ju Chao
Summary: This review discusses the deleterious effects of chronic right ventricular (RV) pacing on cardiac function, including the development of arrhythmias, heart failure, and cardiac mortality. The adverse effects of RV pacing are more pronounced in patients with pre-existing left ventricular dysfunction. The review also explores the mechanisms, risk factors, clinical and echocardiographic features, and strategies to minimize RV pacing-induced cardiac dysfunction based on the latest data.
TRENDS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Brittany M. Navarre, Katie L. Clouthier, Xuhuai Ji, Anne Taylor, Chad S. Weldy, Anne M. Dubin, Sushma Reddy
Summary: Chronic ventricular pacing in children with congenital complete AV block (CCAVB) can lead to pacing-induced cardiomyopathy (PICM). This study evaluated the miR profile associated with chronic right ventricular pacing and identified potential miRs for longitudinal monitoring. The results showed differentially regulated miRs between paced children and controls, with both adaptive and maladaptive miR signaling predicted. Greater profibrotic signaling and sodium and calcium channel dysregulation were observed in patients paced for more than 10 years, particularly in a patient with sudden death. These miRs may be useful for early identification of adverse remodeling.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Review
Biology
Letizia Rosa Romano, Carmen Anna Maria Spaccarotella, Ciro Indolfi, Antonio Curcio
Summary: Common triggers for sudden cardiac death (SCD) include ischemia, hemodynamic fluctuations, neurocardiovascular influences, and environmental factors. Revascularization can prevent SCD and heart failure (HF) due to left ventricular dysfunction (LVD). Implantable cardioverter-defibrillator (ICD) is superior to antiarrhythmic drugs for patients with LVD and VT/VF. However, the management strategy for ICD and revascularization in patients with LVD is still debated.
Article
Biology
Mohammad Albatat, Hermenegild Arevalo, Jacob Bergsland, Vilde Strom, Ilangko Balasingham, Hans Henrik Odland
Summary: This study aimed to investigate the performance of a newly developed method to analyze electrical wavefront propagation in a heart model and compare it to clinical benchmark studies. The results demonstrated the utility of maximum activation front (MAF) in predicting optimal electrode placements in different pacing scenarios including scar and multi-site LV pacing, showing the potential value of computational simulations in understanding and planning CRT.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Parikshit S. Sharma, Neil R. Patel, Venkatesh Ravi, Dipen Zalavadia, Sujitraj Dommaraju, Varun Garg, Timothy R. Larsen, Angela M. Naperkowski, Jeremiah Wasserlauf, Kousik Krishnan, Wilson Young, Parash Pokharel, Jess W. Oren, Randle H. Storm, Richard G. Trohman, Henry D. Huang, Faiz A. Subzposh, Pugazhendhi Vijayaraman
Summary: This study compared the clinical outcomes between LBBAP and RVP in patients undergoing pacemaker implantation, showing that LBBAP resulted in improved clinical outcomes, especially in patients with higher burden of ventricular pacing.
Review
Biochemistry & Molecular Biology
Sean P. Gaine, Hugh Calkins
Summary: In the English summary, the authors highlight the important role of antiarrhythmic medications in reducing ventricular arrhythmias in ARVC patients. However, they note that current prescribing practices are based on expert opinion and extrapolation from other diseases due to the lack of high-quality studies with consistent methodology. The authors call for further research to improve management and ensure evidence-based prescribing of antiarrhythmic drugs in ARVC.