Article
Cardiac & Cardiovascular Systems
Hirosuke Yamaji, Souhei Kawafuji, Masaya Sano, Shunichi Higashiya, Takashi Murakami, Hiroshi Kawamura, Masaaki Murakami, Shigeshi Kamikawa, Shozo Kusachi
Summary: This study identified a small solitary atrial fractionated EGM (SAFE) zone using fractionation mapping in patients with persistent atrial fibrillation (perAF) and longstanding persistent AF (ls-perAF). In 5.8% of patients, a small SAFE zone was identified and ablation of this zone successfully terminated AF in all patients. The AF/atrial tachycardia-free rate at follow-up was 93% at 6 months, demonstrating the importance of this zone as a substrate for perpetuated AF.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Wen-Rui Shi, Shao-Hui Wu, Guang-Chen Zou, Kai Xu, Wei-Feng Jiang, Yu Zhang, Mu Qin, Xu Liu
Summary: This study used multiscale entropy (MSE) analysis to guide catheter ablation for persistent atrial fibrillation (PsAF) and predict ablation outcomes. The results showed that the RA < LA mMSE gradient before ablation could predict freedom from arrhythmia.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Antonio Frontera, Luca Rosario Limite, Stefano Pagani, Manuela Cireddu, Kostantinos Vlachos, Claire Martin, Masateru Takigawa, Takeshi Kitamura, Felix Bourier, Ghassen Cheniti, Thomas Pambrun, Frederic Sacher, Nicolas Derval, Meleze Hocini, Alfio Quarteroni, Paolo Della Bella, Michel Haissaguerre, Pierre Jais
Summary: This study investigated the mechanisms of bipolar EGM fragmentation in patients with atrial fibrillation during sinus rhythm. The results indicated that fragmentation can occur above a voltage threshold of 0.5 mV, with slow conduction being the main mechanism, followed by wavefront collision and pivot points.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Urszula Hangiel, Jacek Kusnierz, Aleksander Bardyszewski, Dobromila Dzwonkowska, Magdalena Polanska-Skrzypczyk, Pawel Derejko
Summary: The aim of this study was to evaluate the beat-to-beat variability of bipolar atrial electrogram amplitude in patients undergoing atrial fibrillation ablation. The results showed significant variability in the amplitude, particularly during remapping.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Seigo Yamashita, Michifumi Tokuda, Saagar Mahida, Hidenori Sato, Hirotsugu Ikewaki, Hirotsuna Oseto, Masaaki Yokoyama, Ryota Isogai, Kenichi Tokutake, Kenichi Yokoyama, Ryohsuke Narui, Mika Kato, Shin-ichi Tanigawa, Ken-ichi Sugimoto, Michihiro Yoshimura, Teiichi Yamane
Summary: The study compared long-term outcomes between linear ablation and EGM-guided ablation for PsAF, demonstrating superior arrhythmia-free survival with linear ablation after the initial and last procedure. EGM-guided ablation and longer AF duration remained as independent predictors of atrial arrhythmia recurrence. Linear ablation may be a more effective complementary technique to PVI than EGM-guided ablation for PsAF ablation.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Diego Osorio, Aikaterini Vraka, Aurelio Quesada, Fernando Hornero, Raul Alcaraz, Jose J. Rieta
Summary: This study developed a novel optimized method for detecting Local Activation Waves (LAWs) in Complex Fractionated Atrial Electrograms (CFAEs). By introducing a new preprocessing technique and modifying the band-pass filter, the method showed high efficiency in accurately detecting LAWs in CFAEs.
Article
Cardiac & Cardiovascular Systems
Shin Yoo, Markus Rottmann, Jason Ng, David Johnson, Bassel Shanab, Anna Pfenniger, Gail Elizabeth Geist, Suman Mandava, Amy Burrell, Wenwei Zhang, Andrew Wasserstrom, Bradley P. Knight, Rod Passman, Jeffrey J. Goldberger, Rishi Arora
Summary: By studying the relationship between electrogram morphology recurrence (EMR) and AF electrogram parameters and tissue characteristics in a canine AF model, it was found that EMR may be a viable therapeutic target for persistent AF.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Jeffrey J. Goldberger, Ghaith Zaatari, Raul D. Mitrani, Catherine Blandon, Jorge Bohorquez, Jason Ng, Justin Ng, Alex Velasquez, Litsa Lambrakos, Rishi Arora
Summary: Introduction: Multiple analysis techniques evaluate electrograms during atrial fibrillation (AF), but none have been established to guide catheter ablation. This study compares electrogram properties recorded from multiple right (RA) and left atrial (LA) sites. Methods: Multisite LA/RA mapping (281 +/- 176/239 +/- 166 sites/patient) was performed in 42 patients (30 males, age 63 +/- 9 years) undergoing first (n = 32) or redo-AF ablation (n = 10). All electrogram recordings were visually reviewed and artifactual signals were excluded leaving a total of 21 846 for analysis. Electrogram characteristics evaluated were cycle length (CL), amplitude, Shannon's entropy (ShEn), fractionation interval, dominant frequency, organizational index, and cycle length of most recurrent morphology (CLR) from morphology recurrence plot analysis. Results: Electrogram characteristics were correlated to each other. All pairwise comparisons were significant (p < .001) except for dominant frequency and CLR (p = .59), and amplitude and dominant frequency (p = .38). Only ShEn and fractionation interval demonstrated a strong negative correlation (r = -.94). All other pairwise comparisons were poor to moderately correlated. The relationships are highly conserved among patients, in the RA versus LA, and in those undergoing initial versus redo ablations. Antiarrhythmic drug therapy did not have a significant effect on electrogram characteristics, except minimum ShEn. Electrogram characteristics associated with ablation outcome were shorter minimum CLR, lower minimum ShEn, and longer mimimum CL. There was minimal overlap between the top 10 sites identified by one electrogram characteristic and the top 10 sites identified by the other 10 characteristics. Conclusion: Multiple techniques can be employed for electrogram analysis in AF. In this analysis of eight different electrogram characteristics, seven were poorly to moderately correlated and do not identify similar locations. Only some characteristics were predictive of ablation outcome. Further studies to consider electrogram properties, perhaps in combination, for categorizing and/or mapping AF are warranted.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Chin-Yu Lin, Yenn-Jiang Lin, Men-Tzung Lo, Chia-Hsin Chiang, Yun-Yu Chen, Ling Kuo, Shih-Lin Chang, Li-Wei Lo, Yu-Feng Hu, Tze-Fan Chao, Fa-Po Chung, Jo-Nan Liao, Ting-Yung Chang, Chen Lin, Ta-Chuan Tuan, Cheng-I. Wu, Chih-Min Liu, Shin-Huei Liu, Wen-Han Cheng, Isaiah C. Lugtu, Ankit Jain, An Nu-Khanh Ton, Dony Yugo Hermanto, Shih-Ann Chen
Summary: This article provides supplemental digital content.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ghaith Zaatari, Raul Mitrani, Jorge Bohorquez, Jason Ng, Justin Ng, Harold Rivner, Alex Velasquez, Litsa Lambrakos, Rishi Arora, Jeffrey J. Goldberger
Summary: This study compared the recurrence of electrogram morphology in the left and right atria in patients undergoing initial and repeat ablation for persistent atrial fibrillation. The results showed that electrogram morphology recurrence was mainly observed in the left atrium, and the shortest cycle length recurrence occurred during the initial ablation process. Most sites had low recurrence, suggesting that they may not be critical for maintaining atrial fibrillation.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Gregory F. Michaud, William G. Stevenson
Summary: A 63-year-old healthy male with atrial fibrillation presents with symptoms of dyspnea and irregular heartbeat. Physical examination reveals high blood pressure, irregular pulse, and ECG confirms atrial fibrillation. Further evaluation and treatment plan are needed.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Engineering, Biomedical
Amina Ghrissi, Douglas Almonfrey, Fabien Squara, Johan Montagnat, Vicente Zarzoso
Summary: The study aims to automate the identification of spatiotemporal dispersion patterns in EGMs of atrial fibrillation patients using machine learning. Four data formats were considered and classification results show that automatically extracting features with VGG16 yields comparable results to classifying raw EGM recordings.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2022)
Article
Multidisciplinary Sciences
Ines Assum, Julia Krause, Markus O. Scheinhardt, Christian Mueller, Elke Hammer, Christin S. Boerschel, Uwe Voelker, Lenard Conradi, Bastiaan Geelhoed, Tanja Zeller, Renate B. Schnabel, Matthias Heinig
Summary: This study integrates genomics, transcriptomics, and proteomics data to investigate the consequences of genetic variants for transcript and protein levels in atrial tissue. The authors reveal the regulatory network underlying atrial fibrillation and provide a resource for cardiac gene prioritization.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Sen Liu, Jiacheng He, Aiguo Wang, Cuiwei Yang
Summary: In this study, an adaptive system for atrial fibrillation (AF) detection based on electrocardiogram (ECG) was proposed. The system achieved improved accuracy and performance through the use of transfer learning and data augmentation techniques. After model adaptation and post-processing, the detection accuracy was significantly improved. The results demonstrate that this method can promote research on AF detection based on atrial activity.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2024)
Article
Engineering, Biomedical
Tiago P. Almeida, Diogo C. Soriano, Michela Mase, Flavia Ravelli, Arthur S. Bezerra, Xin Li, Gavin S. Chu, Joao Salinet, Peter J. Stafford, G. Andre Ng, Fernando S. Schlindwein, Takashi Yoneyama
Summary: Utilizing unsupervised classification and AEG-derived markers, five distinct classes of AEGs were identified with significant differences in characteristics, potentially offering a more comprehensive substrate characterization for ablation target identification in future clinical studies.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Po-Lin Hsu, Sean J. Cheng, Richard C. Saumarez, William N. Dawes, Richard A. McMahon
Article
Cardiac & Cardiovascular Systems
Richard C. Saumarez, Mariusz Pytkowski, Maciej Sterlinski, John P. Bourke, Jonathan R. Clague, Stuart M. Cobbe, Derek T. Connelly, Michael J. Griffith, Pascal P. McKeown, Karen Mcleod, John M. Morgan, Nicolas Sadoul, Lidia Chojnowska, Christopher L. -H. Huang, Andrew A. Grace
EUROPEAN HEART JOURNAL
(2008)
Letter
Cardiac & Cardiovascular Systems
Richard Saumarez, John Silberbauer, Jack Scannell, Mariusz Pytkowski, Nicolas Peters
Article
Cardiac & Cardiovascular Systems
Richard C. Saumarez, Mariusz Pytkowski, Maciej Sterlinski, Richard N. W. Hauer, Richard Derksen, Martin D. Lowe, Hannah Szwed, Christopher L. -H. Huang, David E. Ward, A. John Camm, Andrew A. Grace
Article
Cardiac & Cardiovascular Systems
I Turner, CLH Huang, RC Saumarez
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2005)
Article
Neurosciences
R Balasubramaniam, AA Grace, RC Saumarez, JI Vandenberg, CLH Huang
JOURNAL OF PHYSIOLOGY-LONDON
(2003)
Article
Cardiac & Cardiovascular Systems
RC Saumarez, L Chojnowska, R Derksen, M Pytkowski, M Sterlinski, CLH Huang, N Sadoul, RNW Hauer, W Ruzyllo, AA Grace
Article
Multidisciplinary Sciences
GA Papadatos, PMR Wallerstein, CEG Head, R Ratcliff, PA Brady, K Benndorf, RC Saumarez, AEO Trezise, CLH Huang, JI Vandenberg, WH Colledge, AA Grace
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2002)
Article
Peripheral Vascular Disease
N Carter, H Snieder, S Jeffery, R Saumarez, C Varma, L Antoniades, TD Spector
JOURNAL OF HUMAN HYPERTENSION
(2000)