Article
Biochemistry & Molecular Biology
Jeremy Charriot, Maeva Zysman, Laurent Guilleminault, Mathilde Volpato, Aurelie Fort-Petit, Isabelle Vachier, Jeremy Patarin, Carey Suehs, Engi Ahmed, Nicolas Molinari, Arnaud Bourdin
Summary: This study aims to provide an objective biomarker for guiding the prescription of azithromycin in COPD patients, by using sputum rheology to assess their condition and reduce antibiotic exposure. The study is a multicentric, randomized, controlled trial with 36 patients, having a one-year follow-up to evaluate the number of COPD exacerbations as the primary outcome.
Article
Critical Care Medicine
Charles R. Esther, Wanda K. O'Neal, Wayne H. Anderson, Mehmet Kesimer, Agathe Ceppe, Claire M. Doerschuk, Neil E. Alexis, Annette T. Hastie, R. Graham Barr, Russell P. Bowler, J. Michael Wells, Elizabeth C. Oelsner, Alejandro P. Comellas, Yohannes Tesfaigzi, Victor Kim, Laura M. Paulin, Christopher B. Cooper, MeiLan K. Han, Yvonne J. Huang, Wassim W. Labaki, Jeffrey L. Curtis, Richard C. Boucher
Summary: This study identified altered physiologic pathways associated with COPD airway pathophysiologic features through the analysis of sputum samples. Several biomarkers were found to be correlated with disease severity and predicted exacerbations in COPD patients.
Article
Veterinary Sciences
Alanna Farrell, Kevin Kersh, Rachel Liepman, Katarzyna A. Dembek
Summary: A colic survival scoring system was developed and validated in a study involving 67 horses with acute abdominal pain. The system showed high sensitivity and specificity in predicting survival outcomes, indicating its potential clinical utility for equine practices.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Dayna Jodzio, Sally DeNotta, Caryn Plummer, Chris Sanchez
Summary: The study aims to evaluate the horse grimace scale (HGS) and behavior pain score (BPS) in hospitalized horses with ocular disease, hypothesizing that HGS and BPS would be associated with different clinical progressions.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Genetics & Heredity
Eric Van Buren, Giorgia Radicioni, Sarah Lester, Wanda K. K. O'Neal, Hong Dang, Silva Kasela, Suresh Garudadri, Jeffrey L. L. Curtis, MeiLan K. K. Han, Jerry A. Krishnan, Emily S. S. Wan, Edwin K. K. Silverman, Annette Hastie, Victor E. Ortega, Tuuli Lappalainen, Martijn C. C. Nawijn, Maarten van den Berge, Stephanie A. A. Christenson, Yun Li, Michael H. H. Cho, Mehmet Kesimer, Samir N. P. Kelada
Summary: Excessive mucus production is a defining feature of chronic obstructive pulmonary disease (COPD), and recent studies have identified genetic variants associated with the concentration of key proteins in mucus. In particular, a variant on chromosome 11 that affects MUC5B concentration has been linked to COPD features such as chronic bronchitis and acute exacerbations. The findings suggest that genetic variation influences mucus protein concentrations and may impact COPD outcomes.
Article
Surgery
Oscar Akesson, Isak Heyman, Jan Johansson, Pehr Rissler, Dan Falkenback
Summary: This study used early endoscopic assessment and a novel endoscopy score system to predict anastomotic complications after esophagectomy, with the results showing that the combined endoscopy score was the only predictor and an accurate tool for predicting anastomotic complications.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Microbiology
Diego A. Rojas, Carolina A. Ponce, Adriel Bustos, Vicente Cortes, Daniela Olivares, Sergio L. Vargas
Summary: Inflammation and mucus hypersecretion are common features of chronic respiratory diseases. Pneumocystis infection can aggravate disease by activating pathways that induce airway pathology. This study demonstrates that Pneumocystis is a co-factor for disease severity in an elastase-induced COPD model, highlighting the relevance of the STAT6 pathway in Pneumocystis pathogenesis.
Article
Cell Biology
Hataitip Tasena, Wim Timens, Maarten van den Berge, Joy van Broekhuizen, Brian K. Kennedy, Machteld N. Hylkema, Corry-Anke Brandsma, Irene H. Heijink
Summary: The identified miRNAs, including miR-708-5p, let-7a-5p, miR-31-5p, and miR-146a-5p, play important roles in the communication between fibroblasts and epithelium in COPD-related CMH. miR-708-5p directly regulates mucin production, while let-7a-5p, miR-31-5p, and miR-146a-5p may be involved in CMH via fibroblasts-epithelium crosstalk, including extracellular matrix gene regulation. These findings provide insights into the miRNA-mediated mechanisms underlying CMH, an important symptom in COPD.
Review
Medicine, General & Internal
Trevor Tabone, Anastasios Koulaouzidis, Pierre Ellul
Summary: Colon capsule endoscopy is increasingly recognized as a safe diagnostic tool, especially in the context of reduced endoscopy services. It allows for standardization of reporting and reproducibility through various scores, and can be used to monitor inflammatory bowel disease activity and for colorectal cancer screening.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Reena Khanna, Christopher Ma, Malcolm Hogan, Guangyong Zou, Talat Bessissow, Brian Bressler, Jean-Frederic Colombel, Silvio Danese, Marco Daperno, James E. East, Lawrence Hookey, Edward V. Loftus Jr, John W. D. Mcdonald, Remo Panaccione, Laurent Peyrin-Biroulet, Matt Rutter, Bruce E. Sands, Serverine Vermerire, Julie Remillard, Stefanie C. McFarlane, William J. Sandborn, Geert R. D'Haens, Brian G. Feagan, Vipul Jairath
Summary: This study aimed to define appropriate items for evaluating endoscopic activity and conventions for consistent endoscopic scoring rules in Crohn's disease (CD). The results showed that ulcers, narrowing, and healing should be included in the endoscopic scoring, while scarring and inflammatory polyps should not. The optimal method for defining ulcer depth remains uncertain. This study identified priorities for future research to develop a more representative endoscopic index for CD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Respiratory System
Miguel J. Divo, Congjian Liu, Francesca Polverino, Peter J. Castaldi, Bartolome R. Celli, Yohannes Tesfaigzi
Summary: A predictive model consisting of FEV1/FVC, smoking history, BMI, and symptoms of chronic bronchitis can help identify middle-aged smokers at high risk of developing chronic airflow limitation.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Allergy
Philippe Gevaert, Jarno De Craemer, Claus Bachert, Manon Blauwblomme, Adam Chaker, Cemal Cingi, Peter W. Hellings, Claire Hopkins, Valerie Hox, Wytske J. Fokkens, Ludger Klimek, Valerie Lund, Ralph Moesges, Joaquim Mullol, Oliver Pfaar, Glenis Scadding, Peter Valentin Tomazic, Thibaut Van Zele, Stephan Vlaminck, Martin Wagenmann, Sanna Toppila-Salmi, Isam Alobid
Summary: Nasal endoscopy is an important tool for both diagnosis and monitoring of chronic rhinosinusitis with nasal polyps (CRSwNP). Unlike patient-reported outcomes, endoscopic nasal polyp scoring provides an objective measurement that is not influenced by the placebo effect. It is a safer and more cost-effective alternative to computed tomography imaging for assessing the extent of the disease.
Article
Gastroenterology & Hepatology
Mao Matsubayashi, Taku Kobayashi, Shinji Okabayashi, Masaru Nakano, Shintaro Sagami, Ryo Ozaki, Hiroki Kiyohara, Hiromu Morikubo, Kunio Asonuma, Yusuke Miyatani, Shin Maeda, Toshifumi Hibi
Summary: CSUC score can predict relapse within one year in UC patients during clinical remission, especially when used 6 months after induction treatment.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Surgery
Ilay Habaz, Silvana Perretta, Allan Okrainec, Anton Svendrovski, Ludovica Guerriero, Fabio Longo, Pietro Mascagni, Ethan Weiss, Louis W. C. Liu, Lee L. Swanstrom, Eran Shlomovitz
Summary: The study developed a scoring system to evaluate user performance in endoscopic training. Results from retrospective and prospective analysis showed that the scoring system can effectively distinguish between experts and trainees, correlate with other endoscopic skill assessment systems, and have good reliability. Prospective testing using the scoring system demonstrated significant differences in average scores between the expert group and the trainee group.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Veterinary Sciences
Chiara Maria Lo Feudo, Luca Stucchi, Elena Alberti, Giovanni Stancari, Bianca Conturba, Enrica Zucca, Francesco Ferrucci
Summary: This study found that horses with SEA and MEA + EIPH had higher ultrasonographic scores, which were associated with increased BALf neutrophils and hemosiderophages. PLH scores were higher in younger horses affected by SEA and MEA, and associated with increased eosinophils and hemosiderophages. TM and TB scores were greater in older horses affected by SEA, associated with increased neutrophils, and inversely correlated with hemosiderophages. In addition, TM grade was negatively correlated with mast cells. Thoracic ultrasonography and airway endoscopy can provide valuable information about the inflammatory status of upper and lower airways in horses.
VETERINARY SCIENCES
(2021)
Article
Multidisciplinary Sciences
Maria B. Ospina, Don Voaklander, Ambikaipakan Senthilselvan, Michael K. Stickland, Malcolm King, Andrew W. Harris, Brian H. Rowe
Article
Environmental Sciences
William A. Suk, Hamid Ahanchian, Kwadwo Ansong Asante, David O. Carpenter, Fernando Diaz-Barriga, Eun-Hee Ha, Xia Huo, Malcolm King, Mathuros Ruchirawat, Emerson R. da Silva, Leith Sly, Peter D. Sly, Renato T. Stein, Martin van den Berg, Heather Zar, Philip J. Landrigan
ENVIRONMENTAL HEALTH PERSPECTIVES
(2016)
Article
Public, Environmental & Occupational Health
Heather Castleden, Robert Watson, Ella Bennett, Jeffrey Masuda, Malcolm King, Miriam Stewart
PREVENTING CHRONIC DISEASE
(2016)
Article
Public, Environmental & Occupational Health
Gustavo Zayas, Ming C. Chiang, Eric Wong, Fred MacDonald, Carlos F. Lange, Ambikaipakan Senthilselvan, Malcolm King
Editorial Material
Psychiatry
Malcolm King
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2011)
Review
Respiratory System
Maria B. Ospina, Donald C. Voaklander, Michael K. Stickland, Malcolm King, Ambikaipakan Senthilselvan, Brian H. Rowe
CANADIAN RESPIRATORY JOURNAL
(2012)
Article
Respiratory System
Richard Long, Vernon Hoeppner, Pamela Orr, Martha Ainslie, Malcolm King, Sylvia Abonyi, Maria Mayan, Dennis Kunimoto, Deanne Langlois-Klassen, Courtney Heffernan, Angela Lau, Dick Menzies
CANADIAN RESPIRATORY JOURNAL
(2013)
Article
Obstetrics & Gynecology
Richard T. Oster, Malcolm King, Donald W. Morrish, Maria J. Mayan, Ellen L. Toth
BMC PREGNANCY AND CHILDBIRTH
(2014)
Article
Public, Environmental & Occupational Health
Rob Watson, Heather Castleden, Jeffrey Masuda, Malcolm King, Miriam Stewart
PREVENTING CHRONIC DISEASE
(2012)
Article
Respiratory System
Gustavo Zayas, Ming C. Chiang, Eric Wong, Fred MacDonald, Carlos F. Lange, Ambikaipakan Senthilselvan, Malcolm King
BMC PULMONARY MEDICINE
(2012)
Letter
Public, Environmental & Occupational Health
Marie Noel-Brune, Fiona C. Goldizen, Maria Neira, Martin van den Berg, Nancy Lewis, Malcolm King, William A. Suk, David O. Carpenter, Robert G. Arnold, Peter D. Sly
LANCET GLOBAL HEALTH
(2013)
Article
Public, Environmental & Occupational Health
Ambikaipakan Senthilselvan, Selvanayagam John Niruban, Malcolm King, Carina Majaesic, Paul Veugelers, Lory Laing, Brian H. Rowe
CANADIAN JOURNAL OF PUBLIC HEALTH-REVUE CANADIENNE DE SANTE PUBLIQUE
(2015)
Letter
Public, Environmental & Occupational Health
Malcolm King
CANADIAN JOURNAL OF PUBLIC HEALTH-REVUE CANADIENNE DE SANTE PUBLIQUE
(2015)
Article
Nursing
Miriam Stewart, Malcolm King, Roxanne Blood, Nicole Letourneau, Jeffrey R. Masuda, Sharon Anderson, Lisa Bourque Bearskin
CANADIAN JOURNAL OF NURSING RESEARCH
(2013)
Article
Public, Environmental & Occupational Health
Susan Chatwood, Jessica Bytautas, Anthea Darychuk, Peter Bjerregaard, Adalsteinn Brown, Donald Cole, Howard Hu, Micheal Jong, Malcolm King, Siv Kvernmo, Jeremy Veillard
INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH
(2013)