Review
Neurosciences
Benjamin L. Zaepfel, Jeffrey D. Rothstein
Summary: ALS is a progressive and fatal neurodegenerative disease that affects motor neurons, with familial and genetic components. Studies suggest dysregulated RNA metabolism and RNA toxicity may contribute to the degeneration of neurons. Current research focuses on toxic RNA as a potential initiator of disease, defects in disease-linked RNA metabolism pathways, and potential RNA-based therapies.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Medicine, Research & Experimental
Xin-qiu Song, Qian Li, Jing Zhang
Summary: DLG5 is a scaffold molecule for signal transduction complexes, responsible for assembling receptors and adapters. It stabilizes adhesion and tight bonding complexes and is involved in maintaining epithelial polarity. It has been linked to the onset and development of several diseases, impacting cancer progression through interactions with various signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Immunology
Kehinde Adebayo Babatunde, Oluwadamilola Fatimat Adenuga
Summary: Neutrophils play an important role in malaria, both in the defense against the malaria parasite and in the pathogenesis of the disease. However, malaria parasites inhibit the antimicrobial function of neutrophils, which may make malaria patients more susceptible to bacterial infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Haixia Ji, Wenzhe Wang, Xia Li, Xiaoying Han, Xinyu Zhang, Juan Wang, Changxiao Liu, Luqi Huang, Wenyuan Gao
Summary: This review discusses the role of the p53 gene in regulating ferroptosis, primarily through influencing metabolic networks and signaling pathways that affect tumor cell sensitivity to ferroptosis. This has important implications for further understanding the role of p53 in tumor ferroptosis and developing new strategies for cancer treatment.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Nutrition & Dietetics
Rachel Marion-Letellier, Mathilde Leboutte, Asma Amamou, Maitreyi Raman, Guillaume Savoye, Subrata Ghosh
Summary: Intestinal fibrosis is a major complication of inflammatory bowel diseases, especially Crohn's disease, for which effective treatments are lacking. Diet may play a role in influencing the predisposition to develop intestinal fibrosis or alter its natural history by modifying the host immune response and intestinal microbial composition. Further studies are needed to investigate the effects of dietary factors on IBD-induced intestinal fibrosis and potential therapies to inhibit or promote fibrosis factors in the gut.
Editorial Material
Hematology
Brian D. Friend
Summary: In this study, the authors demonstrate that treatment intensification and improved supportive care measures have significantly improved long-term survival for childhood AML survivors. However, they also highlight the unwanted effects of treatment intensification, including increased burden of late effects and toxicity in recent patients.
Review
Biochemistry & Molecular Biology
Chengfei Xu, Ziling Liu, Jiangwei Xiao
Summary: Ferroptosis is a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation. It has unique biological processes and pathophysiological characteristics compared to other forms of cell death. Understanding the role of ferroptosis in disease progression, particularly in gastrointestinal diseases, has potential implications for novel therapeutic interventions in clinical settings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Qiu Yan, Yong Zhang, Qi Wang, Ligang Yuan
Summary: Autophagy is an important cell reprogramming mechanism in the testes, playing a crucial role in spermatogenesis, testicular endocrinology, and the function of SCs and LCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Rachel L. Washburn, Taylor Hibler, Gurvinder Kaur, Jannette M. Dufour
Summary: Sertoli cells serve a dual role in protecting germ cells from autoimmune destruction and activating immune responses against infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Chen Sun, Yunze Han, Ruoyu Zhang, Simon Liu, Jing Wang, Yuqing Zhang, Xuemei Chen, Chao Jiang, Junmin Wang, Xiaochong Fan, Jian Wang
Summary: COVID-19 infection triggers regulated necrosis under low apoptosis condition, releasing cytokines and cell contents, leading to severe inflammation. Understanding the mechanism of regulated necrosis in COVID-19 can help in assessing disease severity, prognosis, and guiding treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Anil Kumar, Adeleh Taghi Khani, Ashly Sanchez Ortiz, Srividya Swaminathan
Summary: GM-CSF is a cytokine that drives the generation of myeloid cell subsets in response to stress, infections, and cancers. The levels of GM-CSF can either promote or inhibit cancer aggressiveness, depending on the specific conditions. The impact of GM-CSF signaling on cancer progression varies depending on the levels of GM-CSF, the cancer type, and the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Li Peng, Guangqiang Hu, Qianfang Yao, Jianming Wu, Ziyang He, Betty Yuen-Kwan Law, Guishan Hu, Xiaogang Zhou, Junrong Du, Anguo Wu, Lu Yu
Summary: This paper summarizes the beneficial and harmful effects of microglia in ischemic stroke (IS). Additionally, it discusses the interplay between microglia autophagy and ischemic inflammation, along with its application in IS treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Development Studies
Tassew Woldehanna, Yisak Tafere, Manex B. Yonis
Summary: This study analyzes the impact of social capital on sustained poverty escapes in Ethiopia. It finds that families able to escape poverty possess a combination of material wealth, human, political, and social capital. However, maintaining social capital can also have negative effects, leading to indebtedness for some families.
Review
Oncology
Nafiseh Behranvand, Farzad Nasri, Zolfaghari Emmameh, Pouria Khani, Asieh Hosseini, Johan Garssen, Reza Falak
Summary: Chemotherapy is a well-known and effective treatment for cancers, but its efficiency in eradicating all cancer cells falls short of expectations. Research suggests that alterations in the tumor microenvironment's physiological conditions may contribute to this. Using mild anti-inflammatory drugs during chemotherapy could potentially lead to more successful clinical outcomes.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Review
Cell Biology
Fangli Zhou, Xiaoli Sun
Summary: The role of cholesterol in HCC and its association with the pathogenesis of NAFLD-related HCC is complex, and conflicting research results suggest that further studies are needed to clarify their relationship.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Mathematics, Applied
Yajun Mao, Zhihai Rong, Zhi-Xi Wu
Summary: This study examines how individuals' diverse collective influence affects the evolution of cooperation in the evolutionary prisoner's dilemma game on scale-free networks. It suggests that influential cooperators at medium or small degrees are able to spread their behaviors more efficiently among neighbors, promoting the emergence of cooperation. The combination of time scale mechanism plays a crucial role in bridging the feedback between strategy-updating time scale and individual performance.
APPLIED MATHEMATICS AND COMPUTATION
(2021)
Article
Mathematical & Computational Biology
Xinchun Zhou, Ningning Ma, Benseng Song, Zhixi Wu, Guangyao Liu, Liwei Liu, Lianchun Yu, Jianfeng Feng
Summary: The optimal organization for functional segregation and integration in the brain is evident through the small-world feature of functional connectivity networks, supported by critical neural dynamics. The critical dynamics play a crucial role in forming an optimal organization of FC networks in the brain, potentially applicable to understanding abnormal FC configurations in neuropsychiatric disorders.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2021)
Article
Engineering, Civil
Wen Su, Haifeng Zhang, Quan Zhou, Wenzhen Yang, Zengfu Wang
Summary: This paper proposes a method for monocular depth estimation using an information exchange convolutional neural network, effectively integrating local and global context, and improving supervision signals and feature representation.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2021)
Article
Mathematics, Interdisciplinary Applications
Bin-Quan Li, Zhi-Xi Wu, Jian-Yue Guan
Summary: This paper introduces an extended model based on the snowdrift game model to study the impact of inequality on the evolution of cooperation. The study finds that within the limited resource range, the larger the resource is, the larger the critical proportion of benefits that defectors can exploit. Inequality is stronger in social structures with sparse connections and weaker in those with dense connections. Introducing incentives and punishments makes it harder for cooperators to get a fair share of the profits.
CHAOS SOLITONS & FRACTALS
(2022)
Article
Physics, Multidisciplinary
Liang Zhang, Chao-Ran Cai, Ji-Qiang Zhang, Xu-Sheng Liu, Chong-Yang Wang, Zhi-Xi Wu
Summary: Linear mapping is commonly used in dynamic modeling and empirical data analysis, but it is not effective when time intervals are large. This study proposes a theoretical framework that provides a nonlinear mapping between continuous and discrete-time dynamics by considering the coupling effects of multiple events. The effectiveness of the proposed mapping is verified using classical epidemic models.
Article
Mathematics, Applied
Cong Liu, Chong-Yang Wang, Zhi-Xi Wu, Han-Xin Yang, Jian-Yue Guan
Summary: This study reveals that a moderate degree of diversity can significantly enhance the collective response of coupled extended systems. It demonstrates that the standard deviation and the ratio of negative entities jointly modulate diversity-induced resonance, and the coexistence of negative and positive entities is a prerequisite for this resonant behavior.
Article
Mechanics
Ze-Hao Chen, Zhi-Xi Wu, Jian-Yue Guan
Summary: In this study, a floor field cellular automaton model is used to investigate the bidirectional pedestrian flow in a straight corridor. A game-theoretical framework is introduced to handle conflicts between pedestrians, where they can act as cooperators or defectors depending on their responses to conflicts. The study explores the effects of different parameters (delta, corridor width, anticipation floor field parameter) on pedestrian dynamics and identifies resonance-like behavior in average separation time. The research provides valuable insights into lane formation, jam dissolution, and the design of efficient policies for pedestrian flow.
JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT
(2022)
Article
Mathematics, Interdisciplinary Applications
Bin-Quan Li, Zhi-Xi Wu, Jian-Yue Guan
Summary: This paper describes the phenomenon of alternating rotation of coordinated and anti-coordinated behaviors using environmental feedback dynamics, and derives the conditions for the stability of these behaviors. The research findings suggest that stochastic noise plays a crucial role in the alternating rotation phenomenon.
CHAOS SOLITONS & FRACTALS
(2022)
Article
Physics, Multidisciplinary
Peng-Bi Cui, Zhi-Xi Wu, Tao Zhou
Summary: Self-regulation and government regulation, community policing and external powerful forces are vital components of the global economy and social management. The implementation of self-regulation or community policing requires disciplined members, while government or external forces are more likely to intervene. Addressing both dilemmas and supporting altruistic individuals remains a significant challenge.
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2022)
Article
Mathematics, Applied
Cong Liu, Zhi-Xi Wu, Chong-Yang Wang, Han-Xin Yang, Jian-Yue Guan
Summary: The study shows that astrocytes can listen to the talk between neurons, give advice, and contribute to heterogeneous couplings. The research focuses on the regulation function of astrocytes and explores the role of heterogeneous couplings among neuron-astrocyte components in signal response.
Article
Automation & Control Systems
Kezan Li, Mengchen Wang, Qi Yang, Yi Qin, Haifeng Zhang
Summary: In this article, a new nonlinear stochastic network model is proposed to achieve successive lag synchronization. Both constant and adaptive pinning control strategies are designed to regulate the synchronization. The theoretical results are validated through numerical simulations.
INTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL
(2023)
Article
Engineering, Electrical & Electronic
Zhixi Wu, Jiajiang Sun, Yujin Song, Jin Zhao
Summary: A novel open-circuit fault diagnosis method for the four-wire T-type three-level rectifier (four-wire 3LT(2)R) is proposed in this article, considering power factor regulation. The diagnostic method is designed based on the deep analysis of the relationship between the power factor and the working interval of the transistor. The faults with different features related to the size of working intervals are detected using the zero current in each phase current, and the fault transistor is located according to the polarities of the currents and the modulated voltages, without additional sensors.
IEEE JOURNAL OF EMERGING AND SELECTED TOPICS IN POWER ELECTRONICS
(2023)
Article
Computer Science, Interdisciplinary Applications
Jia-Wei Wang, Hai-Feng Zhang, Xiao-Jing Ma, Jing Wang, Chuang Ma, Pei-Can Zhu
Summary: In this paper, a privacy-preserving framework named HE-ranking is proposed to identify influential nodes in networks based on homomorphic encryption protocol. The method collaboratively computes the nodes' importance and protects the sensitive information of each private network, effectively identifying the influential nodes while preserving privacy.
INTERNATIONAL JOURNAL OF MODERN PHYSICS C
(2023)
Article
Physics, Multidisciplinary
Hong-Yi Ma, Cong Liu, Zhi-Xi Wu, Jian-Yue Guan
Summary: A balance in nature is maintained through the coexistence of multiple species via interspecific competition. The evolutionary dynamics of cyclic interactions in nature involve different biological behaviors. The stability of ecosystems is influenced by the external environment, which affects the biological behavior. In this study, we investigated how periodic changes in the external environment affect interspecific competition and its evolutionary dynamics.
Proceedings Paper
Automation & Control Systems
Min Chu, Jin Zhao, YuJin Song, ZhiXi Wu, XinZhong Ding
Summary: This paper proposes an integration fault diagnosis approach for a three-level inverter feeding induction motor, combining signal-driven and data-driven methods. By analyzing the current paths under different situations and using the average values and ratios of positive and negative currents as the input features of a neural network, the effectiveness of the proposed method is verified through experiments.
2022 41ST CHINESE CONTROL CONFERENCE (CCC)
(2022)
