Journal
EPILEPSY RESEARCH
Volume 105, Issue 3, Pages 396-400Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.eplepsyres.2013.03.007
Keywords
Sodium pump; Epilepsy; Convulsion; Phosphorylation
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Funding
- Fapergs [10/0685-8, 11/1630-1]
- CNPq
- PIBIC
- Capes
- PBDA/Unipampa
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The present study aimed to investigate whether Na+,K+-ATPase activity and phosphorylation state of the catalytic alpha subunit are altered by pentylenetetrazol (PTZ)-induced seizures. PTZ (30, 45 or 60 g/kg, i.p.) was administered to adult male Swiss mice, and Na+,K+-ATPase activity and phosphorylation state were measured in the cerebral cortex 15 min after PTZ administration. Na+,K+-ATPase activity significantly decreased after PTZ-induced seizures (60 mg/kg). Immunoreactivity of phosphorylated Ser943 at alpha subunit was increased after PTZ-induced seizures. A significant positive correlation between Na+,K+-ATPase activity and latency to myoclonic jerks and generalized seizures was found. Conversely, a strong negative correlation between Ser943 phosphorylation and latency to generalized seizures was detected. Given the role of Na+,K+-ATPase as a major regulator of brain excitability, Ser943 at Na+,K+-ATPase a subunit may represent a potentially valuable new target for drug development for seizure disorders. (C) 2013 Elsevier B.V. All rights reserved.
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