Journal
EPILEPSY RESEARCH
Volume 87, Issue 1, Pages 102-105Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.eplepsyres.2009.07.009
Keywords
Tuberous Sclerosis Complex; Transcranial Magnetic Stimulation; Functional cortical connectivity
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Abnormal connectivity might be involved in the pathophysiology of Tuberous Sclerosis Complex (TSC). We used twin-coil Transcranial Magnetic Stimulation protocol to investigate connectivity between posterior parietal cortex (PPC) and motor cortex (M1) in TSC patients. In comparison with healthy subjects and TSC patients treated with antiepileptic drugs, non-medicated TSC patients exhibited abnormal excitability of PPC-M1 connection. Such altered connectivity might play a role in TSC epileptic phenotype. (C) 2009 Elsevier B.V. All rights reserved.
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