Article
Clinical Neurology
Dana Marafi, Jawid M. Fatih, Rauan Kaiyrzhanov, Matteo P. Ferla, Charul Gijavanekar, Aljazi Al-Maraghi, Ning Liu, Emily Sites, Hessa S. Alsaif, Mohammad Al-Owain, Mohamed Zakkariah, Ehab El-Anany, Ulviyya Guliyeva, Sughra Guliyeva, Colette Gaba, Ateeq Haseeb, Amal M. Alhashem, Enam Danish, Vasiliki Karageorgou, Christian Beetz, Alaa A. Subhi, Sureni Mullegama, Erin Torti, Monisha Sebastin, Margo Sheck Breilyn, Susan Duberstein, Mohamed S. Abdel-Hamid, Tadahiro Mitani, Haowei Du, Jill A. Rosenfeld, Shalini N. Jhangiani, Zeynep Coban Akdemir, Richard A. Gibbs, Jenny C. Taylor, Khalid A. Fakhro, Jill Hunter, Davut Pehlivan, Maha S. Zaki, Joseph G. Gleeson, Reza Maroofian, Henry Houlden, Jennifer E. Posey, V. Reid Sutton, Fowzan S. Alkuraya, Sarah H. Elsea, James R. Lupski
Summary: SLC38A3 is a novel disease gene for developmental and epileptic encephalopathy, and the likely pathophysiology of the disease is perturbations in glutamine homeostasis.
Article
Neurosciences
Dillon J. McGovern, Abigail M. Polter, David H. Root
Summary: Glutamate and GABA are the main excitatory and inhibitory neurotransmitters of the nervous system, with distinct inputs to VTA glutamate neurons participating in reward and aversion-based behaviors. Through the use of genetically-encoded fluorescent indicators, the study identified differential and dynamic signaling of glutamate and GABA inputs to VTA glutamate neurons in response to reward and aversion cues and outcomes, shedding light on the neurochemical mechanisms underlying motivated behaviors. The research provides foundational evidence linking specific neurotransmitters to the regulation of motivated behaviors by VTA glutamate neurons.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Michael Dietrich, Hans-Peter Hartung, Philipp Albrecht
Summary: 4-aminopyridine is used as a symptomatic therapy in various neurological disorders, with potential neuroprotective features beyond its symptomatic action, particularly in patients with multiple sclerosis.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Zhengxiang Cai, Abbas Sohrabpour, Haiteng Jiang, Shuai Ye, Boney Joseph, Benjamin H. Brinkmann, Gregory A. Worrell, Bin He
Summary: High-frequency oscillations (HFOs) serve as a promising biomarker for localizing epileptogenic brain and guiding successful neurosurgery. The consistent concurrence of HFOs with epileptiform spikes (pHFOs) offers a tractable means to automatically identify pathological HFOs, enhancing presurgical diagnosis and postsurgical evaluation. This method shows significant improvements in localization of epileptogenic tissue and surgical outcomes, particularly in patients with multitype spikes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Sina Hafizi, Tarek K. Rajji
Summary: This review proposes a conceptual model that links 12 potentially modifiable risk factors for dementia with Excitation-Inhibition (E -I) imbalance. The model aims to address the current knowledge gap and provides a framework for future studies in dementia prevention, discovery of new biomarkers, and development of new interventions.
AGEING RESEARCH REVIEWS
(2023)
Article
Medicine, Research & Experimental
Kouji Fukuyama, Motohiro Okada
Summary: In this study, we investigated the effects of high-frequency oscillation (HFO) on synaptic transmission, astroglial expression, and intracellular signaling in a rat model of carbamazepine-resistant epilepsy. We found that HFO increased glutamate release and activated signaling pathways in astrocytes. These findings suggest that HFO may contribute to the development of epilepsy by enhancing astroglial transmission and signaling activation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
B. Spurny-Dworak, M. B. Reed, P. Handschuh, T. Vanicek, M. Spies, W. Bogner, R. Lanzenberger
Summary: Seasonal changes in neurotransmitter systems were explored in 159 healthy individuals, and the results indicated that glutamate and GABA levels remain stable throughout the year in healthy individuals, without the need for seasonal correction.
HUMAN BRAIN MAPPING
(2023)
Article
Chemistry, Analytical
Nicolaie Moldovan, Iuliu-Ioan Blaga, Sanjeev Billa, Imran Hossain, Chenggong Gong, Claire E. Jones, Teresa A. Murray, Ralu Divan, Shabnam Siddiqui, Prabhu U. Arumugam
Summary: Glutamate (GLU) and gamma-aminobutyric acid (GABA) play crucial roles in signal transmission in the brain. Imbalances in GLU-GABA homeostasis are linked to brain disorders, and a silicon multifunctional biosensor microarray probe has been developed for real-time simultaneous GLU-GABA detection with high sensitivity and selectivity in vivo.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Neurosciences
Luke Ziolkowski, Isaac Mordukhovich, Daniel M. Chen, Mariangela Chisari, Hong-Jin Shu, Peter M. Lambert, Mingxing Qian, Charles F. Zorumski, Douglas F. Covey, Steven Mennerick
Summary: Neuroactive steroids are emerging as a new class of drugs for treating neuropsychiatric disorders, with effects on ligand-gated neurotransmitter receptors being a major mechanism of action. MQ-221, a sulfated, 3 beta-hydroxy neurosteroid analogue, inhibits NMDAR function while potentiating GABA(A)R function, showing potentially unique and clinically desirable effects. It may represent a new class of compound with unique psychoactive effects and beneficial prospects for treating neuropsychiatric disorders.
Article
Neurosciences
B. Spurny, T. Vanicek, R. Seiger, M. B. Reed, M. Kloebl, V Ritter, J. Unterholzner, G. M. Godbersen, L. R. Silberbauer, D. Pacher, S. Klug, M. E. Konadu, G. Gryglewski, S. Trattnig, W. Bogner, R. Lanzenberger
Summary: The study focused on investigating the effects of associative relearning and SSRI treatment on GABAergic and glutamatergic function, revealing a significant interaction effect on hippocampal and thalamic Glx/tCr levels following SSRI treatment.
Article
Neurosciences
Yanez Lopez Maria, Anthony N. Price, Nicolaas A. J. Puts, Emer J. Hughes, Richard A. E. Edden, Grainne M. McAlonan, Tomoki Arichi, Enrico De Vita
Summary: The balance between inhibitory and excitatory neurotransmitter systems, as well as the protective role of the antioxidant glutathione, play a crucial role in early brain development. Using edited MRS techniques, specific regional differences in neurochemical substances were identified in the neonatal brain, showing the unique features of GABA+ in neonates compared to adults. This method can provide important insight into the pathophysiology of neurodevelopmental disorders.
Article
Pharmacology & Pharmacy
Chuqiao Pan, Shijie Mao, Zeping Xiong, Zhao Chen, Ning Xu
Summary: Glutamate dehydrogenase (GDH) is a key enzyme in mammalian glutamate metabolism, participating in multiple metabolic pathways and cellular activities. Its dysfunction may lead to various neurodegenerative diseases. Activators and gene therapy targeting GDH have shown potential in protecting neurons and improving motor disorders caused by glutamate metabolism disorders. This approach offers new insights and treatment strategies for neurodegenerative diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Food Science & Technology
Yucui Zhang, Ming Zhang, Ting Li, Xinxia Zhang, Li Wang
Summary: Quinoa, when subjected to cold stress treatment, showed a significant increase in GABA content, making it a promising functional food with enhanced bioactive ingredients.
Review
Medicine, General & Internal
Beatriz Sousa, Joao Martins, Miguel Castelo-Branco, Joana Goncalves
Summary: Transcranial direct current stimulation (tDCS) has been proposed as a promising therapy for neurodevelopmental disorders by modulating excitatory and/or inhibitory activity to restore the balance disrupted in these disorders. Clinical studies show positive effects of tDCS treatment on behavior and cognition, but further research and optimization of treatment protocols are needed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Juan Guo, Mingzi Ran, Zilong Gao, Xinxin Zhang, Dan Wang, Huiming Li, Shiyi Zhao, Wenzhi Sun, Hailong Dong, Ji Hu
Summary: The study reveals that during anaesthetic-induced loss of consciousness, there is a general decrease in cortical GABA transmission and variations in glutamate transmission among different cell types, indicating a disrupted excitatory-inhibitory network leading to consciousness loss.
Review
Neurosciences
Massimo Avoli, Maxime Levesque
Summary: This article reviews the role of GABA(B) receptors in focal epileptic disorders, including how GABA(B) receptor function affects seizure initiation and controls seizure-like discharges. Despite being less studied, GABA(B) receptors remain important in focal epilepsy research.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Physics, Applied
Margherita Ronchini, Milad Zamani, Hai Au Huynh, Yasser Rezaeiyan, Gabriella Panuccio, Hooman Farkhani, Farshad Moradi
Summary: Recent research shows the application of neuromorphic systems in processing biological signals and interfacing with biological tissues, primarily for automatic anomaly detection. This approach lightens the burden on healthcare professionals and enables on-site processing without the need for external processors. The study proposes a neuromorphic device implemented in CMOS technology for the detection of epileptic seizures, demonstrating promising results with low power consumption.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2022)
Article
Clinical Neurology
Maria Isabel Carreno-Munoz, Bidisha Chattopadhyaya, Kristian Agbogba, Valerie Cote, Siyan Wang, Maxime Levesque, Massimo Avoli, Jacques L. Michaud, Sarah Lippe, Graziella Di Cristo
Summary: Among the numerous genes associated with intellectual disability, SYNGAP1 stands out for its high frequency and penetrance of loss-of-function variants and the wide range of co-morbid disorders associated with its mutation. By studying mouse models, researchers have found specific alterations in auditory and visual processing caused by SYNGAP1 haploinsufficiency, as well as lack of habituation to repetitive auditory stimuli. These findings have also been validated in human patients, suggesting their potential as biomarkers for sensory-processing alterations associated with SYNGAP1 mutation.
Article
Neurosciences
Siyan Wang, Cristen Kfoury, Alexis Marion, Maxime Levesque, Massimo Avoli
Summary: Our study demonstrates that optogenetic stimulation of PV-positive interneurons can trigger epileptiform synchronization and onset, with increased frequency during 4AP application.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Neurosciences
Maxime Levesque, Siyan Wang, Guillaume Etter, Sylvain Williams, Massimo Avoli
Summary: Bilateral activation of PV interneurons in the hippocampus promotes seizures and high-frequency oscillations in a mouse model of mesial temporal lobe epilepsy.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Clinical Neurology
Simone Beretta, Alessandro Versace, Gianfranco Fiore, Marco Piola, Beatrice Martini, Vittorio Bigiogera, Lorenzo Coppadoro, Jacopo Mariani, Lorenzo Tinti, Silvia Pirovano, Laura Monza, Davide Carone, Matteo Riva, Giada Padovano, Gilda Galbiati, Francesco Santangelo, Marco Rasponi, Francesco Padelli, Isabella Giachetti, Domenico Aquino, Susanna Diamanti, Laura Librizzi, Maria Grazia Bruzzone, Marco De Curtis, Carlo Giussani, Erik P. Sganzerla, Carlo Ferrarese
Summary: The development of an intraventricular cooling device called V-COOL allows for targeted hypothermia in the affected cerebral hemisphere without significant effects on systemic temperature. The device effectively decreases cerebral cortical temperature in a flow rate-dependent manner, resulting in no significant differences in survival or neurological outcomes.
Article
Neurosciences
Massimo Avoli, Marco de Curtis, Maxime Levesque, Laura Librizzi, Laura Uva, Siyan Wang
Summary: Under physiological conditions, neuronal network synchronization can lead to specific EEG patterns related to behavioral and cognitive functions. However, excessive synchronization can cause epileptic activities. Experimental studies have found that GABA(A) signaling plays a paradoxical role in generating interictal discharges and initiating focal seizures. There is also evidence suggesting its involvement in epileptogenesis.
FRONTIERS IN NEURAL CIRCUITS
(2022)
Article
Clinical Neurology
Michael Wenzel, Gilles Huberfeld, David B. Grayden, Marco de Curtis, Andrew J. Trevelyan
Summary: A critical question in understanding the onset of focal seizures is whether specific cell classes can be identified as drivers of the pathological process. This topic was debated at the recent International Conference for Technology and Analysis of Seizures (ICTALS) meeting in Bern, Switzerland in July 2022, and we provide a summary here. Advances in manipulating subpopulations of cells in relative isolation, particularly through optogenetics, have fueled this debate in recent years. The motivation behind resolving this debate is to identify new targets for therapeutic interventions based on a deeper understanding of the etiology of seizures.
Article
Engineering, Biomedical
Margherita Ronchini, Yasser Rezaeiyan, Milad Zamani, Gabriella Panuccio, Farshad Moradi
Summary: This study introduces a fully-analog neuromorphic device implemented in CMOS technology for analyzing LFP signals in an in vitro model of acute ictogenesis. The developed system can detect ictal and interictal events with ms-latency and with high precision, consuming on average 3.50 nW during the task. The significance of this work lies in paving the way for a new generation of brain implantable devices for personalized closed-loop stimulation for epilepsy treatment.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Clinical Neurology
Gareth Morris, Massimo Avoli, Christophe Bernard, Kate Connor, Marco de Curtis, Chris G. Dulla, John G. R. Jefferys, Caterina Psarropoulou, Kevin J. Staley, Mark O. Cunningham
Summary: In vitro preparations offer valuable tools for studying and modeling seizures and epilepsy, as well as screening anti-seizure compounds. However, these models are simplifications of reality and have limitations. Therefore, a combination of in vitro models, in vivo studies, chronic epilepsy animal models, and human cell/tissue-derived preparations is recommended to maximize their potential value.
Article
Engineering, Biomedical
Davide Caron, Stefano Buccelli, Angel Canal-Alonso, Javad Farsani, Giacomo Pruzzo, Bernabe Linares Barranco, Juan Manuel Corchado, Michela Chiappalone, Gabriella Panuccio
Summary: The objective of this study is to evaluate the efficacy and robustness of an artificial bridge in controlling ictogenesis and restoring the functional connectivity of the hippocampal loop in the treatment of epilepsy. The main results show that the bridge significantly decreased or prevented ictal activity and recovered the functional connectivity of the hippocampal loop. The significance of this work lies in its potential to shift the conceptual design of stimulation devices for epilepsy treatment towards functional restoration of brain circuits.
JOURNAL OF NEURAL ENGINEERING
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Maria Isabel Carreno Munoz, Bidisha Chattopadhyaya, Kristian Agbogba, Valerie Cote, Siyan Wang, Maxime Levesque, Massimo Avoli, Jacques Michaud, Sarah Lippe, Graziella Di Cristo
JOURNAL OF NEUROCHEMISTRY
(2022)
Meeting Abstract
Cell & Tissue Engineering
Natalia Gostynska, Giulia Della Rosa, John Wesley Ephraim, Monica Moroni, Gabriella Panuccio, Nicola Tirelli, Gemma Palazzolo
TISSUE ENGINEERING PART A
(2022)
Article
Engineering, Electrical & Electronic
Dennis Christensen, Regina Dittmann, Bernabe Linares-Barranco, Abu Sebastian, Manuel Le Gallo, Andrea Redaelli, Stefan Slesazeck, Thomas Mikolajick, Sabina Spiga, Stephan Menzel, Ilia Valov, Gianluca Milano, Carlo Ricciardi, Shi-Jun Liang, Feng Miao, Mario Lanza, Tyler J. Quill, Scott T. Keene, Alberto Salleo, Julie Grollier, Danijela Markovic, Alice Mizrahi, Peng Yao, J. Joshua Yang, Giacomo Indiveri, John Paul Strachan, Suman Datta, Elisa Vianello, Alexandre Valentian, Johannes Feldmann, Xuan Li, Wolfram H. P. Pernice, Harish Bhaskaran, Steve Furber, Emre Neftci, Franz Scherr, Wolfgang Maass, Srikanth Ramaswamy, Jonathan Tapson, Priyadarshini Panda, Youngeun Kim, Gouhei Tanaka, Simon Thorpe, Chiara Bartolozzi, Thomas A. Cleland, Christoph Posch, Shihchii Liu, Gabriella Panuccio, Mufti Mahmud, Arnab Neelim Mazumder, Morteza Hosseini, Tinoosh Mohsenin, Elisa Donati, Silvia Tolu, Roberto Galeazzi, Martin Ejsing Christensen, Sune Holm, Daniele Ielmini, N. Pryds
Summary: This article introduces the characteristics and advantages of von Neumann architecture and neuromorphic computing systems. While traditional von Neumann architecture is powerful, it has high power consumption and cannot handle complex data. Neuromorphic computing systems, inspired by biological concepts, can achieve lower power consumption for storing and processing large amounts of digital information. The aim of this article is to provide perspectives on the current state and future challenges in the field of neuromorphic technology, and to provide a concise yet comprehensive introduction and future outlook for readers.
NEUROMORPHIC COMPUTING AND ENGINEERING
(2022)