Article
Clinical Neurology
Kayela Arrotta, Anny Reyes, Erik Kaestner, Carrie R. McDonald, Bruce P. Hermann, William B. Barr, Nehaw Sarmey, Swetha Sundar, Efstathios Kondylis, Imad Najm, William Bingaman, Robyn M. Busch
Summary: This study identified four cognitive phenotypes in frontal lobe epilepsy (FLE) that were largely indistinguishable in clinical and demographic features, aside from education and extent of epileptogenic zone.
Article
Environmental Sciences
Travis J. Beckwith, Kim N. Dietrich, John P. Wright, Mekibib Altaye, Kim M. Cecil
Summary: Childhood lead exposure is linked to decreased brain volumes in regions responsible for cognition and emotional regulation, which in turn are associated with increased rates of criminal arrests in adulthood.
ENVIRONMENTAL RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicolin Hainc, Mary Pat McAndrews, Taufik Valiante, Danielle M. Andrade, Richard Wennberg, Timo Krings
Summary: This study provides an updated description of the spectrum and frequency of dedicated 3T MRI findings in adult medically refractory epilepsy (MRE) patients at a tertiary epilepsy center, aiming to familiarize radiologists with potential imaging findings in this population.
INSIGHTS INTO IMAGING
(2022)
Article
Behavioral Sciences
Kayela Arrotta, Sara J. Swanson, Julie K. Janecek, Marla J. Hamberger, William B. Barr, Sallie Baxendale, Carrie R. McDonald, Anny Reyes, Bruce P. Hermann, Robyn M. Busch
Summary: This study applied the IC-CoDE classification to patients with frontal lobe epilepsy (FLE) and found higher rates of cognitive impairment compared to patients with temporal lobe epilepsy (TLE). The results demonstrate the applicability of IC-CoDE to epilepsy syndromes outside of TLE and highlight opportunities for further refinement of the IC-CoDE guidelines.
EPILEPSY & BEHAVIOR
(2023)
Article
Clinical Neurology
Pauline Samia, Nicholas Odero, Maureen Njoroge, Shem Ochieng, Jacqueline Mavuti, Sheila Waa, Samson Gwer
Summary: In a tertiary hospital in Nairobi, Kenya, a study found that up to a third of children with epilepsy who underwent MRI had abnormal findings, including encephalomalacia, cerebral atrophy, and disorders of neuronal migration. Clinical comorbidity and inter-ictal epileptiform activity on EEG were associated with abnormal imaging findings.
FRONTIERS IN NEUROLOGY
(2021)
Article
Behavioral Sciences
Lisa Ferguson, Margaret Miller, Alexander Whiting, Jennifer Haut, Patricia Klaas, William Bingaman, Deepak Lachhwani, Tara T. Lineweaver, Darlene Floden, Robyn M. Busch
Summary: After frontal lobe resection for pharmacoresistant epilepsy in pediatric patients, using reliable change indices, it was found that a large proportion did not show significant cognitive change in each domain. Postoperative cognitive improvement was most common in processing speed, while decline was most frequent in visuospatial skills. Factors such as younger age at surgery, older age at seizure onset, and higher baseline cognitive performance were associated with cognitive improvement or decline.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Davide Giampiccolo, Lawrence P. Binding, Lorenzo Caciagli, Roman Rodionov, Chris Foulon, Jane de Tisi, Alejandro Granados, Roisin Finn, Debayan Dasgupta, Fenglai Xiao, Beate Diehl, Emma Torzillo, Jan Van Dijk, Peter N. Taylor, Matthias Koepp, Andrew W. McEvoy, Sallie Baxendale, Fahmida Chowdhury, John S. Duncan, Anna Miserocchi
Summary: Around 50% of patients experience seizure freedom after frontal lobe surgery for drug-resistant epilepsy, but only about 30% maintain long-term seizure freedom. Early seizure recurrence may result from incomplete removal of the epileptogenic lesion, while delayed recurrence can still happen after complete excision. This suggests the presence of a common epileptogenic network that facilitates seizures in both nearby and distant dormant epileptic foci. Our study indicates that dysfunction within the thalamic and striatal networks may contribute to epileptogenesis, and disconnection of cortico-thalamostriatal pathways may underpin long-term seizure freedom.
Article
Clinical Neurology
Shefali Chaudhary, S. Senthil Kumaran, Vinay Goyal, M. Kalaivani, Gauri Shanker Kaloiya, Rajesh Sagar, Nalin Mehta, Achal Kumar Srivastava, N. R. Jagannathan
Summary: Through multi-voxel proton magnetic resonance spectroscopic imaging, it was found that metabolic alterations in the frontal lobe of cognitively impaired PD patients could be potential biomarkers for PD cognitive impairment, involving neuronal function loss, altered energy metabolism, and cholinergic neural transmission. These findings may serve as promising indicators for early diagnosis and monitoring of PD cognitive impairment.
NEUROLOGICAL SCIENCES
(2021)
Article
Neurosciences
Ke Xu, Xiongfei Wang, Jian Zhou, Yuguang Guan, Tianfu Li, Guoming Luan
Summary: This study investigates the clinical discrepancies and predictors of anterior temporal lobectomy (ATL) in children and adults with temporal lobe epilepsy (TLE). Significant differences in clinical manifestations, MRI examinations, number of preoperative AEDs, and pathologies were observed between TLE children and adults. The early complete resection of MRI-detected epileptogenic focus in TLE children predicts favorable seizure outcome, while the concordance of MRI-detected focus with EEG-detected epileptogenic zone predicts favorable seizure outcomes in TLE adults.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Olivia Goodkin, Hugh G. Pemberton, Sjoerd B. Vos, Ferran Prados, Ravi K. Das, James Moggridge, Bianca De Blasi, Philippa Bartlett, Elaine Williams, Thomas Campion, Lukas Haider, Kirsten Pearce, Nuria Bargallo, Esther Sanchez, Sotirios Bisdas, Mark White, Sebastien Ourselin, Gavin P. Winston, John S. Duncan, Jorge Cardoso, John S. Thornton, Tarek A. Yousry, Frederik Barkhof
Summary: This study found that using QReports of HS imaging biomarkers can improve rater accuracy and confidence, particularly in challenging bilateral cases. Improvements were seen across all raters, with large effect sizes, greatest for image analysts. These findings may have positive implications for clinical radiology services and justify further validation in larger groups.
EUROPEAN RADIOLOGY
(2021)
Article
Neurosciences
Yuchao Jiang, Wei Li, Yingjie Qin, Le Zhang, Xin Tong, Fenglai Xiao, Sisi Jiang, Yunfang Li, Qiyong Gong, Dong Zhou, Dongmei An, Dezhong Yao, Cheng Luo
Summary: This study used T1-weighted and T2-weighted MRI to investigate the myelination changes in temporal lobe epilepsy (TLE) patients. The mSCN analysis showed decreased myelination in frontotemporal regions, amygdala, and thalamus in both patient groups compared to healthy controls. Left TLE patients also had lower myelination in left medial temporal regions. The findings suggest that myelination alterations in TLE are related to epileptic seizures.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Aileen McGonigal
Summary: Frontal lobe seizures are debilitating and diverse, making them challenging to evaluate. Research has shown that motor symptoms reflect the hierarchical organization of the frontal lobe, aiding in presurgical localization. Distinguishing between different frontal sublobar regions is possible based on motor and emotional signs. The semiology of frontal lobe seizures also provides valuable in vivo human behavioral data for neuroscience.
JOURNAL OF NEUROLOGY
(2022)
Article
Behavioral Sciences
Keran Ma, Xiaonan Zhang, Chengru Song, Shaoqiang Han, Wenbin Li, Kefan Wang, Xinyue Mao, Yong Zhang, Jingliang Cheng
Summary: This study aimed to investigate abnormalities in topological properties in unilateral temporal lobe epilepsy (TLE) with hippocampal sclerosis and their correlations with cognitive functions. The results showed that patients with left TLE exhibited decreased clustering coefficient, global efficiency, and local efficiency, while patients with right TLE showed decreased local efficiency. In addition, right TLE had some compensatory nodes with reduced shortest path length in regions of the default mode network. These findings provide new insights into the effect of lateralization on TLE and help us understand the cognitive impairment of patients with TLE.
EPILEPSY & BEHAVIOR
(2023)
Article
Clinical Neurology
Alexander C. Whiting, Marcia Morita-Sherman, Manshi Li, Deborah Vegh, Brunno Machado de Campos, Fernando Cendes, Xiaofeng Wang, William Bingaman, Lara E. Jehi
Summary: This study demonstrates that preoperative cortical volume loss in both frontal and extrafrontal regions can be predictive of seizure outcome after frontal lobectomy, and models can be developed with excellent predictive capabilities using preoperative MRI data.
Article
Clinical Neurology
Ryan W. S. Wee, Adina Nash, Heather Angus-Leppan
Summary: This study aims to comprehensively phenotype frontal lobe epilepsy (FLE) and differentiate it from other epilepsy syndromes. The results show that FLE is distinct from generalized epilepsy and has differences in clinical features and EEG/MRI findings compared to temporal lobe epilepsy (TLE).
JOURNAL OF NEUROLOGY
(2023)
Article
Behavioral Sciences
Heidi I. L. Jacobs, Ed H. B. M. Gronenschild, Elisabeth A. T. Evers, Inez H. G. B. Ramakers, Paul A. M. Hofman, Walter H. Backes, Jelle Jolles, Frans R. J. Verhey, Martin P. J. Van Boxtel
Article
Gastroenterology & Hepatology
Doenja M. J. Lambregts, Luc A. Heijnen, Monique Maas, Iris J. G. Rutten, Milou H. Martens, Walter H. Backes, Robert G. Riedl, Frans C. H. Bakers, Vincent C. Cappendijk, Geerard L. Beets, Regina G. H. Beets-Tan
Article
Neurosciences
Maarten J. Vaessen, Jacobus F. A. Jansen, Marielle C. G. Vlooswijk, Paul A. M. Hofman, H. J. Marian Majoie, Albert P. Aldenkamp, Walter H. Backes
Article
Clinical Neurology
Hilde M. H. Braakman, Maarten J. Vaessen, Jacobus F. A. Jansen, Mariette H. J. A. Debeij-van Hall, Anton de Louw, Paul A. M. Hofman, Johan S. H. Vles, Albert P. Aldenkamp, Walter H. Backes
Article
Clinical Neurology
Geke M. Overuliet, Rene M. H. Besseling, Sylvie J. M. van der Kruijs, Johan S. H. Vles, Walter H. Backes, Jos G. Hendriksen, Saskia C. M. Ebus, Jacobus F. A. Jansen, Paul A. M. Hofman, Albert P. Aldenkamp
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2013)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bart D. van Rooijen, Anouk A. J. J. van der Lans, Boudewijn Brans, Joachim E. Wildberger, Felix M. Mottaghy, Patrick Schrauwen, Walter H. Backes, Wouter D. van Marken Lichtenbelt
INVESTIGATIVE RADIOLOGY
(2013)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martijn Wolters, Seyede G. Mohades, Tilman M. Hackeng, Mark J. Post, Marianne E. Kooi, Walter H. Backes
INVESTIGATIVE RADIOLOGY
(2013)
Review
Neurosciences
Saartje Burgmans, Harm J. van de Haar, Frans R. J. Verhey, Walter H. Backes
JOURNAL OF ALZHEIMERS DISEASE
(2013)
Article
Clinical Neurology
Sylvie J. M. van der Kruijs, Nynke M. G. Bodde, Evelien Carrette, Richard H. C. Lazeron, Kristl E. J. Vonck, Paul A. J. M. Boon, Geert R. Langereis, Pierre J. M. Cluitmans, Loe M. G. Feijs, Paul A. M. Hofman, Walter H. Backes, Jacobus F. A. Jansen, A. P. Aldenkamp
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2014)
Article
Surgery
Bas Versluis, Tim Leiner, Patty J. Nelemans, Joachim E. Wildberger, Geert-Willem Schurink, Walter H. Backes
JOURNAL OF VASCULAR SURGERY
(2013)
Article
Clinical Neurology
Bart D. van Rooijen, Walter H. Backes, Olaf E. M. G. Schijns, Albert Colon, Paul A. M. Hofman
Article
Multidisciplinary Sciences
Ellen J. L. Brunenberg, Pim Moeskops, Walter H. Backes, Claudio Pollo, Leila Cammoun, Anna Vilanova, Marcus L. F. Janssen, Veerle E. R. M. Visser-Vandewalle, Bart M. ter Haar Romeny, Jean-Philippe Thiran, Bram Platel
Article
Multidisciplinary Sciences
Rene M. H. Besseling, Jacobus F. A. Jansen, Geke M. Overvliet, Maarten J. Vaessen, Hilde M. H. Braakman, Paul A. M. Hofman, Albert P. Aldenkamp, Walter H. Backes
Article
Radiology, Nuclear Medicine & Medical Imaging
Michaela E. Gaens, Walter H. Backes, Stefan Rozel, Matthijs Lipperts, Stefan N. Sanders, Karolien Jaspers, Jacques P. M. Cleutjens, Judith C. Sluimer, Sylvia Heeneman, Mat J. A. P. Daemen, Rob J. T. J. Welten, Jan-Willem H. Daemen, Joachim E. Wildberger, Robert M. Kwee, M. Eline Kooi
Review
Clinical Neurology
Evelien M. Barendse, Marc P. H. Hendriks, Jacobus F. A. Jansen, Walter H. Backes, Paul A. M. Hofman, Geert Thoonen, Roy P. C. Kessels, Albert P. Aldenkamp
JOURNAL OF NEURODEVELOPMENTAL DISORDERS
(2013)