Journal
EPILEPSIA
Volume 52, Issue -, Pages 32-34Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1528-1167.2011.03149.x
Keywords
Diffusion tensor imaging; White matter; Temporal lobe epilepsy; New-onset epilepsy
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Funding
- Canadian Institute of Health Research
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Although mesial temporal sclerosis (MTS) has long been recognized in association with temporal lobe epilepsy (TLE), there is a growing body of literature suggesting structural abnormalities extending beyond the temporal lobe in patients with TLE. Diffusion tensor imaging (DTI) is a novel imaging technique that provides insight into the structural integrity of cerebral white matter. DTI studies have demonstrated extensive bilateral white matter abnormalities in TLE that extend far beyond the temporal lobe, even in patients with unilateral MTS. The relationship between white matter abnormalities, seizures, and comorbidity in TLE remains unclear.
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