Article
Clinical Neurology
Joshua M. Diamond, Benjamin E. Diamond, Michael S. Trotta, Kate Dembny, Sara K. Inati, Kareem A. Zaghloul
Summary: Our study suggests that ictal activity observed by intracranial EEG may reflect propagated activity from a relatively focal seizure source, even during later time points when ictal activity is more widespread. By analyzing the time differences between ictal discharges in adjacent electrodes, we were able to estimate the location of the hypothesized focal source, which was found to closely match the clinically and neurophysiologically determined brain region giving rise to seizures. Furthermore, we found that this focal source is a dynamic entity that moves and evolves over the time course of a seizure, challenging the traditional conceptualization of the seizure source.
Article
Medicine, General & Internal
Dongyeop Kim, Taekyung Kim, Yoonha Hwang, Chae Young Lee, Eun Yeon Joo, Dae-Won Seo, Seung Bong Hong, Young-Min Shon
Summary: This study compares the directed transfer function (DTF) derived from scalp EEGs between responder and nonresponder groups with vagus-nerve stimulation (VNS) for drug-resistant epilepsy. The findings show that responders have similar DTF profiles to control group, while nonresponders exhibit increased connectivity measures. Furthermore, presurgical normal DTF profiles may predict good responsiveness to VNS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Jintao Sun, Yihan Li, Ke Zhang, Yulei Sun, Yingfan Wang, Ailiang Miao, Jing Xiang, Xiaoshan Wang
Summary: The study investigated the dynamics of functional connectivity networks during seizure termination in patients with childhood absence epilepsy using magnetoencephalography and graph theory analysis. Changes in FC networks involving the frontal cortex were significant during seizure termination compared to the ictal period. The topological properties of FC networks in different frequency bands could serve as new biomarkers to characterize the dynamics of FC networks related to seizure termination.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Krishnakant V. Saboo, Irena Balzekas, Vaclav Kremen, Yogatheesan Varatharajah, Michal Kucewicz, Ravishankar K. Iyer, Gregory A. Worrell
Summary: Verbal memory dysfunction is common in focal, drug-resistant epilepsy, and the surgical removal of seizure-generating brain tissue can lead to further memory decline. This study used iEEG recordings during a verbal memory task to investigate word encoding in focal epilepsy. The results showed that successful word encoding led to decreases in local electrographic functional connectivity and interictal epileptiform spike rates, with potential implications for identifying functioning memory circuits and localizing the seizure onset zone.
Article
Chemistry, Multidisciplinary
Haiteng Jiang, Vasileios Kokkinos, Shuai Ye, Alexandra Urban, Anto Bagic, Mark Richardson, Bin He
Summary: This study developed a new method to localize the seizure onset zone (SOZ) and predict seizure outcome using short-time resting-state SEEG data. They found that greater differences in resting-state information flow between SOZ and non-SOZ regions are associated with favorable seizure outcome.
Article
Chemistry, Multidisciplinary
Christina Maher, Arkiev D'Souza, Michael Barnett, Omid Kavehei, Chenyu Wang, Armin Nikpour
Summary: The study aims to investigate the implications of combining structural and functional connectivity in quantifying the most active brain regions during seizure onset. The results suggest that the combination of diffusion MRI and EEG can improve the identification of the seizure onset zone. The model proposed in this study may be valuable in guiding individualized electrode placement.
APPLIED SCIENCES-BASEL
(2022)
Article
Psychiatry
Binglin Fan, Linlin Pang, Siyi Li, Xia Zhou, Zongxia Lv, Zexiang Chen, Jinou Zheng
Summary: This study investigated the changes in structure and function of basal forebrain (BF) subregions in patients with temporal lobe epilepsy (TLE) and their association with vigilance impairment. The results showed that patients with focal to bilateral tonic-clonic seizures (FBTCS) had lower functional connectivity between certain BF subregions and brain regions such as the striatum and cerebellum. Compared to healthy controls, TLE patients had reduced functional connectivity between BF subregions and brain regions involved in vigilance. Additionally, the findings indicated that the altered functional connectivity between BF subregions and the striatum was correlated with vigilance measures in TLE patients.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Stefan Rampp, Martin Kaltenhaeuser, Nadia Mueller-Voggel, Arnd Doerfler, Burkhard S. Kasper, Hajo M. Hamer, Sebastian Brandner, Michael Buchfelder
Summary: Epilepsy surgery is an effective treatment option for patients with drug-resistant focal epilepsies, and accurate localization of the epileptogenic zone is essential. This study investigates the relationship between node degree (ND) and the seizure onset zone (SOZ) in resting state magnetoencephalography (MEG) data. The findings suggest that ND in certain frequency bands is significantly related to the SOZ, indicating its potential as a new tool for presurgical evaluation of epilepsy surgery.
Article
Engineering, Biomedical
Joseph Young, Curtis L. Neveu, John H. Byrne, Behnaam Aazhang
Summary: The study introduces a model-free framework, graphical directed information (GDI), which accurately infers pairwise directed functional connections in networks with improved scaling performance. By utilizing an advanced mutual information estimation technique, GDI effectively reduces indirect connections in neural data analysis. This technique successfully inferred circuitry in various types of networks and addressed the critical issue of indirect connections.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Neurosciences
Dhanalekshmi P. Yedurkar, Shilpa P. Metkar, Thompson Stephan
Summary: This research proposes a novel human-centered cognitive computing method for segment-wise seizure classification using multiresolution extracted data and directed transfer function features. The method achieved high sensitivity, specificity, and accuracy in classifying EEG signals into non-seizure and seizure data. The proposed technique can assist neurologists in accurately locating seizure activity, reducing the burden of time-consuming analysis.
COGNITIVE NEURODYNAMICS
(2022)
Article
Clinical Neurology
Ali A. Asadi-Pooya, Mohsen Farazdaghi
Summary: The study compared auras among different groups of epilepsy patients and found that patients with TLE were more likely to experience auras, with emotional, cognitive, epigastric, and olfactory/gustatory auras being common. Patients with FS were more likely to experience headache and dizziness/vertigo as auras.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2021)
Article
Neurosciences
Ignacio Cifre, Maria T. Miller Flores, Lucia Penalba, Jeremi K. Ochab, Dante R. Chialvo
Summary: The center stage of neuro-imaging is currently focused on studying functional correlations between brain regions, which define brain functional networks. This study proposes a new measure of nonlinear dynamic directed functional connectivity across regions of interest, providing directed information of functional correlations and a measure of temporal lags without extensive numerical complications. This approach offers a different and complementary perspective in analyzing brain co-activation patterns.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Lucas E. Sainburg, Andrew P. Janson, Graham W. Johnson, Jasmine W. Jiang, Baxter P. Rogers, Catie Chang, Dario J. Englot, Victoria L. Morgan
Summary: Epilepsy surgery involves the resection of the epileptic focus and is used to treat drug-resistant focal epilepsy. However, focal brain lesions can have effects in distant brain regions. This study investigates the effects of focal disconnections in the brain network on function in distant brain regions using epilepsy surgery.
Article
Neurosciences
Junxia Chen, Sisi Jiang, Bao Lu, Jiangyan Liao, Zhihuan Yang, Hechun Li, Haonan Pei, Jianfu Li, Yasser Iturria-Medina, Dezhong Yao, Cheng Luo
Summary: This study investigated the functional interaction in the cerebello-cerebral circuit in patients with idiopathic generalized epilepsy (IGE). The results revealed altered mapping of cerebral motor components to cerebellum and compressed cerebellar gradient between motor and cognition modules in IGE patients. These findings suggest insufficient integration of sensorimotor information processing in patients with IGE.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Kristin M. Gunnarsdottir, Adam Li, Rachel J. Smith, Joon-Yi Kang, Anna Korzeniewska, Nathan E. Crone, Adam G. Rouse, Jennifer J. Cheng, Michael J. Kinsman, Patrick Landazuri, Utku Uysal, Carol M. Ulloa, Nathaniel Cameron, Iahn Cajigas, Jonathan Jagid, Andres Kanner, Turki Elarjani, Manuel Melo Bicchi, Sara Inati, Kareem A. Zaghloul, Varina L. Boerwinkle, Sarah Wyckoff, Niravkumar Barot, Jorge Gonzalez-Martinez, Sridevi Sarma
Summary: There are over 15 million epilepsy patients worldwide, many of whom have drug-resistant epilepsy. Surgical treatment is often successful, but the success rate varies due to the lack of validated biological markers of the epileptogenic zone. This study aimed to develop a new network-based interictal iEEG marker of the epileptogenic zone by analyzing interictal iEEG data. The algorithm developed in this study showed promising accuracy in identifying epileptogenic regions and predicting surgical outcomes, outperforming clinicians' predictions.
Review
Oncology
Christopher Wilke, David Grosshans, Joseph Duman, Paul Brown, Jing Li
Article
Hematology
Vit Prochazka, Rakhee S. Gawande, Zuzan Cayci, Jerry W. Froelich, Qing Cao, Chris Wilke, Kathryn Dusenbery, Daniel J. Weisdorf, Veronika Bachanova
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2018)
Article
Oncology
Ahmed M. Amer, Mohamed Zaid, Baishali Chaudhury, Dalia Elganainy, Yeonju Lee, Christopher T. Wilke, Jordan Cloyd, Huamin Wang, Anirban Maitra, Robert A. Wolff, Gauri Varadhachary, Michael J. Overman, Jeffery E. Lee, Jason B. Fleming, Ching Wei Tzeng, Matthew H. Katz, Emma B. Holliday, Sunil Krishnan, Bruce D. Minsky, Joseph M. Herman, Cullen M. Taniguchi, Prajnan Das, Christopher H. Crane, Ott Le, Priya Bhosale, Eric P. Tamm, Eugene J. Koay
Article
Oncology
Brendan G. Coutu, Christopher T. Wilke, Jianling Yuan, Qing Cao, Matthew R. Vernon, Chung Lee, Veronika Bachanova, Kathryn E. Dusenbery
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2018)
Article
Otorhinolaryngology
Joel Stanek, Shifteh Vahidi, Christopher T. Wilke, Sobia F. Khaja
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Article
Oncology
Mohamed Zaid, Nimit Bajaj, Hannah Burrows, Ryan Mathew, Annie Dai, Christopher T. Wilke, Stephen Palasi, Ryan Hergenrother, Caroline Chung, Clifton D. Fuller, Jack Phan, G. Brandon Gunn, William H. Morrison, Adam S. Garden, Steven J. Frank, David I. Rosenthal, Michael Andersen, Adegbenga Otun, Mark S. Chambers, Eugene J. Koay
RADIATION ONCOLOGY
(2019)
Article
Hematology
Malvi Savani, Mehmet Gencturk, Ryan Shanley, Zuzan Cayci, Christopher Wilke, Erica D. Warlick, Fiona He, Murali Janakiram, Daniel J. Weisdorf, Claudio G. Brunstein, Veronika Bachanova
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2020)
Article
Oncology
Mohamed Zaid, Eugene J. Koay, Nimit Bajaj, Ryan Mathew, Lianchun Xiao, Anshuman Agrawal, Pearl Fernandes, Hannah Burrows, Millicent A. Roach, Christopher T. Wilke, Caroline Chung, Clifton D. Fuller, Jack Phan, G. Brandon Gunn, William H. Morrison, Adam S. Garden, Steven J. Frank, David Rosenthal, Michael Andersen, Adegbenga Otun, Mark S. Chambers
Article
Radiology, Nuclear Medicine & Medical Imaging
Christopher Wilke, Vinita Takiar, He Wang, Amy C. Moreno, Shih-Ming Samuel Tung, Sean R. Quinlan-Davidson, Adam S. Garden, David I. Rosenthal, Clifton D. Fuller, Gary B. Gunn, Jay P. Reddy, William H. Morrison, Congjun Wang, George Zhao, Katherine A. Hutcheson, Jack Phan
Summary: This study compared three commonly used intensity modulated radiation therapy approaches for laryngeal sparing in patients with oropharyngeal cancer treated to the bilateral neck. The results indicated that modern whole-field techniques can effectively spare the larynx in patients with advanced oropharyngeal cancers.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2021)
Article
Multidisciplinary Sciences
Hannah Able, Amber Wolf-Ringwall, Aaron Rendahl, Christopher P. Ober, Davis M. Seelig, Chris T. Wilke, Jessica Lawrence
Summary: This study aimed to correlate radiomic features from canine pulmonary tumors to histopathologic characteristics and outcome. The results showed longer overall survival time for adenocarcinomas compared to non-adenocarcinomas and significant differences in first-order radiomic statistics among different tumor types. Furthermore, completeness of excision, mitotic index, and histologic score were associated with survival outcomes in dogs with adenocarcinoma.
Article
Veterinary Sciences
Rami Shaker, Christopher Wilke, Christopher Ober, Jessica Lawrence
Summary: The study aimed to build a predictive model for liver malignancy through quantitative evaluation of CT heterogeneity. Results showed that heterogeneity indices extracted from delayed postcontrast CT hepatic mass contours were more informative about tumor type compared to indices from whole liver contours or from precontrast hepatic mass and whole liver contours.
VETERINARY RADIOLOGY & ULTRASOUND
(2021)
Article
Oncology
Isabela Pena Pino, Jun Ma, Yusuke S. Hori, Elena Fomchenko, Kathryn Dusenbery, Margaret Reynolds, Christopher Wilke, Jianling Yuan, Ethan Srinivasan, Matthew Grabowski, Peter Fecci, Evidio Domingo-Musibay, Naomi Fujioka, Gene H. Barnett, Veronica Chang, Alireza M. Mohammadi, Clark C. Chen
Summary: This study retrospectively collected clinical outcomes of 20 patients with BMRS treated with SLA followed by consolidation SRS and >6 months follow-up. The results showed a 100% local control rate at 6 and 12 months, with no new neurological deficits or complications. These findings support further investigation of SLA/cSRS as a treatment strategy for BMRS.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Oncology
Kellen Mulford, Mariah McMahon, Andrew M. Gardeck, Matthew A. Hunt, Clark C. Chen, David J. Odde, Christopher Wilke
Summary: This study developed a non-invasive method to predict the motility of glioblastoma cells using radiomics features. It showed the feasibility of a quantitative MRI feature-based regression model in predicting the cellular motility of glioblastomas.
Article
Oncology
Kellen Mulford, Chuyu Chen, Kathryn Dusenbery, Jianling Yuan, Matthew A. Hunt, Clark C. Chen, Paul Sperduto, Yoichi Watanabe, Christopher Wilke
Summary: This study evaluated the predictive capability of radiomic-based models in predicting local tumor control of surgically resected brain metastases following adjuvant radiosurgery. Results showed that radiomics features provided more robust predictive models compared to clinical features alone, suggesting their potential usefulness in clinical settings and warranting further investigation.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2021)
Article
Oncology
Amy C. Moreno, Christopher Wilke, He Wang, Shi-Ming Samuel Tung, Courtney Pollard, Adam S. Garden, William H. Morrison, David Rosenthal, Clifton D. Fuller, Gary B. Gunn, Jay P. Reddy, Shalin J. Shah, Steven J. Frank, Vinita Takiar, Jack Phan
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2019)