Article
Biotechnology & Applied Microbiology
Ro'ee Gilron, Simon Little, Randy Perrone, Robert Wilt, Coralie de Hemptinne, Maria S. Yaroshinsky, Caroline A. Racine, Sarah S. Wang, Jill L. Ostrem, Paul S. Larson, Doris D. Wang, Nick B. Galifianakis, Ian O. Bledsoe, Marta San Luciano, Heather E. Dawes, Gregory A. Worrell, Vaclav Kremen, David A. Borton, Timothy Denison, Philip A. Starr
Summary: The use of an implantable two-way neural interface enables wireless neural monitoring and stimulation for up to 15 months following implantation. This technological approach may have wide applicability to brain disorders treatable by invasive neuromodulation.
NATURE BIOTECHNOLOGY
(2021)
Article
Clinical Neurology
Zachary Kons, Amir Hadanny, Alan Bush, Pranav Nanda, Todd M. M. Herrington, R. Mark Richardson
Summary: The study aimed to determine whether temporary subdural electrode strip placement during deep brain stimulation (DBS) surgery affects lead implantation accuracy. The results suggest that performing R-ECoG during DBS implantation surgery does not affect the accuracy of lead placement.
OPERATIVE NEUROSURGERY
(2023)
Article
Engineering, Biomedical
Chenchen Cheng, Yan Liu, Bo You, Yuanfeng Zhou, Fei Gao, Liling Yang, Yakang Dai
Summary: A multilevel feature learning method was proposed in this study for accurate spike detection, which avoids the subjectivity and inefficiency of visual inspection and enables highly accurate detection of spikes.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2022)
Article
Neurosciences
Nanxi Lai, Zhisheng Li, Cenglin Xu, Yi Wang, Zhong Chen
Summary: In this review, the authors briefly describe the electrographic characteristics of high-frequency oscillations (HFOs), interictal spikes (ISs), and slow wave activities (SWAs) in the interictal state, and discuss their various roles in epilepsy. They summarize representative evidence from experimental and clinical epilepsy to address their critical roles in seizure generation and epileptogenesis, indicating their potential as electrophysiological biomarkers of epilepsy. Importantly, they propose perspectives for further research in the field.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Jonatan Biskamp, Sara Isla Cainzos, Focko L. Higgen, Christian Gerloff, Tim Magnus
Summary: This study aims to investigate the electrophysiological signatures of the mouse cortex after ischemic stroke, in order to deepen the understanding of the recovery mechanisms. The results show that ischemic strokes affect sensory cortical areas and lead to motor deficits in the contralateral forepaw of mice. Analyses of electrocorticography signals reveal changes in power spectral density near the infarct, indicating alterations in neuronal activity. Exponents derived from motor areas significantly correlate with motor recovery, suggesting functional modifications.
Article
Multidisciplinary Sciences
Leon Taquet, Brian J. J. Conway, Timothy F. F. Boerger, Sarah C. C. Young, Stephanie Schwartz, Brian D. D. Schmit, Max O. O. Krucoff
Summary: Awake craniotomies provide unique scientific opportunities for neurophysiological experimentation in human subjects. However, there is a lack of rigorous reporting on data synchronization across multiple platforms, hindering reproducibility and translatability. In this study, we present an intraoperative data synchronization methodology that can be used across various platforms and tasks, aiming to support scientific rigor and reproducibility in future studies.
Article
Behavioral Sciences
Beth Leeman-Markowski, Richard Hardstone, Lynn Lohnas, Benjamin Cowen, Lila Davachi, Werner Doyle, Patricia Dugan, Daniel Friedman, Anli Liu, Lucia Melloni, Ivan Selesnick, Binhuan Wang, Kimford Meador, Orrin Devinsky
Summary: Study on the impact of interictal epileptiform discharges (IEDs) on memory found that IEDs during encoding, maintenance, and recall did not significantly affect performance, with no significant difference between correct recall and periods of no response. Post hoc analysis suggested a potential negative impact of IED count during the maintenance period. Future research may focus on the influence of IEDs during maintenance.
EPILEPSY & BEHAVIOR
(2021)
Article
Biochemical Research Methods
Audrey Laurence, Denahin H. Toffa, Ke Peng, Manon Robert, Alain Bouthillier, Dang K. Nguyen, Frederic Leblond
Summary: This study evaluated the possibility of using an intraoperative multispectral imaging system combined with electrocorticography (ECoG) to measure the average hemodynamic response function (HRF) associated with interictal epileptiform discharges (IEDs) in patients with epilepsy. The study found inter-patient variability of the HRF and identified a sub-region that corresponded to the most active area identified by ECoG.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Neurosciences
Su Shu, Shen Luo, Miao Cao, Ke Xu, Lang Qin, Li Zheng, Jing Xu, Xiongfei Wang, Jia-Hong Gao
Summary: Combining SEEG with MEG or EEG can improve the accurate localization of interictal spikes in epilepsy surgery, leading to better presurgical evaluation of the epileptogenic zone.
Article
Neurosciences
Parham Mostame, Sepideh Sadaghiani
Summary: The study analyzed ECoG recordings of 18 presurgical human patients and found that oscillation-based functional connectivity exhibits highly similar spatial organization across different cognitive states, primarily intrinsic in nature. Each frequency band also showed independent connectivity dynamics to support frequency-specific information exchange.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Zhejun Guo, Fang Wang, Longchun Wang, Kejun Tu, Chunpeng Jiang, Ye Xi, Wen Hong, Qingda Xu, Xiaolin Wang, Bin Yang, Bomin Sun, Zude Lin, Jingquan Liu
Summary: This study proposes a MEMS-fabricated flexible interface device for low-invasive brain-computer interface applications. The device has a small cross-section to reduce trauma and can record neuronal signals for a long period.
MICROSYSTEMS & NANOENGINEERING
(2022)
Review
Chemistry, Analytical
Divya, Monalisha Ghosh Dastidar, Supratim Mahapatra, Rohini Kumari, Daphika S. Dkhar, Sharmili Roy, Pranjal Chandra
Summary: In recent years, implantable biosensors conjugated with different kinds of nanomaterials have been used for in vivo detection, showing significant effects on imaging, diagnostics, and therapeutics. Nanomaterials such as nanoparticles, carbon fibers, dendrimers, quantum dots, and nano-conjugates offer better biocompatibility, sensitivity, selectivity, and low detection limits to in vivo opto-electrochemical biosensing platforms. This article elaborates on the deployment of various nanomaterials in the fabrication of in vivo sensors and provides examples. Commercially available devices for in vivo monitoring are also discussed. Major challenges during experimentation and possible confronting strategies are depicted vividly.
MICROCHEMICAL JOURNAL
(2023)
Review
Virology
Peiwen Zhou, Zonghui Li, Linqing Xie, Dong An, Yaohua Fan, Xiao Wang, Yiwei Li, Xiaohong Liu, Jianguo Wu, Geng Li, Qin Li
Summary: Coronaviruses are highly pathogenic RNA viruses that pose a threat to human health. Developing effective vaccines against these viruses is crucial, but there are numerous obstacles and challenges in vaccine research and development, including the lack of understanding of virus transmission, pathogenesis, and immune response.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Clinical Neurology
Valerio Frazzini, Stephen Whitmarsh, Katia Lehongre, Pierre Yger, Jean-Didier Lemarechal, Bertrand Mathon, Claude Adam, Dominique Hasboun, Virginie Lambrecq, Vincent Navarro
Summary: Periventricular nodular heterotopia (PNH) is a malformation of cortical development that often leads to drug-resistant epilepsy. In this study, consistent interictal patterns were identified within the nodules, with specific patterns associated with seizure generation. The results suggest that PNH nodules may play a significant role in initiating seizures.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Simon Henin, Anita Shankar, Helen Borges, Adeen Flinker, Werner Doyle, Daniel Friedman, Orrin Devinsky, Gyorgy Buzsaki, Anli Liu
Summary: The spatiotemporal characteristics of cortical high-gamma activity, hippocampal ripple activity, and interictal epileptiform discharges have a significant impact on memory performance during an associative memory task, particularly in the hippocampal region. Interictal epileptiform discharges may impair associative memory by disrupting physiological activity, making them a promising therapeutic target for memory remediation in patients with epilepsy.
Review
Clinical Neurology
Andrew T. Hale, Meredith A. Monsour, John D. Rolston, Robert P. Naftel, Dario J. Englot
NEUROSURGICAL REVIEW
(2020)
Letter
Clinical Neurology
Michael Karsy, Herschel Wilde, John D. Rolston
Article
Clinical Neurology
Bornali Kundu, John D. Rolston, Ramesh Grandhi
NEUROSURGICAL FOCUS
(2019)
Review
Clinical Neurology
Bornali Kundu, Brandon Lucke-Wold, Chase Foster, Dario J. Englot, Ogaga Urhie, Divine Nwafor, John D. Rolston
Review
Medicine, General & Internal
Rose M. Caston, Elliot H. Smith, Tyler S. Davis, John D. Rolston
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Clinical Neurology
Bornali Kundu, Tyler S. Davis, Brian Philip, Elliot H. Smith, Amir Arain, Angela Peters, Blake Newman, Christopher R. Butson, John D. Rolston
Article
Clinical Neurology
Saramati Narasimhan, Keshav B. Kundassery, Kanupriya Gupta, Graham W. Johnson, Kristin E. Wills, Sarah E. Goodale, Kevin Haas, John D. Rolston, Robert P. Naftel, Victoria L. Morgan, Benoit M. Dawant, Hernan F. J. Gonzalez, Dario J. Englot
Editorial Material
Clinical Neurology
Andrea A. Brock, Bornali Kundu, John D. Rolston
Summary: Asleep image-guided deep brain stimulation (DBS) offers greater patient comfort and comparable accuracy, using the ClearPoint system and intraoperative magnetic resonance imaging for precise electrode placement. This method reduces risks, does not require awake surgery or additional equipment, and can be more tolerable for patients with Parkinson disease.
OPERATIVE NEUROSURGERY
(2021)
Article
Clinical Neurology
Jonathan P. Scoville, Evan Joyce, Joshua Hunsaker, Jared Reese, Herschel Wilde, Amir Arain, Robert L. Bollo, John D. Rolston
Summary: The study showed that patients who underwent epilepsy mapping surgery via minimally invasive stereotactically placed SEEG electrodes had significantly lower opioid use compared to those who underwent the more invasive ECoG procedure. Additionally, there was a significant difference in pain scores between the two surgical groups.
OPERATIVE NEUROSURGERY
(2021)
Review
Clinical Neurology
Lahoud Touma, Benedicte Dansereau, Alvin Y. Chan, Nathalie Jette, Churl-Su Kwon, Kees P. J. Braun, Daniel Friedman, Lara Jehi, John D. Rolston, Sumeet Vadera, Lily C. Wong-Kisiel, Dario J. Englot, Mark R. Keezer
Summary: Neurostimulation modalities are effective in treating drug-resistant epilepsy, with improving outcomes over time and few major complications.
Article
Clinical Neurology
Chantel M. Charlebois, Daria Nesterovich Anderson, Kara A. Johnson, Brian J. Philip, Tyler S. Davis, Blake J. Newman, Angela Y. Peters, Amir M. Arain, Alan D. Dorval, John D. Rolston, Christopher R. Butson
Summary: This study aimed to investigate the effectiveness of responsive neurostimulation in the mesial temporal lobe and identify stimulation-dependent networks associated with seizure reduction. The results showed that patient-specific stimulation-dependent connectivity was correlated with treatment effectiveness, while normative connectivity was not. Increased connectivity to the medial prefrontal cortex, cingulate cortex, and precuneus was associated with greater seizure reduction.
Article
Clinical Neurology
Justin M. Campbell, Bornali Kundu, James N. Lee, Michelle Miranda, Amir Arain, Philipp Taussky, Ramesh Grandhi, John D. Rolston
Summary: This study evaluated the accuracy of task-based fMRI compared to Wada testing for language lateralization in patients with drug-resistant epilepsy. The findings suggest that fMRI is generally a precise and low-risk alternative to Wada testing. However, patients with atypical language lateralization may benefit from subsequent Wada testing or intraoperative language mapping.
INTERVENTIONAL NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Bornali Kundu, Amir Arain, Tyler Davis, Chantel M. Charlebois, John D. Rolston
Summary: This case report describes a patient with unilateral diffuse frontotemporal epilepsy who was successfully treated with an implanted responsive neurostimulation system. Chronic recordings showed that ictal activity in the centromedian nucleus consistently preceded the anterior nucleus, suggesting the presence of a temporally organized seizure network involving the thalamus. This study demonstrates the potential efficacy of closed-loop neurostimulation of multiple thalamic nuclei in controlling seizures.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Clinical Neurology
Bornali Kundu, Chantel M. Charlebois, Daria Nesterovich Anderson, Angela Peters, John D. Rolston
Summary: We observed a phenomenon of electrical running down and a consistent spectral change in interictal ECoG of a patient with drug-resistant epilepsy after surgery. The patient remained seizure-free for 2.5 years without the need for neurostimulation. There was a decrease in epileptiform electrographic detections and a gradual decrease in the aperiodic exponent of the power spectrum over time.
Article
Neurosciences
Melissa M. J. Chua, Aaron E. L. Warren, G. Rees Cosgrove, John D. Rolston
Summary: This study examines the characteristics of deep brain stimulation (DBS) and responsive neurostimulation (RNS) trials from 1997 to 2022, as well as the frequency and completeness of results reporting. The results show that over one-third of trials remain unpublished >1 year after completion, pediatric trials are scarce, most of the thalamus remains unexplored, about one-in-five trials fail to report stimulation parameters, and movement disorders comprise the most studied indications.
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2023)