Article
Computer Science, Information Systems
Mustafa Sameer, Bharat Gupta
Summary: Researchers propose a new one-dimensional convolutional neural network (CNN) model for detecting epilepsy, which automatically extracts features and significantly reduces training time. The model achieves a high accuracy in distinguishing between healthy and epileptic patients, as validated by applying various machine learning techniques.
MULTIMEDIA TOOLS AND APPLICATIONS
(2022)
Article
Multidisciplinary Sciences
Eung Chang Kim, Jiaren Zhang, Andy Y. Tang, Eric C. Bolton, Justin S. Rhodes, Catherine A. Christian-Hinman, Hee Jung Chung
Summary: This study reveals that impaired axonal surface expression of K(v)7 channels in KCNQ2-related epileptic encephalopathy is associated with epileptic seizures, cognitive and behavioral deficits, and neuronal loss.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Veterinary Sciences
Thomas R. Harcourt-Brown, Michael Carter
Summary: The long-term effect of implantable vagus nerve stimulators (VNS) on seizures in epileptic dogs has not been investigated.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Review
Medicine, General & Internal
Muhammad Shoaib Farooq, Aimen Zulfiqar, Shamyla Riaz
Summary: Epilepsy is a life-threatening neurological disorder characterized by recurrent unprovoked seizures due to abnormal chemical changes in the brain. Studies have focused on using machine learning methods for automatic diagnosis and early prediction of epileptic seizures. These studies primarily involve feature extraction from EEG data and classification using machine learning classifiers. This study provides a systematic literature review of feature selection methods and classification performance, identifying commonly used techniques and classifiers for accurate classification. The research also examines benchmark datasets, analyzes the performance of classifiers, and highlights gaps and opportunities for further research in predicting epileptic seizures.
Article
Biochemistry & Molecular Biology
Roberto Rodriguez-Ortiz, Ataulfo Matinez-Torres
Summary: Epilepsy is a chronic neurological disorder affecting 50 million people worldwide, with zebrafish used to model the disease. Mutations in the activated HCN channel were generated and phenotypic characteristics related to epilepsy were observed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Friederike Neuss, Felix von Podewils, Zhong Irene Wang, Marie Suesse, Uwe Klaus Zettl, Matthias Grothe
Summary: This study described a cohort of patients with both MS and epileptic seizures, finding that a significant percentage of MS patients with seizures had competing causes at the time of the first seizure. A detailed diagnostic setup including patient history, EEG, and MRI is recommended for evaluation and treatment decisions.
JOURNAL OF NEUROLOGY
(2021)
Editorial Material
Clinical Neurology
Anna Rada, Christian G. Bien
Summary: Seizures resulting from cerebral autoimmunity can be either symptomatic in the context of autoimmune encephalitis (AIE) with neural surface antibodies or indicative of an enduring predisposition to seizures, known as autoimmune encephalitis-associated epilepsy (AEAE). AEAE can be diagnosed in cases where seizures persist for at least 2 years after immunotherapy initiation, no signs of encephalitis are observed on imaging, cerebrospinal fluid cell count is normal, and antibody titers decrease substantially. The distinction between AIE and AEAE has practical consequences for treatment and social limitations.
Article
Genetics & Heredity
Pan Gong, Xianru Jiao, Dan Yu, Zhixian Yang
Summary: KCNT2 gene mutations have been found to cause developmental and epileptic encephalopathies. This study presented detailed clinical features and genetic analysis of two unrelated patients with de novo variants in KCNT2, along with a review of eight previous cases. The most common phenotypes associated with KCNT2 mutations were infantile spasms and epilepsy of infancy with migrating focal seizures, suggesting potential overlap between gain- and loss-of-function mutations in epilepsy phenotype.
FRONTIERS IN GENETICS
(2021)
Article
Neurosciences
Tohru Okanishi, Ayataka Fujimoto
Summary: The corpus callosotomy (CC) was first proposed as a surgical procedure for epilepsy, particularly for treating drop attacks. In recent years, there has been an increasing number of studies on using CC to treat epileptic spasms. Compared to resection surgeries, CC is more commonly used for patients without lesions observed on imaging or with bilateral lesions.
Article
Clinical Neurology
Loay Shoubash, Stephan Nowak, Stephan Greisert, Ahmed Al Menabbawy, Eico Rathmann, Felix von Podewils, Steffen Fleck, Henry H. W. Schroeder
Summary: This study analyzed the outcome and predictive factors after surgery for cavernoma-related epilepsy (CRE). The results showed that surgical treatment resulted in favorable seizure control in the majority of patients, although factors such as long duration of epilepsy before surgery, high seizure frequency, and drug-resistant epilepsy were associated with worse seizure outcomes. Early surgical resection of the cavernoma after careful presurgical planning is recommended to achieve optimal results.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Willemiek J. E. M. Zweiphenning, Nicolas von Ellenrieder, Francois Dubeau, Laurence Martineau, Lorella Minotti, Jeffery A. Hall, Stephan Chabardes, Roy Dudley, Philippe Kahane, Jean Gotman, Birgit Frauscher
Summary: Comparing abnormal high-frequency oscillation rates to rates in healthy tissue improves focus identification and outcome prediction in epileptic patients undergoing surgery.
Article
Clinical Neurology
Tianren Yang, Caitlin Roberts, Toby Winton-Brown, Michael Lloyd, Patrick Kwan, Terence J. O'Brien, Dennis Velakoulis, Genevieve Rayner, Charles B. Malpas
Summary: Childhood trauma is a risk factor for psychogenic nonepileptic seizures (PNES). Patients with PNES report a higher frequency of childhood trauma compared to patients with epilepsy, with differences across various types of trauma. Inquiry about a history of sexual abuse shows promise as a screening measure.
Article
Biochemistry & Molecular Biology
Anna Volnova, Vassiliy Tsytsarev, Olga Ganina, Grace E. Velez-Crespo, Janaina M. Alves, Alla Ignashchenkova, Mikhail Inyushin
Summary: Gap junctions between astrocytes play a crucial role in regulating epileptic seizures by controlling the synchronization of pathological neuronal activity. Blocking these intercellular channels could be an important mechanism in suppressing epileptic activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Clinical Neurology
Aliya Frederick, Kimberly Sherer, Linda Nguyen, Shawn Ali, Anupam Garg, Richard Haas, Michelle Sahagian, Jonathan Bui
Summary: This case report presents an 8-year-old girl with developmental delay, autism, and intractable epilepsy found to have a pathogenic variant in the CAD gene. The patient exhibited a rapid response to treatment with the uridine pro-drug triacetyluridine (TAU), suggesting a potential new approach for treating refractory epilepsy.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Editorial Material
Neurosciences
Andrew J. Larner, Anthony G. Marson
Summary: Epileptic seizures are increasingly recognized as part of the clinical phenotype of patients with Alzheimer's disease. However, there is limited evidence to guide treatment decisions for these patients. This study explores the potential implications of a recently published pragmatic study on the treatment of seizures in Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
