Journal
EPIGENETICS
Volume 6, Issue 2, Pages 247-255Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/epi.6.2.13791
Keywords
placenta; preeclampsia; intra-uterine growth restriction; placental diseases; lipid metabolism
Funding
- Paris 7 Denis Diderot University
- Fondation pour la Recherche Medicale (FRM)
- Association de Neonatologie de Port-Royal
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Preeclampsia (PE) and vascular intra-uterine growth restriction (vIUGR) are two pathological obstetrical conditions originating from placental dysfunction. Recently, methylation changes at the placental level have been shown to be indicative of these diseases. The alteration of such epigenetic marks is therefore a novel pathway that might be critical for these pathologies. Here, we identified a region located in the distal promoter of the T-box-containing transcription factor TBX15 that is differentially methylated in pathological placentas. The level of methylation correlated significantly with the weight and stature of the newborn. The promoter was found to be hypomethylated in vIUGR coinciding with the downregulation of its expression. PDX1, a transcription factor important for the regulation of insulin metabolism regulation was able to repress the TBX15 promoter in a methylation-dependent manner, which might, at least partially, explain the specific mRNA decrease of TBX15 observed in vIUGR placentas. Overall, the data presented herein suggest that TBX15 might be involved in the pathophysiology of placental diseases.
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