Article
Biochemistry & Molecular Biology
Tong-tong He, Hong-wei Xiao, Maierhaba Wusiman, Dinuerguli Yishake, Ai-ping Fang, Yan Luo, Xiao-zhan Liu, Zhao-yan Liu, Hui-lian Zhu
Summary: The research suggests that a high level of methionine intake may improve survival in patients with newly diagnosed HCC, but no significant association was observed between other micronutrients involved in one-carbon metabolism and HCC survival.
Article
Oncology
Xuan Zhou, Lijuan Wang, Jiarui Xiao, Jing Sun, Lili Yu, Han Zhang, Xiangrui Meng, Shuai Yuan, Maria Timofeeva, Philip J. Law, Richard S. Houlston, Kefeng Ding, Malcolm G. Dunlop, Evropi Theodoratou, Xue Li
Summary: Alcohol consumption is associated with colorectal cancer risk, and DNA methylation may be one of the mechanisms by which alcohol exerts its carcinogenic effect on colorectal cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Ricardo Costeira, Laila Evangelista, Rory Wilson, Xinyu Yan, Fabian Hellbach, Lucy Sinke, Colette Christiansen, Sergio Villicana, Olatz Masachs, Pei-Chien Tsai, Massimo Mangino, Cristina Menni, Sarah Berry, Marian Beekman, Diana van Heemst, P. Eline Slagboom, Bastiaan Heijmans, Karsten Suhre, Gabi Kastenmueller, Christian Gieger, Annette Peters, Kerrin Small, Jakob Linseisen, Melanie Waldenberger, Jordana Bell
Summary: This study investigates blood metabolomic biomarkers of folate and vitamins B6 and B12 and carries out epigenome-wide analyses across three European cohorts. The results show that intake of B vitamins is associated with specific metabolites and differentially methylated positions in the epigenome.
CLINICAL EPIGENETICS
(2023)
Article
Multidisciplinary Sciences
Zhen Li, Ji Zhang, Wei Zou, Qi Xu, Siyuan Li, Jie Wu, Li Zhu, Yunjiao Zhang, Lei Xu, Ying Zhang, Qingsong Luo, Jianyun Nie, Xingxu Li, Tianning Zou, Ceshi Chen
Summary: The MTHFR C677T polymorphism is significantly associated with susceptibility to breast cancer subtypes, with increased risk for TNBC and protective effect for luminal A. Individuals with hypertension have a higher risk for BC, especially TNBC.
Review
Oncology
Can Kong, Tao Fu
Summary: Colorectal cancer is a complex process influenced by genetic and epigenetic variations in normal epithelial cells. Abnormal methylation of genes is common in CRC, and methylation markers in cell-free DNA are potential non-invasive biomarkers with high sensitivity and specificity for detecting CRC. Studying and utilizing methylation markers in CRC may have important clinical implications for screening, predicting, prognosticating, and treating the disease.
Article
Biochemistry & Molecular Biology
Xiao Han, Fang Fang, Weiwei Cui, Ya Liu, Yuxin Liu
Summary: This study investigates the effect of alcohol consumption on cervical cancer by examining the methylation status of cervical cancer cells. The results suggest that ethanol can affect the expression of DNMT by inducing methyl donor consumption, leading to genome-wide hypomethylation in cervical cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jiande Wu, Lu Zhang, Aditi Kuchi, David Otohinoyi, Chindo Hicks
Summary: This study investigated the use of DNA methylation for predicting survival in colorectal cancer (CRC). The researchers discovered signatures of CpG sites and genes associated with CRC and predictive of survival. Functional analysis revealed molecular networks and signaling pathways driving clinical outcomes.
Article
Biochemistry & Molecular Biology
Imaduddin Mirza, Dina Naquiallah, Ariej Mohamed, Uzma Abdulbaseer, Chandra Hassan, Mario Masrur, Mohamed M. Ali, Shane A. Phillips, Abeer M. Mahmoud
Summary: A large percentage of obese patients in the United States have comorbid substance use disorders, mainly alcohol use. This study found that alcohol consumption is associated with lower DNA methylation, increased inflammation, and higher cardiometabolic risk in obese individuals.
Review
Biochemistry & Molecular Biology
Herbert Ryan Marini, Bianca Arianna Facchini, Raffaele di Francia, Jose Freni, Domenico Puzzolo, Liliana Montella, Gaetano Facchini, Alessandro Ottaiano, Massimiliano Berretta, Letteria Minutoli
Summary: In cases of cellular injury, excessive production of reactive oxygen species (ROS) can lead to various conditions, including cancerogenesis. Glutathione (GSH), the most abundant thiol-containing antioxidant, is crucial for restoring redox homeostasis. The conjugation of GSH with xenobiotics, such as anti-cancer drugs, can either reduce their harmful effects or enhance their toxicity. Further studies are needed to better understand the relationship between GSH and cancer. The use of GSH should only be considered under medical supervision, taking into account the appropriate timing and setting, as self-prescribed GSH lacks strong scientific evidence for its efficacy in reducing toxicity.
Article
Public, Environmental & Occupational Health
Ju Eun Seol, Jeongseon Kim, Bong-Hwa Lee, Dae-Yong Hwang, Jinyoung Jeong, Hun-Jae Lee, Yoon-Ok Ahn, Jung Eun Lee, Dong-Hyun Kim
Summary: This study found that alcohol intake increased the risk of colorectal cancer in East Asian populations, and there may be an interaction between ALDH2 gene and methyl diets, where a low methyl diet increased the risk of CRC among individuals with the ALDH2 A allele.
PUBLIC HEALTH NUTRITION
(2021)
Article
Oncology
Maria Dobre, Alessandro Salvi, Iulia Andreea Pelisenco, Florina Vasilescu, Giuseppina De Petro, Vlad Herlea, Elena Milanesi
Summary: Colorectal cancer is characterized by mutations and abnormal DNA methylation in tumor suppressor and proto-oncogenes. This study identified nine genes with high methylation levels in tumor tissues compared to normal tissues. Molecular sub-classification based on mutations and epigenetic modifications may help identify epigenetic biomarkers for personalized treatment strategies to improve patient outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Armina-Lyn M. Frederick, Chi Guo, Ann Meyer, Liying Yan, Sallie S. Schneider, Zhenhua Liu
Summary: The study revealed a reverse association between obesity and premenopausal breast cancer, with obesity being linked to increased mammary folate levels, genome-wide DNA methylation, and SFRP1 gene expression in premenopausal women.
Article
Biochemistry & Molecular Biology
Alexei J. Stuckel, Shuai Zengb, Zhen Lyub, Wei Zhang, Xu Zhang, Urszula Dougherty, Reba Mustafi, Tripti Khare, Qiong Zhang, Trupti Joshi, Marc Bissonnette, Sharad Khare
Summary: This study reports for the first time that SPRY4, which is frequently downregulated and considered as a tumor suppressor, is epigenetically upregulated in colorectal cancer (CRC). The promoter region of SPRY4 undergoes hypomethylation, while the gene body region shows decreased hydroxymethylation and increased methylation, which are correlated with increased expression in CRC patients.
Article
Pharmacology & Pharmacy
Lauren A. Bertocci, Jeffrey R. Rovatti, Alex Wu, Amber Morey, Diptiman D. Bose, Shannon R. M. Kinney
Summary: Calcium signaling and DNA methylation are connected in tumor development, potentially regulating apoptosis in cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sanne D. D. van Otterdijk, Hagen Klett, Melanie Boerries, Karin B. B. Michels
Summary: This study examines the influence of folate and S-Adenosylmethionine (SAM) on placental DNA methylation. The study finds that maintaining sufficient levels of folate and SAM is particularly important for individuals carrying the MTHFR C677T polymorphism. The MTHFR genotype is associated with DNA methylation.
Article
Chemistry, Analytical
Michael McFarlane, Ramesh P. Arasaradnam, Beryl Reed, Emma Daulton, Alfian Wicaksono, Heena Tyagi, James A. Covington, Chuka Nwokolo
Summary: Coeliac disease patients can be distinguished from healthy individuals through the analysis of urinary volatile organic compounds (VOCs). This analysis method can also be used to monitor dietary compliance in coeliac disease patients.
Letter
Oncology
John C. Mathers, Faye Elliott, D. Timothy Bishop, John Burn
CANCER PREVENTION RESEARCH
(2023)
Article
Nutrition & Dietetics
Dominic N. Farsi, Jose Lara Gallegos, Georgios Koutsidis, Andrew Nelson, Tim J. A. Finnigan, William Cheung, Jose L. Munoz-Munoz, Daniel M. Commane
Summary: This study investigated the effects of replacing high red and processed meat intake with mycoprotein on markers of intestinal genotoxicity and gut health. The results showed that mycoprotein significantly reduced faecal genotoxicity and genotoxin excretion, and increased the abundance of microbial genera with putative health benefits in the gut. This suggests that mycoprotein may be a beneficial alternative to meat for gut health and colorectal cancer prevention.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Review
Chemistry, Analytical
Ashwin Krishnamoorthy, Subashini Chandrapalan, Sofie Bosch, Ayman Bannaga, Nanne K. H. De Boer, Tim G. J. De Meij, Marcis Leja, George B. Hanna, Nicoletta De Vietro, Donato Altomare, Ramesh P. Arasaradnam
Summary: This paper aims to investigate the impact of mechanical bowel preparation on the production and measurement of volatile organic compounds (VOCs) by conducting a systematic search. The findings suggest that mechanical bowel preparation does not affect VOC profiles in breath, but it does alter urinary VOC profiles.
Article
Biochemistry & Molecular Biology
Paula N. Brandao-Lima, Gabrielli B. de Carvalho, Tanyara B. Payolla, Flavia M. Sarti, Regina M. Fisberg, Fiona C. Malcomson, John C. Mathers, Marcelo M. Rogero
Summary: This study evaluated the levels of 21 miRNAs in plasma according to MetS components and sex in adults. The results showed that miR-16 and miR-363 levels were reduced in women with MetS, while men with one or more risk factors showed higher levels of miR-let-7c and miR-30a. Individuals with raised waist circumference, blood pressure, low HDL-cholesterol concentrations, and high fasting plasma glucose and/or insulin resistance exhibited specific miRNA patterns in plasma. These findings suggest that plasma miRNA levels may serve as early biomarkers for the cardiometabolic components of MetS and highlight sex differences in individuals with MetS.
Article
Nutrition & Dietetics
Sineaid M. M. Collins, Glenn R. R. Gibson, Gavin N. N. Stainton, Andrea Bertocco, Orla B. B. Kennedy, Gemma E. E. Walton, Daniel M. M. Commane
Summary: This study aimed to investigate whether chronic consumption of I + AX could decrease appetite and energy intake, and increase intestinal propionate production in humans. The results showed that I + AX was associated with a reduction in energy intake, increased faecal SCFA concentration, and an increase in cell counts of beneficial microbial genera.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
John C. Mathers
Summary: This paper reviews the progress in research on dietary fibre and human health over the past fifty years. The findings indicate that diets low in dietary fibre are associated with increased risk of common non-communicable diseases. Advances in microbiome research have allowed for better understanding of the associations between dietary fibre, the gut microbiome, and human health. The challenge now lies in determining the characteristics of a healthy gut microbiome and implementing interventions to increase dietary fibre intake.
PROCEEDINGS OF THE NUTRITION SOCIETY
(2023)
Article
Nutrition & Dietetics
Longgang Zhao, Michael D. Wirth, Fanny Petermann-Rocha, Solange Parra-Soto, John C. Mathers, Jill P. Pell, Frederick K. Ho, Carlos A. Celis-Morales, James R. Hebert
Summary: Diet can affect the incidence and severity of COVID-19. Analysis of data from the UK biobank found that higher dietary inflammatory index (DII) scores were associated with an increased risk of COVID-19 and greater disease severity. Approximately one-quarter of the positive associations between DII and COVID-19 outcomes were mediated by body mass index.
Article
Biochemistry & Molecular Biology
F. C. Malcomson, J. C. Mathers
Summary: Personalised and precision nutrition uses individual characteristics and responses to nutrients, foods, and dietary patterns to develop targeted nutritional advice for improving health. This approach is moving away from the 'one size fits all' model and may have potential for better population health and disease prevention. While most efforts have focused on obesity and cardiovascular diseases, there is a need to apply personalised and precision nutrition approaches in cancer prevention and for cancer survivors, taking advantage of the understanding of dietary factors, genetics, and the microbiome.
Review
Oncology
Melina Pelling, Subashini Chandrapalan, Emily West, Ramesh P. Arasaradnam
Summary: Hepatobiliary cancers are difficult to detect early, and current biomarkers lack sensitivity and specificity. Volatile organic compounds (VOCs) have the potential to be an alternative biomarker for the early diagnosis of these cancers. This systematic review shows that VOCs can be used alone or in combination with other biomarkers for the early detection of hepatobiliary and pancreatic cancers.
Review
Medicine, General & Internal
Ian I. Lei, Gohar J. Nia, Elizabeth White, Hagen Wenzek, Santi Segui, Angus J. M. Watson, Anastasios Koulaouzidis, Ramesh P. Arasaradnam
Summary: Artificial intelligence (AI) has gained popularity in healthcare, with colon capsule endoscopy (CCE) being adopted to alleviate the backlog caused by the COVID pandemic. AI-assisted colon capsule video analysis has become a prominent research area, but healthcare professionals face challenges in understanding complex machine learning concepts. This paper aims to bridge the knowledge gap, simplify technical terms, and explore the impact of AI in CCE, while discussing ethical challenges and potential flaws.
Article
Nutrition & Dietetics
Dominic N. Farsi, Jose Lara Gallegos, Tim J. A. Finnigan, William Cheung, Jose Munoz Munoz, Daniel M. Commane
Summary: The study found that replacing red and processed meat with mycoprotein could potentially provide cardiovascular benefits. However, longer trials with higher risk study populations are needed to fully understand its potential benefits for blood pressure and body composition.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Endocrinology & Metabolism
Khalil Elgendy, Fiona C. Malcomson, Sorena Afshar, Michael D. Bradburn, John C. Mathers
Summary: This study was conducted to investigate the effects of weight loss induced by bariatric surgery on DNA methylation in obese patients. The results showed that bariatric surgery reversed DNA methylation in the rectal mucosa to levels similar to those in individuals without obesity. These findings suggest that bariatric surgery can potentially reduce the risk of cancer and other diseases by reversing DNA methylation.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Review
Medicine, General & Internal
Kumar Jayant, Thomas G. Cotter, Isabella Reccia, Francesco Virdis, Mauro Podda, Nikolaos Machairas, Ramesh P. Arasaradnam, Diego Di Sabato, John C. LaMattina, Rolf N. Barth, Piotr Witkowski, John J. Fung
Summary: This study compared the outcomes of high-MELD and low-MELD living-donor liver transplant recipients and found no significant differences in patient survival, graft survival, and most complications between the two groups. However, the high-MELD group had a higher risk of pulmonary infection, abdominal fluid collection, and prolonged ICU stay.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Marie Vibeke Vestergaard, Kristine H. Allin, Carsten Eriksen, Oliwia Zakerska-Banaszak, Ramesh P. Arasaradnam, Mohammad T. Alam, Karsten Kristiansen, Susanne Brix, Tine Jess
Summary: This study re-analyzed fecal microbiota data from 45 cohorts of inflammatory bowel disease (IBD) patients. The analysis identified a large number of genera associated with IBD, providing potential new treatment targets.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
