Letter
Immunology
Himali S. Jayasinghearachchi, Vaithehi R. Francis, Harindra D. Sathkumara, Shivankari Krishnananthasivam, Jayanthi Masakorala, Thilini Muthugama, Aruna D. De Silva, Enoka M. Corea
Summary: A cluster of melioidosis cases occurred in eastern Sri Lanka, with four infections caused by Burkholderia pseudomallei isolates of sequence type 594. Whole-genome analysis revealed genetic diversity among the isolates and showed that the cluster was nonclonal.
EMERGING INFECTIOUS DISEASES
(2021)
Review
Immunology
Vanitha Mariappan, Kumutha Malar Vellasamy, Muttiah Barathan, A. S. Smiline Girija, Esaki M. Shankar, Jamuna Vadivelu
Summary: B. pseudomallei infection causes melioidosis with varying severity, diverse pathological manifestations, complex mechanisms of latency and relapse, and the crucial role of immune response in eradicating the pathogen. However, the question of why some individuals are asymptomatic while others are life-threatening remains unanswered.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Microbiology
Kasturi Selvam, Muhammad Fazli Khalid, Khairul Mohd Fadzli Mustaffa, Azian Harun, Ismail Aziah
Summary: Melioidosis is a severe disease caused by Burkholderia pseudomallei, mainly affecting immunocompromised populations such as patients with type 2 diabetes mellitus. Laboratory diagnosis is challenging due to non-specific clinical manifestations and the imperfect sensitivity of culture methods.
Article
Multidisciplinary Sciences
Sandra Appelt, Anna-Maria Rohleder, Daniela Jacob, Heiner Von Buttlar, Enrico Georgi, Katharina Mueller, Ulrich Wernery, Joerg Kinne, Marina Joseph, Shantymol V. Jose, Holger C. Scholz
Summary: This study developed a core genome-based Multi Locus Sequence Typing Assay (cgMLST) for the typing and identification of the etiological agent of glanders, Burkholderia mallei. The assay has high resolution and can distinguish between strains from different geographic regions and epidemiologically related strains based on allele differences. It is robust and reliable, and can be used for outbreak investigations and epidemiological studies.
Article
Multidisciplinary Sciences
Khemngeun Pongmala, Alain Pierret, Priscia Oliva, Anne Pando, Viengmon Davong, Sayaphet Rattanavong, Norbert Silvera, Manophab Luangraj, Laurie Boithias, Khampaseuth Xayyathip, Ludovic Menjot, Melina Macouin, Emma Rochelle-Newall, Henri Robain, Amphone Vongvixay, Andrew J. H. Simpson, David A. B. Dance, Olivier Ribolzi
Summary: This paper provides novel information about the distribution of Burkholderia pseudomallei in soil and its potential association with soil biogeochemical heterogeneity and vertical distribution. The study highlights the complexity of soil and emphasizes the importance of collecting samples below the water table in environmental sampling for B. pseudomallei.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Yanshuang Wang, Xuemiao Li, David A B Dance, Han Xia, Chen Chen, Nini Luo, Anyang Li, Yanmei Li, Qiao Zhu, Qinghui Sun, Xingyong Wu, Yingfei Zeng, Lin Chen, Shen Tian, Qianfeng Xia
Summary: The study evaluated the clinical potential of Burkholderia pseudomallei phages isolated from Hainan, China, for treating melioidosis. Results showed that the phage exhibited promising lytic properties and stability, significantly improving cell and nematode survival rates.
INFECTIOUS DISEASES OF POVERTY
(2022)
Article
Microbiology
Daniel Tapia, Javier I. Sanchez-Villamil, Heather L. Stevenson, Alfredo G. Torres
Summary: The study introduces an elegant multicomponent glycoconjugate vaccine formulation capable of eliciting both humoral and cell-mediated responses against lethal B. pseudomallei challenge.
Article
Immunology
Quyen T. L. Tran, Phuc H. Phan, Linh N. H. Bui, Ha T. Bui, Ngoc T. B. Hoang, Dien M. Tran, Trung T. Trinh
Summary: Within 8 months, 3 children from 1 family in northern Vietnam died from melioidosis caused by Burkholderia pseudomallei. The same sequence type, 541, was isolated from clinical samples, borehole water, and garden and rice field soil.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Microbiology
Christopher P. P. Klimko, Jennifer L. L. Shoe, Nathaniel O. O. Rill, Melissa Hunter, Jennifer L. L. Dankmeyer, Yuli Talyansky, Lindsey K. K. Schmidt, Caitlyn E. E. Orne, David P. P. Fetterer, Sergei S. S. Biryukov, Mary N. N. Burtnick, Paul J. J. Brett, David DeShazer, Christopher K. K. Cote
Summary: Researchers have found that combining current vaccine strategies and co-trimoxazole regimens can provide near uniform protection against melioidosis. This combinatorial strategy shows significant improvement in several antibiotic regimens and works similarly with both protein subunit and live attenuated vaccines.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Muhammad Shafiq, Bixia Ke, Xin Li, Mi Zeng, Yumeng Yuan, Dongmei He, Xiaoling Deng, Xiaoyang Jiao
Summary: The study identified high genetic diversity among 8 clinical Burkholderia pseudomallei isolates, which were susceptible to commonly used antibiotics for melioidosis treatment. Various antibiotic-resistant genes and mutation factors, as well as 165 virulence factors were discovered, indicating different pathogens responsible for various disorders. Phylogenetic analysis showed diverse strains with implications for disease management.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anna Di Fiore, Viviana De Luca, Emma Langella, Alessio Nocentini, Martina Buonanno, Simona Maria Monti, Claudiu T. Supuran, Clemente Capasso, Giuseppina De Simone
Summary: This paper presents a detailed characterization of BpsyCA, a y-carbonic anhydrase from Burkholderia pseudomallei, highlighting its catalytic activity, crystal structure, and the role of residues in its catalytic mechanism and ligand recognition. These findings provide an important starting point for the development of new anti-melioidosis drugs targeting BpsyCA.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Immunology
Nicole M. Bzdyl, Clare L. Moran, Justine Bendo, Mitali Sarkar-Tyson
Summary: Burkholderia pseudomallei, a soil saprophyte, is responsible for melioidosis, a prevalent disease in Southeast Asia and northern Australia. This review highlights the various mechanisms employed by B. pseudomallei to survive and spread within host cells.
Article
Veterinary Sciences
Himali S. Jayasinghearachchi, Thilini A. Muthugama, Jayanthi Masakorala, Upeksha S. Kulasekara, Kumari Jayaratne, D. A. Dasun N. Jayatunga, Aruna D. De Silva, Enoka M. Corea
Summary: This study provides evidence for the presence of Burkholderia pseudomallei in soil and water in Sri Lanka. It highlights the risk of melioidosis for populations using contaminated water sources and cultivating crops in these areas. Identifying positive sites can help raise public awareness and facilitate remediation efforts.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Infectious Diseases
Cindy Shuan Ju Teh, Polly Soo Xi Yap, Noorfatin Jihan Zulkefli, Prasanna Subramaniam, Pik San Sit, Zhi Xian Kong, Chun Wie Chong, Kumutha Malar Vellasamy, Vanitha Mariappan, Sasheela Ponnampalavanar, Jamuna Vadivelu
Summary: The study conducted MLST analysis on B. pseudomallei strains in Malaysia, revealing a high diversity of sequence types and indicating localized evolution giving rise to new STs, with host and environmental factors playing a crucial role in the evolutionary changes of B. pseudomallei.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Medicine, General & Internal
Noorah Alsowayeh, Aqel Albutti
Summary: This study developed a multi-epitope-based vaccine against Burkholderia pseudomallei using advanced bacterial pan-genome analysis. The constructed vaccine showed a high population coverage of 99.74% and potential binding efficacy with human toll-like receptors-5. Molecular dynamics simulation also suggested a stable immunological response within the host body. This in-silico vaccine design could be valuable for formulating a highly effective vaccine for B. pseudomallei.
FRONTIERS IN MEDICINE
(2022)
Article
Environmental Sciences
Chih-Ching Chang, Pei-Shih Chen, Chun-Yuh Yang
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2015)
Article
Infectious Diseases
Pei-Shih Chen, Yao-Shen Chen, Hsi-Hsun Lin, Pei-Ju Liu, Wei-Fan Ni, Pei-Tan Hsueh, Shih-Hsiung Liang, Chialin Chen, Ya-Lei Chen
PLOS NEGLECTED TROPICAL DISEASES
(2015)
Article
Allergy
Yi-Shan Tsai, Yu-Ting Tseng, Pei-Shih Chen, Meng-Chih Lin, Chao-Chien Wu, Ming-Shyan Huang, Chin-Chou Wang, Kang-Shin Chen, Yuan-Chung Lin, Tsu-Nai Wang
ALLERGY AND ASTHMA PROCEEDINGS
(2016)
Article
Integrative & Complementary Medicine
Ting-Hao Chen, Tao-Hsin Tung, Pei-Shih Chen, Shu-Hui Wang, Chuang-Min Chao, Nan-Hsing Hsiung, Ching-Chi Chi
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2016)
Article
Immunology
Yao-Shen Chen, Hsi-Hsun Lin, Pei-Tan Hsueh, Wei-Fen Ni, Pei-Ju Liu, Pei-Shih Chen, Hsin-Hou Chang, Der-Shan Sun, Ya-Lei Chen
Article
Environmental Sciences
Yen-Hsiung Liao, Pei-Shih Chen, Hui-Fen Chiu, Chun-Yuh Yang
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2013)
Article
Infectious Diseases
Ya-Lei Chen, Yu-Chuan Yen, Chun-Yuh Yang, Min Sheng Lee, Chi-Kung Ho, Kristina D. Mena, Peng-Yau Wang, Pei-Shih Chen
PLOS NEGLECTED TROPICAL DISEASES
(2014)
Article
Environmental Sciences
Yu-Chuan Yen, Chun-Yuh Yang, Kristina Dawn Mena, Yu-Ting Cheng, Chung-Shin Yuan, Pei-Shih Chen
ENVIRONMENTAL POLLUTION
(2019)
Review
Medicine, General & Internal
Chia-Hsien Hsu, Ching-Chi Chi, Pei-Shih Chen, Shu-Hui Wang, Tao-Hsin Tung, Shih-Chung Wu
Article
Environmental Sciences
Chih-Cheng Chen, Pei-Shih Chen, Chun-Yuh Yang
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2019)
Article
Environmental Sciences
Yu-Chuan Yen, Chun-Yuh Yang, Chi-Kung Ho, Pei-Chun Yen, Yu-Ting Cheng, Kristina D. Mena, Tzu-Chi Lee, Pei-Shih Chen
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Chemistry, Multidisciplinary
Yu-Chuan Yen, Chun-Yuh Yang, Kristina Dawn Mena, Yu-Ting Cheng, Pei-Shih Chen
APPLIED SCIENCES-BASEL
(2019)
Article
Environmental Sciences
Yu-Chuan Yen, Chun-Yuh Yang, Tsu-Nai Wang, Pei-Chun Yen, Chi-Kung Ho, Kristina D. Mena, Tzu-Chi Lee, Kang-Shin Chen, Yuan-Chung Lin, Pei-Shih Chen
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Review
Medicine, General & Internal
Jhih-Yuan Lu, Tao-Hsin Tung, Sheng-Ang Shen, Chien Huang, Pei-Shih Chen