Article
Nutrition & Dietetics
Michelle Shardell, Anne R. Cappola, Jack M. Guralnik, Gregory E. Hicks, Stephen B. Kritchevsky, Eleanor M. Simonsick, Luigi Ferrucci, Richard D. Semba, Nancy Chiles Shaffer, Tamara Harris, Gudny Eiriksdottir, Vilmundur Gudnason, Mary Frances Cotch, Eric Orwoll, Kristine E. Ensrud, Peggy M. Cawthon
Summary: This study established and validated sex-specific threshold serum 25(OH)D concentrations for older adults' physical function. The appropriate threshold for women was 24.0 ng/mL, and for men was 21.0 ng/mL. The findings suggest that these thresholds may inform the design of vitamin D intervention trials for older adults.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Anna Zhu, Sabine Kuznia, Tobias Niedermaier, Bernd Holleczek, Ben Schoettker, Hermann Brenner
Summary: This large prospective cohort study in Germany found inverse associations between serum vitamin D-binding protein (VDBP), total bioavailable, complementary non-bioavailable, and free 25-hydroxyvitamin D (25(OH)D) levels and the risk of developing diabetes among non-diabetic older adults. However, associations were smaller and statistically insignificant for bioavailable and free 25(OH)D. The study also highlighted the importance of adequate vitamin D status among individuals without impaired glucose tolerance.
Article
Geriatrics & Gerontology
Jennifer A. Schrack, Yurun Cai, Jacek K. Urbanek, Amal A. Wanigatunga, Christine M. Mitchell, Edgar R. Miller III, Jack M. Guralnik, Stephen P. Juraschek, Erin D. Michos, David L. Roth, Lawrence J. Appel
Summary: This study aimed to assess whether vitamin D-3 supplementation could attenuate the decline in daily physical activity in low-functioning older adults. The results showed that supplementation with 1000 IU/day or higher of vitamin D-3 did not attenuate the decline in physical activity compared to 200 IU/day. Individuals with baseline serum 25(OH)D levels < 20 ng/mL experienced accelerated declines in physical activity.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Nutrition & Dietetics
Avril Beirne, Kevin McCarroll, James Bernard Walsh, Miriam Casey, Eamon Laird, Helene McNulty, Mary Ward, Leane Hoey, Anne M. Molloy, Martin Healy, Catherine Hughes, Sean Strain, Conal Cunningham
Summary: This study found an independent prospective association between vitamin D deficiency and increased hospitalization among older adults. Lower vitamin D concentrations were associated with higher rates of ED attendance and hospital admission, highlighting the potential importance of vitamin D supplementation beyond bone health in this population. Further investigation through randomized controlled trials is needed to evaluate current recommendations regarding vitamin D supplementation.
Review
Biochemistry & Molecular Biology
Nipith Charoenngam, Aunchalee Jaroenlapnopparat, Sofia K. Mettler, Ashna Grover
Summary: The activation of vitamin D receptor (VDR) has beneficial effects on mitigating the susceptibility and severity of COVID-19 infection. Vitamin D-binding protein (DBP) also affects the immune system and may influence inflammation associated with COVID-19. Low levels of serum 25-hydroxyvitamin D have been associated with increased risk and severity of COVID-19 infection. However, the effectiveness of vitamin D supplementation as a treatment for COVID-19 based on randomized clinical trials is still uncertain.
Article
Nutrition & Dietetics
Anna Zhu, Sabine Kuznia, Tobias Niedermaier, Bernd Holleczek, Ben Schoettker, Hermann Brenner
Summary: The study investigated the distributions and determinants of different vitamin D biomarkers in a large cohort of older adults. It found seasonal variations, correlations with age, body mass index, and C-reactive protein, as well as differential impacts of VDBP genotypes on 25(OH)D levels.
Article
Endocrinology & Metabolism
John D. Sluyter, Yoshihiko Raita, Kohei Hasegawa, Ian R. Reid, Robert Scragg, Carlos A. Camargo
Summary: Using machine learning models to predict vitamin D deficiency showed higher accuracy in predicting 25(OH)D <25 nmol/L compared to traditional models, suggesting a potential role for machine learning models in participant selection for vitamin D supplement trials.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Thurayya ALbuloshi, Ahmed M. Kamel, Jeremy P. E. Spencer
Summary: This study examined the factors associated with vitamin D deficiency in older people in Kuwait and found that lack of vitamin D supplements, low sun exposure duration, dark skin pigmentation, and lower caloric intake were risk factors for deficiency. A significant inverse relationship was also found between vitamin D levels and parathyroid hormone levels.
Article
Endocrinology & Metabolism
Jiseon Lee, Hye Won Woo, Jihye Kim, Min-Ho Shin, InSong Koh, Bo Youl Choi, Mi Kyung Kim
Summary: Limited information is available on the inter-relationships between genetic and non-genetic factors on serum 25(OH)D concentration, thus a cross-sectional study was conducted among 2,721 adults to examine these associations. Results showed that season, dietary vitamin D intake, and specific SNPs were independently or interactively associated with serum 25(OH)D concentration. Notably, rs10500804-CYP2R1 was found to interact significantly with season, influencing serum 25(OH)D concentration during high sunlight exposure in summer/fall.
Article
Dentistry, Oral Surgery & Medicine
Masanori Iwasaki, Keiko Motokawa, Maki Shirobe, Misato Hayakawa, Yuki Ohara, Yoshiko Motohashi, Ayako Edahiro, Hisashi Kawai, Yoshinori Fujiwara, Yasuyuki Sakata, Kazushige Ihara, Yutaka Watanabe, Shuichi Obuchi, Hirohiko Hirano
Summary: This study aimed to evaluate the association between vitamin D status and periodontal inflammation in communitydwelling older adults. The results showed a non-linear relationship between serum 25-hydroxyvitamin D (25(OH)D) levels and periodontal inflammation, with low vitamin D levels being associated with a higher risk of periodontal inflammation. This has important implications for the prevention and treatment of periodontal inflammation in older adults.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Nutrition & Dietetics
Vanessa de la Cruz-gongora, Aaron Salinas-Rodriguez, Mario Flores-Aldana, Salvador Villalpando
Summary: Anemia in older adults in Mexico is associated with an inflammatory component, with vitamin A deficiency linked to anemia of inflammation and vitamin D deficiency linked to nutritional deficiencies and anemia of multiple causes.
Article
Nutrition & Dietetics
Orlagh Feehan, David J. Armstrong, Pamela J. Magee, Kirsty L. Pourshahidi, J. J. Strain, Laura Beggan, Diego F. Cobice, Emeir M. McSorley
Summary: This study examined the association between vitamin D status and health outcomes in care home residents in Northern Ireland. The study found a high prevalence of vitamin D deficiency and insufficiency, and higher vitamin D levels were associated with greater supplement use and reduced bone turnover.
Article
Medicine, General & Internal
Anna Zhu, Sabine Kuznia, Tobias Niedermaier, Bernd Holleczek, Ben Schoettker, Hermann Brenner
Summary: This study compared the prognostic values of different vitamin D biomarkers for total and cause-specific mortality in older adults and found that total, nonbioavailable, bioavailable, and free 25(OH)D were all inversely associated with mortality, with the strongest associations seen in participants with low vitamin D levels.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Kazi Lutfar Rahman, Qazi Shamima Akhter, Md Sayedur Rahman, Ridwana Rahman, Samina Rahman (Sami), Farzana Yeasmin Mukta, Sudipta Sarker
Summary: This study aimed to determine the frequency of variants of rs10741657 of CYP2R1 gene and its association with low serum 25(OH)D level among Bangladeshi adults. The presence of 'GG' and 'GA' genotypes of rs1041657 in CYP2R1 gene is associated with low serum 25(OH)D level among Bangladeshi adults in this pilot study.
Article
Nutrition & Dietetics
Ting-Yi Wang, Hung-Wei Wang, Ming-Yan Jiang
Summary: This study investigated the prevalence of vitamin D deficiency and its association with mortality risk among non-institutional middle-aged and older adults in the United States. The results showed that nearly 20% of the study population were vitamin D deficient and vitamin D deficiency was associated with increased mortality risk.
FRONTIERS IN NUTRITION
(2023)
Article
Medicine, General & Internal
Sha Sha, Thi Mai Ngoc Nguyen, Sabine Kuznia, Tobias Niedermaier, Anna Zhu, Hermann Brenner, Ben Schoettker
Summary: A study on the UK Biobank cohort found that the use of vitamin D supplements is associated with lower all-cause mortality and reduced mortality from cancer, cardiovascular disease, and respiratory disease.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Tomotaka Ugai, Naohiko Akimoto, Koichiro Haruki, Tabitha A. Harrison, Yin Cao, Conghui Qu, Andrew T. Chan, Peter T. Campbell, Sonja Berndt, Daniel D. Buchanan, Amanda J. Cross, Brenda Diergaarde, Steven J. Gallinger, Marc J. Gunter, Sophia Harlid, Akihisa Hidaka, Michael Hoffmeister, Hermann Brenner, Jenny Chang-Claude, Li Hsu, Mark A. Jenkins, Yi Lin, Roger L. Milne, Victor Moreno, Polly A. Newcomb, Reiko Nishihara, Mireia Obon-Santacana, Rish K. Pai, Lori C. Sakoda, Robert E. Schoen, Martha L. Slattery, Wei Sun, Efrat L. Amitay, Elizabeth Alwers, Stephen N. Thibodeau, Amanda E. Toland, Bethany Van Guelpen, Syed H. Zaidi, John D. Potter, Jeffrey A. Meyerhardt, Marios Giannakis, Mingyang Song, Jonathan A. Nowak, Ulrike Peters, Amanda Phipps, Shuji Ogino
Summary: This study analyzed 13,101 colorectal cancer cases and found a significant association between tumor location and molecular features. The detailed colonic location and tumor molecular features play an important role in the prognostication and precision medicine of colon cancer.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Thomas Heisser, Jens Kretschmann, Bernd Hagen, Tobias Niedermaier, Michael Hoffmeister, Hermann Brenner
Summary: A study in Germany found that the prevalence of cancer or adenomas at least 10 years after a negative colonoscopy result was low. The extension of the currently recommended 10-year screening intervals may be necessary, especially for female and younger participants without gastrointestinal symptoms.
JAMA INTERNAL MEDICINE
(2023)
Article
Pathology
Elizabeth Alwers, Jakob N. Kather, Matthias Kloor, Alexander Brobeil, Katrin E. Tagscherer, Wilfried Roth, Amelie Echle, Efrat L. Amitay, Jenny Chang-Claude, Hermann Brenner, Michael Hoffmeister
Summary: This study examined and validated the association between an immune cell score similar to the Immunoscore and CRC patient survival as well as established molecular tumor markers. The immune cell score was found to be significantly associated with better patient survival, indicating its potential as a strong prognostic marker.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2023)
Letter
Gastroenterology & Hepatology
Thomas Heisser, Michael Hoffmeister, Hermann Brenner
Article
Oncology
Rafael Cardoso, Michael Hoffmeister, Hermann Brenner
Summary: This study analyzed the key characteristics of breast cancer screening programs and mammography use in European countries. The findings showed significant variations in screening programs and mammography use across different countries, calling for improved utilization of mammography screening across Europe, especially in countries with lower development levels.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Nutrition & Dietetics
Tobias Niedermaier, Thomas Gredner, Michael Hoffmeister, Ute Mons, Hermann Brenner
Summary: Consumption of processed meat is carcinogenic, particularly in relation to colorectal cancer risk, according to the IARC. Reducing intake of processed and red meat in Germany can significantly reduce the incidence of colorectal cancer.
Article
Nutrition & Dietetics
Tafirenyika Gwenzi, Petra Schrotz-King, Ben Schoettker, Michael Hoffmeister, Hermann Brenner
Summary: According to recent evidence, the prognostic value of Vitamin D (VitD) status for colorectal cancer (CRC) patients might be confined to patients with the GG genotype of Cdx2, a functional polymorphism of the VitD receptor gene. In this study, the researchers aimed to validate these findings in a cohort of CRC patients by measuring serum VitD concentration and performing Cdx2 genotyping. The results showed that VitD deficiency is associated with poorer survival, particularly in patients with the GG genotype of Cdx2.
Article
Oncology
Fatemeh Safizadeh, Marko Mandic, Dianne Pulte, Tobias Niedermaier, Michael Hoffmeister, Hermann Brenner
Summary: This study aimed to investigate the association between excess weight and colorectal cancer (CRC) risk, taking into account prediagnostic weight loss. The results showed that the association between overweight/obesity and CRC risk became stronger with longer follow-up duration, and excluding the initial years of follow-up further strengthened the association. Therefore, the impact of excess weight on CRC risk has been underestimated.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Niki Dimou, Andre E. Kim, Orlagh Flanagan, Neil Murphy, Virginia Diez-Obrero, Anna Shcherbina, Elom K. Aglago, Emmanouil Bouras, Peter T. Campbell, Graham Casey, Steven Gallinger, Stephen B. Gruber, Mark A. Jenkins, Yi Lin, Victor Moreno, Edward Ruiz-Narvaez, Mariana C. Stern, Yu Tian, Kostas K. Tsilidis, Volker Arndt, Elizabeth L. Barry, James W. Baurley, Sonja I. Berndt, Stephane Bezieau, Stephanie A. Bien, D. Timothy Bishop, Hermann Brenner, Arif Budiarto, Robert Carreras-Torres, Tjeng Wawan Cenggoro, Andrew T. Chan, Jenny Chang-Claude, Stephen J. Chanock, Xuechen Chen, David V. Conti, Christopher H. Dampier, Matthew Devall, David A. Drew, Jane C. Figueiredo, Graham G. Giles, Andrea Gsur, Tabitha A. Harrison, Akihisa Hidaka, Michael Hoffmeister, Jeroen R. Huyghe, Kristina Jordahl, Eric Kawaguchi, Temitope O. Keku, Susanna C. Larsson, Loic Le Marchand, Juan Pablo Lewinger, Li Li, Bharuno Mahesworo, John Morrison, Polly A. Newcomb, Christina C. Newton, Mireia Obon-Santacana, Jennifer Ose, Rish K. Pai, Julie R. Palmer, Nikos Papadimitriou, Bens Pardamean, Anita R. Peoples, Paul D. P. Pharoah, Elizabeth A. Platz, John D. Potter, Gad Rennert, Peter C. Scacheri, Robert E. Schoen, Yu-Ru Su, Catherine M. Tangen, Stephen N. Thibodeau, Duncan C. Thomas, Cornelia M. Ulrich, Caroline Y. Um, Franzel J. B. van Duijnhoven, Kala Visvanathan, Pavel Vodicka, Ludmila Vodickova, Emily White, Alicja Wolk, Michael O. Woods, Conghui Qu, Anshul Kundaje, Li Hsu, W. James Gauderman, Marc J. Gunter, Ulrike Peters
Summary: Diabetes is a risk factor for colorectal cancer, but the mechanisms and genetic variants affecting this relationship are still unclear. Through genome-wide gene-environment interaction analysis, it was found that variations in insulin signaling gene (SLC30A8) and immune function gene (LRCH1) may modify the association between diabetes and colorectal cancer risk.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Hanla A. Park, Dominic Edelmann, Federico Canzian, Petra Seibold, Tabitha A. Harrison, Xinwei Hua, Qian Shi, Allison Silverman, Axel Benner, Angelica Macauda, Martin Schneider, Richard M. Goldberg, Steven R. Alberts, Michael Hoffmeister, Hermann Brenner, Andrew T. Chan, Ulrike Peters, Polly A. Newcomb, Jenny Chang-Claude
Summary: We conducted the first large-scale genome-wide association study to identify genetic variants that can predict the prognosis of colorectal cancer patients undergoing different chemotherapy treatments. Our analysis revealed specific loci associated with overall survival in stage III colon cancer patients and metastatic colorectal cancer patients. These findings may have significant implications for personalized treatment and improved clinical outcomes.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Melissa S. Y. Thong, Daniela Doege, Linda Weisser, Lena Koch-Gallenkamp, Lina Jansen, Heike Bertram, Andrea Eberle, Bernd Holleczek, Alice Nennecke, Annika Waldmann, Sylke Ruth Zeissig, Hermann Brenner, Volker Arndt
Summary: This study aimed to compare the health-related quality of life (HRQOL) between colorectal cancer (CRC) survivors and non-cancer controls. The results showed that CRC survivors had poorer social functioning but better health status/QOL. They also experienced a higher level of symptom burden, especially diarrhea and constipation, regardless of demographic or clinical factors. HRQOL differed based on factors such as age, sex, cancer type, and having a permanent stoma.
Article
Oncology
Hengjing Li, Xuechen Chen, Michael Hoffmeister, Hermann Brenner
Summary: The incidence of colorectal cancer (CRC) in younger adults is increasing in many countries. This study aimed to evaluate the association of smoking exposure with early-onset CRC (EOCRC) risk and compare it with late-onset CRC (LOCRC). The results showed that smoking is a strong risk factor for both EOCRC and LOCRC.
JNCI CANCER SPECTRUM
(2023)
Review
Oncology
Xianzhe Li, Lara Stassen, Petra Schrotz-King, Zitong Zhao, Rafael Cardoso, Janhavi R. Raut, Megha Bhardwaj, Hermann Brenner
Summary: This systematic review evaluated fecal carcinoembryonic antigen (FCEA) as a biomarker for the noninvasive diagnosis and diagnosis of colorectal cancer (CRC). The study found significant differences in FCEA levels between CRC and control groups, and the diagnostic performance of FCEA was superior to that of serum carcinoembryonic antigen (SCEA), suggesting its potential role as a novel and easily measurable biomarker for the diagnosis of CRC. However, more comprehensive evaluation in screening settings is needed due to limited evidence from clinical studies.
Article
Oncology
Mani Etemad, Foteini Christodoulou, Stefanie Uhlig, Jessica C. Hassel, Petra Schrotz-King, Hermann Brenner, Cornelia M. Ulrich, Karen Bieback, Harald Klueter, Peter Bugert
Summary: This study investigated the effect of platelet activation on CLEC-2 expression and sCLEC-2 plasma level. PDPN significantly increased the aggregation response induced by classical agonists. Stimulation of platelets with ADP or PDPN caused a significant decrease in CLEC-2 on platelets and sCLEC-2 in the plasma. The plasma level of sCLEC-2 was lower in most tumor patients, except for glioblastoma patients who displayed higher levels.