Review
Environmental Sciences
Yifan Hong, Shengde Wu, Guanghui Wei
Summary: Microplastics and nanoplastics have raised concerns regarding their potential toxicity to the reproductive system and their impact on human health. These particles can enter the body through ingestion, inhalation, and skin contact, causing disturbances in the development of reproductive cells and other somatic cells. Furthermore, the synergistic reproductive toxicity of these plastic particles and the contaminants they carry has been observed.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Kate M. Annunziato, Marjorie Marin, Wenle Liang, Sarah M. Conlin, Weipeng Qi, Jeffery Doherty, Jonghwa Lee, John M. Clark, Yeonhwa Park, Alicia R. Timme-Laragy
Summary: The study examined the effects of maternal preconception PFBS exposure on egg and offspring development, finding that early exposure significantly reduced embryo survival and late exposure impacted embryo development with unique patterns between different genotypes. Preconception PFBS exposures altered egg and embryo development, mediated by direct toxicant loading in the eggs, nutrient loading into eggs, and the function of Nrf2a. These findings provide insight into the reproductive and developmental effects of PFBS and identify maternal preconception as a novel critical window of exposure.
Article
Environmental Sciences
Huanliang Liu, Susu Ding, Huipeng Nie, Yue Shi, Wenqing Lai, Xuan Liu, Kang Li, Lei Tian, Zhuge Xi, Bencheng Lin
Summary: This study elucidates the molecular mechanisms of PM2.5 exposure in the male reproductive system, identifying a possible relationship between endoplasmic reticulum stress (ERS), oxidative stress, and reproductive toxicity. It shows that PM2.5 triggers ERS pathway activation and induces DNA damage and apoptosis in testicular cells through oxidative stress. Moreover, high-concentration intermittent inhalation poses greater harm than low-concentration continuous inhalation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Environmental Sciences
Fa-Li Zhang, Li Kong, Ai-Hong Zhao, Wei Ge, Zi-Hui Yan, Lan Li, Massimo De Felici, Wei Shen
Summary: Natural and synthetic environmental estrogens have raised concerns due to their potential deleterious effects on human and animal health, particularly on reproduction, by interfering with the body's estrogens. These estrogens may induce various reproductive dysfunctions, with potential pro-and anti-apoptotic effects in the ovary through diverse signaling pathways. Inflammatory factors, particularly tumor necrosis factor, are suggested to be a major cause of apoptosis induction by environmental estrogens in mammalian ovaries, leading to potential strategies for prevention.
ENVIRONMENTAL RESEARCH
(2021)
Review
Plant Sciences
Alexander Sirotkin
Summary: Curcumin affects female reproductive processes by altering the release and reception of hormones, growth factors, and cytokines, as well as influencing ovarian cell response to these substances and external environmental factors. This suggests its potential for stimulating female reproductive processes and treating various reproductive disorders.
Article
Pharmacology & Pharmacy
Priscila Cunha Nascimento, Maria Karolina Martins Ferreira, Leonardo Oliveira Bittencourt, Paulo Antonio Martins-Junior, Rafael Rodrigues Lima
Summary: This study analyzed the landscape and consequences of maternal methylmercury exposure based on the 100 most-cited papers. The findings showed that non-systematic reviews and cohort studies from Anglo-Saxon countries were the most frequent. Clarkson, Grandjean, and Myers were the authors with higher citation density.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
G. S. Bondy, I. H. C. Curran, L. C. Coady, C. Armstrong, C. Bourque, S. Bugiel, D. Caldwell, K. Kwong, D. E. Lefebvre, C. Maurice, F. Marchetti, P. P. Pantazopoulos, N. Ross, A. M. Gannon
Summary: Continuous dietary exposure to OTA was found to cause post-implantation fetotoxicity in dams and renal and reproductive toxicity in their male and female offspring, leading to delayed puberty, ovarian changes, reduced testosterone levels, and decreased sperm quality.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Reproductive Biology
Alexander V. Sirotkin, Adam Tarko, Zuzana Fabova, Igor Valocky, Saleh Alwasel, Jan Kotwica, Abdel Halim Harrath
Summary: The aim of this in vitro study was to examine the potential effect of functional food plant extracts on mare ovarian cell functions and their response to the environmental contaminant toluene. The study found that toluene reduced cell proliferation, viability, and the release of certain hormones, but not oxytocin. Flaxseed and puncture vine extracts mitigated toluene's harmful effects, while chia extract had no effect. Toluene was able to modify the inhibitory effects of flaxseed and other plant extracts on hormone release. This study provides important insights into the effects of functional food plant extracts and toluene on mare ovarian cell functions.
Article
Environmental Sciences
Alexander V. Sirotkin, Martina Macejkova, Adam Tarko, Zuzana Fabova, Saleh Alwasel, Abdel Halim Harrath
Summary: The study found that xylene suppresses ovarian cell functions, but buckwheat, rooibos, and vitex can mitigate these effects, acting as natural protectors against the adverse effects of xylene on ovarian cells.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Pai Liu, Yeming Zhao, Sheng Wang, Hao Xing, Wen-Fei Dong
Summary: The study found that SiNPs and CdCl2 have synergistic adverse effects on zebrafish ovaries, leading to changes in ovarian structure and function, reduced number of mature oocytes, and malformed offspring. Deep-sequencing analysis indicated that lipid metabolism, estrogen metabolism, and oocyte development processes were significantly affected by the exposure.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Fangfang Di, Danfeng Gao, Lihua Yao, Runjie Zhang, Jin Qiu, Liwen Song
Summary: Polycystic ovary syndrome (PCOS) often coexists with a metabolic disorder, and dysfunction of adipose tissue, especially abdominal adipose tissue, can worsen reproductive and metabolic problems in PCOS patients. The study used LC-MS/MS to analyze adipose samples from PCOS patients, and identified PCOS biomarkers engaged in inflammatory diseases and mitochondrial beta-oxidation. In vitro experiments showed that isoleucine could ameliorate the effects of hyperandrogenism on granulosa cells and related metabolic disorders. GC-MS/MS analysis revealed significantly decreased levels of isoleucine in PCOS patients. The findings suggest that metabolome alterations could be a novel therapeutic target for PCOS treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Book Review
Biochemistry & Molecular Biology
Graziela P. F. Dantas, Fausto S. Ferraz, Lidia M. Andrade, Guilherme M. J. Costa
Summary: The use of nanoscale materials for biomedical applications has raised concerns about their toxic effects on human health. This systematic review focuses on the reproductive toxicity of different types of inorganic nanoparticles in male rodents. The findings indicate that these nanoparticles can cause structural and functional alterations in testicular cells, leading to oxidative stress, apoptosis, and/or necrosis. However, the lack of standardized protocols in the studies results in highly variable outcomes.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Xueting Li, Ce Chen, Mingyue He, Lidong Yu, Renhao Liu, Chunmeng Ma, Yu Zhang, Jianbo Jia, Bingsheng Li, Li Li
Summary: Lead is an important raw material for industrial production, but it poses serious harm to aquatic ecosystems, especially causing spinal malformations in zebrafish embryos, which is mainly attributed to Pb2+-induced endoplasmic reticulum stress and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xiuying Jiang, Xiangning Xu, Bicheng Wang, Ke Song, Jiaqi Zhang, Ye Chen, Ying Tian, Jing Weng, Yuanjing Liang, Wei Ma
Summary: 2-Methoxyestradiol (2-ME2), a metabolite of 17 beta-estradiol, is being studied as an antitumor agent. This study found that while 2-ME2 levels remain stable in the ovaries of aging mice, it declines in the serum. Exposure to 2-ME2 affects the meiotic maturation of mouse oocytes, leading to abnormal spindle structure and chromosome alignment. The study suggests that the impairment of oocyte maturation caused by 2-ME2 exposure is due to mitochondrial imbalance, oxidative stress, and apoptosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Reproductive Biology
Masoumeh Faghani, Sahar Saedi, Korosh Khanaki, Fahimeh Mohammadghasemi
Summary: Co-treatment with Panax Ginseng can protect folliculogenesis in nicotine-treated ovaries by altering the HPG axis, inducing proliferation in ovarian somatic cells, reducing lipid peroxidation, and downregulating apoptotic markers.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Multidisciplinary Sciences
Hye-Youn Kim, Hanyong Jin, Jeehyeon Bae, Hyung-Kyoon Choi
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Miae Won, Yongyang Luo, Dong-Ho Lee, Eunkyoung Shin, Dae-Shik Suh, Tae-Hyoung Kim, Hanyong Jin, Jeehyeon Bae
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Sungjin Jeon, Tae-Il Kim, Hanyong Jin, Uisung Lee, Jeehyeon Bae, Jean Bouffard, Youngmi Kim
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Multidisciplinary Sciences
Hanyong Jin, Boeun Lee, Yongyang Luo, Yuri Choi, Eui-Hwan Choi, Hong Jin, Kee-Beom Kim, Sang Beom Seo, Yong-Hak Kim, Hyung Ho Lee, Keun Pil Kim, Kangseok Lee, Jeehyeon Bae
NATURE COMMUNICATIONS
(2020)
Article
Microbiology
Minho Lee, Minkyung Ryu, Minju Joo, Young-Jin Seo, Jaejin Lee, Hong-Man Kim, Eunkyoung Shin, Ji-Hyun Yeom, Yong-Hak Kim, Jeehyeon Bae, Kangseok Lee
Summary: Recent studies have revealed that pathogenic bacteria with ribonuclease mutations exhibit attenuated virulence, impaired mobility, and decreased proliferation in host cells. This study demonstrates that the coordinated modulation of endoribonuclease activity in Salmonella Typhimurium plays a crucial role in virulence, with RNase G impacting hns mRNA stability to regulate pathogenicity. Under anaerobic conditions, the FNR-mediated transcriptional repression of RNase III and simultaneous induction of RNase G result in rapid degradation of hns mRNA and activation of the SPI-1 T3SS in Salmonella.
Article
Chemistry, Multidisciplinary
Uisung Lee, Tae-Il Kim, Sungjin Jeon, Yongyang Luo, Siyoung Cho, Jeehyeon Bae, Youngmi Kim
Summary: meso-Carboxyl-BODIPY exhibits significant changes in fluorescence in response to small electronic changes during acyl substitution reactions, making it useful for constructing fluorescent probes for specific detection of cysteine and aminopeptidase N in live cancer cells.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Correction
Biochemistry & Molecular Biology
Eunkyoung Shin, Hanyong Jin, Dae-Shik Suh, Yongyang Luo, Hye-Jeong Ha, Tae Heon Kim, Yoonsoo Hahn, Seogang Hyun, Kangseok Lee, Jeehyeon Bae
Letter
Biochemistry & Molecular Biology
Eunkyoung Shin, Hanyong Jin, Dae-Shik Suh, Yongyang Luo, Wooseok Song, Hye-Jeong Ha, Tae Heon Kim, Yoonsoo Hahn, Seogang Hyun, Kangseok Lee, Jeehyeon Bae
Article
Oncology
Yongyang Luo, Hanyong Jin, Je Hyeong Kim, Jeehyeon Bae
Summary: The study reveals that GBPs induce apoptosis in CML and AML cells by interacting with MCL-1, upregulating BAK expression, and affecting the PI3K/AKT pathway. Knockout of GBP2 compromises paclitaxel-induced apoptosis in CML cells. Bioinformatics analyses show that downregulated GBP transcripts are favorable prognostic markers in leukemia patients.
Article
Oncology
Heayyean Lee, Hwanhui Lee, Sujeong Park, Myeongsun Kim, Ji Young Park, Hanyong Jin, Kyungsoo Oh, Jeehyeon Bae, Young Yang, Hyung-Kyoon Choi
Summary: This study conducted metabolomic and lipidomic profiling of lung SQCC to predict its metastatic potential and suggest potential therapeutic targets, identifying characteristic metabolites and intact lipid species associated with lung SQCC metastatic potential. The findings offer valuable insights for the inhibition of lung SQCC metastasis and may lead to the development of potential biomarkers and therapeutic strategies for NSCLC.
Article
Biochemistry & Molecular Biology
Haifeng Liu, Hanyong Jin, Guenhwi Kim, Jeehyeon Bae
Summary: This study demonstrates that BPA at very low concentrations can increase expression of FOXL2, leading to enhanced levels of CYP19A1 and production of estradiol in human ovarian granulosa cells. The molecular signaling cascade involving BPA-CTNNB1-FOXL2-CYP19A1-E2 contributes to the endocrine-disrupting activities of BPA in human ovarian granulosa cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Microbiology
Jaeyeong Park, Eunkyoung Shin, Ji-Hyun Yeom, Younkyung Choi, Minju Joo, Minho Lee, Je Hyeong Kim, Jeehyeon Bae, Kangseok Lee
Summary: This study demonstrates that AuNP-Apt loaded with Lys AB2 P3-His can effectively inhibit Acinetobacter baumannii infection in mice, leading to increased survival.
JOURNAL OF MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuri Choi, Yongyang Luo, Seunghwa Lee, Hanyong Jin, Hye-Jin Yoon, Yoonsoo Hahn, Jeehyeon Bae, Hyung Ho Lee
Summary: This study reveals the cooperative binding of FOX family proteins to the TP53 promoter, which regulates the transcription activity of p53 tumor suppressor. The findings also show distinct dimerization patterns of FOXA1 and FOXL2 in recognition of p53-DNA.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Microbiology
Jaemin Lee, Minkyung Ryu, Dayeong Bae, Hong-Man Kim, Seong-il Eyun, Jeehyeon Bae, Kangseok Lee
Summary: Aptamers are short single-stranded DNA or RNA oligonucleotides that can bind to target molecules with high affinity and specificity. They are widely used in the biomedical field due to their durability and ease of synthesis. Researchers have developed a modified SELEX method that efficiently produces high yields of aptamers, allowing for the selection of an aptamer that specifically binds to an antimicrobial peptide. This method holds potential for the development of therapeutic agents utilizing small therapeutic peptides.
JOURNAL OF MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eunkyoung Shin, Hanyong Jin, Dae-Shik Suh, Yongyang Luo, Hye-Jeong Ha, Tae Heon Kim, Yoonsoo Hahn, Seogang Hyun, Kangseok Lee, Jeehyeon Bae