4.6 Article

Toxic effects of perinatal arsenic exposure on the brain of developing rats and the beneficial role of natural antioxidants

Journal

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 36, Issue 1, Pages 73-79

Publisher

ELSEVIER
DOI: 10.1016/j.etap.2013.03.018

Keywords

Brain; Arsenic; Antioxidants; Zinc; Oxidative stress

Ask authors/readers for more resources

The aim of this study was to determine what changes in biochemical parameters and in the antioxidant capacity occur in the brain of arsenic-exposed rats (50 mg As/L in drinking water) and investigate the protective effect of antioxidants as Zn, vitamin C and vitamin E during pregnancy and lactation. After arsenic-exposure, alkaline phosphatase (ALP) activity was enhanced in arsenic group, returning to normal levels in the arsenic + antioxidants one. A significant increase of acetylcholinesterase (AChE) activity was noted in both arsenic groups. Metalloide exposure caused a significant increase in lipid peroxidation (TSARS), whereas antioxidant administration reversed it. Catalase (CAT) activity in arsenic groups was increased, but no changes were found in the other groups. No significant effect of arsenic in superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and reduced glutathione concentration (GSH) was noted. This study provides evidence of the deleterious effect of arsenic exposure during gestation and lactation and the beneficial role of antioxidants. (C) 2013 Elsevier B.V. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Multidisciplinary Sciences

Prevalence and Genetic Diversity of Avipoxvirus in House Sparrows in Spain

Jorge Ruiz-Martinez, Martina Ferraguti, Jordi Figuerola, Josue Martinez-de la Puente, Richard Alexander John Williams, Amparo Herrera-Duenas, Jose Ignacio Aguirre, Ramon Soriguer, Clara Escudero, Michael Andre Jean Moens, Javier Perez-Tris, Laura Benitez

PLOS ONE (2016)

Article Physiology

Oxidative Challenges of Avian Migration: A Comparative Field Study on a Partial Migrant

Cas Eikenaar, Emma Kallstig, Martin N. Andersson, Amparo Herrera-Duenas, Caroline Isaksson

PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY (2017)

Article Biology

Urban blackbirds have shorter telomeres

Juan Diego Ibanez-Alamo, Javier Pineda-Pampliega, Robert L. Thomson, Jose I. Aguirre, Alazne Diez-Fernandez, Bruno Faivre, Jordi Figuerola, Simon Verhulst

BIOLOGY LETTERS (2018)

Article Environmental Sciences

Oxidative stress in birds along a NOx and urbanisation gradient: An interspecific approach

Pablo Salmon, Emilie Stroh, Amparo Herrera-Duenas, Maria von Post, Caroline Isaksson

SCIENCE OF THE TOTAL ENVIRONMENT (2018)

Article Biodiversity Conservation

Oxidative stress of House Sparrow as bioindicator of urban pollution

Amparo Herrera-Duenas, Javier Pineda, Maria Teresa Antonio, Jose I. Aguirre

ECOLOGICAL INDICATORS (2014)

Article Environmental Sciences

Effect of β-N-methylamino-L-alanine on oxidative stress of liver and kidney in rat

Estefania de Munck, Emma Munoz-Saez, Maria Teresa Antonio, Javier Pineda, Amparo Herrera, Begona G. Miguel, Rosa Maria Arahuetes

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2013)

Article Pathology

Hematological effects of arsenic in rats after subchronical exposure during pregnancy and lactation: The protective role of antioxidants

Maria Teresa Antonio Garcia, Amparo Herrera Duenas, Javier Pineda Pampliega

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY (2013)

Article Biology

Antioxidant supplementation slows telomere shortening in free-living white stork chicks

Javier Pineda-Pampliega, Amparo Herrera-Duenas, Ellis Mulder, Jose Aguirre, Ursula Hofle, Simon Verhulst

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2020)

Article Microbiology

Foraging at Solid Urban Waste Disposal Sites as Risk Factor for Cephalosporin and Colistin ResistantEscherichia coliCarriage in White Storks (Ciconia ciconia)

Ursula Hofle, Juan Jose Gonzalez-Lopez, Maria Cruz Camacho, Marc Sola-Gines, Albert Moreno-Mingorance, Jose Manuel Hernandez, Javier De la Puente, Javier Pineda-Pampliega, Jose Ignacio Aguirre, Fernando Torres-Medina, Antoni Ramis, Natalia Majo, Julio Blas, Lourdes Migura-Garcia

FRONTIERS IN MICROBIOLOGY (2020)

Article Environmental Sciences

A multidisciplinary approach to the evaluation of the effects of foraging on landfills on white stork nestlings

Javier Pineda-Pampliega, Yolanda Ramiro, Amparo Herrera-Duenas, Monica Martinez-Haro, Jose Manuel Hernandez, Jose Aguirre, Ursula Hoefle

Summary: Nestlings fed with a higher proportion of food from landfills show better nutritional status and body condition, with potential negative effects including higher percentage of methaemoglobin in the blood and the presence of antibiotic-resistant Escherichia coli.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Ecology

The Influence of Urban Environments on Oxidative Stress Balance: A Case Study on the House Sparrow in the Iberian Peninsula

Amparo Herrera-Duenas, Javier Pineda-Pampliega, Maria T. Antonio-Garcia, Jose I. Aguirre

FRONTIERS IN ECOLOGY AND EVOLUTION (2017)

No Data Available