Article
Pharmacology & Pharmacy
Mengqi Qin, Cynthia Yu-Wai-Man
Summary: Glaucoma is a chronic neurodegenerative disease that affects 1% of the world's population, characterized by the loss of retinal ganglion cells and visual field defects. Elevated intraocular pressure (IOP) is a major risk factor and a therapeutic target for hypertensive glaucoma. Fibrosis, characterized by excessive deposition of extracellular matrix components and myofibroblasts, can impair trabecular meshwork (TM) function and contribute to the pathogenesis of glaucoma. This paper provides an overview of current anti-fibrotic therapeutics targeting the TM, including their mechanisms, efficacy, and research progress.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Physiology
Yu-long Bao, Li Wang, Hai-ting Pan, Tai-ran Zhang, Ya-hong Chen, Shan-jing Xu, Xin-li Mao, Shao-wei Li
Summary: Liver fibrosis is a crucial process in chronic liver disease progression, with significant impact on prognosis. Research on liver fibrosis involves assessing different models and characteristics, providing essential insights into disease mechanisms and therapeutic approaches.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Haiyan Zhang, Linxue Yang, Qianqian Han, Wei Xu
Summary: Quercetin inhibits proliferation and fibrotic changes in vocal fold fibroblasts, and has an anti-fibrotic effect after vocal fold injuries.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Food Science & Technology
Ivonne Peugnet-Gonzalez, Sandra Luz Martinez-Hernandez, Manuel Enrique Avila-Blanco, David Alejandro Hernandez-Marin, Jose Roberto Macias-Perez, Liseth Rubi Aldaba-Muruato, Teodulo Quezada-Tristan, Joaquin Sosa-Ramirez, Gloria Stephanie Villa-Jaimes, Javier Ventura-Juarez, Martin Munoz-Ortega, David Ibarra-Martinez
Summary: The study found that watercress extract can prevent liver fibrosis induced by CCl4 through its antioxidant and hepatoprotective effects. Watercress extract can improve steatosis and fibrosis, increase IL-10 expression, and regulate the expression of fibrogenic markers.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Oncology
Rong Qiu, Soichiro Murata, Chao Cheng, Akihiro Mori, Yunzhong Nie, Satoshi Mikami, Shunsuke Hasegawa, Tomomi Tadokoro, Satoshi Okamoto, Hideki Taniguchi
Summary: This study aims to develop a new method to generate an HCC mouse model with human tumors and imitates the tumor microenvironment of clinical patients. By generating human HCC organoids in vitro and implanting them into immune-deficient mice, the study successfully introduced controllable tumor microenvironments and studied their roles in HCC tumor growth. The results showed the importance of immune response in slowing down tumor growth at an early stage, providing insights for studying HCC development and developing new treatment options.
Article
Biochemistry & Molecular Biology
Qi Tan, Patrick A. Link, Jeffrey A. Meridew, Tho X. Pham, Nunzia Caporarello, Giovanni Ligresti, Daniel J. Tschumperlin
Summary: Fibroblast activation is transient in successful wound repair but persistent in fibrotic pathologies; understanding fibroblast deactivation in successful wound healing may provide new therapeutic approaches; RNA sequencing analysis combined with cell culture experiments offers insights into novel regulators of fibroblast deactivation in lung fibrosis resolution.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Tongqi Qian, Naoto Fujiwara, Bhuvaneswari Koneru, Atsushi Ono, Naoto Kubota, Arun K. Jajoriya, Matthew G. Tung, Emilie Crouchet, Won-Min Song, Cesia Ammi Marquez, Gayatri Panda, Ayaka Hoshida, Indu Raman, Quan-Zhen Li, Cheryl Lewis, Adam Yopp, Nicole E. Rich, Amit G. Singal, Shigeki Nakagawa, Nicolas Goossens, Takaaki Higashi, Anna P. Koh, C. Billie Bian, Hiroki Hoshida, Parissa Tabrizian, Ganesh Gunasekaran, Sander Florman, Myron E. Schwarz, Spiros P. Hiotis, Takashi Nakahara, Hiroshi Aikata, Eisuke Murakami, Toru Beppu, Hideo Baba, Rew Warren, Sangeeta Bhatia, Masahiro Kobayashi, Hiromitsu Kumada, Austin J. Fobar, Neehar D. Parikh, Jorge A. Marrero, Steve Hategekimana Rwema, Venugopalan Nair, Manishkumar Patel, Seunghee Kim-Schulze, Kathleen Corey, Jacqueline G. O'Leary, Goran B. Klintmalm, David L. Thomas, Mohammed Dibas, Gerardo Rodriguez, Bin Zhang, Scott L. Friedman, Thomas F. Baumert, Bryan C. Fuchs, Kazuaki Chayama, Shijia Zhu, Raymond T. Chung, Yujin Hoshida
Summary: This study developed a surrogate biomarker to predict liver fibrosis progression and evaluated the effectiveness of antifibrotic drugs. Results showed that a 20-gene surrogate biomarker could accurately predict fibrosis progression within 5 years. Furthermore, rational combination therapies based on epigallocatechin gallate were identified and validated for enhanced antifibrotic effect. This biomarker has potential clinical significance for the development of antifibrotics.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ella Wilczynski, Efrat Sasson, Uzi Eliav, Gil Navon, Uri Nevo
Summary: This study investigates the microstructural changes in liver disease using quantitative MRI. The MEX sequence and its derived macromolecular fraction are found to be correlated with collagen deposition and inflammation. This research is significant for liver fibrosis models.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Nanoscience & Nanotechnology
Rong Liu, Min Zhu, Jiaojiao Chen, Junwei Gai, Jing Huang, Yingqun Zhou, Yakun Wan, Chuantao Tu
Summary: In this study, a novel nanobody (Nb) against human connective tissue growth factor (CTGF) was identified, which showed antifibrotic effects in vitro by regulating the biological functions of human stellate cells. This study is of great importance for the development of antifibrotic therapies for liver fibrosis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Cell Biology
Elena G. Varlamova, Michail Victorovich Goltyaev, Vladimir Vladimirovich Rogachev, Sergey V. Gudkov, Elena V. Karaduleva, Egor A. Turovsky
Summary: For the first time, this study proposes key markers of endoplasmic reticulum stress and molecular mechanisms for the regulation of fibrosis and accompanying negative processes caused by thioacetamide injections and subsequent injections of selenium-containing nanoparticles and sorafenib. Selenium nanoparticles, both with and without sorafenib, significantly decrease the expression of pro-fibrotic and pro-inflammatory genes. Sorafenib injections also reduce the expression of these genes, but less effectively than selenium nanoparticles. Additionally, this study shows for the first time that thioacetamide can induce endoplasmic reticulum stress and activate apoptotic and pyroptotic pathways. Selenium-containing nanoparticles mitigate the negative effects caused by thioacetamide and activate an adaptive response through the PERK signaling pathway. The advantages of selenium-containing nanoparticles over sorafenib are emphasized as an important factor for the further development of clinical drugs based on selenium.
Article
Cell & Tissue Engineering
Hiroshi Takahashi, Taku Nakashima, Takeshi Masuda, Masashi Namba, Shinjiro Sakamoto, Kakuhiro Yamaguchi, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
Summary: The study reveals that lung-resident ALDH(br) cells play a crucial role in pulmonary fibrosis, as transferring these cells can ameliorate fibrosis and the decrease in ALDH(br) cells is more significant in aged mice.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Chemistry, Medicinal
Dimitrios Triantafyllos Gerokonstantis, Christiana Mantzourani, Dimitrios Gkikas, Kai-Chen Wu, Huy N. Hoang, Ierasia Triandafillidi, Ilianna Barbayianni, Paraskevi Kanellopoulou, Alexandros C. Kokotos, Panagiota Moutevelis-Minakakis, Vassilis Aidinis, Panagiotis K. Politis, David P. Fairlie, George Kokotos
Summary: Benzamides, as HDAC inhibitors, have shown promising anticancer activity and potential for treating fibrotic disorders.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Diana M. Lindquist, Elizabeth M. Fugate, Jiang Wang, Akanksha Sharma, Chandrashekhar R. Gandhi, Jonathan R. Dillman
Summary: The study demonstrated that Amide Proton Transfer (APT) and Tissue Sodium Concentration (TSC) correlate with fibrosis in a mouse model of chronic liver disease, suggesting potential clinical applications.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Respiratory System
Joy Zhao, Joseph Fares, Gautam George, Arlene Maheu, Giorgos Loizidis, Jesse Roman, Daniel Kramer, Michael Li, Ross Summer
Summary: This study found that Black IPF patients had lower antifibrotic use compared to White, Hispanic, and Asian patients. Additionally, mortality was lower in White patients on antifibrotic therapy. These findings suggest the need for urgent action to understand racial disparities in the treatment of IPF.
Article
Pharmacology & Pharmacy
Lu Cheng, Dan Wang, Bochuan Deng, Jieru Li, Jiao Zhang, Xiaomin Guo, Tiantian Yan, Xin Yue, Yingying An, Bangzhi Zhang, Junqiu Xie
Summary: Pulmonary fibrosis (PF) is an interstitial lung disease with a poor prognosis and lacks an ideal clinical treatment strategy. Researchers have discovered that the antioxidant peptide DR8, extracted and purified from rapeseed, can alleviate PF. They have synthesized a DR8 analog called DR7dA, which demonstrated superior anti-fibrotic activity compared to DR8. Additionally, DR7dA attenuated PF by inhibiting extracellular matrix deposition and oxidative stress through the blockade of the MAPK pathway.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2022)
